Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailDevelopment of the lemann index to assess digestive tract damage in patients with Crohn's disease.
Pariente, Benjamin; Mary, Jean-Yves; Danese, Silvio et al

in Gastroenterology (2015), 148(1), 52-63

BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for ... [more ▼]

BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for measuring disease progression. We developed the Lemann Index and assessed its ability to measure cumulative structural bowel damage in patients with Crohn's disease (CD). METHODS: We performed a prospective, multicenter, international, cross-sectional study of patients with CD evaluated at 24 centers in 15 countries. Inclusions were stratified based on CD location and duration. All patients underwent clinical examination and abdominal magnetic resonance imaging analyses. Upper endoscopy, colonoscopy, and pelvic magnetic resonance imaging analyses were performed according to suspected disease locations. The digestive tract was divided into 4 organs and subsequently into segments. For each segment, investigators collected information on previous operations, predefined strictures, and/or penetrating lesions of maximal severity (grades 1-3), and then provided damage evaluations ranging from 0.0 (no lesion) to 10.0 (complete resection). Overall level of organ damage was calculated from the average of segmental damage. Investigators provided a global damage evaluation (from 0.0 to 10.0) using calculated organ damage evaluations. Predicted organ indexes and Lemann Index were constructed using a multiple linear mixed model, showing the best fit with investigator organ and global damage evaluations, respectively. An internal cross-validation was performed using bootstrap methods. RESULTS: Data from 138 patients (24, 115, 92, and 59 with upper tract, small bowel, colon/rectum, and anus CD location, respectively) were analyzed. According to validation, the unbiased correlation coefficients between predicted indexes and investigator damage evaluations were 0.85, 0.98, 0.90, 0.82 for upper tract, small bowel, colon/rectum, anus, respectively, and 0.84 overall. CONCLUSIONS: In a cross-sectional study, we assessed the ability of the Lemann Index to measure cumulative structural bowel damage in patients with CD. Provided further successful validation and good sensitivity to change, the index should be used to evaluate progression of CD and efficacy of treatment. [less ▲]

Detailed reference viewed: 94 (5 ULg)
Full Text
Peer Reviewed
See detailDevelopment of the National Forest Inventory in Luxembourg
Rondeux, Jacques ULg; Wagner, Marc

in Tomppo, Erkki; Gschwantner, Thomas; Lawrence, Mark (Eds.) et al National Forest Inventories - Pathways for common reporting (2010)

Detailed reference viewed: 21 (6 ULg)
Full Text
Peer Reviewed
See detailDevelopment of the Osteoporosis Risk Assessment by Composite Linear Essay (ORACLE)
Richy, Florent; Uhoda, Emmanuelle ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2002, November), 13(Suppl.3), 11

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailDevelopment of the paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.
Peyrin-Biroulet, Laurent; Billioud, Vincent; D'Haens, Geert et al

in American Journal of Gastroenterology (2012), 107(12), 1770-6

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen ... [more ▼]

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD. [less ▲]

Detailed reference viewed: 38 (3 ULg)
Full Text
Peer Reviewed
See detailDevelopment of the Regional Forest Inventory (RFI) in Wallonia
Rondeux, Jacques ULg; Sanchez, Christine; Latte, Nicolas ULg

in Tomppo, Erkki; Gschwantner, Thomas; Lawrence, Mark (Eds.) et al National Forest Inventories. Pathways for Common Reporting (2010)

Detailed reference viewed: 40 (10 ULg)
Full Text
Peer Reviewed
See detailDevelopment of the surface structure of TRIP steels prior to hot-dip galvanizing
Bellhouse, Erika M.; Mertens, Anne ULg; McDermid, Joe R.

in Materials Science & Engineering : A (2007), 463

Focusing on improving the reactive wetting of transformation-induced plasticity (TRIP) steels during hot-dip galvanizing, the effect of the alloying elements manganese, silicon and aluminum on the surface ... [more ▼]

Focusing on improving the reactive wetting of transformation-induced plasticity (TRIP) steels during hot-dip galvanizing, the effect of the alloying elements manganese, silicon and aluminum on the surface structure prior to galvanizing was studied. A C-Mn steel and two TRIP steels with aluminum either completely or partially replacing silicon were investigated. [less ▲]

Detailed reference viewed: 44 (2 ULg)
See detailDevelopment of the surface structure of TRIP steels prior to hot-dip galvanizing
Bellhouse, Erika M.; Mertens, Anne ULg; McDermid, Joe R.

Conference (2006, March)

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailDevelopment of the ultrastructure of sonic muscles: a kind of neoteny?
Millot, Sandie; Parmentier, Eric ULg

in BMC Evolutionary Biology (2014), 14

Detailed reference viewed: 46 (9 ULg)
Full Text
Peer Reviewed
See detailDevelopment of thermal comfort models for various climatic zones of North-East India
Singh, Manoj Kumar ULg; Mahapatra, Sadhan; Teller, Jacques ULg

in Sustainable Cities and Society (2015), 14

Thermal comfort study provides crucial information about thermal performance of naturally ventilated buildings. Humphreys and Auliciems comfort model uses indoor and outdoor temperatures to predict ... [more ▼]

Thermal comfort study provides crucial information about thermal performance of naturally ventilated buildings. Humphreys and Auliciems comfort model uses indoor and outdoor temperatures to predict comfort temperatures. It is found that the comfort temperatures obtained by using these methods do not take into account the occupant behavioral adaptability to a particular climatic zone. This demands development of new set of comfort models based on local environmental parameters, socio-cultural setup and behavioral action. Analysis shows that four major variables like indoor and outdoor temperature, relative humidity and clothing pattern plays an important role in defining comfort and greatly influence the occupant’s perception and acceptance on thermal comfort. In this study, comfort models are developed based on these variables. The computed neutral temperatures based on the models are compared with the comfort temperatures obtained through comfort survey. The models are developed using the measured data of January and July months and validated with the measured data of April and October months. This study also concludes that it is not possible to obtain a generalized thermal comfort model for all climatic zone because adaptation process, expectation and perception of people are region specific and governed by local socio-cultural requirement. [less ▲]

Detailed reference viewed: 49 (7 ULg)
Full Text
Peer Reviewed
See detailDevelopment of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors
Francotte, Pierre ULg; Goffin, Eric ULg; Fraikin, Pierre et al

in Journal of Medicinal Chemistry (2013), 56(20), 7838-7850

On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the ... [more ▼]

On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the design of original isosteric 3,4-dihydro-2H-thieno-1,2,4-thiadiazine 1,1-dioxides. Owing to the sulfur position, three series of compounds were developed and their activity as AMPA potentiators was characterized. In each of the developed series, potent compounds were discovered. After screening the selected active compounds on a safety in vivo test, 6-chloro-4-ethyl-3,4-dihydro-2H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide (24) appeared as the most promising compound and was further evaluated. Its effects on long-term potentiation in vivo and on AMPA-mediated noradrenaline release were measured to predict its potential cognitive enhancing properties. Finally, an object recognition test performed in mice revealed that 24 was able to significantly enhance cognition, after oral administration, at doses as low as 0.3 mg/kg. This study validates the interest of the isosteric replacement of the benzene or pyridine nuclei by the thiophene nucleus in the ring-fused thiadiazine dioxides class of AMPA potentiators. [less ▲]

Detailed reference viewed: 38 (10 ULg)
Peer Reviewed
See detailDevelopment of thromboxane A2 modulators as promising anti-metastatic and anti-angiogenic compounds
De Leval, X.; Dassesse, T.; Benoit, V. et al

Conference (2004, May)

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailDevelopment of thymus autografts under the kidney capsule in the pig: a new 'organ' for xenotransplantation
Lambrigts, Denis; Franssen, Colette ULg; Martens, Henri ULg et al

in Xenotransplantation (1996), 3

Detailed reference viewed: 31 (1 ULg)
Full Text
Peer Reviewed
See detailDevelopment of upland cotton plants highly resistant to the reniform nematode from the G. Hirsutum x G. Thurberi x G. Longicalyx hybrid
Mergeai, Guy ULg; Konan, N.O; Baudoin, Jean-Pierre ULg

in Proceedings of the beltwide cotton improvement conference (2010)

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailDevelopment of urine-based DNA methylation assay for prostate cancer screening
Vener, T. I.; Derecho, C.; Varde, S. et al

Poster (2007)

Introduction: The best outcome for patients with prostate cancer (PCa) is seen for those treated at an early stage of the disease. A digital rectal examination (DRE) and the measurement of serum prostate ... [more ▼]

Introduction: The best outcome for patients with prostate cancer (PCa) is seen for those treated at an early stage of the disease. A digital rectal examination (DRE) and the measurement of serum prostate specific antigen (PSA) levels are the current standards for PCa early detection. However, serum PSA testing lacks both sensitivity and specificity, and core biopsies frequently fail to identify small foci of PCa. The availability of non-invasive diagnostic molecular tests that could allow for a more precise identification of malignant prostate cells in asymptomatic men would be of great clinical value to improve PCa diagnosis. Study design: 114 men scheduled to undergo a prostate biopsy were enrolled in the study. The biopsies were triggered either by an abnormally high PSA value or by suspicious findings on DRE. Patients with other known or suspected urinary malignancy were excluded from the study. Morning, post-prostate massage and post-biopsy urine samples were collected from all individuals. The main goals of this study were a) to determine if prostate massage can improve the prostate DNA quantity compared to urine collected in the morning or after biopsy, and b) to evaluate the methylation status of a gene panel in urine samples from subjects with cancer found in prostate biopsy tissue cores versus subjects without cancer. Methods: Gene promoter methylation is associated with prostate cancer and has been successfully used for the molecular detection of neoplasia in urine. We have developed real-time methylation specific PCR assays to define the methylation status of several genes. Results: Median age of the patients was 65 years (range 48-85). PCa was found in 51% of the patients. Histological diagnosis of the biopsies was compared to methylation results in urine from 102 samples (89% success rate due low DNA yields for 12 samples). The comparison between different urine sampling techniques showed that prostate massage is needed. The best results were obtained in post massage urine samples with a combination of GSTP1, p14, p16, RARβ2 and RASSF1A resulting in a sensitivity of 74% and a specificity of 75%. Future: A multiplex assay using the Cepheid SmartCycler™ II platform is under development. Further studies are in progress to validate the assay across multiple centers. [less ▲]

Detailed reference viewed: 65 (0 ULg)
Peer Reviewed
See detailThe development of visual memory span : The role of expertise
Thibaut, Jean-Pierre; Comblain, Annick ULg

Poster (1999, May 20)

Detailed reference viewed: 11 (0 ULg)
Full Text
See detailDevelopment path and capital structure of belgian biotechnology firms
Bastin, Veronique; Corhay, Albert ULg; Hübner, Georges ULg et al

in Butzen, Paul (Ed.) Firms' investment and finance decisions: Theory and empirical methodology (2003)

Detailed reference viewed: 22 (5 ULg)
See detailDevelopment, Environment and Migration. Analysis of Linkages and Consequences.
Stojanov, Robert; Novosak, Jiri; Opiniano, Jeremiah et al

Book published by Université Palacky (2008)

Detailed reference viewed: 58 (5 ULg)