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See detailDeep near-infrared interferometric search for low-mass companions around β Pictoris
Absil, Olivier ULg; Le Bouquin, Jean-Baptiste; Lebreton, Jérémy et al

in Astronomy and Astrophysics (2010), 520

Aims. We search for low-mass companions in the innermost region (<300 mas, i.e., 6 AU) of the β Pic planetary system. Methods. We obtained interferometric closure phase measurements in the K-band with the ... [more ▼]

Aims. We search for low-mass companions in the innermost region (<300 mas, i.e., 6 AU) of the β Pic planetary system. Methods. We obtained interferometric closure phase measurements in the K-band with the VLTI/AMBER instrument used in its medium spectral resolution mode. Fringe stabilization was provided by the FINITO fringe tracker. Results. In a search region of between 2 and 60 mas in radius, our observations exclude at 3σ significance the presence of companions with K-band contrasts greater than 5×10^-3 for 90% of the possible positions in the search zone (i.e., 90% completeness). The median 1σ error bar in the contrast of potential companions within our search region is 1.2×10^-3. The best fit to our data set using a binary model is found for a faint companion located at about 14.4 mas from β Pic, which has a contrast of 1.8×10^-3 ± 1.1×10^-3 (a result consistent with the absence of companions). For angular separations larger than 60 mas, both time smearing and field-of-view limitations reduce the sensitivity. Conclusions. We can exclude the presence of brown dwarfs with masses higher than 29 MJup (resp. 47 MJup) at a 50% (resp. 90%) completeness level within the first few AUs around β Pic. Interferometric closure phases offer a promising way to directly image low-mass companions in the close environment of nearby young stars. [less ▲]

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See detailDeep Reinforcement Learning Solutions for Energy Microgrids Management
François-Lavet, Vincent ULg; Taralla, David; Ernst, Damien ULg et al

in European Workshop on Reinforcement Learning (EWRL 2016) (2016, December)

This paper addresses the problem of efficiently operating the storage devices in an electricity microgrid featuring photovoltaic (PV) panels with both short- and long-term storage capacities. The problem ... [more ▼]

This paper addresses the problem of efficiently operating the storage devices in an electricity microgrid featuring photovoltaic (PV) panels with both short- and long-term storage capacities. The problem of optimally activating the storage devices is formulated as a sequential decision making problem under uncertainty where, at every time-step, the uncertainty comes from the lack of knowledge about future electricity consumption and weather dependent PV production. This paper proposes to address this problem using deep reinforcement learning. To this purpose, a specific deep learning architecture has been designed in order to extract knowledge from past consumption and production time series as well as any available forecasts. The approach is empirically illustrated in the case of a residential customer located in Belgium. [less ▲]

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See detailDeep remission: A new concept?
Colombel, Jean-Frédéric; Louis, Edouard ULg; Peyrin-Biroulet, Laurent et al

in Digestive Diseases (2012)

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See detailDeep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Rivas, Manuel A.; Beaudoin, Melissa; Gardet, Agnes et al

in Nature Genetics (2012), 43(11), 1066-73

More than 1,000 susceptibility loci have been identified through genome-wide association studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of causal variants ... [more ▼]

More than 1,000 susceptibility loci have been identified through genome-wide association studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of causal variants underlying these findings have not yet been defined. Here we used pooled next-generation sequencing to study 56 genes from regions associated with Crohn's disease in 350 cases and 350 controls. Through follow-up genotyping of 70 rare and low-frequency protein-altering variants in nine independent case-control series (16,054 Crohn's disease cases, 12,153 ulcerative colitis cases and 17,575 healthy controls), we identified four additional independent risk factors in NOD2, two additional protective variants in IL23R, a highly significant association with a protective splice variant in CARD9 (P < 1 x 10(-16), odds ratio approximately 0.29) and additional associations with coding variants in IL18RAP, CUL2, C1orf106, PTPN22 and MUC19. We extend the results of successful GWAS by identifying new, rare and probably functional variants that could aid functional experiments and predictive models. [less ▲]

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See detailDeep sequencing reveals abundant non-canonical retroviral microRNAs in B-cell leukemia/lymphoma
Durkin, Keith ULg

Scientific conference (2013, January 28)

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See detailDeep sequencing reveals abundant non-canonical retroviral microRNAs in B-cell leukemia/lymphoma
Rosewick, Nicolas; Momont, Mélanie ULg; Durkin, Keith ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2013)

Viral tumor models have significantly contributed to our understanding of oncogenic mechanisms. How transforming delta-retroviruses induce malignancy however remains poorly understood, especially as viral ... [more ▼]

Viral tumor models have significantly contributed to our understanding of oncogenic mechanisms. How transforming delta-retroviruses induce malignancy however remains poorly understood, especially as viral mRNA/protein are tightly silenced in tumors. Here, using deep sequencing of broad windows of small RNA sizes in the Bovine Leukemia Virus ovine model of leukemia/lymphoma, we provide in vivo evidence of the production of non-canonical Pol IIItranscribed viral microRNAs in leukemic B-cells in the complete absence of Pol II 5’ LTR-driven transcriptional activity. Processed from a cluster of five independent self-sufficient transcriptional units located in a proviral region dispensable for in vivo infectivity, BLV microRNAs represent ~ 40 % of all microRNAs in both experimental and natural malignancy. They are subject to strong purifying selection and associate with Argonautes, consistent with a critical function in silencing of important cellular and/or viral targets. BLV microRNAs are strongly expressed in preleukemic and malignant cells in which structural and regulatory gene expression is repressed, suggesting a key role in tumor onset and progression. Understanding how Pol III-dependent microRNAs subvert cellular and viral pathways will contribute in deciphering the intricate perturbations that underlie malignant transformation. [less ▲]

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See detailDeep structure of Southern Tian Shan (China) and its neotectonic expression
Hubert, Aurelia ULg; Suppe, J.; Wang, X et al

Conference (1999, April)

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See detailDeep Water Formation in the North Pacific during the Last Glacial Termination
Okazaki, Y.; Timmermann, A.; Menviel, L. et al

in Science (2010), 329

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See detailDeep-Sky Observing with Small Telescopes -- David J. Eicher
Manfroid, Jean ULg

in Ciel et Terre (1990), 106

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See detailDeepening a precautionary european policy
Deblonde, M.; du Jardin, Patrick ULg

in Journal of Agricultural & Environmental Ethics (2005), 18

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See detailLa défaillance des PME : processus et (auto)diagnostic
Crutzen, Nathalie ULg; Van Caillie, Didier ULg

Conference (2007, June 11)

This presentation provides both a large overview of the different processes leading to business failure in SMEs and a proposal of a structured tool organized as a self-diagnosis mechanism to prevent ... [more ▼]

This presentation provides both a large overview of the different processes leading to business failure in SMEs and a proposal of a structured tool organized as a self-diagnosis mechanism to prevent bankruptcy in a particular SME. [less ▲]

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See detailLa défaillance du consommateur
Renson, Florence ULg; Biquet, Christine ULg

in Biquet, Christine; Beguin, Etienne (Eds.) Le crédit hypothécaire au consommateur : Etat de la question. (2017)

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See detailLa défaillance du crédité
Renson, Florence ULg; Biquet, Christine ULg

in Biquet, Christine (Ed.) Crédit aux consommateurs et aux P.M.E (2016)

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See detailDéfaillance neurologique au cours de l'insuffisance hépatique aigüe
DETRY, Olivier ULg

Conference (2011, June 16)

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See detailDéfaire le discours d'autorité. Les 'Physiologies' à la limite de l'essai
Stienon, Valérie ULg

in Glaudes, Pierre; Lyon-Caen, Boris (Eds.) Essai et essayisme en France au XIXe siècle (2014)

Les Physiologies déferlent sous la Monarchie de juillet, alimentant les dépôts de pittoresques et prolongeant les caricatures en vitrine des passages parisiens. Si, presqu’un siècle plus tard, l’emprunt ... [more ▼]

Les Physiologies déferlent sous la Monarchie de juillet, alimentant les dépôts de pittoresques et prolongeant les caricatures en vitrine des passages parisiens. Si, presqu’un siècle plus tard, l’emprunt littéraire à la «physiologie» compose encore un effet de titre pour un essai théorique tel que la Physiologie de la critique d’Albert Thibaudet (1920), le petit genre du même nom, qui présente d’autres caractéristiques formelles et thématiques, n’est pas nettement défini par rapport à une conception et une pratique de l’essai. Au mieux peut-on lui trouver certaines parentés avec la chronique sous la forme de la notation des faits-Paris et avec une fiction d’actualité féconde en savoirs culturels et sociaux. Cette indétermination générique est particulièrement intéressante en raison de la diversité des paramètres poétiques et contextuels sur lesquels elle repose. Ce sont ces aspects qui font l’objet du présent parcours synthétique dans un corpus foisonnant, en préalable à une étude plus spécifiquement dédiée aux infinies nuances qui caractérisent ces textes. [less ▲]

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See detailDéfaire le discours d'autorité. Les Physiologies à la limite de l'essai
Stienon, Valérie ULg

Conference (2013, May 23)

Un siècle après l’essoufflement de la mode panoramique des années 1830-1840, l’emprunt littéraire à la « physiologie » constitue encore un effet de titre pour un essai théorique tel que Physiologie de la ... [more ▼]

Un siècle après l’essoufflement de la mode panoramique des années 1830-1840, l’emprunt littéraire à la « physiologie » constitue encore un effet de titre pour un essai théorique tel que Physiologie de la critique d’Albert Thibaudet. Pourtant, sous la Monarchie de Juillet, le petit genre du même nom, qui présente d’autres caractéristiques formelles et thématiques, n’est pas nettement défini par rapport à une conception et une pratique de l’essai. Au mieux peut-on lui découvrir des parentés significatives avec une certaine écriture journalistique. Les Physiologies se rapprochent en effet de la chronique sous la forme de la notation des faits-Paris et développent une fiction d’actualité féconde en savoir culturel et social. Leur engagement satirique contre le gouvernement en place et leur inscription dans un contexte de vulgarisation scientifique accrue sous l’influence londonienne de la « connaissance utile » ne suffisent pas à apparenter ces Physiologies à de la prose d’idées. Au contraire, elles contournent volontiers les conventions d’écriture du texte d’idées à travers des formes parodiques et déceptives. Il s’agit, de la sorte, d’empêcher le dogmatisme de prendre consistance en oeuvrant contre le discours d’autorité, en particulier scientifique, et contre l’assertivité qui lui est inhérente. Les informations traitées sont non seulement modelées par la distanciation humoristique et la saturation polyphonique, mais elles se trouvent également travaillées en profondeur par la contamination volontaire avec la rhétorique publicitaire dans un contexte de prolifération journalistique de la « réclame ». Le genre physiologique résiste de la sorte aux structures textuelles normatives et assertives d’exposition du savoir. Il ne se les approprie que pour mieux les disqualifier par l’humour et le raisonnement paralogique. Cette caractéristique se traduit par certaines postures discursives récurrentes, en particulier celle du faux spécialiste exhibé comme tel, posture qui consiste à feindre de se rendre ponctuellement expert d’une fraction réduite et caricaturalement recréée de la société, tout en opérant des décrochages réguliers par rapport à cette position énonciative investie d’une autorité. L’étude discursive et générique de tels modes d’expression biaisée du discours d’autorité doit permettre d’éclairer la dynamique d’écriture de l’essai dans les Physiologies parisiennes des années 1830-1840. Cet examen sera orienté par la question des redistributions qui sont ainsi rendues possibles à propos de la frontière entre l’essai-cognitif, caractérisé par une structuration théorique à vocation objectivante, et l’essai-méditation, centré sur une expressivité individualisante de l’instance énonciative. [less ▲]

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See detailDefault mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers.
Patel, Krishna T.; Stevens, Michael C.; Pearlson, Godfrey D. et al

in Brain Imaging and Behavior (2013), 7(1), 60-7

Alzheimer's disease (AD) is most commonly detected during old age, but the underlying neuropathologic changes likely appear decades earlier, especially among patients possessing genetic risk factors, such ... [more ▼]

Alzheimer's disease (AD) is most commonly detected during old age, but the underlying neuropathologic changes likely appear decades earlier, especially among patients possessing genetic risk factors, such as the isoform E4 of the apolipoprotein E (ApoE4). In this study, we used magnetic resonance imaging (MRI) to assess default mode network (DMN) connectivity in 22 ApoE4 non-carriers and 14 matched ApoE4 carriers as well as white matter fractional anisotropy (FA) in 15 ApoE4 non-carriers and 11 demographically matched ApoE4 carriers. Cognitive tests were also administered. All of the participants were middle-aged adults. The analysis revealed no cognitive or white matter FA differences between carriers and non-carriers. However, in DMN regions previously implicated in AD, we did detect decreased functional connectivity. Our findings suggest that functional MRI abnormalities may be detectable well before cognitive decline or white matter changes among individuals at increased genetic risk for AD. [less ▲]

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