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Peer Reviewed
See detailEffects of consolidation of procedural motor memory traces on slow and fast spindles
Barakat, M; Doyon, J; Debas, K et al

Poster (2009, April)

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See detailEffects of constitutively active GTPases on fibroblast behavior.
Zhang, Z.-G.; Lambert, Charles ULg; Servotte, S. et al

in Cellular and Molecular Life Sciences : CMLS (2006), 63(1), 82-91

The GTP-binding proteins RhoA, Cdc42 and Rac1 regulate the organization and turnover of the cytoskeleton and cell-matrix adhesions, structures bridging cells to their support, and translating forces ... [more ▼]

The GTP-binding proteins RhoA, Cdc42 and Rac1 regulate the organization and turnover of the cytoskeleton and cell-matrix adhesions, structures bridging cells to their support, and translating forces, external or generated within the cell. To investigate the specific requirements of Rho GTPases for biomechanical activities of clonal cell populations, we compared side-by-side stable lines of human fibroblasts expressing constitutively active (CA) RhoA, Cdc42 or Rac1. There was no marked effect of any CA GTPase on cell adhesion to different extracellular matrix proteins. Cell spreading was CA Rho GTPase specific and independent of the extracellular matrix proteins allowing adhesion. Mechanical properties were dramatically restricted by CA RhoA on bi- and in tri-dimensional surroundings, were boosted by CA Rac1 on bi-dimensional surroundings only, and were not or marginally affected by CA Cdc42. In conclusion, the action of Rho GTPases appears to depend on the task cells are performing. [less ▲]

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See detailEffects of copper sulfate given alone or with alpha-MSH and L-tyrosine on B16 melanoma cells cultured in serum-free media.
Gillet, Marie-Claire ULg; wang, François; Simonon, A. et al

in Archives of Biology (1987), 98(3), 327-39

This study shows that copper sulphate (0.1mM) has antiproliferative effects in B16 melanoma cells cutured in various serum-free media.

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See detailEffects of COX-2 inhibitors on ROS produced by Chlamydia pneumoniae-primed human promonocytic cells (THP-1)
Mouithys-Mickalad, Ange ULg; Deby, Ginette ULg; Dogné, Jean-Michel ULg et al

in Biochemical and Biophysical Research Communications (2004), 325(4), 1122-1130

Chronic inflammation through foam cells and macrophages is important in atherosclerosis development, and can be considered as therapeutic targets. Cyclooxygenase and NADPH-oxidase were expressed within ... [more ▼]

Chronic inflammation through foam cells and macrophages is important in atherosclerosis development, and can be considered as therapeutic targets. Cyclooxygenase and NADPH-oxidase were expressed within atherosclerotic lesions. Reactive oxygen species produced by NADPH oxidase were found to trigger the cyclooxygenase-2 expression. The effects of preferential COX-2 inhibitors on ROS produced by Chlamydia-primed human monocytes (THP-1 cells) were evaluated by fluorescence, chemiluminescence, oxymetry, and EPR spin trapping. Fluorescence assays showed an increased production of ROS with Chlamydia versus cells primed by 10(-8) M PMA. COX-2 inhibitors inhibited in a dose-dependent manner the luminol-enhanced CL while ibuprofen and diclofenac increased the chemiluminescence response. By EPR spin trapping, COX-2 inhibitors, ibuprofen, and diclofenac, exhibited a dose-dependent inhibiting effect (10 and 100 muM) on the EPR signal appearance. Our cell model combining EPR, chemiluminescence, and oxymetry appeared relevant to study the modulating effects of preferential COX-2 inhibitors on the cell oxidant activity and chronic inflammatory diseases. (C) 2004 Elsevier Inc. All rights reserved. [less ▲]

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See detailEffects of cromakalim analogues on rat pancreatic B-cells, rat aorta rings and rat uterus. Study of their mechanism of action as potassium channel activators
Sebille, S.; Boverie, S.; Becker, B. et al

Poster (2003, November 22)

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See detailEffects of cromakalim analogues on rat pancreatic B-cells, rat aorta rings and rat uterus. Study of their mechanism of action as potassium channel activators
Sebille, S.; Boverie, S.; Becker, B. et al

in Fundamental & Clinical Pharmacology (2004)

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See detailEffects of crops on solute transport in undisturbed soil
Garré, Sarah ULg; Javaux, Mathieu; Vanderborght, Jan

Poster (2009)

Models predicting movement of surface applied chemicals incorporate knowledge on the water velocity field and moisture content distribution. Although the influence of root water uptake on solute transport ... [more ▼]

Models predicting movement of surface applied chemicals incorporate knowledge on the water velocity field and moisture content distribution. Although the influence of root water uptake on solute transport is commonly recognized as important, it has been studied sparsely. Yet, plants may take up a large part of the infiltrating water, thereby influencing the water flow pattern in the soil and concurrently solute transport processes. For this reason, experiments are required to investigate the relationship between plant root water uptake and flow field variability. The role of root water uptake on solute transport will be elucidated in two undisturbed soil columns. During three consecutive experiments, the influence of growing barley on tracer movement through a silty soil in two lysimeters will be followed. At the first stage, an inert tracer is put on the two bare lysimeters and leached with constant irrigation. As steady-state flow can be assumed, it is possible to follow the tracer movement in the column by ERT and to identify regions of preferential flow and solute transport parameters. During the second experiment, the tracer will be applied to mature barley grown in the lysimeters. Combining the information about the water content obtained with TDR with the relation between water content, soil solution salinity and bulk electrical conductivity, the soil solution salinity distribution can be derived from images of bulk electrical conductivity obtained with ERT. Root growth will be monitored using a minirhizotron. By comparing the transport parameters obtained after these two experiments, the effect of root water on the transport process can be quantified. When the columns are washed out and the barley is harvested, the third phase will be carried out under the same steady state flow conditions as in the first experiment to investigate the effect of dead roots on soil structure. [less ▲]

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See detailEffects of culture conditions on the synthesis of human chorionic gonadotropin by placental organ cultures.
Huot, R. I.; Foidart, Jean-Michel ULg; Stromberg, K.

in In Vitro (1979), 15(7), 497-502

Culture conditions for maintaining first trimester human placenta in organ culture, which enhance the secretion of human chorionic gonadotropin (hCG), are described. Nutrient medium, oxygen tension and ... [more ▼]

Culture conditions for maintaining first trimester human placenta in organ culture, which enhance the secretion of human chorionic gonadotropin (hCG), are described. Nutrient medium, oxygen tension and Gelfoam support matrix influence the synthesis of hCG by these cultures. Placental tissue remained viable for the duration of experiments (12 days) as judged by the incorporation of tritiated thymidine into DNA and the lack of release of incorporated [125I]iododeoxyuridine. Optimal conditions for hCG synthesis in placental organ culture included an atmosphere of 95% air and 5% Co2 (approximately 20% O2), CMRL 1066 medium containing fetal human or bovine serum, insulin, hydrocortisone and retinal acetate. Multiple pieces of placenta could be cultured in the same dish with an additive effect on hCG secretion. The functional responsiveness of these placental cultures was demonstrated by modulation of hCG synthesis with theophylline and 3'5' dibutyryl cyclic AMP. [less ▲]

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See detailEffects of curing sodium nitrite additive and natural meat fat on growth control of Listeria monocytogenes by the bacteriocin-producing Lactobacillus curvatus strain CWBI-B28.
Kouakou, P.; Ghalfi, H.; Destain, Jacqueline ULg et al

in Food Microbiology (2009), 26

In realistic model meat systems, the separate and combined effects of fat content and sodium nitrite on the antilisterial activity of the bacteriocin of Lactobacillus curvatus CWBI-B28 were studied. In ... [more ▼]

In realistic model meat systems, the separate and combined effects of fat content and sodium nitrite on the antilisterial activity of the bacteriocin of Lactobacillus curvatus CWBI-B28 were studied. In laboratory fermentations where Listeria monocytogenes was co-cultured at 4 C with bacteriocin-producing CWBIB28 in lean pork meat (fat content: 13%) without added nitrite, a strong antilisterial effect was observed after one week. The effect was maintained for an additional week, after which a slight and very gradual rebound was observed. Both added nitrite (20 ppm) and a high-fat content (43%) were found to antagonise this antilisterial effect, the Listeria cfu count reached after six weeks being 200 times as high in high-fat meat with added nitrite than in lean meat without nitrite. This antagonism could not be attributed to slower growth of the bacteriocin-producing strain, since CWBI-B28 grew optimally in fatrich meat with 20 ppm sodium nitrite. Bacteriocin activity was also measured in the samples. The observed activity levels are discussed in relation to the degree of antilisterial protection conferred [less ▲]

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See detailEffects of cyanamide and acetaldehyde accumulation on the locomotor stimulant and sedative effects of ethanol in mice
Tambour, Sophie ULg; Closon, Catherine; Tirelli, Ezio ULg et al

in Behavioural Pharmacology (2007), 18(8), 777-784

Ethanol administration induces both locomotor stimulant and sedative effects depending upon blood ethanol concentrations. Recent studies in rats and mice suggest that acetaldehyde, the first product of ... [more ▼]

Ethanol administration induces both locomotor stimulant and sedative effects depending upon blood ethanol concentrations. Recent studies in rats and mice suggest that acetaldehyde, the first product of ethanol metabolism, might be involved in the expression of both the stimulant and the sedative effects of ethanol. A number of studies have used the drug cyanamide in an attempt to clarify the role of acetaldehyde in the behavioral effects of ethanol. The results of such studies are, however, difficult to interpret because cyanamide is an inhibitor of the enzymes catalase and aldehyde dehydrogenase, two enzymes with opposite effects on brain acetaldehyde concentrations. This study was aimed at clarifying the effects of cyanamide on ethanol-induced locomotor stimulant and sedative effects in Swiss mice. The locomotor stimulant effects of ethanol were measured in standard activity boxes, whereas the sedative effects of ethanol were quantified using the loss of righting reflex procedure. Cyanamide prevented the locomotor stimulant effects of 2 g/kg ethanol, although this was mainly due to a potentiation of the inhibitory effects of ethanol as evidenced by a prolongation of ethanol-induced loss of righting reflex. Additionally, 4-methylpyrazole, an inhibitor of the enzyme alcohol dehydrogenase, prevented these effects of cyanamide. It is concluded that in vivo the effects of cyanamide are predominantly due to the inhibition of the enzyme aldehyde dehydrogenase, rather than to its effects on catalase. [less ▲]

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See detailThe effects of daylength and light intensiy on the reproductive development of Lolium temulentum
Périlleux, Claire ULg; Kinet, Jean-Marie; Bernier, Georges ULg

in Archives internationales de Physiologie et de Biochimie (1988), 96

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See detailEffects of delayed introduction of calcineurin inhibitor on GFR in liver transplant: 12 month data from a multi-centre randomised controlled study
Pirenne, J.; Boon, N.; Colle, I. et al

in Acta Gastro-Enterologica Belgica (2009, January), 72(1), 30

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See detailEffects of desert dust on air quality and human health. What do we know about West Africa compared to other regions?
De Longueville, Florence ULg; Henry, Sabine; Ozer, Pierre ULg

Conference (2009, February 24)

The main source of atmospheric mineral dust is the Sahara and its desertified margins that produce about half of the yearly global mineral dust. Saharan dust is often transported far away to the sources ... [more ▼]

The main source of atmospheric mineral dust is the Sahara and its desertified margins that produce about half of the yearly global mineral dust. Saharan dust is often transported far away to the sources and causes air quality deterioration impacting northwards the Mediterranean and Europe, westwards crossing the Atlantic Ocean to the United States, the Caribbean and South America, and southwards to the Gulf of Guinea. Saharan dust storms can lead to particulate levels that exceed internationally recommended levels and transport allergens, including bacteria and fungi. Therefore special attention is paid to dust storms as such mineral particulate matter air pollution may be a serious health threat in various regions of the world because it may promote respiratory infection, cardiovascular disease and other ailments. [less ▲]

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See detailEffects of design and kinematic parameters of rotary cultivators on soil structure
Destain, Marie-France ULg; Houmy, K.

in Soil & Tillage Research (1990), 17(3-4), 291-301

In comparison with drawn implements, rotary cultivators are of particular interest in final seedbed preparation. In this paper, a quantitative basis for the description of soil structure created by rotary ... [more ▼]

In comparison with drawn implements, rotary cultivators are of particular interest in final seedbed preparation. In this paper, a quantitative basis for the description of soil structure created by rotary tillers is given. Undisturbed Ap horizon samples were collected, impregnated with polyester resin, sectioned by sawing and analysed by means of image analysis. Total porosity, area and size of pores are related to the design and kinematic parameters of the rotary cultivator, arising from an analysis based upon the location of instant centres of velocity. It is shown that using a rotary cultivator with a higher ratio of peripheral to forward velocity leads to a smaller total mean porosity which is more homogeneous. [less ▲]

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See detailEffects of Dexamethasone on the Profile of Cytokine Secretion in Human Whole Blood Cell Cultures
Franchimont, Denis; Louis, Edouard ULg; Dewé, Walthère ULg et al

in Regulatory Peptides (1998), 73(1), 59-65

EXPERIMENTAL OBJECTIVES: The interaction between the endocrine and immune systems is a very intriguing area. Endogenous glucocorticoids, as end-effectors of the hypothalamo-pituitary-adrenal axis, inhibit ... [more ▼]

EXPERIMENTAL OBJECTIVES: The interaction between the endocrine and immune systems is a very intriguing area. Endogenous glucocorticoids, as end-effectors of the hypothalamo-pituitary-adrenal axis, inhibit the immune and inflammatory responses and are used as immunosuppressive drugs in many inflammatory, autoimmune and allergic diseases. The aims of this study were to investigate the effects of dexamethasone on the profile of cytokine secretion in whole blood cell cultures from healthy subjects and to analyse the gender-related sensitivity to dexamethasone on each cytokine secretion. RESULTS: There was a significant inhibition by dexamethasone (from 1 to 100 nM) on the secretion of monokines (IL-1beta, IL-6, IL-8 and TNF alpha) and lymphokines (IL-2, IL-4, IL-10 and IFN gamma), either after LPS or PHA stimulation (P < 0.01). Interleukin 4 and IL-10 were less inhibited than IFN gamma (P < 0.05 at 1 nM, P < 0.01 at 10 nM and P < 0.001 from 100 nM to 10 microM). No gender difference was observed in the rate of inhibition of the secretion of each cytokine. CONCLUSION: This study shows that the inhibition of cytokine secretion by dexamethasone is more marked on Th1-type cytokines than on Th2-type cytokines. These data support the idea that glucocorticoids may induce a shift from the Th1 to Th2 profile of cytokine secretion. [less ▲]

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See detailEffects of dexamethasone treatment on growth performances, sexual axis and hormonal status in finishing bulls
Renaville, Robert ULg; Massart, Serge; Devolder, Anne et al

Poster (1993)

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See detailEffects of dexamethasone treatment on growth performances, sexual axis and hormonal status in finishing bulls
Renaville, Robert ULg; Massart, Serge; Devolder, Anne et al

in Journal of Animal Science (1993), 71(suppl 1), 232

Detailed reference viewed: 5 (0 ULg)