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See detailThe effects of selection on linkage analysis for quantitative traits
Mackinnon, M. J.; Georges, Michel ULg

in Genetics (1992), 132

The effects of within-sample selection on the outcome of analyses detecting linkage between genetic markers and quantitative traits were studied. It was found that selection by truncation for the trait of ... [more ▼]

The effects of within-sample selection on the outcome of analyses detecting linkage between genetic markers and quantitative traits were studied. It was found that selection by truncation for the trait of interest significantly reduces the differences between marker genotype means thus reducing the power to detect linked quantitative trait loci (QTL). The size of this reduction is a function of proportion selected, the magnitude of the QTL effect, recombination rate between the marker locus and the QTL, and the allele frequency of the QTL. Proportion selected was the most influential of these factors on bias, e.g., for an allele substitution effect of one standard deviation unit, selecting the top 80%, 50% or 20% of the population required 2,6 or 24 times the number of progeny, respectively, to offset the loss of power caused by this selection. The effect on power was approximately linear with respect to the size of gene effect, almost invariant to recombination rate, and a complex function of QTL allele frequency. It was concluded that experimental samples from animal populations which have been subjected to even minor amounts of selection will be inefficient in yielding information on linkage between markers and loci influencing the quantitative trait under selection. [less ▲]

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See detailEffects of sertraline on depressive symptoms and attentional and executive functions in major depression
Constant, Eric; Adam, Stéphane ULg; Gillain, B. et al

in Depression and Anxiety (2005), 21(2), 78-89

Reports on the severity and reversibility of cognitive disturbances in major depression in the literature diverge due to methodological biases. The present study, using a precise methodology, examined ... [more ▼]

Reports on the severity and reversibility of cognitive disturbances in major depression in the literature diverge due to methodological biases. The present study, using a precise methodology, examined attention and executive functions in 20 relatively young, depressed patients presenting a first or second episode of unipolar major depression without psychotic or melancholic characteristics and all being treated with the same psychopharmacological treatment (sertraline) to investigate the changes in potential attentional and executive loss during a subacute period of treatment of 7 weeks. We compared their performance with a group of 26 control subjects who were administered the same cognitive tests. This study confirmed psychomotor slowing associated with attentional and executive disturbance in adults with major depression. Conscious attentional interference for words with a negative emotional valence also was shown. After the first weeks of treatment, the effect of the antidepressant treatment with sertraline was accompanied by a beneficial effect on psychomotor slowing on attentional and executive functions. © 2005 Wiley-Liss, Inc. [less ▲]

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See detailEffects of sex steroids on aromatase mRNA expression in the male and female quail brain.
Voigt, Cornelia; Ball, Gregory F; Balthazart, Jacques ULg

in General and Comparative Endocrinology (2011), 170(1), 180-8

Castrated male quail display intense male-typical copulatory behavior in response to exogenous testosterone but ovariectomized females do not. The behavior of males is largely mediated by the central ... [more ▼]

Castrated male quail display intense male-typical copulatory behavior in response to exogenous testosterone but ovariectomized females do not. The behavior of males is largely mediated by the central aromatization of testosterone into estradiol. The lack of behavioral response in females could result from a lower rate of aromatization. This is probably not the case because although the enzymatic sex difference is clearly present in gonadally intact sexually mature birds, it is not reliably found in gonadectomized birds treated with testosterone, in which the behavioral sex difference is always observed. We previously discovered that the higher aromatase activity in sexually mature males as compared to females is not associated with major differences in aromatase mRNA density. A reverse sex difference (females>males) was even detected in the bed nucleus of the stria terminalis. We analyzed here by in situ hybridization histochemistry the density of aromatase mRNA in gonadectomized male and female quail that were or were not exposed to a steroid profile typical of their sex. Testosterone and ovarian steroids (presumably estradiol) increased aromatase mRNA concentration in males and females respectively but mRNA density was similar in both sexes. A reverse sex difference in aromatase mRNA density (females>males) was detected in the bed nucleus of subjects exposed to sex steroids. Together these data suggest that although the induction of aromatase activity by testosterone corresponds to an increased transcription of the enzyme, the sex difference in enzymatic activity results largely from post-transcriptional controls that remain to be identified. [less ▲]

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See detailEffects of sex steroids on fear reactions in cattle and sheep
Bouissou, M. F.; Boissy, A.; Vandenheede, Marc ULg

Conference (1993)

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See detailEffects of shading and sediment alterations on Posidonia oceanica meadows: in situ experiments
Pete, Dorothée ULg; Velimirov, Branko; Lepoint, Gilles ULg et al

Conference (2010, November 24)

In the Mediterranean Sea, the seagrass Posidonia oceanica is affected by many threats from anthropogenic sources. One of them is the increasing development of fish farming, which is responsible of the ... [more ▼]

In the Mediterranean Sea, the seagrass Posidonia oceanica is affected by many threats from anthropogenic sources. One of them is the increasing development of fish farming, which is responsible of the destruction of some meadows. Within troubles cause by those fish farms on the surrounding environment, the increase of phytoplankton biomass in the water column (leading to a shading effect) and a modification of the sediment are often cited as a reason of seagrass disappearance. To understand how those troubles are affecting P. oceanica and its sedimentary compartment, in situ experiments were led during three months, from the end of May til the end of August 2009, in STARESO (STAtion de REcherches Sous-marines et Océanographiques, Corsica, France), at a depth of 10 meters. The shading was mimicked by three replicated shading frames (3 x 1 m), which stopped around 50 % of the incident light. To modify the sedimentary compartment, some sediment was taken from under the fish farm of Calvi (Corsica, France) and added once a week on marked zones in the seagrass meadow. Those sites were compared with a control site, situated in the same meadow. Samples were taken once a month and consisted in pore water, sediment cores and shoots of P. oceanica. An estimation of the density of the meadow in every sampling zones was also performed. Measured parameters are the concentration of nutrients in pore water, grain size, redox potential discontinuity (RPD), biomass of bacteria, organic matter, meiofauna and microphytobenthos within the sediment, total carbon and nitrogen in the sediment and leaves, the length, width and biomass of leaves and shoots, the biomass of epiphytes and the content of chlorophyll a in leaves. During those experiments, Posidonia oceanica was not very affected. However, some parameters of the sedimentary compartment were modified (RPD, biomass of bacteria, organic matter, nutrients in pore water,…), suggesting a modification in the functioning of the ecosystem. These results are important because they show that the sedimentary compartment reacts more rapidly to threats then the seagrass itself. So, it could be an interesting tool in quality assessments. [less ▲]

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See detailEffects of short chain fructo-oligosaccharides on insulin sensitivity and gene expression of fat tissues in obese dogs
Respondek, F.; Swanson, K.; Herpigny, F. et al

in Proceedings of the Nutrition Society (2008), 67

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See detailEffects of short-range interactions on transport through quantum point contacts: A numerical approach
Lassl, Andreas; Schlagheck, Peter ULg; Richter, Klaus

in Physical Review. B : Condensed Matter (2007), 75(4),

We study electronic transport through a quantum point contact, where the interaction between the electrons is approximated by a contact potential. Our numerical approach is based on the nonequilibrium ... [more ▼]

We study electronic transport through a quantum point contact, where the interaction between the electrons is approximated by a contact potential. Our numerical approach is based on the nonequilibrium Green-function technique which is evaluated at the Hartree-Fock level. We show that this approach allows us to reproduce relevant features of the so-called "0.7 anomaly" observed in the conductance at low temperatures, including the characteristic features in recent shot-noise measurements. This is consistent with a spin-splitting interpretation of the process, and indicates that the 0.7 anomaly should also be observable in transport experiments with ultracold fermionic atoms. [less ▲]

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See detailThe effects of shunting sytemic venous blood into the portal circulation. Review, experiences and future perspectives
D'Silva, Milbhor; Wolf, P.; Bonnet, Pierre ULg

in Archives of Hellenic Medecine (1997), 14(3), 246-264

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See detailEffects of silicon addition on the electrical and magnetic properties of copper-doped (La,Ca)MnO3 compounds
Vertruyen, Bénédicte ULg; Rulmont, André ULg; Cloots, Rudi ULg et al

in Journal of Magnetism and Magnetic Materials (2004), 268(3), 364-373

In this paper we report about the electrical properties of La0.7Ca0.3MnO3 compounds substituted by copper on the manganese site and/or deliberately contaminated by SiO2 in the reactant mixture. Several ... [more ▼]

In this paper we report about the electrical properties of La0.7Ca0.3MnO3 compounds substituted by copper on the manganese site and/or deliberately contaminated by SiO2 in the reactant mixture. Several phenomena have been observed and discussed. SiO2 addition leads to the formation of an apatite-like secondary phase that affects the electrical conduction through the percolation of the charge carriers. On the other hand, depending on the relative amounts of copper and silicon, the temperature dependence of the electrical resistivity can be noticeably modified: our results enable us to compare the effects of crystallographic vacancies on the A and B sites of the perovskite with the influence of the copper ions substituted on the manganese site. The most original result occurs for the compounds with a small ratio Si/Cu, which display double-peaked resistivity vs. temperature curves. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailEffects Of Six Apoa5 Variants, Identified In Patients With Severe Hypertriglyceridemia, On In Vitro Lipoprotein Lipase Activity And Receptor Binding
Dorfmeister, B.; Zeng, Ww.; Dichlberger, A. et al

in Arteriosclerosis, Thrombosis, and Vascular Biology (2008), 28(10), 1866-71

OBJECTIVE: The purpose of this study was to identify rare APOA5 variants in 130 severe hypertriglyceridemic patients by sequencing, and to test their functionality, since no patient recall was possible ... [more ▼]

OBJECTIVE: The purpose of this study was to identify rare APOA5 variants in 130 severe hypertriglyceridemic patients by sequencing, and to test their functionality, since no patient recall was possible. METHODS AND RESULTS: We studied the impact in vitro on LPL activity and receptor binding of 3 novel heterozygous variants, apoAV-E255G, -G271C, and -H321L, together with the previously reported -G185C, -Q139X, -Q148X, and a novel construct -Delta139 to 147. Using VLDL as a TG-source, compared to wild type, apoAV-G255, -L321 and -C185 showed reduced LPL activation (-25% [P=0.005], -36% [P<0.0001], and -23% [P=0.02]), respectively). ApoAV-C271, -X139, -X148, and Delta139 to 147 had little affect on LPL activity, but apoAV-X139, -X148, and -C271 showed no binding to LDL-family receptors, LR8 or LRP1. Although the G271C proband carried no LPL and APOC2 mutations, the H321L carrier was heterozygous for LPL P207L. The E255G carrier was homozygous for LPL W86G, yet only experienced severe hypertriglyceridemia when pregnant. CONCLUSIONS: The in vitro determined function of these apoAV variants only partly explains the high TG levels seen in carriers. Their occurrence in the homozygous state, coinheritance of LPL variants or common APOA5 TG-raising variant in trans, appears to be essential for their phenotypic expression. [less ▲]

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See detailEffects of sleepiness on emergency physicians’ technical and non-technical skills
Gillet, Aline ULg; Nyssen, Anne-Sophie ULg; Vergnion, Michel et al

Conference (2014, February 25)

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See detailEffects of small-scale atmospheric activity on precise positioning
Wautelet, Gilles ULg; Lejeune, Sandrine; Stankov, Stanimir et al

Report (2008)

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See detailEffects of social experience on subsequent sexual performance in naïve male Japanese quail (Coturnix japonica)
Cornil, Charlotte ULg; Ball, Gregory

in Hormones & Behavior (2010), 57

On their first sexual encounter, naïve male Japanese quail will attend to and approach a female; they sometimes mount but they do not always copulate. During the second encounter, most males successfully ... [more ▼]

On their first sexual encounter, naïve male Japanese quail will attend to and approach a female; they sometimes mount but they do not always copulate. During the second encounter, most males successfully copulate. Although sexual experience facilitates subsequent sexual interactions, sensory cues provided by females, independent of any sexual encounter, may also enhance sexual performance. To investigate whether previous exposure to a conspecific affects subsequent sexual behavior, we allowed inexperienced males to observe an empty box, or a conspecific consisting of either an experienced female or male for 2.5 min/day on 7 days. Measures of appetitive sexual behavior were recorded during these tests. On day 8, subjects were allowed to copulate with a novel female for 5 min. On the following days, all subjects were repeatedly provided with visual access to a female and allowed to mate. In the pre-copulatory trials males initially exhibited a high frequency of appetitive responses that dissipated with repetition. Pre-copulatory experience also significantly affected motivation to mate with subjects exposed to females copulating more quickly than other subjects. Post-copulatory appetitive behavior also differed between groups: control subjects showed the highest behavioral frequency followed by males exposed to females and finally males exposed to males. These data indicate that pre-copulatory social experience profoundly influences subsequent sexual behavior and probably reproductive success. This experience effect is independent of any hormonal effect (such as one resulting from changes in secretion following different social interactions) given that the subjects were castrates chronically treated with testosterone. [less ▲]

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See detailEffects of somatic growth, sex and circadian rhythm on respiratory parameters assessed by whole body barometric plethysmography in healthy cats
Leemans, J.; Kirschvink, N.; Delvaux, François ULg et al

in 14th ESVIM Meeting - Barcelona - Espagne (2004)

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See detailEffects of space allowance on gas emissions from group-housed gestating sows
Philippe, François-Xavier ULg; Cabaraux, Jean-François ULg; Canart, Bernard et al

in Book of abstract of the 60th Annual meeting of the European Association for Animal Production (2009)

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See detailEffects of space allowance on the welfare of dry sows kept in dynamic groups and fed with an electronic sow feeder
Remience, Virginie; Wavreille, José; Canart, Bernard et al

in Applied Animal Behaviour Science (2008), 112(3-4), 284-296

The minimal legal space allowance for grouped pregnant sows in the EU is 2.25 m(2)/sow. The effect of higher space per animal on agonistic behaviour and social stress of animals living in dynamic groups ... [more ▼]

The minimal legal space allowance for grouped pregnant sows in the EU is 2.25 m(2)/sow. The effect of higher space per animal on agonistic behaviour and social stress of animals living in dynamic groups is not known. Two groups of 34 pregnant Belgian Landrace sows were housed in two pens of respectively 102 m(2) (3 m(2)/sow) and 76.5 m(2) (2.25 m(2)/sow). Each sow lived there for 15 weeks. Sows were fed through an electronic sow feeder. According to the dynamic system, one third of each group (i.e. 11 or 12 nearly parturient sows) was replaced every 5 weeks by the same number of recently inseminated sows. Welfare indicators were collected during six of these 5 week-periods: performance, agonistic behaviour, skin lesion score and salivary cortisol. No differences were observed for production parameters, or for fighting activity. However, the mean number of one-way aggressions, when observed during 2 h-periods at 3 and 8 days after grouping, was significantly lower in the large pen than in the small one (respectively 16 +/- 2 versus 26 +/- 3, p < 0.01, and 10 +/- 2 versus 20 +/- 5, p < 0.05). The mean number of injuries was also lower with the 3 m(2) space allowance, when collected on the introduced sows one, 2 and 3 weeks after grouping. Some contradictory differences in salivary cortisol were noted 2 and 26 h after mixing, but without reaching statistical significance. An available area 33% higher than the EU legal minimum reduced agonistic behaviour and consecutive wounds and thus induced better welfare conditions for sows living in dynamic groups and fed with an electronic sow feeder. The impact on productivity and social physiological stress need further research. [less ▲]

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See detailEffects of space allowance on the welfare of pregnant sows housed in dynamic groups.
Remience, Virginie; Wavreille, José; Cloet, D. et al

in Proceedings of the 40th International Congress of the Internationnal Society for Applied Ethology (2006)

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See detailEffects of specific dopaminergic agonists and antagonists in the open-field test.
Bruhwyler, J.; Chleide, E.; Liégeois, Jean-François ULg et al

in Pharmacology, Biochemistry & Behavior (1991), 39(2), 367-71

It has been found that dopaminergic transmission could be involved in some aspects of anxiety. The present study aims to explore this hypothesis further, using specific DA1 (SKF 38393) and DA2 ... [more ▼]

It has been found that dopaminergic transmission could be involved in some aspects of anxiety. The present study aims to explore this hypothesis further, using specific DA1 (SKF 38393) and DA2 (bromocriptine) agonists or DA1 (SCH 23390), and DA2 (zetidoline) antagonists in the open-field test. The results confirm previous studies indicating that DA1 and DA2 agonists predominantly increase locomotor activity, while DA1 and DA2 antagonists predominantly decrease it. However, at low doses, the four drugs increase the peripheral ambulation score significantly and, with the exception of zetidoline, also increase the central ambulation score. The observations made with zetidoline confirm the hypothesis that a specific presynaptic DA2 antagonism could be determinant for the disinhibitory effects of low doses of neuroleptics. A collateral action on 5HT transmission is also suggested to explain an hypothetic anxiolytic action of DA agonists and SCH 23390 at lower doses. [less ▲]

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See detailEffects of sphingosine and sphingosine analogues on the free radical production by stimulated neutrophils: ESR and chemiluminescence studies.
Mouithys-Mickalad, Ange ULg; Deby, Ginette ULg; Hoebeke, Maryse ULg et al

in Mediators of Inflammation (1997), 6(5-6), 327-33

Sphingolipids inhibit the activation of the neutrophil (PMN) NADPH oxidase by protein kinase C pathway. By electron spin resonance spectroscopy (ESR) and chemiluminescence (CL), we studied the effects of ... [more ▼]

Sphingolipids inhibit the activation of the neutrophil (PMN) NADPH oxidase by protein kinase C pathway. By electron spin resonance spectroscopy (ESR) and chemiluminescence (CL), we studied the effects of sphingosine (SPN) and ceramide analogues on phorbol 12-myristate 13-acetate (PMA, 5 x 10(-7)M) stimulated PMN (6 x 10(6) cells). By ESR with spin trapping (100 mM DMPO: 5,5-dimethyl-1-pyrroline-Noxide), we showed that SPN (5 to 8 x 10(-6)M), C(2)-ceramide (N-acetyl SPN) and C(6)-ceramide (N-hexanoyl SPN) at the final concentration of 2 x 10(-5) and 2 x 10(-4)M inhibit the production of free radicals by stimulated PMN. The ESR spectrum of stimulated PMN was that of DMPO-superoxide anion spin adduct. Inhibition by 5 x 10(-6)M SPN was equivalent to that of 30 U/ml SOD. SPN (5 to 8 x 10(-6)M) has no effect on in vitro systems generating superoxide anion (xanthine 50 mM/xanthine oxidase 110 mU/ml) or hydroxyl radical (Fenton reaction: 88 mM H(2)O(2), 0.01 mM Fe(2+) and 0.01 mM EDTA). SPN and N-acetyl SPN also inhibited the CL of PMA stimulated PMN in a dose dependent manner (from 2 x 10(-6) to 10(-5)M), but N-hexanoyl SPN was less active (from 2 x 10(-5) to 2 x 10(-4)M). These effects were compared with those of known PMN inhibitors, superoxide dismutase, catalase and azide. SPN was a better inhibitor compared with these agents. The complete inhibition by SPN of ESR signal and CL of stimulated PMN confirms that this compound or one of its metabolites act at the level of NADPH-oxidase, the key enzyme responsible for production of oxygen-derived free radicals. [less ▲]

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