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See detailEffects of Inhaled Nitric Oxide on Pulmonary Hemodynamics in a Porcine Model of Endotoxin Shock
Lambermont, Bernard ULg; D'Orio, Vincenzo ULg; Kolh, Philippe ULg et al

in Critical Care Medicine (1999), 27(9), 1953-7

OBJECTIVE: To evaluate the effects of inhaled nitric oxide (NO) on pulmonary circulation in a porcine endotoxin shock model. DESIGN: Prospective, randomized trial. SETTING: Laboratory at a large ... [more ▼]

OBJECTIVE: To evaluate the effects of inhaled nitric oxide (NO) on pulmonary circulation in a porcine endotoxin shock model. DESIGN: Prospective, randomized trial. SETTING: Laboratory at a large university medical center. SUBJECTS: Twelve pathogen-free pigs weighing 15 to 31 kg. INTERVENTIONS: After surgical preparation, all pigs received a 0.5 mg/kg endotoxin infusion over 30 mins. One hour after the start of endotoxin, NO inhalation (40 ppm) was initiated in six pigs, whereas the six remaining pigs served to control the progression of shock in this model. Consecutive changes in systemic and pulmonary hemodynamics, including characteristic resistance, vascular compliance, peripheral vascular resistance, and inductance, were continuously assessed during the experimental protocol using a four-element Windkessel model of the pulmonary circulation. MEASUREMENTS AND MAIN RESULTS: Endotoxin insult resulted in a biphasic pulmonary artery pressure increase from 14 +/- 2 to 32 +/- 4 mm Hg. Inhaled NO reversed the resistance to blood flow in small pulmonary arteries from 596 +/- 69 to 424 +/- 36 dyne-sec/ cm5. In contrast, the vascular capacitance of the entire pulmonary circuit, which decreased from 2.4 +/- 0.2 to 0.8 +/- 0.1 mL/mm Hg throughout endotoxin challenge, remained insensitive to NO administration. CONCLUSION: In endotoxin-induced pulmonary hypertension, inhaled NO may function as a modulator of distal pulmonary arterial tone but fails to act as a regulator of larger capacitance pulmonary vessels. [less ▲]

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See detailEffects of insecticide treatments on insect density and diversity in vegetable open fields.
Colignon, P.; Hastir, Pierre; Gaspar, Charles ULg et al

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2001), 66(2a), 403-411

Vegetable open field areas increased for 15 years in Wallonia, mainly in Hesbaye. To be in accordance with quality standards, especially in terms of agro-chimical residues (R.M.L.), biological pest ... [more ▼]

Vegetable open field areas increased for 15 years in Wallonia, mainly in Hesbaye. To be in accordance with quality standards, especially in terms of agro-chimical residues (R.M.L.), biological pest control was developed and allowed to reduce the insecticide use, leading to have safer fresh products. Among cultivated species in Wallonia, leguminous crops represent more than 85% of the vegetable production. To assess the impact of insecticide treatment on both pests (mainly aphids) and beneficial insects (predators and parasitoids), broad bean (Vicia faba L.) fields were investigated during all the production duration. Twelve fields between Waremme and Hannut were visited weakly from May to July. In each field, control untreated and treated plots were investigated. Insects were caught using yellow traps and determined until the family level. Approximately 90.000 insects belonging to 59 major families (99% of captures) and 64 minor families were identified. These results showed that biodiversity in terms of family numbers was significantly higher in unsprayed plots. In addition, biodiversity and biomass (insect density) increased gradually during the season. Evaluation of pest and beneficial diversity and density was discussed in relation to aphicid (lambda-cyhalothrin, pirimicarb) treatments and the development of I.P.M. program in vegetable crops. [less ▲]

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See detailEffects of insulin therapy in insulin-requiring type 2 diabetic patients.
DUYSINX, Bernard ULg; SCHEEN, André ULg; PAQUOT, Nicolas ULg et al

in Acta Clinica Belgica (1993), 48

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See detailEffects of interaction of incubator CO2 levels and mixing hatching eggs of different embryo growth trajectory on embryo physiological and hatching parameters.
Tona, K.; Everaert, Nadia ULg; Willemsen, H. et al

in British poultry science (2013), 54(4), 545-51

1. Two experiments were designed to investigate the effects of mixing eggs of different genotype and incubating with different CO2 concentrations on embryonic parameters. Half of the eggs were incubated ... [more ▼]

1. Two experiments were designed to investigate the effects of mixing eggs of different genotype and incubating with different CO2 concentrations on embryonic parameters. Half of the eggs were incubated in a CO2 controlled incubator (VCO2) during the first 10 d of incubation and the other half was incubated at standard incubation ventilation rate (SV). 2. From 10 to 18 d of incubation, thick albumen and embryos were weighed. Blood samples were collected at d 18 of incubation, at internal pipping and at hatch for determination of triiodothyronine (T3), thyroxine (T4) and corticosterone concentration. During the last 2 d of incubation, hatching events of individual eggs were monitored every 2 h. 3. From 4 to 5 d of incubation in the SV group of Experiment 1, pH values of Ross strain chickens were lower than those of Isa Brown. From d 12 of incubation onwards, Ross embryos grew faster than those of Isa Brown. At 14 and 16 d of incubation, Ross eggs in the CO2 controlled incubator had lower albumen weights compared to all other treatments. 4. T3 concentrations in Ross embryos were higher than those of Isa Brown embryos. Chicken weight at hatch was in the following order: Isa Brown SV < Isa Brown VCO2 = Ross SV < Ross VCO2. 5. In Experiment 2, incubation time of VCO2 eggs until internal pipping, external pipping and hatch was significantly shorter than that of SV eggs. 6. It was concluded that mixing of hatching eggs of differential embryo developmental trajectory affects their hatching process. [less ▲]

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See detailEffects of interleukin-1 beta and dexamethasone on the expression by chondrocytes of antioxidant enzymes
Mathy, Marianne ULg; Devel, Philippe; Sanchez, Christelle ULg et al

in Osteoarthritis and Cartilage (2004), 12(Suppl. B), 51-52

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See detailEffects of intraovarian application of insulin-like growth factor-1 (IGF-1) on the superovulatory response of diary cattle.
Velazquez, M. A.; Hadeler, K. G.; Beckers, Jean-François ULg et al

in Reproduction in Domestic Animals (2009), 44(S1), 38

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See detailEffects of intrapleural pressure changes on pulmonary haemodynamics measurements in unsedated cattle
Amory, Hélène ULg; Rollin, Frédéric ULg; Art, Tatiana ULg et al

in Archives Internationales de Physiologie et de Biochimie (1989)

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See detailEffects of intravascular volume expansion on lung fluid balance in a canine model of septic shock
D'Orio, Vincenzo ULg; WAHLEN, C; HALLEUX, J et al

in Critical Care Medicine (1987), 15

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See detailEffects of intravenous infusions of sodium bicarbonate on blood oxygen binding in calves with diarrhoea
Cambier, Carole ULg; Clerbaux, Thierry; Detry, Bruno et al

in Veterinary Record : Journal of the British Veterinary Association (2005), 156(22), 706-710

Twelve diarrhoeic calves were treated intravenously with an isotonic solution containing sodium bicarbonate, and their oxygen equilibrium curves (OECs) were calculated under standard conditions and ... [more ▼]

Twelve diarrhoeic calves were treated intravenously with an isotonic solution containing sodium bicarbonate, and their oxygen equilibrium curves (OECs) were calculated under standard conditions and compared with those of a group of healthy calves. The relationships between the OECs for arterial and venous blood and the oxygen extraction ratio were investigated. in the diarrhoeic calves, the affinity of haemoglobin for oxygen, measured under standard conditions, was increased compared with the healthy animals. During the infusion, the standard partial oxygen pressure at 50 per cent saturation of haemoglobin (P50) values stayed below the values recorded in the healthy animals. At the end of the infusion the mean standard P50 of the diarrhoeic calves was lower than before the infusion. The combined effects of all the regulating factors on blood oxygen binding resulted in the OECS of the arterial and jugular venous blood of the diarrhoeic calves remaining unchanged compared with the healthy calves. However, the administration of the infusion decreased the P50 of both the arterial and venous blood to below the value recorded in the healthy calves. oxygen extraction by the tissues was impaired in the diarrhoeic calves throughout the infusion, and they remained dehydrated and depressed until 120 minutes after the infusion began [less ▲]

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See detailEffects of intravenous lidocaïne in healthy adult horses.
Amory, Hélène ULg; Lopez Arevaldo, Diégo; Maes, An et al

Poster (2008, January)

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See detailEffects of ionospheric small-scale structures on GNSS
Wautelet, Gilles ULg; Lejeune, Sandrine; Warnant, René ULg

in The Institution of Engineering and Technology 11th International Conference on Ionospheric Radio Systems and Techniques (IRST 2009) (2009, April)

Nowadays, Global Navigation Satellite Systems or GNSS allow to measure positions in real-time with an accuracy ranging from a few meters to a few centimeters mainly depending on the type of observable ... [more ▼]

Nowadays, Global Navigation Satellite Systems or GNSS allow to measure positions in real-time with an accuracy ranging from a few meters to a few centimeters mainly depending on the type of observable (code or phase measurements) and on the positioning mode used (absolute or differential). The best precisions can be reached in differential mode using phase measurements. In differential mode, mobile users improve their positioning precision thanks to so-called “differential corrections” provided by a fixed reference station. For example, the Real-Time Kinematic technique (RTK) allows to measure positions in real-time with a precision usually better than a decimeter. In practice, the ionospheric effects on GNSS radio signals remain the main factor which limits the precision and the reliability of real-time differential positioning. As differential applications are based on the assumption that the measurements made by the reference station and by the mobile user are affected in the same way by ionospheric effects, these applications are influenced by gradients in TEC between the reference station and the user. For this reason, local variability in the ionospheric plasma can be the origin of strong degradations in positioning precision. In this paper, we characterize local variability in the ionosphere which can pose a threat to high precision real-time differential positioning. GNSS carrier phase measurements can be used to monitor local TEC variability: small-scale ionospheric structures can be detected by monitoring TEC high frequency changes at a single station; as ionospheric disturbances are moving, we can expect that such structures will induce TEC temporal variability which can be detected at a single station. We applied this method (called the “one-station” method) to the GPS data collected at the permanent (mid-latitude) station of Brussels from 1994 to 2007 and performed a climatological study of the ionospheric structures on this period which covers more than one solar cycle. Two main types of structures have been observed: Traveling Ionospheric Disturbances (TID’s) and “noise-like” structures. TID’s have strong seasonal and solar cycle dependence when noise-like structures are “ionospheric variability” which is usually observed during geomagnetic storms. The largest Rate of TEC (RoTEC) detected at Brussels during the period considered in our study were observed during severe geomagnetic storms. Moreover, we found that strong irregularities occur even during solar minimum. This means that, even during periods where the probability of occurrence of ionospheric irregularities is very low, large RoTEC can occur. The one-station method allows to measure variability in time but GNSS differential applications are affected by variability in space between the user and the reference station. Therefore, in a second step, we measured TEC differential variability (using double differences of phase measurements) during few typical ionospheric conditions: quiet ionospheric activity, medium and large amplitude TID’s and noise-like variability due to a severe geomagnetic storm. We also analyzed the effects of the baseline length and orientation on the residual ionospheric term. As a last step, we developed a software which reproduces positioning conditions experienced by RTK users on the field. We used this software to assess positioning errors due to the different ionospheric conditions considered in the previous step. Again, the largest effects were observed during the occurrence of geomagnetic storms. [less ▲]

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See detailEffects of ipratropium bromide on repeated cadmium inhalation-induced lune inflammation and airspace enlargement in rats
Zhang, W. H.; Fievez, Laurence ULg; Cheu, Esteban ULg et al

in Fundamental & Clinical Pharmacology (2010), 10

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See detailEffects of ipriflavone and its metabolites on human articular chondrocytes cultivated in clusters
Franchimont, P; Bassleer, C; Henrotin, Yves ULg et al

in Osteoarthritis and Cartilage (1994), 2(S1), 51

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See detailEffects of Ipriflavone and Its Metabolites on Human Articular Chondrocytes Cultivated in Clusters
Bassleer, C. T.; Franchimont, P. P.; Henrotin, Y. E. et al

in Osteoarthritis and Cartilage (1996), 4

Ipriflavone (IP) is an isoflavone derivative that was suggested to have bone-sparing effects in post-menopausal and senile osteoporosis. A moderate stimulatory effect of IP and its metabolites on ... [more ▼]

Ipriflavone (IP) is an isoflavone derivative that was suggested to have bone-sparing effects in post-menopausal and senile osteoporosis. A moderate stimulatory effect of IP and its metabolites on proliferation of osteoblastic cells was reported in rat osteoblastic osteosarcoma cell line. We investigated the effects of different concentrations (0, 1, 10 and 100 micrograms/ml) of IP and its metabolites (MET I, II, III and V) on the incorporation of [3H] thymidine and production of proteoglycans (PG) and type II collagen (COL II) by human articular chondrocytes during a 12-day period, in a three-dimensional chondrocyte culture model. [3H]thymidine uptake was measured in chondrocyte clusters, and specific PG and COL II radioimmunoassays were performed every 4 days on the culture medium and cell clusters. Incubation with IP or its metabolites did not affect [3H]thymidine uptake regardless of the dose. PG released into the culture medium and PG cluster content rose significantly (P < 0.025) in presence of IP (1, 10 and 100 micrograms/ml). MET I increased PG release in culture medium (10 and 100 micrograms/ml) and PG cluster content (100 micrograms/ml). MET II has no effect on PG production. MET III increased PG in culture medium (100 microgram/ml) but did not influence PG cluster content while MET V (100 micrograms/ml) increased both PG release in culture medium and PG cluster content. COL II release in culture medium and COL II cluster content were significantly (P < 0.025) increased in presence of IP (10 and 100 micrograms/ml), MET III (1, 10 and 100 micrograms/ml) or MET V (100 micrograms/ml). MET I and II did not significantly affect COL II production. [less ▲]

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See detailEffects of iproflavone and its metabolites on human articular chondrocytes
Bassleer, Corinne; Franchimont, Paul; Henrotin, Yves ULg et al

in Osteoarthritis and Cartilage (1995), 4

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See detailEffects of iron deficiency on physical aptitude
Mouton, G.; Sluse, Francis ULg; Welter, A. et al

in Revue Médicale de Liège (1987), 42

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See detailEffects of iron depletion on articular biomarkers and joint symptoms in patients with genetic hemochromatosis: a prospective, longitudinal study.
Richette, P; Eymard, C; Deberg, M et al

in Annals of the Rheumatic Diseases (2009), 68(Suppl 3), 679

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See detailEffects of isothiocyanates on the glutathione S-transferases activity from Adalia bipunctata L. (Coleoptera : Coccinellidae).
Francis, Frédéric ULg; Haubruge, Eric ULg; Gaspar, Charles

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (1999), 64(3a), 297-303

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See detailThe effects of JL 13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia
Ellenbroek, Bart; Liégeois, Jean-François ULg; Bruhwyler, Jacques et al

in Journal of Pharmacology and Experimental Therapeutics (2001), 298

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