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See detail3-Alkylamino-7-halogeno-4H-1,2,4-benzothiadiazine 1,1-dioxides as new potent KATP channels activators
De Tullio, Pascal ULg; Somers, F.; Boverie, S. et al

in European Journal of Pharmaceutical Sciences (1998), suppl.1

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See detail3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potent KATP-channel activators: structural study and influence of stereochemistry
De Tullio, Pascal ULg; Khelili, S.; Ouedraogo, R. et al

in Pharmacy and Pharmacology Communications (1999), 5

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See detail3-Amino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Boverie, S. et al

in Acta Crystallographica (2001), E57

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See detail3-Benzamido-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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See detail3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo
Kempen, I.; Papapostolou, D.; Thierry, N. et al

in British Journal of Cancer (2003), 88(7), 1111-1118

In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important ... [more ▼]

In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate, Both drugs were able to inhibit cell invasion markedly in a Boyden chamber assay, the bromo derivative being more potent than the reference matrix metalloprotease (MMP) inhibitor GI 129471. In vivo, tumour growth was reduced when nude mice grafted with HT 1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative. These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9. The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents. [less ▲]

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See detail3-D cinéma : Quelques reliefs du discours du cinéma total
Tomasovic, Dick ULg

Conference (2012, March 21)

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See detail3-D Cinéma: Quelques reliefs du discours du "cinéma total"
Tomasovic, Dick ULg

in Federici, Francesco; Saba, Cosetta (Eds.) Cinéma : immersivité, surface, exposition (2013)

Dans un livre peu connu publié en 1944, René Barjavel imagine dans le futur un cinéma en relief. L’expression « cinéma total » utilisée alors par l’écrivain français désigne un cinéma apte à faire exister ... [more ▼]

Dans un livre peu connu publié en 1944, René Barjavel imagine dans le futur un cinéma en relief. L’expression « cinéma total » utilisée alors par l’écrivain français désigne un cinéma apte à faire exister comme par magie un monde imaginaire dans lequel serait totalement immergé le spectateur. Partant de ce texte, l'article interroge l'idéologie et l'esthétique contemporaine des récents films en 3D. [less ▲]

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See detail3-D conformal photon boost in the treatment of early stage breast cancer: four year follow up results.
Kovacs; LAKOSI, Ferenc ULg; Liposits et al

in Pathology Oncology Research (2011), 17(1), 17-23

In the treatment of early stage breast cancer, breast conserving surgery (BCS) followed by whole breast irradiation (WBI) is the standard treatment. The impact of the tumor bed boost following WBI is well ... [more ▼]

In the treatment of early stage breast cancer, breast conserving surgery (BCS) followed by whole breast irradiation (WBI) is the standard treatment. The impact of the tumor bed boost following WBI is well-defined, but there are various delivery methods. In this study we demonstrate our 4 year experience with the 3-D conformal boost technique. Between January 2004 and June 2005, 77 early stage (Stage I-II) breast cancer patients were treated in our institute with whole breast irradiation (WBI, 50.4 Gy in 28 fractions) after breast conserving surgery. Following WBI, 3-D conformal photon boost was delivered (10-16 Gy in five to eight fractions) for all patients. The clinical outcome was retrospectively recorded in terms of survival and local control. The side effect profile (fibrosis, fat necrosis and cosmetic outcome) was also recorded and studied. In our patient group the mean follow up time was 46.8 months (median: 52, range: 17-71, SD: 14.4) The 4-year probability of local tumor control was 96% (crude rate: 74/77-96.1%), the 4-year probability of overall survival was 96% (crude rate: 74/77-96.1%) in this patient group. In case of the distant metastasis free survival the probability was 89, 5% (crude rate: 70/77-90, 1%). Probability of disease specific survival was 98% (crude rate: 76/77-98. 7%). Local relapse occurred in three cases (3.9%). In ten cases (12.9%) asymptomatic grade I-II breast fibrosis, in eight cases (10.4%) asymptomatic breast fat necrosis were registered. For 14 patients (18.2%) asymptomatic lung fibrosis was recorded on the control CT scans. In term of the relapse free survival, the close resection margin and the nodal positivity resulted in significant difference in favor of the clear resection margin group and the node negative group. In this study the 3-D conformal photon boost resulted in good local control and side effect profile. The presence of tumor bed clips resulted in significantly lower boost PTV volumes, but no correlation was found between the irradiated boost volume and the breast fibrosis. In the relapse free survival analysis, nodal negativity and clear margin status resulted in significantly better RFS. [less ▲]

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See detailThe 3-D extent of the Io UV footprint on Jupiter
Bonfond, Bertrand ULg

in Journal of Geophysical Research. Space Physics (2010), 115

The Io footprint (IFP) is the auroral signature of the electromagnetic interaction between Io and Jupiter's magnetosphere. It consists of several spots followed by an extended tail, which are located ... [more ▼]

The Io footprint (IFP) is the auroral signature of the electromagnetic interaction between Io and Jupiter's magnetosphere. It consists of several spots followed by an extended tail, which are located close to the feet of the magnetic field lines connecting Io to Jupiter. The size of the main spot is a controversial issue, and previously published values range from ~400 to ~8000 km. However, this question is crucial to understand the processes at play, since this quantity is expected to reflect the size of the interaction region at Io. The present study provides estimates of the size of the Io footprint on a much larger image sample than before, paying a particular attention to the differentiation of the spots and to their 3-D structure. The length of the Main Alfven Wing (MAW) spot and the length of the trans-hemispheric electron beam (TEB) spot along the footpath are similar to 850 km, while their width perpendicular to the footpath is < 200 km. Larger lengths are sometimes observed, but these configurations may be attributed to the overlaps of the different spots. The spot lengths are larger than the projected diameter of Io along unperturbed magnetic field lines, which is consistent with recent simulations. The narrowness of the IFP will need to be carefully accounted for in future studies of its brightness. Additionally, the peak altitudes of the MAW and the TEB spot are as high as 900 and 700 km, respectively, which seem to confirm their different origins. [less ▲]

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