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See detailThe effects of flowering signals on root architecture in Arabidopsis
Mathieu, Laura ULg; Lobet, Guillaume ULg; Périlleux, Claire ULg

Poster (2014, May 15)

Roots are responsible for water and nutrient uptake and hence are critical to sustain the whole plant life cycle. This study aims at characterizing how root development is affected by flowering. We ... [more ▼]

Roots are responsible for water and nutrient uptake and hence are critical to sustain the whole plant life cycle. This study aims at characterizing how root development is affected by flowering. We therefore focused on the effects of systemic signals produced in the leaves at floral transition, namely the proteins FLOWERING LOCUS T (FT) and TWIN SISTER OF FT (TSF), on root growth and branching. These proteins act in the shoot apical meristem as potent promoters of flowering [1] but their effects in other parts of the plant are still unknown. [less ▲]

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See detailEffects of formoterol and ipratropium bromide on repeated cadmium inhalation -induced pulmonary inflammation and emphysema in rats
Zhang, Whenhui; Fievez, Laurence ULg; Zhang, F. et al

in European Journal of Pharmacology (2010), 25(647), 178-187

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See detailEffects of formoterol on repeated cadmium inhalation-induced lung inflammation and emphysema in rats
Zhang, W.; Fievez, Laurence ULg; Cheu, Esteban ULg et al

in Proceedings : Congrès de physiologie, de pharmacologie et de thérapeutique P2T (2007)

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See detailThe effects of forodesine in murine and human multiple myeloma cells
Bieghs, Liesbeth; Caers, Jo ULg; De Bruyne, Elke et al

in Advances in Hematology (2010)

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See detailEffects of fruit maturity on oxidative stability of Lagenaria siceraria (Molina) standl. seed oil extracted with hexane
Loukou, A.L.; Lognay, Georges ULg; Baudoin, Jean-Pierre ULg et al

in Journal of Food Biochemistry (2013), 37(4), 475-484

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See detailEffects Of Fungicide Treatment, N-Fertilisation And Harvest Date On Arabinoxylan, Endoxylanase Activity And Endoxylanase Inhibitor Levels In Wheat Kernels
Dornez, Emmie; Gebruers, Kurt; Joye, Iris J. et al

in Journal of Cereal Science (2008), 47(2), 190-200

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See detailEffects Of Galanin Infusion On Gh Secretion And Ghrh-Induced Gh Release In Prepubertal Male Lambs
Saleri, R.; Baratta, M.; Renaville, Robert ULg et al

in Small Ruminant Research (1999), 33(3),

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See detailEffects of gastrointestinal helminth infections and plane of nutrition on the health and productivity of F1 (West African Dwarf x Sahelian) goat crosses in The Gambia
Faye, D.; Leak, S.; Nouala, S. et al

in Small Ruminant Research (2003), 50(1-2), 153-161

A two by two factorial design including natural helminth infections (dewormed 'D' or not dewormed 'ND') and different levels of diet (basal 'B' or basal diet plus supplement 'S') was used to assess the ... [more ▼]

A two by two factorial design including natural helminth infections (dewormed 'D' or not dewormed 'ND') and different levels of diet (basal 'B' or basal diet plus supplement 'S') was used to assess the effect of helminth infections and plane of nutrition on health and productivity of F1 (West African Dwarf (WAD) x Sahelian) crosses. The pasture composed the basal diet and supplemented animals received cottonseed and rice bran. Feed composition analysis revealed that the pasture did not provide sufficient nutrients for reproduction requirements. Feed supplementation had a significant effect on weight gain of does during pregnancy and lactation, and milk off-take was significantly higher in supplemented does compared to non-supplemented ones (31.3 +/- 2.5 1 versus 17.7 +/- 2.5 1 respectively, P < 0.01). A peri-parturient rise in strongyle egg output was noted, and diet supplementation tended to reduce faecal egg count and to increase packed cell volume (PCV), mainly during the dry season. Deworming had a significant effect on red blood cell (RBC) count, PCV and haemoglobin (Hb) concentration, mainly during the period of peak strongyle egg output (season x deworming: P < 0.001 for RBC and PCV and P < 0.05 for Hb). Helminth infections combined with a basal diet seriously affected weight gain but the interaction of deworming and diet was not significant. In groups receiving the basal diet, dewormed animals had a significantly higher milk yield than those that were not dewormed (23.5 +/- 3.31 versus 12.0 +/- 3.71, respectively; interaction diet x deworming: P < 0.05). The higher daily weight gains of offspring born from dewormed does might be explained by the fact that, in addition to the effect of deworming on milk yield in animals receiving basal diet, the kids were less exposed to helminth eggs, whereas does that were not dewormed constituted a greater source of helminth infection for their kids. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailEffects of gastroplasty on body weight and related biological abnormalities in morbid obesity.
Luyckx, Françoise ULg; Scheen, André ULg; Desaive, Claude ULg et al

in Diabètes & Métabolism (1998), 24(4), 355-61

Obesity is a prevalent metabolic disorder associated with high morbidity and mortality rates. Medical treatment rarely succeeds, and bariatric surgery has been proposed as an alternative therapy. The ... [more ▼]

Obesity is a prevalent metabolic disorder associated with high morbidity and mortality rates. Medical treatment rarely succeeds, and bariatric surgery has been proposed as an alternative therapy. The purpose of this non-controlled retrospective study was to evaluate time-course changes in body weight in severely obese patients who underwent vertical ring gastroplasty or adjustable silicone gastric banding, and to assess the prevalence and potential reversibility of several of the biological abnormalities associated with morbid obesity. From an initial cohort comprising 658 patients, regular body weight measurements and biological data were obtained in 505 patients [419 females, 86 males; age 36 +/- 11 years; body mass index 42.7 +/- 6.9 kg/m2; (mean +/- SD)] with a mean follow-up of 26 +/- 14 months. Mean weight loss was 32 +/- 16 kg. Most weight reduction occurred within the first 6 months, followed by near-stabilisation or even slight weight regain. Most biological parameters were obtained before surgery and after at least 6 months of follow-up. The high prevalence and severity of metabolic disturbances associated with the insulin resistance syndrome (hyperglycaemia, hyperinsulinaemia, decreased HDL cholesterol, hypertriglyceridaemia, elevated fibrinogen levels and hyperuricaemia) before gastroplasty were significantly decreased after weight loss. No major biological deficiencies were observed following gastroplasty, except low iron serum levels. It is concluded that marked weight loss associated with gastroplasty involved a remarkable reduction in the prevalence and severity of several biological abnormalities classically considered as cardiovascular risk factors. [less ▲]

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See detailEffects of genotype and nutrition on growth performance,carcass characteristics, and meat properties of goats in Laos
Nguyen Xuan, Trach; Phiovankham, Bounmy; Do Duc, Luc ULg

in Journal of Southern Agriculture (2011), 42(7), 786-790

【Objective】A 2×2 factorial trial was carried out to determine effects of genotype and nutrition on improved growth performance, carcass characteristics, and meat properties of goats in Laos. 【Method】The ... [more ▼]

【Objective】A 2×2 factorial trial was carried out to determine effects of genotype and nutrition on improved growth performance, carcass characteristics, and meat properties of goats in Laos. 【Method】The indigenous goat breed (Lat) was used as the control in comparison with F1 (BT×L) as a result of crossbreeding Lat does with Bach Thao bucks imported from Vietnam. For each genotype, 30 growing male goats at age of 7 months were chosen and equally divided into 2 groups, one was raised according to the traditional feeding regime (free ranging only) and the other with an improved feeding regime including cassava hay and mineral block provided ad libitum in addition to free ranging. The animals were observed for the average daily gain (ADG) and at the end, three animals per group were slaughtered to determine carcass characteristics (physical composition, primal cuts), and meat properties (shear force, color, pH, drip loss, and cooking loss). 【Result】The results showed that the ADG of F1(60.02 g/head/day) was very much higher (56.09%) than that of the indigenous goat (38.45 g/head/day). The ADG of goats supplemented with cassava hay and mineral block (55.45g/head/day)was also significantly higher (28.89%) than that of those not supplemented (43.02 g/head/day). No significant (P >0.05)effects of the crossbreeding and supplementation were found for dressing percentage and percentages of shoulder-foreleg, rump-rearleg, and breast-rip cuts in the carcass; however, the F1 had a bigger neck (P<0.01) but a smaller loin-abdomen cut (P<0.01) compared with the indigenous goat. No significant differences were observed for the parameters of meat characteristics between Lat and F1 goats under the two different feeding regimes. 【Conclusion】It was therefore concluded that crossbreeding with Bach Thao bucks and supplementation of cassava hay and mineral block improved meat yield without negative effects on meat quality of goats in Laos. [less ▲]

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See detailEffects Of Genotype, Harvest Year And Genotype-By-Harvest Year Interactions On Arabinoxylan, Endoxylanase Activity And Endoxylanase Inhibitor Levels In Wheat Kernels
Dornez, Emmie; Gebruers, Kurt; Joye, Iris J. et al

in Journal of Cereal Science (2008), 47(2), 180-189

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See detailEffects of geographic origin on growth and food intake in Eurasian perch (Perca fluviatilis L.) juveniles under intensive culture conditions
Mandiki, S. N. M.; Blanchard, G.; Mélard, Charles ULg et al

in Aquaculture (2004), 229(1-4), 117-128

Survival, growth, and food intake of Eurasian perch (Perca fluviatilis) juveniles from different stocks originating from various geographic regions of Europe were compared under the same conditions of ... [more ▼]

Survival, growth, and food intake of Eurasian perch (Perca fluviatilis) juveniles from different stocks originating from various geographic regions of Europe were compared under the same conditions of laboratory-scale intensive culture. In Experiment 1, four stocks originating from Italy (1), southwest (SF) and northwest (NF) France, and Belgium (B) were examined at larval and early juvenile (initial body weight, IBW = 0.53 g) stages. In Experiment 2, B stock was compared to a Finnish (F) one in two trials, including small (IBW = 1.26 g) and large (IBW = 32 g) juveniles. In Experiment 3, small (IBW = 1.29 g) and large (IBW = 7.33 g) juveniles from Polish (P), F, and B stocks were examined. In Experiment 1, body weight means at hatching and survival at the end of the larval stage were significantly lower in the I and SF stocks than in the B and NF stocks. In the early juvenile stage, survival and growth rates were significantly lower in the I and SF stocks than in the B and NF ones. In Experiment 2, {early juvenile stage} survival in the F stock was significantly lower than in the B stock, partly due to a higher incidence of cannibalism. During this stage, growth rates and food intake or feed efficiency in the F and B stocks were comparable, but at the end of the juvenile stage, the F stock outperformed the B one. In Experiment 3, survival in all the three stocks was comparable both in small and large juveniles. In contrast to the higher performance of F juveniles in Experiment 2, growth rates were comparable between the B and F stocks, and fish from the P stock had the highest growth rates. The results indicate a high level of variation within and between hatchery stocks in survival rates, growth rates, and food intake. These variations depended on the geographic origin of the fish, with the lowest survival and growth potentials being in the stocks originating from the southern regions. These findings highlight the interest in evaluating growth and food consumption of different Eurasian perch stocks. Such evaluation is a necessary tool for genetic selection in improving performance in perch aquaculture. (C) 2004 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailThe effects of geometrical imperfections on the ultimate strength of aluminium stiffened plates subject to combined uniaxial compression and lateral pressure
Khedmati, Mohammad Reza; Pedram, Masoud; Rigo, Philippe ULg

in Ships and Offshore Structures (2012)

The present study aims at determining the effects of the geometrical imperfections on the ultimate strength and load-carrying capacity of aluminium stiffened plates under combined axial compression and ... [more ▼]

The present study aims at determining the effects of the geometrical imperfections on the ultimate strength and load-carrying capacity of aluminium stiffened plates under combined axial compression and lateral pressure. The finite element models proposed by the Committee III.1 ‘Ultimate Strength’ of ISSC’2003 are used in the present investigation. Initial imperfections as proposed by ISSC committee as well as those recommended by Ship Structure Committee are considered in the analyses. Models are tested using non-linear finite element elastic–plastic analyses. Aluminium alloy AA6082-T6 is selected as the material for the models. The studied models are triple-span panels stiffened by either extruded or non-extruded angle-bar profiles. Different arrangements of heat-affected zone (HAZ) are considered. The main outcomes of this study show the need for a subtle assessment of the real shapes of the initial deformations. The way they affect the ultimate strength of models is clarified through finite element analyses. [less ▲]

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See detailEffects of glucagon in the control of endogenous glucose production in man.
Surmely, J. F.; Schneiter, P.; Henry, S. et al

in Nutrition (1999), 15(4), 267-73

Endogenous glucose production has been shown to increase during administration of glucagon + fructose, but not during administration of fructose alone. To determine the mechanisms by which glucagon exerts ... [more ▼]

Endogenous glucose production has been shown to increase during administration of glucagon + fructose, but not during administration of fructose alone. To determine the mechanisms by which glucagon exerts this action, endogenous glucose production (EGP) and gluconeogenesis from fructose (GNF) were measured in eight healthy subjects infused 1) with graded doses of glucagon (2 and 4 ng.kg-1.min-1 for 3 h each) during constant infusion of 13C-fructose (3 mg.kg-1.min-1), and 2) with graded doses of 13C-fructose (3 and 6 mg.kg-1.min-1) during constant glucagon infusion (2 ng.kg-1.min-1). GNF was estimated from 13C-glucose synthesis. In both protocols, infusion of 3 mg.kg-1.min-1 fructose + 2 ng.kg-1.min-1 glucagon increased EGP by 5-8% (P < 0.05), while GNF represented 43-49% of EGP. Thereafter, increasing the glucagon infusion rate further increased EGP to 118 +/- 3% of basal values (P < 0.01) without altering the proportion due to GNF. In contrast, increasing the fructose infusion rate at constant glucagonemia increased EGP similarly (by 19 +/- 4%, P < 0.05) but enhanced the contribution of GNF to 76 +/- 2% (P < 0.001). Graded infusion of glucagon or fructose alone failed to stimulate EGP. The present findings indicate that hyperglucagonemia stimulates endogenous glucose production during fructose infusion. This effect is not secondary to a stimulation of gluconeogenesis, but to a channelling of glucose-6-phosphate towards systemic release. [less ▲]

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See detailEffects of glucagon on fructose-induced alterations of glucose metabolism in man.
Paquot, Nicolas ULg; Schneiter, Ph; Jéquier, E. et al

in Reproduction Nutrition Development (1996), 36

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See detailEffects of glucagon on fructose-induced alterations of glucose metabolism in man.
Tappy, L.; Schneiter, Ph; PAQUOT, Nicolas ULg et al

in Diabetes (1994), 44(suppl 1), 254

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See detailEffects of glucocorticoids and sympathomimetic agents on basal and insulin-stimulated glucose metabolism.
Paquot, Nicolas ULg; Schneiter, P.; Jequier, E. et al

in Clinical Physiology (1995), 15(3), 231-40

The mechanisms responsible for glucocorticoid-induced insulin resistance remain unclear. Glucocorticoids show several interactions with the sympatho-adrenal system which may contribute to this decrease in ... [more ▼]

The mechanisms responsible for glucocorticoid-induced insulin resistance remain unclear. Glucocorticoids show several interactions with the sympatho-adrenal system which may contribute to this decrease in insulin sensitivity: they enhance the synthesis and actions of catecholamines, but abolish insulin-induced activation of muscle sympathetic nerve activity. The present study was performed in order to investigate the effects of the interactions between glucocorticoids and the sympatho-adrenal system on insulin sensitivity. Basal and insulin-stimulated glucose metabolism was measured in healthy human subjects during four 2-h clamp studies as follows: control (C); after taking oral dexamethasone (2 mg daily) for 2 days (D); after taking oral ephedrine sulphate (40 mg daily) for 2 days (E); and after taking dexamethasone+ephedrine (D+E). Glucose uptake, production and oxidation were calculated from plasma 13C glucose and exhaled 13CO2 during constant tracer infusion of U-13C glucose. Basal glucose production, utilization and oxidation were similar in all four studies. During hyperinsulinaemia, glucose uptake was reduced by 51.5% with treatment D, by 25.9% with treatment E, and by 49.6% with D+E. Glucose oxidation was reduced by 54.0% with treatment D, by 24.0% with treatment E, and by 57.2% with D+E. Hepatic glucose production was completely suppressed in all four studies. It is concluded that both dexamethasone and ephedrine decrease insulin-mediated glucose uptake and oxidation. Co-administration of ephedrine does not suppress the glucocorticoid-induced alterations of glucose metabolism. This indicates that glucocorticoid-induced insulin resistance is not related to the inhibition of muscle sympathetic nerve activity. These results suggest instead that glucocorticoids and sympathomimetic agents may impair glucose metabolism by common actions. [less ▲]

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See detailEffects of glucocorticoids on hepatic sensitivity to insulin and glucagon in man.
Dirlewanger, M.; Schneiter, P. H.; Paquot, Nicolas ULg et al

in Clinical Nutrition (2000), 19(1), 29-34

AIMS: This study was undertaken to determine the effects of a short-term dexamethasone treatment on hepatic sensitivities to insulin and glucagon. METHODS: Eleven healthy subjects were studied during one ... [more ▼]

AIMS: This study was undertaken to determine the effects of a short-term dexamethasone treatment on hepatic sensitivities to insulin and glucagon. METHODS: Eleven healthy subjects were studied during one or several of four protocols. In all protocols, somatostatin was infused continuously to inhibit pancreatic hormone secretion. In protocol 1, basal insulin was infused over 300 min while glucagon was infused at a rate of 0.5 mg/kg(-1)/min(-1)during 180 min, then at a rate of 1.5 ng/kg(-1)/min(-1)during 150 min. In protocol 2, the same experiment was performed after a 2 day treatment with 8 mg/day dexamethasone. In protocol 3, the two-step glucagon infusion was performed during insulin infusion at a rate aimed to reproduce the hyperinsulinemia observed during protocol 2. In protocol 4, continuous basal insulin and low glucagon (0.5 mg/kg(-1)/min(-1)) were infused over 330 min. RESULTS: In protocol 1, plasma glucose rose transiently by 2.0 +/- 0.3 mmol/l when the glucagon rate was increased and glucose production increased by 1.4 +/- 0.5 micromol/kg(-1)/min(-1). In protocol 2, the insulin infusion rate (1.85 +/- 0.36 nmol/kg(-1)/min(-1)) required to maintain glycemia was 3.3-fold higher than during protocol 1. Glucagon-induced stimulation of glycemia (by 1.47 +/- 0.5 mmol/l) and endogenous glucose production (by 0.8 +/- 0.3 micromol/kg(-1)/min(-1)) were blunted, but not abolished. In protocol 3, endogenous glucose production was suppressed by 75% by hyperinsulinemia and was not stimulated when the glucagon infusion rate was increased. In protocol 4, endogenous glucose production did not change significantly with time. CONCLUSION: These results indicate that high dose glucocorticoids induce a marked hepatic insulin resistance. Stimulation of glucose production by hyperglucagonemia was maintained in spite of hyperinsulinemia which can be attributed to either hepatic insulin resistance and/or increased hepatic glucagon sensitivity. [less ▲]

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See detailEffects of glucocorticoids on the respiratory burst of Chlamydia-primed THP-1 cells.
Mouithys-Mickalad, Ange ULg; Deby, Ginette ULg; Mathy, Marianne ULg et al

in Biochemical and Biophysical Research Communications (2004), 318(4), 941-8

We previously observed that the respiratory burst of human monocytes (THP-1 cell line) triggered by phorbol myristate acetate was strongly enhanced by a priming of the cells by Chlamydia pneumoniae ... [more ▼]

We previously observed that the respiratory burst of human monocytes (THP-1 cell line) triggered by phorbol myristate acetate was strongly enhanced by a priming of the cells by Chlamydia pneumoniae [Biochem. Biophys. Res. Commun. 287 (2001) 781]. We describe here the modifications of the responses of Chlamydia-primed THP-1 cells to hydrocortisone (HCT) and methylprednisolone (MPL). HCT and MPL inhibited the production of the cytokines TNFalpha and IL-8. But HCT, which inhibited the respiratory burst in LPS-primed monocytes, paradoxically stimulated the phenomenon in Chlamydia-primed cells; MPL exerted no significant effect. Both glucocorticoids did not significantly modify the triggering effect of Chlamydia on NF-kappaB binding activity. On the expression of p22(phox), a protein subunit of the NADPH oxidase, HCT had an increasing and MPL a decreasing effect. Glucocorticoids thus had unexpected effects on the inflammatory response of Chlamydia-primed monocytes. [less ▲]

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