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See detailEffects of Etodolac on Human Chondrocytes Cultivated in Three Dimensional Culture
Henrotin, Yves ULg; Bassleer, C.; Reginster, Jean-Yves ULg et al

in Clinical Rheumatology (1989), 8(Suppl 1), 36-42

Human chondrocytes in three-dimensional culture were incubated for up to 20 days in the presence of etodolac, a nonsteroidal anti-inflammatory drug which penetrates readily into the synovial fluid. Even ... [more ▼]

Human chondrocytes in three-dimensional culture were incubated for up to 20 days in the presence of etodolac, a nonsteroidal anti-inflammatory drug which penetrates readily into the synovial fluid. Even at an etodolac concentration of 80 micrograms/ml, DNA synthesis, proteoglycan synthesis, and type-II collagen synthesis were unchanged. Collagenase production was also unaffected by etodolac (60 micrograms/ml). In contrast, prostaglandin E2 production was reduced by 84% in the presence of 60 micrograms/ml of etodolac. The 80 micrograms/ml concentration is 5 times that found in the serum of subjects treated with 200 mg of etodolac twice a day for 6 days, and 33 times the concentration in synovial fluid of arthritic patients treated with etodolac 200 mg twice a day for 7 days. These in vitro results indicate that anti-inflammatory levels of etodolac may not damage articular cartilage in vivo. [less ▲]

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See detailEffects of excess nutrients on Posidonia productio in Calvi Bay.
Dauby, Patrick ULg; Noirhomme, Stéphane; Soullard, Mady et al

Conference (1993, January)

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See detailEffects of exercise and oral antioxidant supplementation enriched in (n-3) fatty acids on blood oxidant markers and erythrocyte membrane fluidity in horses
De Moffarts, Brieuc; Portier, Karine; Kirschvink, Nathalie et al

in Veterinary Journal (2007), 174(1), 113-121

The aim of this study was to investigate in a placebo-controlled field study the effect of a (n - 3)-vitamin supplementation on erythrocyte membrane fluidity (ENIF), oxidant/antioxidant markers and ... [more ▼]

The aim of this study was to investigate in a placebo-controlled field study the effect of a (n - 3)-vitamin supplementation on erythrocyte membrane fluidity (ENIF), oxidant/antioxidant markers and plasmatic omega 3/omega 6 fatty acid ratio (FAR) in 12 eventing horses. Venous blood was sampled at rest before (PRE) and after (POST) a three week treatment period with either the supplement (group S, n = 6) or a placebo (group P, n = 6) as well as after 15 min (POST E15') and 24 h (POST E24h) after a standardised exercise test. The following markers were analysed: EMF, plasma antioxidant capacity of water and lipid soluble components, ascorbic acid, uric acid (UA), glutathione (reduced: GSH, oxidised: GSSG), vitamin E (Vit E), beta-carotene, glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity, selenium, copper (Cu), zinc (Zn), oxidised proteins (Protox), lipid peroxides (Pool) and FAR. EMF did not differ between group S and P after treatment, but GPx remained unchanged in group S whereas it decreased in group P and plasma Cu/Zn ratio remained unchanged whereas it increased in group P. FAR were significantly increased in group S. Exercise induced a significant decrease of EMF (POST vs. E24h) in both groups, but which was significantly lower at E15' in group S than in group P. Exercise induced a significant increase of UA and ACW (POST vs. E15') and Protox (POST vs. E24h) in both groups. An exercise-related decrease in GSH and Pool (POST vs. E15') was found in group P, whereas Vit E and FAR (POST vs. E24h) significantly decreased in both groups. The study showed that exercise induced a decrease in ENIF in horses associated with changes of blood oxidative balance. The (omega-3)vitamin supplementation tested improved the oxidative balance poorly but delayed the exercise-induced decrease of EMF and increased the FAR. [less ▲]

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See detailEffects of exercise on concentrations of immunoreactive endothelin in bronchoalveolar lavage fluid of normal horses and horses with chronic obstructive pulmonary disease
Benamou, A. E.; Art, Tatiana ULg; Marlin, David J et al

in Equine Veterinary Journal. Supplement (1999), 30

Chronic obstructive pulmonary disease (COPD) represents a major cause of loss of performance in the horse. The role of endothelin (ET), a potent bronchoconstrictive and vasoactive peptide, is currently ... [more ▼]

Chronic obstructive pulmonary disease (COPD) represents a major cause of loss of performance in the horse. The role of endothelin (ET), a potent bronchoconstrictive and vasoactive peptide, is currently being investigated in asthma and other obstructive respiratory diseases in man. We have previously found elevated systemic and pulmonary endothelin levels in horses during exacerbation of COPD. In the present study, our aim was to examine possible variations in ET concentrations occurring during exercise in COPD horses. We compared the effects of intense treadmill exercise on the recovery of endothelin (ET) in the bronchoalveolar lavage fluid (BALF) as well as in arterial and venous blood, in a group of 5 healthy horses and a group of 5 COPD horses studied alternately in remission and while symptomatic. We also investigated the possible correlations between ET levels and pulmonary function tests during the study. While exercise did not affect the ET levels recovered in BALF among controls, it caused a significant increase (P = 0.02) among symptomatic COPD horses. During remission, wide variations of ET levels among horses, at rest and during exercise, made any significant interpretation difficult. No correlation could be found between exercise-induced changes in ET concentrations and pulmonary function tests or changes in arterial oxygen tension with exercise. We conclude that exercise appears to affect the release of ET by the airways in COPD horses, in contrast to healthy horses. It is still unclear, however, whether these differences relate to adjustments of lung function during exercise. [less ▲]

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See detailEffects of exercise on neuroendocrine secretions and glucose regulation at different times of day.
Scheen, André ULg; Buxton, O. M.; Jison, M. et al

in American Journal of Physiology (1998), 274(6 Pt 1), 1040-9

To study the effects of time of day on neuroendocrine and metabolic responses to exercise, body temperature, plasma glucose, insulin secretion rates (ISR), and plasma cortisol, growth hormone (GH) and ... [more ▼]

To study the effects of time of day on neuroendocrine and metabolic responses to exercise, body temperature, plasma glucose, insulin secretion rates (ISR), and plasma cortisol, growth hormone (GH) and thyrotropin (TSH) were measured in young men, both at bed rest and during a 3-h exercise period (40-60% maximal O2 uptake). Exercise was performed at three times of day characterized by marked differences in cortisol levels, i.e., early morning (n = 5), afternoon (n = 8), and around midnight (n = 9). The subjects were kept awake and fasted, but they received a constant glucose infusion to avoid hypoglycemia. Exercise-induced elevations of temperature were higher in the early morning than at other times of day. The exercise-induced glucose decrease was approximately 50% greater around midnight, when cortisol was minimal and not stimulated by exercise, than in the afternoon or early morning (P < 0.05). This effect of time of day appeared unrelated to decreases in ISR or increases in temperature and GH. Robust TSH increases occurred in all exercise periods and were maximal at night. The results demonstrate the existence of circadian variations in neuroendocrine and metabolic responses to exercise. [less ▲]

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See detailEffects of Existing Tax Treaties on VAT (Relevance of Arts. 24-27 OECD Model for VAT/GST)
Bourgeois, Marc ULg; Romer, Adeline ULg

in Lang, Michael; Melz, Peter; Kristoffersson, Eleonor (Eds.) Value Added Tax and Direct Taxation - Similarities and Differencies (2009)

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See detailEffects of Existing Tax Treaties on VAT (Relevance of Arts. 24-27 OECD Model for VAT/GST)
Bourgeois, Marc ULg

Scientific conference (2009, March 26)

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See detailEffects of exogenous gonadotropic and steroid hormones on the social behaviour and gonadal maturation of male domestic ducklings Anas platyrhynchos L.
Balthazart, Jacques ULg; Hendrick, J. C.

in Archives Internationales de Physiologie et de Biochimie (1979), 87(4), 741-61

Male domestic ducklings were injected during their first month of life with mammalian gonadotrophins (ovine LH or FSH, HMG) or gonadal steroids (testosterone or oestradiol). LH and testosterone stimulated ... [more ▼]

Male domestic ducklings were injected during their first month of life with mammalian gonadotrophins (ovine LH or FSH, HMG) or gonadal steroids (testosterone or oestradiol). LH and testosterone stimulated sexual behaviour while oestradiol inhibited the increase of aggression observed in control birds during the experiment. The mammalian gonadotrophins did not increase plasma testosterone but nevertheless they all stimulated the testis growth. Several hypotheses which could explain this finding (stimulation of spermatogenesis without any apparent effect on testosterone) are discussed and the possibility of a direct action of LH on the sexual behaviour is analysed. Social displays were only moderately stimulated by testosterone and not at all by gonadotrophins. The hormonal controls of these behaviour patterns remains thus largely unknown. [less ▲]

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See detailEffects of exogenous IL-1 beta, TNF alpha, IL-6, IL-8 and LIF on cytokine production by human articular chondrocytes.
Henrotin, Yves ULg; De Groote, D. D.; Labasse, A. H. et al

in Osteoarthritis and Cartilage (1996), 4(3), 163-73

Cytokines are potent regulators of the chondrocyte functions. Some of them are produced by chondrocytes and interact to regulate cartilage metabolism. In this study, we investigated the production of ... [more ▼]

Cytokines are potent regulators of the chondrocyte functions. Some of them are produced by chondrocytes and interact to regulate cartilage metabolism. In this study, we investigated the production of interleukin-1 beta (IL-1 beta), IL-6, IL-8 and leukemia inhibitory factor (LIF) by human chondrocytes and examined the modulation of their secretion by exogenous cytokines. Human articular chondrocytes were isolated from their extracellular matrix by a triple successive enzymatic digestion of the cartilage. Subsequently, chondrocytes were stimulated by increased amounts of human recombinant cytokines [IL-1 beta, tumour necrosis factor alpha (TNF alpha), IL-8, LIF, IL-6]. IL-1 beta, IL-6, IL-8 and LIF were assayed into culture media and inside cell extracts by specific enzyme amplified sensitivity immunoassays (EASIAs). Under these experimental conditions, we have identified various interactions between cytokines. IL-beta and TNF alpha highly stimulated IL-6, LIF and IL-8 productions. IL-6 decreased IL-8 synthesis and increased LIF production. IL-8 slightly enhanced IL-6 production. Finally, LIF stimulated IL-1 beta, IL-6 and IL-8 productions. Using neutralizing antibodies against IL-1, we demonstrated that the effects of LIF were secondary to the stimulation by LIF of IL-1 beta production by the chondrocytes. In conclusion, chondrocytes secrete a variety of immunocompetent cytokines including IL-1 beta, IL-6, IL-8 and LIF that can interact to regulate chondrocytes metabolism. These results also define new biological activities of LIF and IL-6, and raise questions concerning their role in the pathogenesis of joint diseases. [less ▲]

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See detailEffects of exotic invasive plants on soil properties in Belgium
Chapuis-Lardy, L.; Vanderhoeven, Sonia ULg; Dassonville, N. et al

Poster (2004)

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See detailEffects of experimental parameters on elemental analysis of coal by laser-induced breakdown spectroscopy
Li, Jie ULg; Lu, Jidong; Lin, Zhaoxiang et al

in Optics & Laser Technology (2009), 41(8), 907-913

The purpose of this work is to improve the precision of the elemental analysis of coal using laser-induced breakdown spectroscopy (LIBS). The LIBS technique has the ability to allow simultaneous elemental ... [more ▼]

The purpose of this work is to improve the precision of the elemental analysis of coal using laser-induced breakdown spectroscopy (LIBS). The LIBS technique has the ability to allow simultaneous elemental analysis and on-line determination, so it could be used in the elemental analysis of coal. Organic components such as C, H, O, N and inorganic components such as Ca, Mg, Fe, Al, Si, Ti, Na, and K of coal have been identified. The precision of the LIBS technique depends strongly on the experimental conditions, and the choice of experimental parameters should be aimed at optimizing the repeatability of the measurements. The dependences of the relative standard deviation (RSD) of the LIBS measurements on the experimental parameters including the sample preparation parameters, lens-to-sample distance, sample operation mode, and ambient gas have been investigated. The results indicate that the precision of LIBS measurements for the coal sample can be improved by using the optimum experimental parameters. [less ▲]

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See detailEffects of exposure to cadmium on calcium metabolism : a population study
Staessen, Jan; Amery, Antoon; Bernard, Alfred et al

in British Journal of Industrial Medicine (1991), 48

The objective was to investigate the hypothesis that environmental exposure to cadmium may affect calcium metabolism in the population at large. The 1987 participants (965 men and 1022 women), from 20 to ... [more ▼]

The objective was to investigate the hypothesis that environmental exposure to cadmium may affect calcium metabolism in the population at large. The 1987 participants (965 men and 1022 women), from 20 to 80 years old, constituted a random sample of the population of four Belgian districts. The urinary excretion of cadmium, a mesure of lifetime exposure, averaged 9.3 nmo/24h in men (range 0.4-324 nmol/24h) and 7.1 nmol/24h (range 0.1-71 nmol/24h) in women. Serum alkaline phosphatase activity and the urinary excretion of calcium correlated significantly and positively with urinary cadmium excretion in both men and women, and serum total calcium concentration negatively with urinary cadmium excretion in men only. The regression coefficients obtained after adjustment for significant covariates indicated that when urinary cadmium excretion increased twofold, serum alkaline phosphatase activity and urinary calcim excretion rose by 3-4% and 0.25 mmol/24h respectively, whereas in men serum total calcium concentration fell by 6 µmol/l. After adjustment for significant covariates the relation between serum total calcium concentration and urinary cadmium excretion was not significant in women. The findings suggest that even at environmental exposure levels calcium metabolism is gadually affected, as cadmium accumulates in the body. The morbidity associated with this phenomenon in industrialised countries remains presently unknown and requires further investigation. [less ▲]

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See detailEffects of extra-mixing processes on the periods of high-order gravity modes in main-sequence stars
Miglio, Andrea ULg; Montalban Iglesias, Josefa ULg; Noels-Grötsch, Arlette ULg

in Communications in Asteroseismology (2006), 147

In main-sequence stars, the chemical composition gradient that develops at the edge of the convective core is responsible for a non-uniform period spacing of high-order gravity modes. In this work we ... [more ▼]

In main-sequence stars, the chemical composition gradient that develops at the edge of the convective core is responsible for a non-uniform period spacing of high-order gravity modes. In this work we investigate, in the case of a 1.6 M(solar) star, the effects on the period-spacing of extra mixing processes in the core (such as diffusion and overshooting). [less ▲]

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See detailEffects of extraction solvents on phenolic contents and antioxidant activities of Tunisian date varieties (Phoenix dactylifera L.)
Kchaou, W; Abbès, F; Blecker, Christophe ULg et al

in Industrial Crops & Products (2013), 45

Second-grade dates (Phoenix dactylifera L.), with hard texture, from six Tunisian cultivars were analysed for their composition and antioxidant activities. Results showed predominance of total sugars and ... [more ▼]

Second-grade dates (Phoenix dactylifera L.), with hard texture, from six Tunisian cultivars were analysed for their composition and antioxidant activities. Results showed predominance of total sugars and a relatively low content of protein, fat andash. On the other hand, optimisation of extraction of antioxidant was carried using five different solvents. The highest level of phenolic compounds for all dates varieties was found in the 70% acetone extract. This level ranged from 199.43 to 576.48 mg of GAE/100 g fresh weight. However, extraction into 50% methanol gave the highest antioxidant activity from 89.55 to 109.67 mg equivalents of ascorbic acid/g fresh weight. For both two olvents, Bejo exhibited the highest phenolic content and total antioxidant activity, while Baydh El Hamam presented the owest. A positive linear correlation between total antioxidant activity and phenolic contents was observed (R2 = 0.83; R2 = 74 for acetone/H2O and methanol/H2O, respectively). The antioxidant activity of acetone/H2O and methanol/H2O extracts was carried using DPPH radical-scavenging activity and reducing power. These results showed that dates had strongly scavenging activity on DPPH reaching 90.12% in methanol/H2O from Deglet Nour. Whereas, acetone/H2O showed the best reducing power which Bejo was significantly higher than the other varieties. This study demonstrates the potential antioxidant activity with Tunisian date, that we can use these natural extracts as food additives in replacement of synthetic compounds. [less ▲]

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See detailEffects of extreme meteorological conditions on coastal dynamics near a submarine canyon
Skliris, Nikolaos ULg; Lacroix, Geneviève; Djenidi, Salim ULg

in Continental Shelf Research (2004), 24(9), 1033-1045

A 3-D hydrodynamic model is applied to assess shelf/slope exchanges in the Calvi Canyon region (Corsica, NW Mediterranean) during the violent storm that affected the Western Europe in December 1999 ... [more ▼]

A 3-D hydrodynamic model is applied to assess shelf/slope exchanges in the Calvi Canyon region (Corsica, NW Mediterranean) during the violent storm that affected the Western Europe in December 1999. Simulations are carried out using high-frequency sampling meteorological data to take into account the short-term variability of the atmospheric conditions. It is shown that the combined effects of canyon topography and of the wind forcing during the storm are responsible for a large increase of both cross-shore and vertical transports in the area. Strong downwelling motion is simulated all along the continental slope with vertical velocities up to 2cm s(-1) within the canyon. High turbulent diffusion levels are obtained leading to the complete mixing of the water column within the canyon. Results suggest that increased turbulent diffusion and downwelling circulation in the canyon during the storm should result in a large transport of coastal water towards the abyssal plain. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailEffects of extremely low frequency electromagnetic fields (ELF) on human beings
Lilien, Jean-Louis ULg; Dular, Patrick ULg; V Sabariego, Ruth ULg et al

in International Colloquium on Power frequency electromagnetic fields ELF EMF, Sarajevo, Bosnia and Herzegovina (2009)

A rough overview of typical values of ELF fields will be presented followed by a brief literature survey on childhood leukaemia and ELF. The potential carcinogenic effect of ELF would be linked to ... [more ▼]

A rough overview of typical values of ELF fields will be presented followed by a brief literature survey on childhood leukaemia and ELF. The potential carcinogenic effect of ELF would be linked to electrical disturbances in cell behaviour. The major concern linking childhood leukaemia and ELF is thus to determine the response of bone marrow cells under ELF fields. With that purpose, transmembrane potential will be targeted and linked to the E-field at that level. [less ▲]

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See detailEffects of extremely low frequency electromagnétic fields (ELF) on human beings. An electrical engineer viewpoint.
Lilien, Jean-Louis ULg; Dular, Patrick ULg; V Sabariego, Ruth ULg et al

in Revue d'électricité et d'électronique industrielle - tijdschrift voor elektriciteit en industriele elektronika (2008), 3

Since the early seventies, potential health risks from Extremely Low Frequency (ELF) exposure (50 Hz) have been extensively treated in the literature (more than 1000 references registered by WHO1, 2007 ... [more ▼]

Since the early seventies, potential health risks from Extremely Low Frequency (ELF) exposure (50 Hz) have been extensively treated in the literature (more than 1000 references registered by WHO1, 2007). After 30 years of worldwide research, the major epidemiological output is the possible moderate increased risk (by a factor 2) of childhood leukaemia in case of a long exposure to an ambient magnetic flux density (B-field) higher than 0.4 μT. However, this fact has not been confirmed by in vivo and/or in vitro studies. Moreover it has not been validated by any adverse health biological mechanisms neither for adults nor for children. Nobody knows precisely what happens inside the body and what could be a hazardous health effect of the ELF fields at 50 Hz. International recommendations (ICNIRP2) are currently, for general public, not to exceed a B-field of 100 μT (50 Hz) and an E-field of 5 kV/m (50 Hz). The authors are looking for a signal generated in the biological process under electric interactions. Herein, a rough overview of typical values of ELF fields will be presented followed by a brief literature survey on childhood leukaemia and ELF. The potential carcinogenic effect of ELF would be linked to electrical disturbances in cell behaviour. The major concern linking childhood leukaemia and ELF is thus to determine the response of bone marrow cells under ELF fields.With that purpose, transmembrane potential will be targeted and linked to the E-field at that level. This paper is three-folded: First, the electric interactions between ambient ELF fields and the body are studied both qualitatively and quantitatively. Though no adverse health field threshold is defined, a minimum field level is fixed in order to discriminate inherent random noise, in agreement with NIEHS3. This is based on the fact that mechanisms become only plausible under field exposure above a certain strength. Different sources of internal E-field are analysed and classified according to their potential risk. Second, the hypothesis of contact current is detailed. Finally, key actions to undertake are highlighted. Based on the current state of the art and some authors’ own developments, this paper proposes simple low cost modifications of private electrical installations in order to annihilate the major source of potential effects of ELF. Particular emphasis is paid to the situation in Belgium as the authors are part of the BBEMG (see end note) and perform numerous measurements in Belgian residential homes. [less ▲]

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See detailEffects of eythropoietin administration on mitral regurgitation and left ventricular remodeling in heart failure patients.
Cosyns, B.; Velez-Roa, S.; Droogmans, S. et al

in International Journal of Cardiology (2010), 138(3), 306-307

The effects of erythropoietin administration on mitral regurgitation in patients with congestive heart failure have not yet been examined. After 2 months, erythropoietin treatment results in a significant ... [more ▼]

The effects of erythropoietin administration on mitral regurgitation in patients with congestive heart failure have not yet been examined. After 2 months, erythropoietin treatment results in a significant reduction in left ventricular volumes and mitral regurgitation severity and improves hemodynamics. [less ▲]

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