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See detailEffect of timing of surgery on survival after preoperative hyperfractionated accelerated radiotherapy (HART) for locally advanced rectal cancer (LARC): Is it a matter of days?
Coucke, Philippe ULg; Notter, Markus; Matter, Maurice et al

in Acta Oncologica (2006), 45(8), 1086-1093

We intend to analyse retrospectively whether the time interval ("gap duration" = GD) between preoperative radiotherapy and surgery in locally advanced rectal cancer (LARC) has an impact on overall ... [more ▼]

We intend to analyse retrospectively whether the time interval ("gap duration" = GD) between preoperative radiotherapy and surgery in locally advanced rectal cancer (LARC) has an impact on overall survival (OS), cancer specific survival (CSS), disease free survival (DFS) and local control (LC). Two hundred seventy nine patients with LARC were entered in Trial 93-01 (hyperfractionated accelerated radiotherapy 41.6 Gy/26 Fx BID) shortly followed by surgery. From these 250 patients are fully assessable. The median GD of 5 days was used as a discriminator. The median follow-up for all patients was 39 months. GD > 5 days was a significant discriminator for actuarial 5-years OS (69% vs 47%, p = 0.002), CSS (82% vs 57%, p = 0.0007), DFS (62% vs 41%, p = 0.0003) but not for LC (93% vs 90%, p = non-significant). In multivariate analysis, the following factors independently predict outcome; for OS: age, GD, circumferential margin (CM) and nodal stage (ypN); for CSS: GD, ypN and vascular invasion (VI); for DFS: CEA, distance to anal verge, GD, ypN and VI; for LC: CM only. Gap duration predicts survival outcome but not local control. The patients submitted to surgery after a median delay of more than 5 days had a significantly better outcome. [less ▲]

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See detailEffect of topographic stress on circulation in the Western Mediterranean
Alvarez, A.; Tintore, J.; Holloway, G. et al

in Journal of Geophysical Research (1994), 99(C8), 16053-16064

The interaction of eddies with seafloor topography can exert large systematic forces on ocean circulation. Using a statistical mechanics approach it is possible to obtain a parametrization of this effect ... [more ▼]

The interaction of eddies with seafloor topography can exert large systematic forces on ocean circulation. Using a statistical mechanics approach it is possible to obtain a parametrization of this effect (the Neptune effect) for application in large-scale ocean circulation models. Circulation of the western Mediterranean has been observed to follow a definite cyclonic path. Numerical models usually show good qualitative agreement for the large-scale circulation but show systematic deficiencies at a subbasin scale. We have tested the importance of the Neptune effect on the circulation of the western Mediterranean Sea. To perform this test, different numerical experiments on western Mediterranean circulation were done with and without eddy-topography interaction. As a first step we analyze the influence of the Neptune effect in an ideal western Mediterranean with closed straits. After these experiments the more realistic case of open straits is studied. All the experiments show that the Neptune effect may be a significant factor in the basin and subbasin scale circulation in the western Mediterranean Sea. [less ▲]

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See detailThe effect of topography-enhanced diapycnal mixing on ocean and atmospheric circulation and marine biogeochemistry
Friedrich, T.; Timmermann, A.; Decloedt, T. et al

in Ocean Modelling (2011), 3-4

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See detailEffect of total treatment time on event-free survival in carcinoma of the cervix
Delaloye, J-F; COUCKE, Philippe ULg; Pampallona, S et al

in Gynecologic Oncology (1996), 60

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See detailThe effect of training on the calcified zone of equine middle carpal articular cartilage
Murray, R. C.; Whitton, R. C.; Vedi, S. et al

in Equine Veterinary Journal. Supplement (1999), 30

Carpal osteochondral injury is frequently observed in strenuously trained horses. It is clear that the integrity of articular cartilage and subchondral bone are intimately related, although there is ... [more ▼]

Carpal osteochondral injury is frequently observed in strenuously trained horses. It is clear that the integrity of articular cartilage and subchondral bone are intimately related, although there is controversy about which component is the most important. Calcified cartilage provides the mechanical link between soft hyaline cartilage and stiff subchondral bone so it is essential to understand the tissue's response to exercise. Middle carpal calcified and uncalcified (hyaline) cartilage thickness was investigated in horses undergoing high- and low-intensity exercise. Twelve untrained horses (18-21 months) were paired, and randomly assigned to an exercise group. Group 1 underwent 19 weeks progressive high-intensity training on a high-speed treadmill. Group 2 underwent walking exercise only. Osteochondral specimens were obtained from 8 test sites per carpus immediately after euthanasia. Histomorphometric measurements of total cartilage, hyaline layer, and calcified zone thickness were obtained from decalcified and undecalcified samples. Mean +/- s.d. (micron) calcified cartilage thickness for dorsal cartilage from Group 1 was 271 +/- 73 and from Group 2 was 163 +/- 49; for palmar cartilage from Group 1 was 195 +/- 42 and Group 2 was 150 +/- 52. Group 1 horses had significantly thicker total cartilage (P < 0.0001) and calcified zone (P < 0.0001) than Group 2, but there was no difference in hyaline layer. Within each group all dorsal sites had thicker calcified cartilage (P < 0.003) than palmar sites, but no difference in hyaline or total cartilage. These findings indicate that high-intensity exercise leads to greater calcified zone depth without alteration in hyaline cartilage thickness, and that this response is maximal at sites that withstand high, intermittent loads. Increasing calcified cartilage thickness with exercise may maintain the articular surface stiffness gradient in the face of alterations in hyaline cartilage and/or subchondral bone stiffness [less ▲]

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See detailEffect of Transdermal 17 Beta-Estradiol and Oral Conjugated Equine Estrogens on Biochemical Parameters of Bone Resorption in Natural Menopause
Reginster, Jean-Yves ULg; Christiansen, C.; Dequinze, B. et al

in Calcified Tissue International (1993), 53

OBJECTIVE: To evaluate and compare the effects or oral and transdermal estrogen replacement therapy on biochemical markers of bone resorption in early postmenopausal women. DESIGN: Controlled, randomized ... [more ▼]

OBJECTIVE: To evaluate and compare the effects or oral and transdermal estrogen replacement therapy on biochemical markers of bone resorption in early postmenopausal women. DESIGN: Controlled, randomized group comparison. SETTING: Outpatient clinic for menopausal women and research into osteoporosis. SUBJECTS: Sixty healthy women menopausal for less than 5 years and who had never received any medications interfering with bone metabolism. INTERVENTIONS: The 60 women were randomly allocated to 3 months therapy with either oral conjugated estrogens (0.625 mg/day) (n = 28) or transdermal estradiol (50 micrograms/day) (n = 32) in cyclical combination with medroxyprogesterone acetate (5 mg/day). MAIN OUTCOME MEASURES: Traditional (urinary calcium/creatinine and hydroxyproline/creatinine) and the new specific (urinary pyridinoline/creatinine and deoxypyridinoline/creatinine) markers of bone resorption were determined before and after 3 months of treatment. RESULTS: In both groups, circulating levels of estrone and estradiol were significantly (P < 0.001) increased during treatment. In women treated with oral conjugated equine estrogens, urinary calcium/creatinine and hydroxyproline/creatinine ratios were significantly (P < 0.05) reduced. Pyridinoline/creatinine ratio fell from 69.1 (4) [mean (SEM)] to 50 (4) mumol/mumol (P < 0.01) and deoxypyridinoline/creatinine ratio fell from 10.8 (1) [mean (SEM)] to 8.3 (0.8) mumol/mumol (P < 0.01). In the group treated with transdermal estradiol, urinary hydroxyproline/creatinine ratio was significantly (P < 0.05) reduced. Pyridinoline/creatinine ratio fell from 66.3 (4) [mean (SEM)] to 46.2 (3) mumol/mumol (P < 0.01) and deoxypyridinoline/creatinine ratio fell from 11.5 (1.5) [mean (SEM)] to 7.7 (0.6) mumol/mumol (P < 0.01). There were no differences between the evolution of the biochemical variables in the two groups. CONCLUSION: These results suggest that oral conjugated equine estrogens and transdermal estradiol, in the given doses, are equally effective in reducing postmenopausal bone resorption. [less ▲]

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See detailEffect of Transient Creep Strain Model on the Behavior of Concrete Columns Subjected to Heating and Cooling
Gernay, Thomas ULg

in Fire Technology (2012), 48(2), 313-329

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when ... [more ▼]

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when subjected to high temperatures: the transient creep strain. Models integrating explicitly a term for transient creep strain have been proposed in the literature but, in the current Eurocode 2 model, there is no explicit term for transient creep strain. This phenomenon is included in the Eurocode 2 model, but it is implicitly considered in the mechanical strain term. A series of experimental fire tests on axially restrained concrete columns subjected to heating and cooling has been recently performed at South China University of Technology and described by Wu et al. (Fire Technol 46:231–249). In the original paper, it was shown that using the implicit model of Eurocode 2, the behavior of the columns cannot be simulated properly, especially during the cooling phase. The objective of the present paper is to perform again the fire tests simulations using a new formulation of the Eurocode 2 model that contains an explicit term for transient creep. In the first part of the paper, the explicit formulation of the Eurocode 2 model is presented. In the second part, the fire tests are modeled with the software SAFIR using, on the one hand, the implicit Eurocode model and, on the other hand, the new explicit model. It is shown that the transient creep model has significant implications on the global behavior of structural concrete members, as the residual axial load sustained by the columns at the end of the fire can differ by up to 25% of the initial applied load depending on the transient creep strain model that is used for the calculation. The experimental behavior is better matched with the new explicit model than with the current Eurocode model. Particularly, the results given by the Eurocode model during the cooling phase are unconservative as the residual axial load is overestimated. Finally, it is explained why, on the basis of an example, in a performance-based approach, these results can have important implications on the global fire resistance of a structure. [less ▲]

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See detailEffect of transphenoidal surgery on the LH pulsatility in women with microprolactinomas
Stevenaert, Achille ULg; Beckers, Albert ULg; vandalem, jl et al

in Journal of Endocrinological Investigation (1985)

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See detailEffect of transplantation on Posidonia oceanica shoots
Vangeluwe, Denis; Lepoint, Gilles ULg; Bouquegneau, Jean-Marie ULg et al

in Vie et Milieu-Life and Environment (2004), 54(4), 223-230

Posidonia oceanica shoots sampled from the healthy meadow in the bay of Revelatta (Corsica, France) were transplanted on metallic grids at 10 m depth. Transplanted shoots have been regularly monitored by ... [more ▼]

Posidonia oceanica shoots sampled from the healthy meadow in the bay of Revelatta (Corsica, France) were transplanted on metallic grids at 10 m depth. Transplanted shoots have been regularly monitored by the measurement of growth, biomass and C, N and P contents in the leaves and the belowground parts. After six months of experiment, the survival rates varied from 14 to 84 % on the different transplantation sites. Leaf biomass on the transplanted cuttings was lower than biomass in the control shoots but root biomass raised from December 2000 to May 2001 on the transplanted shoots. Transplant growth (8,3 +/- 2,3 mm.d(-1).shoot(-1)) after six months was similar to control growth (8,2 +/- 2,8 mm.d(-1). shoot(-1)). The C, N and P contents in transplants were significatively lower than in control shoots suggesting that transplanted cuttings are unable to meet their nutrient requirements. The modifications of the C, N, P contents in the belowground parts of the transplanted shoots indicate a mobilization of these nutrients in those compartments to produce new roots and restore a normal nutrients absorption. [less ▲]

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See detailEffect of transsphenoidal surgery on the LH pulsatility in women with microprolactinomas.
Beckers, Albert ULg; Stevenaert, Achille ULg; Vandalem, J. L. et al

in Journal of Endocrinological Investigation (1985)

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See detailEffect of trazodone on the firing rate of central monoaminergic neurons
Scuvée-Moreau, Jacqueline ULg; Dresse, Albert ULg

in Archives Internationales de Pharmacodynamie et de Thérapie (1982), 260

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See detailThe effect of treadmill training on motor recovery after a partial spinal cord compression-injury in the adult rat
Multon, Sylvie ULg; Franzen, Rachelle ULg; Poirrier, Anne-Lise ULg et al

in Journal of Neurotrauma (2003), 20(8), 699-706

Locomotor training on a treadmill is a therapeutic strategy used for several years in human paraplegics in whom it was shown to improve functional recovery mainly after incomplete spinal cord lesions. The ... [more ▼]

Locomotor training on a treadmill is a therapeutic strategy used for several years in human paraplegics in whom it was shown to improve functional recovery mainly after incomplete spinal cord lesions. The precise mechanisms underlying its effects are not known. Experimental studies in adult animals were chiefly performed after complete spinal transections. The objective of this experiment was to assess the effects of early treadmill training on recovery of spontaneous walking capacity after a partial spinal cord lesion in adult rats. Following a compression-injury by a subdurally inflated microballoon, seven rats were trained daily on a treadmill with a body weight support system, whereas six other animals were used as controls and only handled. Spontaneous walking ability in an open field was compared weekly between both groups by two blinded observers, using the Basso, Beattie and Bresnahan (BBB) locomotor rating scale. Mean BBB score during 12 weeks was globally significantly greater in the treadmill-trained animals than in the control group, the benefit of training appearing as early as the 2nd week. At week 7, locomotor recovery reached a plateau in both animal groups, but remained superior in trained rats. Daily treadmill training started early after a partial spinal cord lesion in adult rats, which accelerates recovery of locomotion and produces a long-term benefit. These findings in an animal model mimicking the closed spinal cord injury occurring in most human paraplegics are useful for future studies of optimal locomotor training programs, their neurobiologic mechanisms, and their combination with other treatment strategies. [less ▲]

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See detailThe effect of treadmill training on motor recovery after a spinal cord injury (SCI) in the adult rat.
Oliveira, C.; Multon, S.; Scholtes, Félix ULg et al

Conference (2001, May)

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See detailEffect of treatment with octreotide on the morphology of growth hormone secreting pituitary adenomas : study of 24 cases.
Beckers, Albert ULg; Kovacs, K.; Horvwarth, E. et al

in Endocrine Pathology (1991), 2(3), 123-131

Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological ... [more ▼]

Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8 other cases, a slight reduction in tumorsize was observed, and in 3 cases an important shrinkage was documented. At surgery, the adenomatous tissue appeared softer than in nonpretreated patients, facilitating the operation. Pathological examination revealed widening of perivascular spaces with accumulation of fibrous tissue and more crinophagy than in nonpretreated patients but failed to reveal morphologically pronounced cell involution as observed in prolactin-producing adenomas treated with dopamine agonists. No significant difference in frequency or extent of cellular changes was noted between the two groups. These morphological findings seem to be more consistent with a functional inhibition of growth hormone release than with cellular alterations induced by octreotide. [less ▲]

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See detailEffect of trenbolone acetate and zeranol on LH and testosterones responses to LHRH in young double-muscled Belgian bulls
Renaville, Robert ULg; Fabry, Jules

in 2th World Congress on Genetics Applied to Livestock Production (1982)

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See detailEffect of trenbolone acetate associated with 17á-oestradiol on reproductive performances of young growing fattening bulls
Istasse, Louis ULg; Evrard, Pierre; Hanzen, Christian ULg et al

in Journal of Animal Physiology & Animal Nutrition (1988), 59

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See detailEffect of trenbolone acetate associated with 17ß-oestradiol on reproductive performances of young growing fattening bulls
Istasse, Louis ULg; Evrard, Pierre; Coignoul, Freddy ULg et al

in Journal of Animal Physiology & Animal Nutrition (1988), 59

Bulls were implanted with an ear pellet of trenbolone acetate and oestradiol in association. Some treated bulls produced a sperm without spermatozoa but there were no significant differences in ... [more ▼]

Bulls were implanted with an ear pellet of trenbolone acetate and oestradiol in association. Some treated bulls produced a sperm without spermatozoa but there were no significant differences in spermatozoa concentration and sperm quality between treated animals which produced a sperm with spermatozoa and control bulls. The scrotal circumference of the treated animals did not change over the experimental period while that of control bulls regularly increased. After a dynamic stimuation with luteinzing hormone releasing hormone, the luteinizing hormone concentrations did not change in the treated animals and the testosterone kinetic profiles were characterized by a low basal concentration and small peak heights. The microscopic evaluation of the testicles indicated a reduction in the percentage of seminiferous tubules with mature spermatozoa and a reduction in the number of Leydig cells in the islets. [less ▲]

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See detailThe effect of TRH on F waves recorded from antagonistic muscles in human subjects.
Delwaide, P. J.; Schoenen, Jean ULg

in Annals of Neurology (1985), 18(3), 366-7

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See detailEffect of tricyclic antidepressant drugs on the spontaneous activity of noradrenergic neurons
Scuvée-Moreau, Jacqueline ULg; Fischer, Paul; Dresse, Albert ULg

in Archives Internationales de Pharmacodynamie et de Thérapie (1978), 234(2), 344-345

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