Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailEffects of adenosine on lymphangiogenesis.
Lenoir, Bénédicte ULg; Wagner, Daniel R.; Blacher, Silvia ULg et al

in PloS one (2014), 9(3), 92715

BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood ... [more ▼]

BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood but promotes tumor spread and metastasis during adulthood. Blocking lymphangiogenesis may therefore be of therapeutic interest. Production of adenosine is enhanced in the tumor environment and contributes to tumor progression through stimulation of angiogenesis. In this study, we determined whether adenosine affects lymphangiogenesis. METHODS: Lymphatic endothelial cells (HMVEC-dLy) were cultured in presence of adenosine and their proliferation, migration and tube formation was assessed. Gelatin sponges embedded with the stable analogue of adenosine 2-chloro adenosine were implanted in mice ear and lymphangiogenesis was quantified. Mice were intravenously injected with adenoviruses containing expression vector for 5'-endonucleotidase, which plays a major role in the formation of adenosine. RESULTS: In vitro, we observed that adenosine decreased the proliferation of lymphatic endothelial cells, their migration and tube formation. However, in vivo, gelatin sponges containing 2-chloro adenosine and implanted in mice ear displayed an elevated level of lymphangiogenesis (2.5-fold, p<0.001). Adenovirus-mediated over-expression of cytosolic 5'-nucleotidase IA stimulated lymphangiogenesis and the recruitment of macrophages in mouse liver. Proliferation of lymphatic endothelial cells was enhanced (2-fold, p<0.001) when incubated in the presence of conditioned medium from murine macrophages. CONCLUSION: We have shown that adenosine stimulates lymphangiogenesis in vivo, presumably through a macrophage-mediated mechanism. This observation suggests that blockade of adenosine receptors may help in anti-cancer therapies. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailEffects of age and allergen-induced airway inflammation in cats: Radiographic and cytologic correlation
Kirschvink, Nathalie; Kersnak, Emilie; Leemans, Jérôme ULg et al

in Veterinary Journal (2007), 174(3), 644-651

Thoracic radiography is an important diagnostic tool for feline respiratory medicine. The aim of this study was (1) to assess agerelated changes of thoracic radiographic views in healthy young cats and (2 ... [more ▼]

Thoracic radiography is an important diagnostic tool for feline respiratory medicine. The aim of this study was (1) to assess agerelated changes of thoracic radiographic views in healthy young cats and (2) to test if experimentally-induced bronchial inflammation by inhaling Ascaris suum (AS) allergens leads to radiographic changes after single or repeated exposures. Healthy cats (n = 15-30) aged between 6 and 30 months were evaluated. Eight healthy cats and eight AS-sensitised cats, respectively, inhaled sterile saline or allergen. Radiographs were taken 24 h before, and 6, 24 and 48 h after the challenge. Bronchoalveolar lavage (BAL) was performed after the last radiographic examination. AS-sensitised cats underwent three further allergen challenges at 3-month intervals. The radiographic evaluation was based on a scoring system considering bronchial, interstitial and alveolar patterns. A significant age-related increase in interstitial and total radiographic score was detected in healthy cats older than 18 months and in healthy cats older than 24 months. Whilst saline inhalation did not affect radiographic scores, a single AS challenge induced significant changes of all scores within 6-24 h. A significant positive correlation between radiographic scores and BAL neutrophils and eosinophils was found. Repeated AS challenges did not induce irreversible changes in radiographic scores. (c) 2006 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 16 (3 ULg)
Peer Reviewed
See detailEffects of age and Ascaris suum aerosol exposure on the pro- and antigelatinolytic activity in serum and airways of cats
Leemans, Jérôme ULg; Kirschvink, N.; Billen, Frédéric et al

in Proceedings : 17th Congress of the European College of Veterinary Internal Medicine – Companion Animals, Budapest (2007)

Detailed reference viewed: 20 (1 ULg)
Peer Reviewed
See detailEffects of Age and Indomethacin on Response and Sensitivity of Pulmonary Artery to Phenylephrine and to Histamine in Pigs
Gustin, Pascal ULg; Ansay, Michel; Advenier, C.

in Journal of Veterinary Pharmacology & Therapeutics (1993), 16(2), 207-213

The vasoconstrictor effects of phenylephrine and histamine were investigated in isolated strips of pulmonary arteries in pigs during ageing. Interactions between phenylephrine-induced responses and ... [more ▼]

The vasoconstrictor effects of phenylephrine and histamine were investigated in isolated strips of pulmonary arteries in pigs during ageing. Interactions between phenylephrine-induced responses and arachidonic acid derivatives were also studied by incubating the blood-vessels with indomethacin. Potency (pD2 values) and maximal effects (Emaxx) recorded in 5-week-old piglets (group I, n= 5) with phenylephrine [5.71 ± 0.17 and 0.76 ± 0.22 g/mg of dry tissue respectively (mean ± SEM)] were similar to values found in 12-week-old animals (group 2, n = 5) (5.49 ± 0.30 and 1.06 ± 0.27 g/mg of dry tissue respectively). The sensitivity and responsiveness of tissues to this agonist were significantly reduced in 26-week-old mature pigs (group 3, n = 6) as indicated by the decrease in pD2 (3.91 ± 0.23; P < 0.01) and Emax (0.27 ± 0.13 g/mg of dry tissue; P < 0.05) values observed in this group. Histamine (10_3M)-induced maximal responses (Emax) were significantly higher in group 2 (2.23 ± 0.49 g/mg) than in group 1 (0.85 ± 0.11 g/mg; P < 0.05) and in group 3 (0.48 ± 0.10 g/mg; P < 0.01). In 5-week-old animals, indomethacin (3.10˜5M) significantly (P < 0.05) shifted the concentration-response curve to phenylephrine to the right (0.28 log. units) and depressed contractions to this drug as shown by the significant decrease of 39.5% (P < 0.05) in Emax. This cyclo-oxygenase inhibitor had no effect in other groups. These data indicate that phenylephrine is a potent and effective vasoconstrictor agent for the main pulmonary arteries in 5-week-old piglets and that alpha-1-adrenergic-induced contractions are enhanced by cyclo-oxygenase products. These findings can be related with the high reactivity of pulmonary vascular smooth muscles in these animals [less ▲]

Detailed reference viewed: 13 (0 ULg)
Peer Reviewed
See detailThe effects of age and location on the biomechanical and biochemical properties of canine tracheal ring cartilage.
Hamaide, Annick ULg; Arnoczky, Steven; Ciarelli, Mike et al

in American Journal of Veterinary Research (1998), 59

Detailed reference viewed: 10 (5 ULg)
Peer Reviewed
See detailThe effects of age and location on the biomechanical and biochemical properties of canine tracheal ring cartilage.
Hamaide, Annick ULg; Arnoczky, Steven; Ciarelli, Mike et al

Poster (1996)

Detailed reference viewed: 7 (5 ULg)
Full Text
Peer Reviewed
See detailEffects of age on plasma metabolites and hormones in finishing Belgian Blue double-muscled cull females
Cabaraux, Jean-François ULg; Dufrasne, Isabelle ULg; Istasse, Louis ULg et al

in Animal Science (2004), 78(Part 2), 229-235

Two groups of 12 Belgian Blue double-muscled cull females were used successively in a 2-year repeated experiment and divided into three groups according to age, allowing four animals per group each year ... [more ▼]

Two groups of 12 Belgian Blue double-muscled cull females were used successively in a 2-year repeated experiment and divided into three groups according to age, allowing four animals per group each year. The aim of the trial was to relate, during the finishing period, the metabolic and endocrine parameters with age. Females were fattened with a diet based on maize silage and were blood sampled on several occasions. The average daily gain (ADG) decreased with the age of the cows. Plasma glucose and triglycerides decreased also with age while the youngest females showed lower concentrations of urea than those older. The composition of plasma non-esterified fatty acids also differed considerably between groups. The hormones that best related with ADG were IGF-1 and insulin. Plasma concentrations of thyroid hormones were lower in the oldest animals. No difference between groups was found for GH. Heifers presented lower concentrations of GH and IGF-1 than those reported elsewhere in fattening bulls of the same breed. It may be concluded that in Belgian Blue double-muscled females, glucose, IGF-1 and insulin are good indicators of the growth potential. Young adult cows presented intermediate characteristics of metabolic and endocrine status that were close either to younger or to older cows. [less ▲]

Detailed reference viewed: 21 (3 ULg)
Full Text
Peer Reviewed
See detailEffects of agents' mobility on opinion spreading in Sznajd model
Sousa, A. O.; Yu-Song, T.; Ausloos, Marcel ULg

in European Physical Journal B -- Condensed Matter (2008), 66(1), 115-124

Under synchronous updating and allowing the agents to move in the lattice or underlying network, we find that the Sznajd model always reaches a consensus as a steady state, - because agent frustrations ... [more ▼]

Under synchronous updating and allowing the agents to move in the lattice or underlying network, we find that the Sznajd model always reaches a consensus as a steady state, - because agent frustrations are removed due to their diffusion. Moreover, we succeed in obtaining the well-known phase transition of the traditional Sznajd model, which depends on the initial concentration of individuals following an opinion. How the time for reaching consensus depends on the system size, and on the topology have been exhaustively investigated. The analyzed topologies were: annealed and quenched dilution on a square lattice, as well as on a variant of the well-known Barabasi-Albert model, called triad network. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailEffects of aggressive encounters on plasma corticosteroid-binding globulin and its ligands in white-crowned sparrows.
Charlier, Thierry ULg; Underhill, Caroline; Hammond, Geoffrey L. et al

in Hormones & Behavior (2009), 56(3), 339-47

In birds, corticosteroid-binding globulin (CBG) binds corticosterone, progesterone and testosterone. The concentration of each ligand can alter the binding of the other ligands through competitive ... [more ▼]

In birds, corticosteroid-binding globulin (CBG) binds corticosterone, progesterone and testosterone. The concentration of each ligand can alter the binding of the other ligands through competitive interactions. Thus, an increase in corticosterone or progesterone may displace testosterone bound to CBG, leading to an increase in bioactive free testosterone levels without affecting total testosterone levels in the circulation. Aggressive interactions increase plasma total testosterone levels in some birds but not in others. Here, we tested the hypothesis that aggressive encounters in the late breeding season would not increase total testosterone levels in plasma, but would alter CBG, total corticosterone or total progesterone levels in such a way as to modify the number of available binding sites and therefore occupancy by testosterone. A marked decrease in CBG occupancy by testosterone would indirectly suggest an increase in free testosterone levels in plasma. Wild male white-crowned sparrows were exposed to a simulated territorial intrusion (STI) or control for 30 min. Subjects were then caught and bled. We measured CBG using a ligand-binding assay and corticosterone, progesterone and testosterone using highly sensitive radioimmunoassays. STI significantly increased aggressive behaviors but did not affect plasma total testosterone levels. STI significantly increased plasma CBG and total corticosterone levels and decreased plasma total progesterone levels. We predict that CBG occupancy by corticosterone will increase slightly following an aggressive encounter. However, this small change is unlikely to increase free testosterone levels, because of the large number of seemingly unoccupied CBG binding sites in these subjects. [less ▲]

Detailed reference viewed: 21 (6 ULg)
Peer Reviewed
See detailEffects of aging and daytime recovery sleep on N-REM slow oscillations
Lafortune, M; Viens, I; Poirier, J et al

Poster (2009, April)

Detailed reference viewed: 2 (0 ULg)
Full Text
Peer Reviewed
See detailEffects of aging and daytime recovery sleep on N-REM slow oscillations
Lafortune, M; Viens, I; Poirier, G et al

in Sleep (2009), 32(Suppl. 1),

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailThe effects of aging on location-based and distance-based processes in memory for time
Bastin, Christine ULg; Van der Linden, Martial ULg; Michel, Anne-Pascale et al

in Acta Psychologica (2004), 116

Retrieving when an event occurred may depend on an estimation of the age of the event (distance-based processes) or on strategic reconstruction processes based on contextual information associated with ... [more ▼]

Retrieving when an event occurred may depend on an estimation of the age of the event (distance-based processes) or on strategic reconstruction processes based on contextual information associated with the event (location-based processes). Young and older participants performed a list discrimination task that has been designed to dissociate the contribution of both types of processes. An adapted Remember/Know/Guess procedure [Can. J. Exp. Psychol. 50 (1996) 114] was developed to evaluate the processes used by the participants to recognize the stimuli and retrieve their list of occurrence. The results showed that aging disrupts location- based processes more than distance-based processes. In addition, a limitation of speed of processing and working-memory capacities was the main predictor of age-related differences on location-based processes, whereas working-memory capacities mediated partly age differences on distance-based processes. [less ▲]

Detailed reference viewed: 13 (4 ULg)
Peer Reviewed
See detailEffects of aging on task- and stimulus-related attention during a working memory task
Kurth, Sophie ULg; Hagelstein, Catherine ULg; Collette, Fabienne ULg et al

in Proceedings of the Annual Meeting of the Belgian Association for Psychological Sciences (2013)

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailThe effects of aging on the recognition of different types of associations
Bastin, Christine ULg; Van der Linden, Martial ULg

in Experimental Aging Research (2006), 32

The present study examined how aging influences item and associative recognition memory, and compared memory for two types of associations: associations between the same kinds of information and ... [more ▼]

The present study examined how aging influences item and associative recognition memory, and compared memory for two types of associations: associations between the same kinds of information and associations between different kinds of information. A group of young adults and a group of older adults performed a forced-choice face recognition task and two multitrial forced-choice associative recognition tasks, assessing memory for face-face and face-spatial location associations. The results showed disproportionate age-related decline of associative recognition compared to intact item recognition. Moreover, aging affected both types of associative tasks in the same way. The findings support an associative deficit hypothesis (Naveh-Benjamin, Journal of Experimental Psychology: Learning, Memory and Cognition, 26, 1170–1187, 2000), which attributes a substantial part of the age effect on episodic memory tasks to difficulty with binding individual components into a cohesive memory trace. This associative deficit seems to affect same-information associations, as well as different-information associations. [less ▲]

Detailed reference viewed: 47 (14 ULg)
Full Text
Peer Reviewed
See detailThe effects of aging on verbal short-term memory and word production capacities
Verhaegen, Clémence ULg; Poncelet, Martine ULg

Poster (2012, June)

The effects of aging on verbal short-term memory (STM) are still a matter of debate (e.g., Nilsson et al., 2003). Recent models of STM distinguish processes involved in the retention of item information ... [more ▼]

The effects of aging on verbal short-term memory (STM) are still a matter of debate (e.g., Nilsson et al., 2003). Recent models of STM distinguish processes involved in the retention of item information (i.e., the identity of words) and order information (i.e., the order of presentation of items) (see Majerus, 2008, for a review). Finally, these models also incorporate relationships between STM and word production capacities, which are often impaired in aging (Burke et al., 1991). The aims of this study are (1) to explore the effects of aging on both item and order STM capacities, (2) to explore the effects of aging on naming capacities and (3) to explore the relationships between STM and naming in aging. Three groups of participants participated in the present study: (1) 56-64 years old (N=26) – (2) 65-74 years old (N=23) – (3) 75-84 years old (N=22). The participants' hearing thresholds were analyzed with a pure tone audiometer. The participants were asked to perform STM tasks and a picture naming task. The results confirm the presence of naming difficulties in participants above 65 years of age, as previously shown by Verhaegen and Poncelet (in press). By contrast, in STM, the differences become non significant when the hearing status is controlled for. However, the items are presented auditorily in all STM tasks. Therefore, in order to confirm the absence of age-related differences in STM, it would be of interest to assess the participants with visual STM tasks. [less ▲]

Detailed reference viewed: 60 (9 ULg)
Full Text
Peer Reviewed
See detailEffects of allele frequency estimation on genomic predictions and inbreeding coefficients.
VanRaden, P. M.; Tooker, M. E.; Gengler, Nicolas ULg

in Journal of Dairy Science (2008, July), 91

Genetic calculations often require estimating allele frequencies, which differ across time due to selection and drift. Data were 50,000 simulated markers and 39,985 actual markers for 2391 genotyped ... [more ▼]

Genetic calculations often require estimating allele frequencies, which differ across time due to selection and drift. Data were 50,000 simulated markers and 39,985 actual markers for 2391 genotyped Holstein bulls. Gene content of relatives and gene frequencies in the base (founder) population were estimated using pedigrees and a linear model. Ancestors born since 1950 were included, for a total of 22,088 animals. Because pedigrees were very complete, only one unknown-parent group was used. Convergence to 5 digits of accuracy required about 1000 iterations. Total time was 2 processor days and proportional to number of animals times markers, but actual clock time was reduced by processing loci on separate chromosomes in parallel. Simple allele frequencies were obtained from only the known genotypes. True base frequencies were correlated with estimated base frequencies by 0.98 versus 0.94 with simple frequencies. Genomic predictions and inbreeding coefficients were computed in four ways, using true or estimated base frequencies, simple frequencies, or an “estimate” of .5 for each marker. When allele frequencies estimates were used instead of 0.5 to assign mixed model coefficients, solutions converged more slowly but predictions were more accurate. From simulated data, realized reliabilities for young bulls were 62.8% using either true or estimated base frequencies, 62.6% using simple frequencies, and 62.0% using frequencies set to 0.5. Pedigree and genomic inbreeding coefficients were correlated by 0.73 using true base frequencies, 0.67 using estimated base frequencies, 0.12 using simple frequencies, and 0.72 when frequencies were set to 0.5. Genomic inbreeding coefficients were biased downward by 7% to 9% using either frequency estimate, upward by 31% using 0.5, but were reasonable when true frequencies were used. Frequency estimation had small effects on genomic predictions but large effects on genomic inbreeding coefficients in both simulated and real data. [less ▲]

Detailed reference viewed: 55 (3 ULg)
Full Text
Peer Reviewed
See detailEffects of allelochemicals from first (Brassicaceae) and second (Myzus persicae and Brevicoryne brassicae) trophic levels on Adalia bipunctata
Francis, Frédéric ULg; Lognay, Georges ULg; Wathelet, Jean-Paul ULg et al

in Journal of Chemical Ecology (2001), 27(2), 243-256

Three Brassicaceae species, Brassica napus (low glucosinolate content), Brassica nigra (including sinigrin), and Sinapis alba (including sinalbin) were used as host plants for two aphid species: the ... [more ▼]

Three Brassicaceae species, Brassica napus (low glucosinolate content), Brassica nigra (including sinigrin), and Sinapis alba (including sinalbin) were used as host plants for two aphid species: the generalist Myzus persicae and the specialist Brevicoryne brassicae. Each combination of aphid species and prey host plant was used to Feed the polyphagous ladybird beetle, Adalia bipunctata. Experiments with Brassicaceae species including different amounts and kinds of glucosinolates (GLS) showed increased ladybird larval mortality at higher GLS concentrations. When reared on plants with higher GLS concentrations, the specialist aphid, B. brassicae, was found to be more toxic than M. persicae. Identification of GLS and related degradation products, mainly isothiocyanates (ITC), was investigated in the first two trophic levels, plant and aphid species, by high-performance liquid chromatography and gas chromatography-mass spectrometry, respectively. While only GLS were detected in M. persicae on each Brassicaceae species, high amounts of ITC were identified in B. brassicae samples (allyl-ITC and benzyl-ITC from B. nigra and S. alba, respectively) from all host plants. Biological effects of allelochemicals from plants on predators through aphid prey are discussed in relation to aphid species to emphasize the role of the crop plant in integrated pest management in terms of biological control efficacy. [less ▲]

Detailed reference viewed: 38 (6 ULg)