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See detailDiacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO
Pavelka, Karel; Bruyère, Olivier ULg; Cooper, Cyrus et al

in Drugs & Aging (2016)

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been ... [more ▼]

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling. Following the end of the revision procedure by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) constituted a panel of 11 experts to better define the real place of diacerein in the armamentarium for treating OA. Based on a literature review of clinical trials and meta-analyses, the ESCEO confirms that the efficacy of diacerein is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs) after the first month of treatment, and superior to that of paracetamol. Additionally, diacerein has shown a prolonged effect on symptoms of several months once treatment was stopped. The use of diacerein is associated with common gastrointestinal disorders such as soft stools and diarrhoea, common mild skin reactions, and, uncommonly, hepatobiliary disorders. However, NSAIDs and paracetamol are known to cause potentially severe hepatic, gastrointestinal, renal, cutaneous and cardiovascular reactions. Therefore, the ESCEO concludes that the benefit–risk balance of diacerein remains positive in the symptomatic treatment of hip and knee osteoarthritis. Furthermore, similarly to other SYSADOAs, the ESCEO positions diacerein as a first-line pharmacological background treatment of osteoarthritis, particularly for patients in whom NSAIDs or paracetamol are contraindicated [less ▲]

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See detailA diachronic analysis of French ‘à/au travers’ in combination with the preposition ‘de’
Hoelbeek, Thomas ULg

in Neuphilologische Mitteilungen (2015)

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See detailA diachronic analysis of the dynamic of two cities: Kisangani and Lubumbashi (Democratic Republic of Congo): How do the extension and/or of the densification of these cities impact the urban internal and peripheral ecosystems?
Andre, Marie ULg; Mahy, Grégory ULg; Lejeune, Philippe ULg et al

Poster (2014, February 07)

The dynamics of two cities between two years (2002 and 2010 for Kisangani; 2002 and 2008 for Lubumbashi, both part of the Democratic Republic of Congo) have been examined in order to estimate how their ... [more ▼]

The dynamics of two cities between two years (2002 and 2010 for Kisangani; 2002 and 2008 for Lubumbashi, both part of the Democratic Republic of Congo) have been examined in order to estimate how their extension and/or of the densification have impacted the urban internal and peripheral ecosystems. This study singularizes itself from the subjective ones by its quantified and objective approach based on landscape ecology. This discipline assumes that the landscape pattern description is important because, according to its central hypothesis called “pattern-process paradigm”, the ecological processes influence landscape structure and vice versa. Composition metrics, which are commonly used in landscape ecology, describe the pattern among other things in quantifying the presence and the number of patches from the various classes within the landscape. For each city two SPOT 5 images were classified with a oriented-object supervised approach; then built area proportion index, a composition landscape metric, has been evaluated in order to 1) identify the extent of each area (urban, suburban, rural) within the urban-rural gradient, 2) quantify the dynamic of the different areas in the urban-rural gradient during the last decade and 3) quantify the effect of a decade of urban and suburban growth on ecosystems. The similarities and differences between these cities, relevance and gaps in the method have then been identified and discussed. [less ▲]

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See detailDiachronic lexical semantics in Ancient Egyptian–Coptic: The Egyptianness of basic vocabulary in Coptic
Grossman, Eitan; Polis, Stéphane ULg

Conference (2015, November 21)

Coptic, as it comes down to us in written texts, is massively influenced by Greek in the domain of lexicon. The Leipzig-Berlin Dictionary and Database of Greek Loanwords in Coptic project has already ... [more ▼]

Coptic, as it comes down to us in written texts, is massively influenced by Greek in the domain of lexicon. The Leipzig-Berlin Dictionary and Database of Greek Loanwords in Coptic project has already recorded c. 5000 loan word types and c. 60.000 loan word tokens. On this basis, linguists, philologists, and historians often make assumptions about the nature and extent of bilingualism. Some linguists have even proposed that Coptic is a case of ‘code-mixing’ of Egyptian and Greek, which assumes extensive bilingualism among Egyptians in Late Antiquity. In this paper, we tackle this question from another angle, by determining the extent to which Greek influenced Coptic in terms of its *basic vocabulary*. It may be that we can learn more about bilingualism in Late Antique Egypt this way, since overall lexical borrowing need not correlate with lexical borrowing in the domain of basic vocabulary. As a (significant) side effect of this study, we can also describe the rate of replacement of basic vocabulary in Egyptian-Coptic across its 4000 years of attestation, as well as the semantic domains and periods in which lexical replacement was faster or slower. [less ▲]

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See detailDiachronical soil surveys: a way to quantify long term diffuse erosion
Pineux, Nathalie ULg; Michel, Brieuc ULg; Legrain, Xavier ULg et al

in Geophysical Research Abstracts (2015), 17

The loess belt of Western Europe is a high-risk area regarding diffuse erosion. It is due to the climate and the topography but also to the soil type. Loamy soils are naturally highly sensitive to diffuse ... [more ▼]

The loess belt of Western Europe is a high-risk area regarding diffuse erosion. It is due to the climate and the topography but also to the soil type. Loamy soils are naturally highly sensitive to diffuse erosion. Hence, these soils are very fertile. So, they are intensively cultivated which increases their sensitivity to erosion. Sheet erosion is an erosion type strongly represented in these regions. Contrarily to the concentrated form of erosion which happens more brutally, sheet erosion needs long-term observation time-scales, which remains rare. In Belgium, a soil map was established in 1956. This map is quite detailed and notably informs about the different horizons which are in the profile (ploughed horizon, eluvial horizon, clay included between the horizons, carbonate-free loess horizon, and all these were characterised by drainage class) and their depth. It was based on a dense augering network across the country (one point every 75 meters). A new augering campaign was done again in 2014. It consisted in one observation every 50 meters on an agricultural watershed of 124 hectares located in the centre of Belgium. This catchment has been cultivated since the 14th century and is representative of the local context (gentle slope (3-8%), plot size (mean value of 10 ha), …). We compared the two soil maps produced on this site with a 58years time lapse. Results show that the large majority of the watershed falls from upslope soils with weak erosion to slope soils with strong erosion. The soil thickness diminished in some zones to 1m10 (minimum estimation) of erosion. This comparison shows that very few upslope soils are preserved. On the other hand, the areas where colluviums were present to the full depth stay at the same place in the main thalweg of the watershed. Other areas on the watershed seem to be subject to a (minimum estimation) of 40cm of sediments deposition. Large areas in the watershed suffered from erosion and came to deposition areas as the clay horizon is no longer observed under the colluviums. It can be highlighted that soil depths were worryingly lost during 58 years of tillage and that some soils were converted to colluviums which is of lower agronomical quality than the original soils which had a clay horizon below to keep water. Diachronical soil survey offers an unique insight of long term diffuse erosion and should demonstrate the importance of preserving soils even in regions where agricultural yields are not (yet) affected by erosion. [less ▲]

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See detailDiagenèse des monticules micritiques de la partie supérieure du Frasnien du Synclinorium de Dinant (Belgique, France)
Boulvain, Frédéric ULg; Herbosch, A.; Keppens, E.

in Comptes Rendus de l'Académie des Sciences. Série II, Mécanique, Physique, Chimie, Sciences de l'Univers, Sciences de la Terre (1992), 315

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See detailDiagenèse osseuse et genèse de nodules phosphatés, associés aux sédiments fluvio-lacustres de sites à hominidés miocène (Kenya)
DERICQUEBOURG, P.; PERSON, A.; SEGALEN, L. et al

Poster (2010)

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See detailDiagenetic and paleogeographic significance of clay and other sedimentary components in the middle Devonian limestones of Western Ardennes, France
Chamley, H.; Proust, J. N.; Mansy, J. L. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (1997), 129

Givetian deposits accumulated in a more than 300-m-thick succession on a carbonate platform developed on the passive margin of the so-called Rheic ocean. These rocks crop out in the Ardenne massif at ... [more ▼]

Givetian deposits accumulated in a more than 300-m-thick succession on a carbonate platform developed on the passive margin of the so-called Rheic ocean. These rocks crop out in the Ardenne massif at Glageon in a structural context marked by small fault-controlled basins subjected to moderate overburden, tectonic and metamorphic constraints. Data on the clay mineral distribution, associated with detailed information on limestone facies/microfacies, as well as data on the depositional profile and sequence stratigraphic evolution of these rocks indicate strong carbonate diagenesis and moderate clay diagenesis, the latter being favoured by the early occurrence of the former, which prevented further fluid-rock interaction. The clay assemblage distribution, which roughly parallels the palaeomorphologic and palaeobathymetric shape of the Givetian continental margin, is organized in five successive zones indicating large-scale sequence stratigraphic evolution and the control of regional sea-level fluctuations. The clay and other sedimentary components provide additional information on the warm and variably humid climate, northern, relative to southern, terrigenous sources, the open sea relative to restricted depositional environments, the temporary tectonic rejuvenation of the continental hinterland and the chemical conditions allowing early diagenetic modifications. [less ▲]

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See detailDiagenetic factors controlling reservoir quality in the Faraghan Formation (Lower Permian), Darang Field, Southern Iran
Zamanzadeh, Seyed Mohammad; Mirzaei, Saeid; Sardar Abadi, Mehrdad ULg et al

in Energy Exploration & Exploitation (2011), 29(2), 109-128

The role of diagenesis in affecting (reduction or enhancement) reservoir quality in the Faraghan Formation in Darang #1 well was investigated. The Faraghan Formation is mainly composed of sandstone facies ... [more ▼]

The role of diagenesis in affecting (reduction or enhancement) reservoir quality in the Faraghan Formation in Darang #1 well was investigated. The Faraghan Formation is mainly composed of sandstone facies along with minor mudstone and siltstone and grades upward into mixed carbonate –siliciclastic facies and then to Dalan Formation carbonates. Depositional environment of this formation comprises various sub-environments of a delta setting in the lower part of the formation which grades upward into a shallow marine clastic environment in the upper part. The processes enhancing reservoir quality include dissolution of carbonate grains and cements and alteration of feldspar grains. Burial history diagram shows that after deposition during Lower Permain, the formation underwent a rapid burial up to 1000 meters below sea level in Upper Permian. Then a slight uplift (about 100 meters) and gradual burial followed up to Mid- Jurassic. Afterwards the formation experienced a series of rapid and moderate uplift from Mid-Jurassic to Tertiary when the formation uplifted to around 2500 meters above sea level. The suitable conditions resulting in dissolution took place in shallow buried sandstones. These conditions occurred two times during burial history: at the early stages of eodiagenesis and during telodiagenesis. The major processes deteriorating reservoir quality include compaction and cementation. Major cement types include carbonate cements (dolomite, siderite), clay cements (kaolinite, sericite, chlorite), silica cement and pyrite cement. The most abundant cement is the carbonate cement especially dolomite. The dolomite cement occurs as intergranular and poikilotopic forms. The most frequent clay cement is sericite which dominates in sitstones and lithicarenites. Silica cement, where present, fills all the pore spaces. The least frequent cement type is pyrite which is found in two forms of poikilotopic and framboidal. Where it is found in the form of poikilotopic cement, it massively fills the pore spaces and deteriorates the porosity and permeability of the sandstones. [less ▲]

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See detailDiagnosing and treating pediatric Crohn's disease patients: is there a difference between adult and pediatric gastroenterologist's practices ? Results of the BELCRO cohort.
De Greef, E.; Maus, B.; Smets, F. et al

in Acta gastro-enterologica Belgica (2014), 77(1), 25-9

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See detailDiagnosing Cardiac Dysfunction and Guiding Therapy in Critical Care
Starfinger, C.; Chase, J. G.; Hann, C. et al

in Proceedings of the NZBio 2008 Conference & Exposition, (2008)

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See detailDiagnosing entrapment neuropathies: probes and magnets instead of electrodes and needles?
MAERTENS DE NOORDHOUT, Alain ULg

in Clinical Neurophysiology (2006), 117(3), 484-5

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See detailDiagnosing multiple sclerosis with a gait measuring system, an analysis of the motor fatigue, and machine learning
Pierard, Sébastien ULg; Azrour, Samir ULg; Phan-Ba, Rémy et al

in Multiple Sclerosis Journal (2014, September 11), 20(S1), 171

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See detailDiagnosing pulmonary embolism from a model-based cardiac driver function
Stevenson, D; Revie, JA; Chase, JG et al

in Proceedings of ANZICS 2011 (2011)

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See detailDiagnosing structure and composition typologies in uneven-aged broad-leaved forests: a comparison of classification methods
Bonnet, Stéphanie ULg; Brostaux, Yves ULg; Claessens, Hugues ULg et al

Poster (2012, September)

Structure and composition of forest stands are crucial factors for forest planning and biodiversity management. In Belgium, typologies of structure and composition exist to support planning in uneven-aged ... [more ▼]

Structure and composition of forest stands are crucial factors for forest planning and biodiversity management. In Belgium, typologies of structure and composition exist to support planning in uneven-aged broadleaved forests (typically dominated by oak and beech). The principle of these typologies is to classify irregular stands with the percentage of small, medium, large, and very large trees (regarding dbh), and the percentage of basal area of oak and beech. This paper investigates the potential of LiDAR data processed with classification methods (k-nn, K-Means, CART, etc.) to allocate a forest structure and composition type. For this purpose several supervised and unsupervised classification methods are compared, as well as the impact of leaf-on (summer) and leaf-off (winter) data to discriminate the forest types. [less ▲]

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See detailDiagnosing the extreme surface melt event over southwestern Greenland in 2007
Tedesco, Marco; Serreze, Marc; Fettweis, Xavier ULg

in Cryosphere (The) (2008), 2

Analysis of passive microwave brightness temperatures from the space-borne Special Sensor Microwave Imager (SSM/I) documents a record surface snowmelt over high elevations (above 2000 m) of the Greenland ... [more ▼]

Analysis of passive microwave brightness temperatures from the space-borne Special Sensor Microwave Imager (SSM/I) documents a record surface snowmelt over high elevations (above 2000 m) of the Greenland ice sheet during summer of 2007. To interpret this record, results from the SSM/I are examined in conjunction with fields from the National Centers for Environmental Prediction/National Center for Atmospheric Research reanalysis and output from a regional climate model. The record surface melt reflects unusually warm conditions, seen in positive summertime anomalies of surface air temperatures, downwelling longwave radiation, 1000–500 hPa atmospheric thickness, and the net surface energy flux, linked in turn to southerly airflow over the ice sheet. Low snow accumulation may have contributed to the record through promoting anomalously low surface albedo. [less ▲]

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See detailDiagnosis and clinical interest of asthma inflammatory phenotypes
SCHLEICH, FLorence ULg

Doctoral thesis (2014)

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See detailDiagnosis and follow-up of monoclonal gammopathies of undetermined significance; information for referring physicians.
CAERS, Jo ULg; Vekemans, Marie-Christiane; Bries, Greet et al

in Annals of Medicine (2013), 45

The prevalence of monoclonal gammopathy of undetermined significance (MGUS) is generally estimated at 3.4% in the general population over 50 years, and its incidence increases with age. MGUS represents a ... [more ▼]

The prevalence of monoclonal gammopathy of undetermined significance (MGUS) is generally estimated at 3.4% in the general population over 50 years, and its incidence increases with age. MGUS represents a preneoplastic entity that can transform into multiple myeloma or other lymphoproliferative disorders. The risk of malignant transformation is estimated at 1% per year and persists over time. Predictors of malignant transformation have been identified such as the heavy chain isotype, the monoclonal component level, increasing levels of M-protein during the first years of follow-up, bone marrow plasmocytosis, dosage of serum free light chains, the presence of immunophenotypic abnormal plasma cells, aneuploidy and the presence of circulating plasma cells. Prognostic scores that combine certain of these factors have been proposed and allow the identification of high-risk patients. Their use could assist in tailoring the care for each patient, based on his/her risk profile. [less ▲]

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See detailThe diagnosis and management of hypopituitarism
Beckers, Albert ULg; Blevins, L. S.; Beckers, Albert ULg

Book published by OCC Europe Ltd (2002)

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