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See detailDecreased expression of galectin-3 is associated with progression of human breast cancer.
Castronovo, Vincenzo ULg; van den Brule, Frédéric; Jackers, Pascale ULg et al

in Journal of Pathology (The) (1996), 179(1), 43-48

Galectin-3, a member of the beta-galactoside-binding lectin family, is involved in several biological events including binding to the basement membrane glycoprotein laminin. Although the exact role of ... [more ▼]

Galectin-3, a member of the beta-galactoside-binding lectin family, is involved in several biological events including binding to the basement membrane glycoprotein laminin. Although the exact role of galectin-3 during the interactions between cells and laminin is not yet known, it has recently been observed that its expression is down-regulated at both the protein and the mRNA level in colon cancer tissues in correlation with progression of the disease. This study investigated the possibility that breast cancer cells might also exhibit decreased galectin-3 expression in association with their aggressiveness. The expression of galectin-3 was examined by immunoperoxidase staining, using a polyclonal antibody raised against recombinant galectin-3, in a collection of 98 human breast lesions including 12 fibroadenomas, 15 fibrocystic disease lesions, 22 in situ carcinomas, and 49 infiltrating ductal carcinomas, 19 of which had positive axillary lymph nodes. Normal breast tissue adjacent to the lesions was present in 59 biopsies. Normal breast tissue expressed high levels (3+) of galectin-3. High expression (2+ to 3+) was also found in most benign lesions examined. The expression of galectin-3 was significantly decreased in in situ carcinoma and this down-regulation was more pronounced in invasive ductal carcinoma, particularly when associated with infiltration of axillary lymph nodes. These data constitute the first observation that galectin-3 is down-regulated in breast cancer and suggest the decreased expression of this galactoside-binding lectin is associated with the acquisition of the invasive and metastatic phenotype. [less ▲]

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See detailDecreased local control following radiation therapy alone in early larynx cancer with anterior commisure extension
Ozsahin; Bron; COUCKE, Philippe ULg et al

in Radiotherapy & Oncology (2002), 64(supp 1), 243-244

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See detailDecreased local control following radiation therapy alone in early stage glottic carcinoma with anterior commissure extention.
Azria, D; COUCKE, Philippe ULg; Matzinger, O et al

in Sonderbande zur Strahlentherapie und Onkologie (2004), 2

Purpose: To assess the patterns of failure in the treatment of early-stage squamous cell carcinoma of the glottic larynx. Patients and Methods: Between 1983–2000, 122 consecutive patients treated for ... [more ▼]

Purpose: To assess the patterns of failure in the treatment of early-stage squamous cell carcinoma of the glottic larynx. Patients and Methods: Between 1983–2000, 122 consecutive patients treated for early laryngeal cancer (UICC T1N0 and T2N0) by radical radiation therapy (RT) were retrospectively studied. Male-to-female ratio was 106 : 16, and median age 62 years (35–92 years). There were 68 patients with T1a, 18 with T1b, and 36 with T2 tumors. Diagnosis was made by biopsy in 104 patients, and by laser vaporization or stripping in 18. Treatment planning consisted of three-dimensional (3-D) conformal RT in 49 (40%) patients including nine patients irradiated using arytenoid protection. A median dose of 70 Gy (60–74 Gy) was given (2 Gy/fraction) over a median period of 46 days (21–79 days). Median follow-up period was 85 months. Results: The 5-year overall, cancer-specific, and disease-free survival amounted to 80%, 94%, and 70%, respectively. 5-year local control was 83%. Median time to local recurrence in 19 patients was 13 months (5–58 months). Salvage treatment consisted of surgery in 17 patients (one patient refused salvage and one was inoperable; total laryngectomy in eleven, and partial laryngectomy or cordectomy in six patients). Six patients died because of laryngeal cancer. Univariate analyses revealed that prognostic factors negatively influencing local control were anterior commissure extension, arytenoid protection, and total RT dose < 66 Gy. Among the factors analyzed, multivariate analysis (Cox model) demonstrated that anterior commissure extension, arytenoid protection, and male gender were the worst independent prognostic factors in terms of local control. Conclusion: For early-stage laryngeal cancer, outcome after RT is excellent. In case of anterior commissure extension, surgery or higher RT doses are warranted. Because of a high relapse risk, arytenoid protection should not be attempted. [less ▲]

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See detailDecreased number and defect of the initialization process of corticotropin-releasing hormone receptors in adenomatous corticotrophs
Smets, G.; Abs, R.; Verhelst, J. et al

in The 75th Annual meeting of the Endocrine society - Abstract book (1993)

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See detailDecreased number and defect of the internalization process of corticotropin-releasing hormone receptors in adenomatous corticotrophs
verhelst, j; Abs, R.; Beckers, Albert ULg et al

in Acta Clinica Belgica (1993), 48

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See detailDecreased Protein Levels of the C-Cbl Protooncogene in Murine Aids
Trebak, Mohamed; Lambert, Charles A; Rahmouni, Souad ULg et al

in Cellular Immunology (1998), 188(2), 151-7

Murine acquired immunodeficiency syndrome (MAIDS) can be viewed as a lymphoproliferative disease which involves B cells as well as T cells from spleen and lymph nodes while thymus and Peyer's patches do ... [more ▼]

Murine acquired immunodeficiency syndrome (MAIDS) can be viewed as a lymphoproliferative disease which involves B cells as well as T cells from spleen and lymph nodes while thymus and Peyer's patches do not participate in the process. The 120-kDa protooncogene product c-Cbl was initially cloned from the murine Cas NS-1 B cell lymphoma. It is a main target of immunoreceptor (TCR and BCR)-mediated protein tyrosine kinase activity. Moreover, recent data suggest that c-Cbl might play a crucial role in the regulation of cell proliferation through regulation of GTP-binding proteins. Therefore, the involvement of c-Cbl was evaluated in the lymphoproliferative disease induced by the MAIDS virus. The expression of the c-Cbl protein was dramatically reduced in the lymph node of infected mice while it remained normal in the thymus. In contrast, the expression of actin, TCR-zeta chain, ZAP-70, and p59(fyn) remained similar in controls and infected mice. Identical results were obtained with sorted B cells and T cells. Surprisingly, a B cell lymphoma line derived from late stage MAIDS mice displayed a normal level of c-Cbl. [less ▲]

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See detailDecreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent's disease.
Raggi, Claudia; Fujiwara, Kunio; Leal, Teresinha et al

in Pflügers Archiv : European Journal of Physiology (2011), 462(6), 851-60

The clinical use of aminoglycoside (AG) antibiotics is limited by their renal toxicity, which is caused by drug accumulation in proximal tubule (PT) cells. Clinical studies reported that renal clearance ... [more ▼]

The clinical use of aminoglycoside (AG) antibiotics is limited by their renal toxicity, which is caused by drug accumulation in proximal tubule (PT) cells. Clinical studies reported that renal clearance of AG is enhanced in cystic fibrosis (CF) patients, which might reflect the role of CFTR in PT cell endocytosis. In order to assess the role of chloride transporters on the renal handling of AG, we investigated gentamicin uptake and renal accumulation in mice lacking functional CFTR (Cftr ( F/F)) or knock-out for the Cl(-)/H(+) exchanger ClC-5 (Clcn5 ( Y/- )). The latter represent a paradigm of PT dysfunction and defective receptor-mediated endocytosis. As compared with controls, Cftr ( F/F) and Clcn5 ( Y/- ) mice showed a 15% to 85% decrease in gentamicin accumulation in the kidney, respectively, in absence of renal failure. Studies on primary cultures of Cftr ( F/F) and Clcn5 ( Y/- ) mouse PT cells confirmed the reduction in gentamicin uptake, although colocalization with endosomes and lysosomes was maintained. Quantification of endocytosis in PT cells revealed that gentamicin, similar to albumin, preferentially binds to megalin. The functional loss of ClC-5 or CFTR was reflected by a decrease of the endocytic uptake of gentamicin, with a more pronounced effect in cells lacking ClC-5. These results support the concept that CFTR, as well as ClC-5, plays a relevant role in PT cell endocytosis. They also demonstrate that the functional loss of these two chloride transporters is associated with impaired uptake of AG in PT cells, reflected by a decreased renal accumulation of the drug. [less ▲]

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See detailDecreased responsiveness of GH3 cells to the dopaminergic inhibition of prolactin
Faure, Nacia; Cronin, Michaël J; Martial, Joseph ULg et al

in Endocrinology (1980), 107(4), 1022-1026

The inhibitory regulation of PRL secretion by dopamine (DA) or the dopaminergic agonists bromergocryptine (CB-154) and apomorphine was studied in cultured GH3 cells, an established rat anterior pituitary ... [more ▼]

The inhibitory regulation of PRL secretion by dopamine (DA) or the dopaminergic agonists bromergocryptine (CB-154) and apomorphine was studied in cultured GH3 cells, an established rat anterior pituitary cell line which produces both PRL and GH. The basal release of PRL from GH3 cells was unaffected when incubated for 6 h with DA concentrations as high as 10(-4) M. The inability of DA to suppress PRL secretion could not be explained by the catabolism of DA or the presence of unknown inhibitors (e.g. estradiol) in the fetal calf serum present in the incubation media. Apomorphine and CB-154 were only partially effective in suppressing PRL release at high concentrations of 10(-4) and 10(-5) M, respectively. Various concentrations of the dopaminergic antagonist d-butaclamol did not reverse the inhibitory action of 10(-5) M CB-154, while equal concentrations (10(-5) M) of both d- and l-butaclamol significantly suppressed PRL release. The greatly lowered responsiveness of GH3 cells to dopaminergic inhibition of PRL is suggestive of some impairment of DA receptors. This hypothesis is supported by radioligand binding studies in which high affinity dopaminergic binding sites are absent in the same cell line used in this study. [less ▲]

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See detailDecreased Thymosin Beta 4 Expression Results in Poor Prognosis and Decreased Survival in Multiple Myeloma
CAERS, Jo ULg; Hose, Dirk; Kuipers, Ine et al

Poster (2008)

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See detailDécret d'optimalisation du CWATUP
Delnoy, Michel ULg

in Immobilier (2002), 16

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See detailLe décret décumul : Quels impacts pour le mandat local ?
Grandjean, Geoffrey ULg

Scientific conference (2015, October 17)

A l’heure où la relation entre ministre et bourgmestre empêché pose question et contribue à renforcer un sentiment de méfiance de la part de la population à l’égard des mandataires, les débats sur le ... [more ▼]

A l’heure où la relation entre ministre et bourgmestre empêché pose question et contribue à renforcer un sentiment de méfiance de la part de la population à l’égard des mandataires, les débats sur le cumul ou plutôt le décumul des mandats fait la une de l’actualité de manière récurrente. Aujourd’hui, les représentants politiques belges cumulent en moyenne entre cinq et huit mandats. En 2010, sous le gouvernement PS/CDH/Ecolo, était adopté le décret décumul, traduisant certaines préoccupations évoquées plus haut. Depuis lors, un député wallon ne peut plus cumuler son mandat avec une fonction de bourgmestre, d’échevin ou de président d’un CPAS. Toutefois, un quart des membres de chaque groupe politique est autorisé à cumuler. Pour ce faire, ils sont désignés sur la base de leur taux de pénétration. La communication se propose de retracer brièvement le processus législatif du décret, tout en analysant le jeu des multiples acteurs. A travers une analyse politico-juridique, il se penchera sur les effets du décret pour les mandataires liégeois. Enfin, il dressera des pistes de réflexion concernant la notion de bourgmestre empêché. [less ▲]

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See detailLe décret décumul et le Parlement wallon
Grandjean, Geoffrey ULg; Janssens, Frédéric

in Administration Publique: Revue du Droit Public et des Sciences Administratives (2016), 2

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See detailLe décret du 31 mai 2007 relatif à la participation du public en matière d'environnement : avancées et questions
Delnoy, Michel ULg; Jadot, Benoît

in Delnoy, Michel (Ed.) Actualités du droit de l'aménagement du territoire et de l'environnement - plans et permis (2009)

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See detailLe décret du parlement wallon du 5 décembre 2008 relatif à la gestion des sols
Delnoy, Michel ULg

in Chroniques notariales n°49 (2009)

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See detailLe décret mémoire. Exemple d’un projet
Grandjean, Geoffrey ULg

Conference given outside the academic context (2011)

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See detailLe décret relatif au permis d'environnement
Delnoy, Michel ULg

Book published by edi.pro (2003)

Detailed reference viewed: 28 (5 ULg)