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Peer Reviewed
See detailDevelopment of new assessment tools for attentional and executive functioning in children
Catale, Corinne ULg; Meulemans, Thierry ULg

in Books of Conference Abstract: The 8th European Conference on Psychological Assessment, (2005)

In developmental neuropsychology, attentional and executive impairments are commonly reported following acquired neurological/developmental disorders such as Traumatic Brain Injury (TBI), epilepsy, ADHD… ... [more ▼]

In developmental neuropsychology, attentional and executive impairments are commonly reported following acquired neurological/developmental disorders such as Traumatic Brain Injury (TBI), epilepsy, ADHD… Unfortunately, most of attentional tests used in child neuropsychology were originally developed for adults and are of limited interest for children (notably because of their lack of attractiveness or because they require some non-developed skills). From a cognitive perspective, it is therefore often difficult to interpret the results obtained with such tools in children. The aim of this study was to develop assessment tasks of attentional/executive functioning which are more attractive (by using colored/familiar stimuli) and more theoretically relevant for young children. The tasks are based on Posner’s attentional model, which includes selective and sustained attention, attentional shifting and cognitive inhibition. Eighty children aged from 5 to 11 with no developmental/neurological deficits were administered tasks assessing visual selective attention (selecting a specific character among distractors), sustained attention (crossing dinosaurs in 5 minutes), flexibility (shifting between name and colour of stimuli), and inhibition (naming the real colour of a red banana or a yellow strawberry). Results confirmed the interest of these tasks in the assessment of attentional functioning in children, thanks to both their limited duration of administration and the stimuli’s attractiveness. Furthermore, results showed that tasks are sensitive to attentional development from 5 to 11 years old (p < .05). Finally, a preliminary study showed that some tasks can be particularly sensitive to attentional disorders in a clinical population of TBI children. [less ▲]

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See detailDevelopment of new biomimetic biopolymers
Grandfils, Christian ULg

Scientific conference (2013, June 27)

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See detailDevelopment of new drugs for an old target — the penicillin binding proteins.
Zervosen, Astrid ULg; Sauvage, Eric ULg; Frère, Jean-Marie ULg et al

in Molecules (2012), 17(11), 12478-505

The widespread use of β-lactam antibiotics has led to the worldwide appearance of drug-resistant strains. Bacteria have developed resistance to β-lactams by two main mechanisms: the production of β ... [more ▼]

The widespread use of β-lactam antibiotics has led to the worldwide appearance of drug-resistant strains. Bacteria have developed resistance to β-lactams by two main mechanisms: the production of β-lactamases, sometimes accompanied by a decrease of outer membrane permeability, and the production of low-affinity, drug resistant Penicillin Binding Proteins (PBPs). PBPs remain attractive targets for developing new antibiotic agents because they catalyse the last steps of the biosynthesis of peptidoglycan, which is unique to bacteria, and lies outside the cytoplasmic membrane. Here we summarize the “current state of the art” of non-β-lactam inhibitors of PBPs, which have being developed in an attempt to counter the emergence of β-lactam resistance. These molecules are not susceptible to hydrolysis by β-lactamases and thus present a real alternative to β-lactams. We present transition state analogs such as boronic acids, which can covalently bind to the active serine residue in the catalytic site. Molecules containing ring structures different from the β-lactam-ring like lactivicin are able to acylate the active serine residue. High throughput screening methods, in combination with virtual screening methods and structure based design, have allowed the development of new molecules. Some of these novel inhibitors are active against major pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and thus open avenues new for the discovery of novel antibiotics. [less ▲]

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See detailDevelopment of new immunoassays for the quantification of inflammatory related cartilage degradation
Deberg, Michelle ULg; Christgau, Stephan; Henriksen, Dennis et al

in Arthritis and Rheumatism (2002, September), 46(number 9 (suppl.)), 496

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See detailDevelopment of new immunoassays for the quantification of inflammatory related cartilage degradation
Deberg, Michelle ULg; Christgau, Stephan; Cloos, Paul et al

in Osteoporosis International (2002, November), 13(Suppl. 3), 54

Detailed reference viewed: 34 (5 ULg)
See detailDevelopment of new strategies against the tomato leafminer, Tuta absoluta Meyrick
De Backer, Lara ULg; Francis, Frédéric ULg; Verheggen, François ULg

Conference given outside the academic context (2013)

The tomato leafminer, Tuta absoluta (Meyrick), is a Lepidoptera considered as one of the major pest of Solanaceae. It causes important yield loss in South America, where it is originated, and in the West ... [more ▼]

The tomato leafminer, Tuta absoluta (Meyrick), is a Lepidoptera considered as one of the major pest of Solanaceae. It causes important yield loss in South America, where it is originated, and in the West Palearctic region, where it was introduced in 2006. Insecticide applications and the use of the sexual pheromone have been the main control method used against T. absoluta. Insecticides are inefficient because of the endophytic habit of larvae, which are protected in the leaf mesophyll or inside fruits. Moreover, resistances against various insecticides have been reported. The sexual pheromone based strategies also provide poor results. One explanation has been recently provided by the demonstration of a parthenogenetic reproduction in T. absoluta, from the research group in Gembloux Agro-Bio Tech (ULg). Because there is a real need to improve crop protection against T. absoluta and in the meanwhile reducing the use of synthetic insecticidal compounds, researches aim at providing new perspectives to further biocontrol strategies against T. absoluta. [less ▲]

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See detailDevelopment of new thrombolytic agents using recombinant DNA technology.
Pierard, Luc ULg; Bollen, A.

in Journal of biotechnology (1990), 15(4), 283-304

The increasing incidence of thromboembolic diseases has sustained the search for new agents able to stimulate the natural fibrinolytic system. The first generation of antithrombotic agents include ... [more ▼]

The increasing incidence of thromboembolic diseases has sustained the search for new agents able to stimulate the natural fibrinolytic system. The first generation of antithrombotic agents include bacterial streptokinase and human urine urokinase. Because these molecules lack specificity for the fibrin clot, important efforts have been made to produce, using recombinant DNA technology, agents presenting higher fibrin clot selectivity such as t-PA (tissue-type plasminogen activator) and scu-PA (single chain urokinase-type plasminogen activator). In parallel, several laboratories are presently attempting to create mutants and hybrids plasminogen activators displaying improved thrombolytic properties with respect to the natural molecules. In this paper, we describe briefly the mechanisms of fibrinolysis and the role of the different natural thrombolytic agents. In addition, we review the possibilities of genetic engineering for the production of natural and novel plasminogen activators. [less ▲]

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See detailDevelopment of non invasive genetic identification methods for the Pyrenean desman (Galemys pyrenaicus) and first study of its genetic structure in France
Gillet, François ULg; Cabria Garrido, Maria Teresa; Némoz, Mélanie et al

Poster (2011, July)

The Pyrenean desman (Galemys pyrenaicus) is probably one of the most threatened European mammal species. This small insectivorous and semi-aquatic species is endemic to the Pyrenean Mountains and of the ... [more ▼]

The Pyrenean desman (Galemys pyrenaicus) is probably one of the most threatened European mammal species. This small insectivorous and semi-aquatic species is endemic to the Pyrenean Mountains and of the north of the Iberic Peninsula. Many biologic aspects of this species are currently suffering from a major lack of information, particularly those concerning its genetics. Therefore the implementation of conservative efforts for the Pyrenean desman remains extremely difficult. In order to improve the knowledge of this vulnerable species and notably, to better understand its distribution area, the first aim of our research was to develop non invasive genetic identification methods based on faeces. The second aim was to have a first look at the phylogeographic structure of the Pyrenean desman. The identification methods were developed on the basis of the sequencing of a small mitochondrial DNA (cyt b) fragment as well as a RFLP method. These approaches led to the identification of the Pyrenean desman and to the differentiation of the latter from two other species living in the same type of habitat, the white-throated dipper (Cinclus cinclus) and the water shrew (Neomys fodiens). Two haplotypes were found in the studied Pyrenean populations but no phylogeographic structure could be established. A dozen of microsatellites markers were also developed during this work and 5 of these were found to be polymorphic. The results of this preliminary work tend to show a low genetic diversity for the Pyrenean desman but this result needs to be confirmed in the future with a more extended and complete study. [less ▲]

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See detailDevelopment of non radioactive multi-analyte methodes based on the use of a recombinant human beta2-agonists and antagonists residues in food-producing animals
Danyi, Sophie ULg; Degand, Guy ULg; Granier, Benoît et al

in Proceedings Euroresidue V conference on residues of veterinary drugs in food (2004, May)

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See detailDevelopment of noninvasive genetic identification methods and polymorphic microsatellites for the Pyrenean desman (Galemys pyrenaicus)
Gillet, François ULg; Cabria Garrido, Maria Teresa; Némoz, Mélanie et al

Poster (2012, August)

The Pyrenean desman (Galemys pyrenaicus) is probably one of the most threatened European mammal species. This small insectivorous and semi-aquatic species is endemic to the Pyrenean Mountains and of the ... [more ▼]

The Pyrenean desman (Galemys pyrenaicus) is probably one of the most threatened European mammal species. This small insectivorous and semi-aquatic species is endemic to the Pyrenean Mountains and of the north of the Iberic Peninsula. Many biologic aspects of this species are currently suffering from a major lack of information, particularly those concerning its genetics. Therefore the implementation of conservative efforts for the Pyrenean Desman remains extremely difficult. In order to improve the knowledge of this vulnerable species and notably, to better understand its distribution area, the first aim of our research was to develop non invasive genetic identification methods based on faeces. The second aim was the development of several polymorphic microsatellites markers in order to have a first look at the genetic structure of the Pyrenean Desman in its French distribution area. The identification methods were developed on the basis of the sequencing of a small mitochondrial DNA (cyt b) fragment as well as a RFLP method. These approaches led to the identification of the Pyrenean desman and to the differentiation of the latter from two other species living in the same type of habitat, the white-throated dipper (Cinclus cinclus) and the water shrew (Neomys fodiens). More than fifteen polymorphic microsatellites markers could be found for the Pyrenean Desman and their genotyping revealed a low number of alleles per locus (two to five). The results of this preliminary work tend to show a low genetic diversity for the Pyrenean Desman but this result needs to be confirmed in the future with a more extended and complete study. [less ▲]

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See detailDevelopment of novel SOlid Materials for high power Li polymer BATteries (SOMABAT). Recyclability of components.
Zubizarreta, Leire; Gil-Agusti, Mayte; Garcia. et al

in Briec, E.; Müller., B. (Eds.) Electric Vehicle Batteries: Moving from Research towards Innovation. Lecture notes on mobility (2015)

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See detailDevelopment of Numerical Algorithms for Practical Computation of Nonlinear Normal Modes
Peeters, Maxime ULg; Georgiades, Fotios; Viguié, Régis ULg et al

in International Conference on Noise and vibration Engineering, Leuven, 2006 (2006)

When resorting to numerical algorithms, we show that nonlinear normal mode (NNM) computation is possible with limited implementation effort, which paves the way to a practical method for determining the ... [more ▼]

When resorting to numerical algorithms, we show that nonlinear normal mode (NNM) computation is possible with limited implementation effort, which paves the way to a practical method for determining the NNMs of nonlinear mechanical systems. The proposed method relies on two main techniques, namely a shooting procedure and a method for the continuation of NNM motions. In addition, sensitivity analysis is used to reduce the computational burden of the algorithm. A simplified discrete model of a nonlinear bladed disk is considered to demonstrate the developments. [less ▲]

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See detailDevelopment of Object and Grasping Knowledge by Robot Exploration
Kraft, Dirk; Detry, Renaud ULg; Pugeault, Nicolas et al

in IEEE Transactions on Autonomous Mental Development (2010), 2(4), 368--383

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See detailDevelopment of optical ground verification method for mu m to sub-mm reflectors
Stockman, Yvan ULg; Thizy, Cédric ULg; Lemaire, Philippe ULg et al

in Warmbein, B. (Ed.) Proceedings of the 5th International Conference on Space Optics (ICSO) (2004, April 02)

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. The ... [more ▼]

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. The challenging tasks of on-ground testing are to achieve the required accuracy in the measurement of the reflector shapes and antenna structures and to verify their performance under simulated space conditions (vacuum, low temperatures). A small number of infrared interferometers have been commercially developed over the last 10 years but their applications have also been limited due to poor dynamic range and the restricted spatial resolution of their detectors. It has therefore been considered essential, from the viewpoint of supporting future ESA exploration missions, to develop and realise suitable verification tools based on infrared interferometry and other optical techniques for testing large reflector structures, telescope configurations and their performances under simulated space conditions. Two methods and techniques are developed at CSL. The first one is an IR-phase shifting interferometer with high spatial resolution. This interferometer shall be used specifically for the verification of high precision IR, FIR and sub-mm reflector surfaces and telescopes under both ambient and thermal vacuum conditions. The second one presented hereafter is a holographic method for relative shape measurement. The holographic solution proposed makes use of a home built vacuum compatible holographic camera that allows displacement measurements from typically 20 nanometres to 25 microns in one shot. An iterative process allows the measurement of a total of up to several mm of deformation. Uniquely the system is designed to measure both specular and diffuse surfaces [less ▲]

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See detailDevelopment of optical ground verification method for mum to sub-mm reflectors
Stockman, Yvan ULg; Thizy, Cédric ULg; Lemaire, Philippe ULg et al

in 5th International Conference on Space Optics (2004, June 01)

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. Scientific ... [more ▼]

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. Scientific observatories require large telescopes with precisely shaped reflectors for collecting the electro-magnetic radiation from faint sources. The challenging tasks of on-ground testing are to achieve the required accuracy in the measurement of the reflector shapes and antenna structures and to verify their performance under simulated space conditions (vacuum, low temperatures). Due to the specific surface characteristics of reflectors operating in these spectral regions, standard optical metrology methods employed in the visible spectrum do not provide useful measurement results. The current state-of-the-art commercial metrology systems are not able to measure these types of reflectors because they have to face the measurement of shape and waviness over relatively large areas with a large deformation dynamic range and encompassing a wide range of spatial frequencies. 3-D metrology (tactile coordinate measurement) machines are generally used during the manufacturing process. Unfortunately, these instruments cannot be used in the operational environmental conditions of the reflector. The application of standard visible wavelength interferometric methods is very limited or impossible due to the large relative surface roughnesses involved. A small number of infrared interferometers have been commercially developed over the last 10 years but their applications have also been limited due to poor dynamic range and the restricted spatial resolution of their detectors. These restrictions affect also the surface error slopes that can be captured and makes their application to surfaces manufactured using CRFP honeycomb technologies rather difficult or impossible. It has therefore been considered essential, from the viewpoint of supporting future ESA exploration missions, to develop and realise suitable verification tools based on infrared interferometry and other optical techniques for testing large reflector structures, telescope configurations and their performances under simulated space conditions. The first one is an IR-phase shifting interferometer with high spatial resolution. This interferometer shall be used specifically for the verification of high precision IR, FIR and sub-mm reflector surfaces and telescopes under both ambient and thermal vacuum conditions. The second one presented hereafter is a holographic method for relative shape measurement. The holographic solution proposed makes use of a home built vacuum compatible holographic camera that allows displacement measurements from typically 20 nanometres to 25 microns in one shot. An iterative process allows the measurement of a total of up to several mm of deformation. Uniquely the system is designed to measure both specular and diffuse surfaces. [less ▲]

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See detailDevelopment of optical trajectography device for the lagangian study of turbulent flow inside a stirred tank used in pharmaceutical industry
Collignon, Marie-Laure ULg; Delafosse, Angélique ULg; Delvigne, Frank ULg et al

Poster (2012, September 10)

Stirred tanks are devices that are widely used in various process steps of the pharmaceutical industry. The performance of these processes (animal cell culture, crystallization, flocculation …) strongly ... [more ▼]

Stirred tanks are devices that are widely used in various process steps of the pharmaceutical industry. The performance of these processes (animal cell culture, crystallization, flocculation …) strongly depend on the physico-chemical and hydrodynamic environment present locally in these tanks. To fully describe this local environment, an Eulerian - Lagrangian approach must be adopted in order to establish history of conditions met by a particle as a cell, a crystal or a floc. This approach implies to determine the trajectory followed by the particle. To this aim, the Chemical Laboratory of Liege University has developed a prototype of optical trajectography device. The objective of this paper is to present the device, developments that were necessary for its use and the results obtained. The device is composed of two cameras modeled by a pinhole model which record the position of a bead that has a size equal to 490 µm and that perfectly follows local flow structures. The measured trajectory has been validated by comparing average time velocity fields deduced from it to those measured, in the same operating conditions, by particle image velocimetry (P.I.V.). [less ▲]

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See detailDevelopment of organic farming in Wallonia
Burny, Philippe ULg; Debode, Frédéric

in Bran, Florina; Ioan, Ildiko; Maruntelu, Tudor-George (Eds.) et al 5th International Conference "Ecological performance in a competitive economy", Bucharest 7-8 March 2013 : proceedings (2013)

Belgium is a highly densely populated country where agricultural methods usually consume large quantities of inputs, including pesticides and chemical fertilizers. However, organic farming is practiced ... [more ▼]

Belgium is a highly densely populated country where agricultural methods usually consume large quantities of inputs, including pesticides and chemical fertilizers. However, organic farming is practiced since many years and has registered a significant development during the last years, reaching 7% of the number of farmers in Wallonia (South of Belgium) and 7% of the Walloon agricultural area. Presently, the Walloon Minister for Agriculture strongly supports this sector and has proposed a strategic development plan of organic farming, the target being to reach 14% of the Walloon agricultural area in 2020. This paper presents and discusses the situation of organic farming in Wallonia and the main features and challenges of the new strategic development plan. [less ▲]

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See detailDevelopment of organic farming in Wallonia : past, present and perspectives
Burny, Philippe ULg; Debode, Frédéric

in Lorencowicz, Edmund; Uziak, Jacek; Huyghebaert, Bruno (Eds.) VI International Scientific Symposium "Farm Machinery and Processes Management in Sustainable Agriculture" : Symposium Proceedings (2013)

Organic farming is today fully recognized as an alternative to conventional agriculture and its problems (water and air pollution, large use of pesticides and possible impacts on human health, vegetal and ... [more ▼]

Organic farming is today fully recognized as an alternative to conventional agriculture and its problems (water and air pollution, large use of pesticides and possible impacts on human health, vegetal and animal diseases, overproduction, ..) and is clearly supported by the Common Agricultural Policy and its "greening". Belgian (and Walloon) agriculture is an intensive one, with a high "labour force/agricultural area" ratio and high yields thanks to good soils, but also the use of large quantities of inputs like fertilizers and pesticides. However, organic farming increased in importance during the last years and th Walloon regional government has just launched a development plan in June 2013. So, this paper aims to analyse the evolution of organic farming in Wallonia and to present the goals and the measures of the new development plan. [less ▲]

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See detailDevelopment of original 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as thromboxane A2 receptor antagonists
Bambi Nyanguile, Sylvie-Mireille ULg; Hanson, Julien ULg; Dogné, Jean-Michel et al

Poster (2012, August)

A series of novel 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas were synthesized. The newly synthesized compounds were tested in vitro and ex vivo as thromboxane A2 receptor antagonists. Some of the ... [more ▼]

A series of novel 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas were synthesized. The newly synthesized compounds were tested in vitro and ex vivo as thromboxane A2 receptor antagonists. Some of the test compounds showed potent thromboxane A2 receptor antagonist activity. Three compounds (7h, 8h and 8e) were identified as leads for further pharmacological and toxicological studies. [less ▲]

Detailed reference viewed: 45 (2 ULg)