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See detailEarly developmental actions of endocrine disruptors on the hypothalamus, hippocampus, and cerebral cortex.
Parent, Anne-Simone ULg; Naveau, Elise ULg; GERARD, Arlette ULg et al

in Journal of Toxicology and Environmental Health. Part B, Critical Reviews (2011), 14(5-7), 328-45

Sex steroids and thyroid hormones play a key role in the development of the central nervous system. The critical role of these hormonal systems may explain the sensitivity of the hypothalamus, the ... [more ▼]

Sex steroids and thyroid hormones play a key role in the development of the central nervous system. The critical role of these hormonal systems may explain the sensitivity of the hypothalamus, the cerebral cortex, and the hippocampus to endocrine-disrupting chemicals (EDC). This review examines the evidence for endocrine disruption of glial-neuronal functions in the hypothalamus, hippocampus, and cerebral cortex. Focus was placed on two well-studied EDC, the insecticide dichlorodiphenyltrichloroethane (DDT) and polychlorinated biphenyls (PCB). DDT is involved in neuroendocrine disruption of the reproductive axis, whereas polychlorinated biphenyls (PCB) interact with both the thyroid hormone- and sex steroid-dependent systems and disturb the neuroendocrine control of reproduction and development of hippocampus and cortex. These results highlight the impact of EDC on the developing nervous system and the need for more research in this area. [less ▲]

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See detailAn Early Devonian flora, including Cooksonia from the Paraná Basin (Brazil)
Gerrienne, Philippe ULg; Bergamaschi, S.; Pereira, E. et al

in Review of Palaeobotany and Palynology (2001), 116

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See detailThe Early Devonian plants from the Ancenis Basin (Armorican Massif, France): one century later...
Strullu-Derrien, Marie-Christine; Gerrienne, Philippe ULg

Conference (2008)

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See detailEarly diagnosis of myocardial infarction by measuring the tissue isoform of CK-MB in serum
Chapelle, Jean-Paul ULg

in Annales de Biologie Clinique (1993), 51

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See detailEarly diagnosis of myocardial infarction using a new automated immunoassay for serum myoglobin
Chapelle, Jean-Paul ULg; El Allaf, Dia ULg

in European Heart Journal Supplements : Journal of the European Society of Cardiology (1993), 14(Abs. suppl.), 32

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See detailEarly Earth biosphere and possible spectral biosignatures in atmospheres of exoplanets
Riaud, Pierre; Javaux, Emmanuelle ULg

Conference (2005)

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See detailEarly Earth, extremophiles and Exobiology
Javaux, Emmanuelle ULg

Conference (2005)

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See detailEarly effect of hyaluronic acid intra-articular injections on serum and urine biomarkers in patients with knee osteoarthritis: An open-label observational prospective study.
Conrozier, T.; Balblanc, J. C.; Richette, P. et al

in Journal of Orthopaedic Research (2011)

The aim of the study was to investigate the effect of hyaluronic acid (HA) intra articular injections (IA) on osteoarthritis (OA) biomarkers in patients with knee OA. Prospective open label study. Fifty ... [more ▼]

The aim of the study was to investigate the effect of hyaluronic acid (HA) intra articular injections (IA) on osteoarthritis (OA) biomarkers in patients with knee OA. Prospective open label study. Fifty-one patients with unilateral symptomatic K-OA received IA injections of 2mL of HA on days (D) 1, 7, 14 and were followed 3 months. At D-15 patients were examined and X-rays performed, to exclude patients with bilateral K-OA, or those with more than three symptomatic OA joints. From 15 days (D-15) before the first injection to D90 concomitant therapies were unchanged. Walking pain (WP) on VAS was obtained at each visit. Urine (U) and serum (S) samples were obtained at D-15, D1, D30, and D90. S-C2C, S-Cartilage oligomeric matrix protein, S-HA, S-CS 846 epitope, S-type II collagen propeptide, and U-type II collagen C telopeptide (U-CTX II/creatinin) were assayed. Predictive factors of response were analyzed using logistic regression. Correlations between variables were obtained using Spearman test. Forty-five patients were analyzed. Between D-15 and D1 there was no difference for any biomarkers At D1, WP (SD) was correlated with U-CTX II/creat (p = 0.006). Between D1 and D90: U-CTX II/creat decreased significantly. After adjustment for confounding variables there was a significant correlation between clinical response and U-CTX II/creat variation. U-CTX II and S-HA at baseline were independently predictive of clinical response. This study showed that 90 days after HA IA injections, U-CTX II levels significantly decrease compared to baseline, suggesting a slowdown of type II collagen degradation. (c) 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res. [less ▲]

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See detailEarly effect of strontium ranelate on clinical vertebral fractures in women with postmenopausal osteoporosis
Meunier, P. J.; Marquis, P.; Lemmel, E. M. et al

in BONE (2003), 32(S7), 222

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See detailThe early eukaryote fossil record
Javaux, Emmanuelle ULg

in Jékely, Gáspár (Ed.) Evolution of the Eukaryotic Endomembrane System and Cytoskeleton (2006)

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See detailEarly eukaryotes in Paleoproterozoic and Mesoproterozoic oceans
Javaux, Emmanuelle ULg; Marshall, C.; Xiao, S. et al

Poster (2004)

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See detailEarly eukaryotic diversification
Javaux, Emmanuelle ULg; knoll, A. H.; Walter, M.

Conference (2002)

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See detailThe early eukaryotic fossa record
Javaux, Emmanuelle ULg

in Advances in Experimental Medicine and Biology (2007), 607

The Precambrian era records the evolution of the domain Eucarya. Although the taxonomy of fossils is often impossible to resolve beyond the level of domain, their morphology and chemistry indicate the ... [more ▼]

The Precambrian era records the evolution of the domain Eucarya. Although the taxonomy of fossils is often impossible to resolve beyond the level of domain, their morphology and chemistry indicate the evolution of major biological innovations. The late Archean record for eukaryotes is limited to trace amounts of biomarkers. Morphological evidence appears in late Paleoproterozoic and early Mesoproterozoic (1800-1300 Ma) rocks. The moderate diversity of preservable eukaryotic organisms includes cell walls without surface ornament (but with complex ultrastructure), with regularly distributed surface ornamentation, and with irregularly or regularly arranged processes. Collectively, these fossils suggest that eukaryotes with flexible membranes and cytoskeletons existed in mid-Proterozoic oceans. The late Mesoproterozoic-early Neoproterozoic (1300-750 Ma) is a time of diversification and evolution when direct evidence for important biological innovations occurs in the fossil record such as multicellularity, sex, photosynthesis, biomineralization, predation, and heterotrophy. Members of extant clades can be recognized and include bangiophyte red algae, xanthophyte algae, cladophorale green algae, euglyphid, lobose, and filose amoebae and possible fungi. In the late Neoproterozoic, besides more diversification of ornamented fossils, florideophyte red algae and brown algae diversify, and animals take the stage. The record of biological innovations documented by the fossils shows that eukaryotes had evolved most cytological and molecular complexities very early in the Proterozoic but environmental conditions delayed their diversification within clades until oxygen level and predation pressure increased significantly. [less ▲]

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See detailEarly Evidence of Complexity in Lithic Economy: Core-axe Production, Hafting and Use at Late Middle Pleistocene site 8-B-11, Sai Island (Sudan)
Rots, Veerle ULg; Van Peer, Philip

in Journal of Archaeological Science (2006), 33(3), 360-371

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See detailEarly evolution of large microorganisms with cytological complexity revealed by microanalyses of 3.4 Ga organic-walled microfossils.
Sugitani; Mimura, K; Takeuchi, M et al

in Geobiology (2015)

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