Diagnosis and clinical interest of asthma inflammatory phenotypes
Doctoral thesis (2014)Detailed reference viewed: 35 (5 ULg)
Diagnosis and follow-up of monoclonal gammopathies of undetermined significance; information for referring physicians.
CAERS, Jo ; ; et al
in Annals of Medicine (2013), 45
The prevalence of monoclonal gammopathy of undetermined significance (MGUS) is generally estimated at 3.4% in the general population over 50 years, and its incidence increases with age. MGUS represents a ... [more ▼]
The prevalence of monoclonal gammopathy of undetermined significance (MGUS) is generally estimated at 3.4% in the general population over 50 years, and its incidence increases with age. MGUS represents a preneoplastic entity that can transform into multiple myeloma or other lymphoproliferative disorders. The risk of malignant transformation is estimated at 1% per year and persists over time. Predictors of malignant transformation have been identified such as the heavy chain isotype, the monoclonal component level, increasing levels of M-protein during the first years of follow-up, bone marrow plasmocytosis, dosage of serum free light chains, the presence of immunophenotypic abnormal plasma cells, aneuploidy and the presence of circulating plasma cells. Prognostic scores that combine certain of these factors have been proposed and allow the identification of high-risk patients. Their use could assist in tailoring the care for each patient, based on his/her risk profile. [less ▲]Detailed reference viewed: 68 (7 ULg)
Diagnosis and management of odontogenic and non-odontogenic pain
Chavarria Bolanos, Daniel
Scientific conference (2012, June 14)Detailed reference viewed: 13 (0 ULg)
Diagnosis and monitoring of pregnancy in sheep: reality and perspectives
; ; et al
in Productions Animales (2003), 16(2), 79-90
The present review aims at presenting different methods for pregnancy diagnosis. Since these methods are to be used in the herds, precocity, sensitivity, specificity, accuracy to predict pregnant and non ... [more ▼]
The present review aims at presenting different methods for pregnancy diagnosis. Since these methods are to be used in the herds, precocity, sensitivity, specificity, accuracy to predict pregnant and non-pregnant ewes, and the possibility to determine fetal numbers are carefully analysed. The progesterone assay is accurate as early as day 17th after fecundation; but the fertilization day must be precisely known. The pregnancy specific or associated glycoproteins (PSPB/PAG) assay is highly sensitive and specific at day 22 in blood and at day 32 in milk samples. However, this assay does not allow to predict the fetal number. The ultrasonography B-mode used on 30 days of gestation gives very good or excellent performance in terms of sensitivity and specificity depending on the practitioner. The method is also able to predict the real time fetal number. [less ▲]Detailed reference viewed: 170 (0 ULg)
Diagnosis and prophylaxis of infectious bovine rhinotracheitis: the role of virus latency.
Pastoret, Paul-Pierre ; Thiry, Etienne
in Comparative Immunology, Microbiology and Infectious Diseases (1985), 8(1), 35-42
Efficient methods of diagnosis and prophylaxis of infectious bovine rhinotracheitis must consider the concept of latency of the etiological agent, infectious bovine rhinotracheitis virus (Bovine ... [more ▼]
Efficient methods of diagnosis and prophylaxis of infectious bovine rhinotracheitis must consider the concept of latency of the etiological agent, infectious bovine rhinotracheitis virus (Bovine herpesvirus 1; BHV 1). The identification of BHV 1 in nasal mucus samples or a rise in specific antibodies have to be cautiously interpreted, because they can signify either a primary infection or a reexcretion of the virus after reactivation. The isolated virus can also either be a vaccine or a virulent strain. Another aspect of BHV 1 infection diagnosis is the detection of latent carriers, which are able to transmit the virus to uninfected animals; delayed hypersensitivity test seems to be a good candidate. The classical methods of prophylaxis protect the animal against the disease, but they should also impede the reexcretion of virulent strains by latent carriers. Since, in several countries, attenuated viruses are used as vaccines, a special emphasis has to be laid on the persistence of these vaccine viruses in a latent form in the bovine population. [less ▲]Detailed reference viewed: 32 (4 ULg)
Diagnosis and Screening for Cytomegalovirus Infection in Pregnant Women in Cuba as Pronostic Markers of Congenital Infection in Newborns: 2007-2008
; ; et al
in The Pediatrics Infectious Disease Journal (2010), 29(12), 1105-1110
Background: Human cytomegalovirus (HCMV) has established itself as the most significant cause of congenital infection in the developed world. The objective of this research was prenatal identification of ... [more ▼]
Background: Human cytomegalovirus (HCMV) has established itself as the most significant cause of congenital infection in the developed world. The objective of this research was prenatal identification of pregnant women at risk for developing active infection due to HCMV as well as to diagnose congenitally infected newborns. Methods: A diagnostic algorithm based on specific immunoglobulin G (IgG), IgM, and, IgG avidity was used to screen serum from 1131 pregnant women enrolled prospectively from 3 municipalities from Havana City, Cuba during 2007–2008. Qualitative multiplex nested PCR and quantitative real time-based PCR testing for HCMV DNA were performed on urine and saliva specimens from women detected with active infection and from their newborns. Results: Most women were seropositive to HCMV (92.7%), with 2.38% (27 women) having active infection. Primary infection was detected in 20 pregnant women (1.77%) while 7 patients (0.62%) had active nonprimary infection. HCMV DNA was detected in specimens from 9 of the 27 pregnant women by both PCR methods. HCMV congenital infection was diagnosed in 12 (1.06%) of the 26 live children born from 25 mothers with active infection, for a vertical transmission rate of 46.2%. Two fetal deaths were reported from 2 women with active infection; furthermore 2 newborns were symptomatic at birth and 2 showed sequelae during the follow-up done until 6 months age. Conclusions: Mothers with active infection during the pregnancy and with HCMV excretion had significant risks, RR = 1.16 and RR = 1.35, respectively, to have congenitally infected children. [less ▲]Detailed reference viewed: 36 (8 ULg)
Diagnosis and treatment of aneuvrysmal bone cysts and giant cell tumors in children
Conference (2009)Detailed reference viewed: 21 (4 ULg)
Diagnosis and treatment of peripheral arterial disease: recommendations for the medical practice in Belgium.
; Kolh, Philippe ; et al
in Acta Chirurgica Belgica (2007), 107(6), 595-604Detailed reference viewed: 56 (1 ULg)
Diagnosis by PCR of HIV-1 infection in seronegative individuals at risk
Vaira, Dolorès ; ; et al
in AIDS Research and Human Retroviruses (1990), 6(2), 173-174Detailed reference viewed: 15 (1 ULg)
Diagnosis efficiency of a self-evaluating risk assessment for postmenopausal osteoporosis
; Zegels, Brigitte ; et al
in Journal of Bone and Mineral Research (1997), 12(S1), 495Detailed reference viewed: 16 (2 ULg)
Diagnosis of active acromegaly : is it time to amend the consensus of opinions?
Scientific conference (2005, September)Detailed reference viewed: 4 (0 ULg)
Diagnosis of active acromegaly : is it time to amend the consensus of opinions?
Beckers, Albert ; Daly, Adrian ; Petrossians, Patrick et al
in International Novartis Workshop - somatostatin and its natural and synthetic analogues - Update from basic to clinical aspects - Abstract book (2005)Detailed reference viewed: 5 (0 ULg)
Diagnosis of bovine brucellosis by skin test: conditions for the test and evaluation of its performance.
Saegerman, Claude ; ; et al
in Veterinary Record : Journal of the British Veterinary Association (1999), 145(8), 214-8
Brucellergene OCB (Rhone-Merieux) was used as an allergen to define the intrinsic parameters of a skin test and to compare its properties with serology for the diagnosis of bovine brucellosis. The skin ... [more ▼]
Brucellergene OCB (Rhone-Merieux) was used as an allergen to define the intrinsic parameters of a skin test and to compare its properties with serology for the diagnosis of bovine brucellosis. The skin test was also evaluated for its capacity to solve problems associated with false positive reactions in serological tests. The optimal reading delay for the skin test was 72 hours. The brucellosis allergic reaction was two to three times less intense than the tuberculosis allergic reaction. An increase of 1.1 mm or more in the skin thickness was therefore considered to be an adequate cut-off. The specificity calculated for 1192 brucellosis-free animals (including animals from brucellosis-free herds in which false positive serological reactions had been reported) was 99-83 per cent (95 per cent confidence interval [CI] 99-40 to 99-98 per cent). The sensitivity determined from 27 experimentally infected heifers ranged from 93 per cent (95 per cent CI 76 to 100 per cent) to 78 per cent (95 per cent CI 58 to 91 per cent) when measured respectively one and six months after the infection. Allergic reactions could be detected in vaccinated animals up to four-and-a-half years after the vaccination. On the other hand, no sensitisation was recorded in naive animals after up to eight monthly injections of the allergen. The skin test gave valuable information, in combination with the serological tests, in both acute and chronic brucellosis. The skin test discriminated brucellosis clearly from false positive serological reactions due to infections with Yersinia enterocolitica O9. [less ▲]Detailed reference viewed: 14 (1 ULg)
Diagnosis of brucellosis in livestock and wildlife.
; ; Saegerman, Claude
in Croatian Medical Journal (2010), 51(4), 296-305
AIM: To describe and discuss the merits of various direct and indirect methods applied in vitro (mainly on blood or milk) or in vivo (allergic test) for the diagnosis of brucellosis in animals. METHODS ... [more ▼]
AIM: To describe and discuss the merits of various direct and indirect methods applied in vitro (mainly on blood or milk) or in vivo (allergic test) for the diagnosis of brucellosis in animals. METHODS: The recent literature on brucellosis diagnostic tests was reviewed. These diagnostic tests are applied with different goals, such as national screening, confirmatory diagnosis, certification, and international trade. The validation of such diagnostic tests is still an issue, particularly in wildlife. The choice of the testing strategy depends on the prevailing brucellosis epidemiological situation and the goal of testing. RESULTS: Measuring the kinetics of antibody production after Brucella spp. infection is essential for analyzing serological results correctly and may help to predict abortion. Indirect ELISAs help to discriminate 1) between false positive serological reactions and true brucellosis and 2) between vaccination and infection. Biotyping of Brucella spp. provides valuable epidemiological information that allows tracing an infection back to the sources in instances where several biotypes of a given Brucella species are circulating. Polymerase chain reaction and new molecular methods are likely to be used as routine typing and fingerprinting methods in the coming years. CONCLUSION: The diagnosis of brucellosis in livestock and wildlife is complex and serological results need to be carefully analyzed. The B. abortus S19 and B. melitensis Rev. 1 vaccines are the cornerstones of control programs in cattle and small ruminants, respectively. There is no vaccine available for pigs or for wildlife. In the absence of a human brucellosis vaccine, prevention of human brucellosis depends on the control of the disease in animals. [less ▲]Detailed reference viewed: 58 (3 ULg)
Diagnosis of canine sino-nasal aspergillosis: is quantification of Aspergillus DNA a useful technique?
Peeters, Dominique ; ; et al
in Proceedings of the 24th VCRS meeting (2006)Detailed reference viewed: 10 (0 ULg)
Diagnosis of cyst infection in patients with autosomal dominant polycystic kidney disease: attributes and limitations of the current modalities.
JOURET, François ; ; et al
in Nephrology Dialysis Transplantation (2012), 27(10), 3746-51
Cyst infection is a diagnostic challenge in patients with autosomal dominant polycystic kidney disease (ADPKD) because of the lack of specific manifestations and limitations of conventional imaging ... [more ▼]
Cyst infection is a diagnostic challenge in patients with autosomal dominant polycystic kidney disease (ADPKD) because of the lack of specific manifestations and limitations of conventional imaging procedures. Still, recent clinical observations and series have highlighted common criteria for this condition. Cyst infection is diagnosed if confirmed by cyst fluid analysis showing bacteria and neutrophils, and as a probable diagnosis if all four of the following criteria are concomitantly met: temperature of >38 degrees C for >3 days, loin or liver tenderness, C-reactive protein plasma level of >5 mg/dL and no evidence for intracystic bleeding on computed tomography (CT). In addition, the elevation of serum carbohydrate antigen 19-9 (CA19-9) has been proposed as a biomarker for hepatic cyst infection. Positron-emission tomography after intravenous injection of 18-fluorodeoxyglucose, combined with CT, proved superior to radiological imaging techniques for the identification and localization of kidney and liver pyocyst. This review summarizes the attributes and limitations of these recent clinical, biological and imaging advances in the diagnosis of cyst infection in patients with ADPKD. [less ▲]Detailed reference viewed: 41 (15 ULg)
Diagnosis of HIV-1 in African couples : comparison of serology and PCR
Vaira, Dolorès ; Sondag, Danièle ; et al
in Cinquième conférence internationale sur le SIDA : le défi scientifique et social (1989)
OBJECTIVE: Search for the rate of HIV-1 contamination among seronegative sexual partners of seropositive individuals. METHODS: Classical serological methods (EIA, WB) and PCR. SERIES: 36 heterosexual ... [more ▼]
OBJECTIVE: Search for the rate of HIV-1 contamination among seronegative sexual partners of seropositive individuals. METHODS: Classical serological methods (EIA, WB) and PCR. SERIES: 36 heterosexual couples from central Africa, accounting for a total of 73 persons: 13/37 seropositive women, 23/36 seropositive men. All couples were serologically discordant, i.e. one partner was seropositive. CONCLUSIONS: In such a population, particularly at risk of HIV contamination, the rate of false negative serological diagnosis reached 70%. [less ▲]Detailed reference viewed: 33 (0 ULg)