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See detailEffect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group.
McClung, M R; Geusens, P; Miller, P D et al

in New England Journal of Medicine [=NEJM] (2001), 344(5), 333-40

BACKGROUND: Risedronate increases bone mineral density in elderly women, but whether it prevents hip fracture is not known. METHODS: We studied 5445 women 70 to 79 years old who had osteoporosis ... [more ▼]

BACKGROUND: Risedronate increases bone mineral density in elderly women, but whether it prevents hip fracture is not known. METHODS: We studied 5445 women 70 to 79 years old who had osteoporosis (indicated by a T score for bone mineral density at the femoral neck that was more than 4 SD below the mean peak value in young adults [-4] or lower than -3 plus a nonskeletal risk factor for hip fracture, such as poor gait or a propensity to fall) and 3886 women at least 80 years old who had at least one nonskeletal risk factor for hip fracture or low bone mineral density at the femoral neck (T score, lower than -4 or lower than -3 plus a hip-axis length of 11.1 cm or greater). The women were randomly assigned to receive treatment with oral risedronate (2.5 or 5.0 mg daily) or placebo for three years. The primary end point was the occurrence of hip fracture. RESULTS: Overall, the incidence of hip fracture among all the women assigned to risedronate was 2.8 percent, as compared with 3.9 percent among those assigned to placebo (relative risk, 0.7; 95 percent confidence interval, 0.6 to 0.9; P=0.02). In the group of women with osteoporosis (those 70 to 79 years old), the incidence of hip fracture among those assigned to risedronate was 1.9 percent, as compared with 3.2 percent among those assigned to placebo (relative risk, 0.6; 95 percent confidence interval, 0.4 to 0.9; P=0.009). In the group of women selected primarily on the basis of nonskeletal risk factors (those at least 80 years of age), the incidence of hip fracture was 4.2 percent among those assigned to risedronate and 5.1 percent among those assigned to placebo (P=0.35). CONCLUSIONS: Risedronate significantly reduces the risk of hip fracture among elderly women with confirmed osteoporosis but not among elderly women selected primarily on the basis of risk factors other than low bone mineral density. [less ▲]

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See detailEffect of rival males on the courtship of paedomorphic and metamorphic Triturus alpestris (Amphibia : Salamandridae)
Denoël, Mathieu ULg

in Copeia (2003), 2003(3), 618-623

Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and ... [more ▼]

Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and salamanders is a suitable process to explore this question because it implies the coexistence of two different morphological morphs differing by the presence of gills and epigamic traits. The aim of this study was to find out whether paedomorphs and metamorphs use similar tactics to attract mates in the presence of a rival and whether there are differences in sexual activity and success between alternative morphs. Sexual interactions in triadic encounters were staged and analyzed in a standardized experimental design. The two kinds of males did not differ in terms of sexual activity, spermatophore deposition or female responsiveness. Both rival paedomorphic and metamorphic males exhibited sexual interference, but in most encounters, intruders just disturbed the courting pair. Sperm transfer success was lower in triadic encounters than in dyadic encounters. These results illustrate that intermorph breeding also occurs in the presence of competitors but that the success rate of the newts is considerably decreased in such competitive situations. Moreover, newts do not use alternative reproductive tactics depending on their status (i.e., paedomorph or metamorph). [less ▲]

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See detailEffect of rosemary extract and related flavonoid carnosol on chondro-protection and on the bone-cartilage crosstalk
Horcajada, Marie-Noelle; Sanchez, Christelle ULg; Scalfo, Fanny et al

Conference (2010)

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See detailEffect of rosemary extract and related flavonoid carnosol on chondro-protection and on the bone-cartilage crosstalk
Horcajada, Marie-Noelle; Sanchez, Christelle ULg; Scalfo, Fanny et al

in Osteoarthritis and Cartilage (2010), 17(suppl 2), 38-39

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See detailEffect Of Rumen-Degradable Protein Balance Deficit On Voluntary Intake, Microbial Protein Synthesis, And Nitrogen Metabolism In Growing Double-Muscled Belgian Blue Bulls Fed Corn Silage-Based Diet
Valkeners, Damien; Thewis, André ULg; Van Laere, Marc et al

in Journal of Animal Science (2008), 86(3), 680-690

Two trials were conducted to evaluate the effect of rumen-degradable protein balance (OEB) deficit on voluntary intake (trial 1), microbial protein synthesis, andNmetabolism (trial 2) in growing ... [more ▼]

Two trials were conducted to evaluate the effect of rumen-degradable protein balance (OEB) deficit on voluntary intake (trial 1), microbial protein synthesis, andNmetabolism (trial 2) in growing doublemuscled Belgian Blue bulls. In trial 1, six bulls (339 ± 26 kg of initial BW) were used in a replicated 3 × 3 Latin square and received a diet of 60% corn silage and 40% concentrate with ad libitum intake (DM basis). Three concentrates were formulated by adding urea at the expense of barley to give similar dietary contents of intestinal digestible proteins, NE for fattening, and fermentable OM, but with different levels of OEB. Thus, 2 levels of OEB deficit (−23.7 and −9.2 g of OEB/kg of DM) were compared with a diet providing a slight OEB surplus (5.3 g of OEB/kg of DM). Voluntary DMI decreased linearly (P = 0.02) with decreasing rumen-degradable protein balance. This decrease in intake could explain the linear decrease in ADG observed when negative OEB diets were fed. In trial 2, six bulls (304 ± 12 kg of initial BW) with cannulas in the rumen and proximal duodenum were used in a replicated 3 × 3 Latin square and fed diets similar to those used in trial 1 at an intake level of 85 g of DM/kg of BW0.75. Diurnal variations of ruminal NH3-N and plasma urea-N concentrations were greatly influenced by the level of OEB in the diet. No differences in NDF and starch degradation in the rumen, microbial N flow at the duodenum, or efficiency of microbial protein synthesis in the rumen were noted among the levels of OEB in diets. The reductions of the OEB value from 5.3 g/kg of DM to −9.2 g/ kg of DM and −23.7 g/kg of DM were associated with reductions of 26.5 and 48.8% in urinary Noutput. Absolute amounts of N retained by the bulls increased significantly with the level of OEB in diets. Indeed, 51.4% of the incremental supply of N was excreted between −23.7 and −9.2 g of OEB/kg of DM diets, and 74.6% of the incremental supply of N was excreted between −9.2 and 5.3 g of OEB/kg of DM diets. Feeding diets characterized by an adequate intestinal digestible protein supply and a OEB close to −10 g of OEB/kg of DM could be a feeding strategy to reduce N losses from the farm with little effect on the animal performance and voluntary intake. Reduced OEB may reduce N excretion in the environment but may also result in decreased N retention. [less ▲]

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See detailEffect of ruminal degradable ,itrogen defocit on nitrogen metabolismingrowing double muscled Belgian Blue bulls fed beet pulp silage based diet
Valkeners, Damien; Beckers, Yves ULg; Lindebrings, Aurore et al

Poster (2007, September)

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See detailEffect of ruminal degradable nitrogen deficit on nitrogen metabolism in growing double-muscled Belgian Blue bulls fed maize silage based diet.
Valkeners, Damien; Beckers, Yves ULg; Van Laere, Marc et al

in Proceedings of the British Society of Animal Science annual conference2005, York, UK. 4th-6th April, 2005 (2005, April)

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See detailThe effect of salmon calcitonin on blood-ionized calcium in the presence of anti-salmon calcitonin antibodies (from pagetic patients) in young rabbits
Reginster, Jean-Yves ULg; Azria, M; Gaspar, S et al

in Current Therapeutic Research (1990), 47(6), 1063-1072

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See detailEffect of salt depletion on sodium ion transport from human erythrocytes
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Wiener Klinische Wochenschrift. Supplementum (1985), 63

This study was realized to test De Wardener's hypothesis on the presence of a plasmatic and natriuretic factor in essential hypertension. By an indirect approach consisting of modification of plasma ... [more ▼]

This study was realized to test De Wardener's hypothesis on the presence of a plasmatic and natriuretic factor in essential hypertension. By an indirect approach consisting of modification of plasma volume and sodium pool in chronic renal failure and primary hypertension with, at the same time , measurements of ionic flux variations in human erythrocytes, we provide some arguments to confirm the presence of such a factor in hydrosaline overloaded uraemic patients and in "salt-sensitive" essential hypertensive subjects. [less ▲]

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See detailEffect of sample size on the mechanical stresses induced during the convective drying of highly shrinking materials
Léonard, Angélique ULg; Crine, Michel ULg; Jomaa, Wahbi

in Proceedings of the joint conference of AFSIA and Drying Working group of EFCE at Casino Municipal Biarritz, France, 24th and 25th May, 2007 (2007, May)

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See detailEffect of sampling method and culture conditions on the result of fungal culture in the diagnosis of canine sino-nasal aspergillosis.
Legarrérès, A.; Clercx, Cécile ULg; Mignon, Bernard ULg et al

in Proceedings of the 24th VCRS meeting (2006)

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See detailEffect of sampling method and incubation temperature on fungal culture in canine sino-nasal aspergillosis
Billen, Frédéric ULg; Clercx, Cécile ULg; Le Garérrès, Alain et al

in Journal of Small Animal Practice (2009), 50(2), 67-72

OBJECTIVES: To evaluate the most appropriate sampling procedure and the effect of incubation temperature on fungal culture in the diagnosis of canine sinonasal aspergillosis (SNA). METHODS: Sixteen dogs ... [more ▼]

OBJECTIVES: To evaluate the most appropriate sampling procedure and the effect of incubation temperature on fungal culture in the diagnosis of canine sinonasal aspergillosis (SNA). METHODS: Sixteen dogs with SNA and 20 dogs with non-fungal nasal disease entered a prospective study. Nasal secretions and mucosal biopsies were collected in all dogs. Fungal plaques were also sampled in dogs with SNA. Each specimen was taken in duplicate from each dog and incubated at room temperature and 37 degrees C. RESULTS: In dogs with SNA, nasal secretions, mucosal biopsies and fungal plaques yielded fungal growth at room temperature in one, one and seven dogs, respectively, whereas fungal growth was obtained at 37 degrees C in three, 12 and 14 dogs, respectively. No specimen collected from any dog with non-fungal nasal disease yielded fungal growth at room temperature or at 37 degrees C. CLINICAL SIGNIFICANCE: The diagnosis of canine SNA is more likely to be confirmed following culture of mucosal biopsies or fungal plaques than nasal secretions sampled blindly with swabs. Incubating cultures at 37 degrees C is more likely to provide a diagnostic outcome than when samples are cultured at room temperature. Fungal culture of nasal specimens has good specificity for the diagnosis of SNA in dogs. [less ▲]

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See detailEffect of seasonal acclimatization on the expression of the carp transcription factor Pit-1
Kausel, G.; Vera, M. I.; Figueroa, J. et al

in Biochemistry and Molecular Biology International (1998), 45(5), 813-21

We isolated a clone comprising four exons of the carp Pit-1 gene. Using synthetic oligonucleotide probes derived from the carp Pit-1 sequence Pit-1 expression was assessed by in situ hybridization in ... [more ▼]

We isolated a clone comprising four exons of the carp Pit-1 gene. Using synthetic oligonucleotide probes derived from the carp Pit-1 sequence Pit-1 expression was assessed by in situ hybridization in pituitary sections from summer- and winter-acclimatized carp. Semiquantitative analyses of the hybridization signals revealed a significant higher Pit-1 expression in the proximal pars distalis (PPD) and pars intermedia (PI) of the pituitary glands from summer-acclimatized carp, compared to the winter-acclimatized fish. In both adaptive states, relative to the PPD and PI, only a basal Pit-1 expression was detected in the rostral pars distalis. Thus, during seasonal acclimatization of an eurythermal fish, Pit-1 seems to be involved in the mechanisms that underlie the compensatory response. [less ▲]

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See detailEffect of seasonality and short-term light and temperature history on monoterpene emissions from European beech (Fagus sylvatica L.)
Demarcke, M.; Amelynck, Crist; Schoon, N. et al

in Hansel, Armin; Dunkl, Jürgen (Eds.) 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and its Applications (2011, January)

Branch enclosure measurements of monoterpene emision rates have been performed at different positions in the canopy of a European beech tree in natural environmental conditions. Strong and position ... [more ▼]

Branch enclosure measurements of monoterpene emision rates have been performed at different positions in the canopy of a European beech tree in natural environmental conditions. Strong and position-dependent standard emission rate variations were observed in the course of the growth season. By using the obtained dataset and a modified vesrion of the MEGAN algorithm, the response of the emissions to short-term light and temperature history was investigated [less ▲]

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See detailEffect of secondary schools on academic choices and on success in higher education
Pustjens, Heidi; Van De Gaer, Eva ULg; Van Damme, Jan et al

in School Effectiveness & School Improvement (2004)

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See detailEffect of selenium compounds on murine B16 melanoma cells and pigmented cloned pB16 cells
Siwek, Brigitte; Bahbouth, E.; Serra, M. A. et al

in Archives of Toxicology (1994), 68(4), 246-254

Seleno-DL-cysteine and sodium selenate are toxic in B16 cells and this toxicity seems to involve glutathione metabolites.

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See detailEffect of Ser-129 Phosphorylation on Interaction of Alpha-Synuclein with Synaptic and Cellular Membranes.
Wislet-Gendebien, Sabine ULg; Visanji, Naomi; Oschipok, Lauren et al

in Journal of Biological chemistry (2011), 286(41), 35863-73

In the healthy brain, less than 5% of α-synuclein (α-syn) is phosphorylated at serine 129 (Ser(P)-129). However, within Parkinson disease (PD) Lewy bodies, 89% of α-syn is Ser(P)-129. The effects of Ser(P ... [more ▼]

In the healthy brain, less than 5% of α-synuclein (α-syn) is phosphorylated at serine 129 (Ser(P)-129). However, within Parkinson disease (PD) Lewy bodies, 89% of α-syn is Ser(P)-129. The effects of Ser(P)-129 modification on α-syn distribution and solubility are poorly understood. As α-syn normally exists in both membrane-bound and cytosolic compartments, we examined the binding and dissociation of Ser(P)-129 α-syn and analyzed the effects of manipulating Ser(P)-129 levels on α-syn membrane interactions using synaptosomal membranes and neural precursor cells from α-syn-deficient mice or transgenic mice expressing human α-syn. We first evaluated the recovery of the Ser(P)-129 epitope following either α-syn membrane binding or dissociation. We demonstrate a rapid turnover of Ser(P)-129 during both binding to and dissociation from synaptic membranes. Although the membrane binding of WT α-syn was insensitive to modulation of Ser(P)-129 levels by multiple strategies (the use of phosphomimic S129D and nonphosphorylated S129A α-syn mutants; by enzymatic dephosphorylation of Ser(P)-129 or proteasome inhibitor-induced elevation in Ser(P)-129; or by inhibition or stable overexpression of PLK2), PD mutant Ser(P)-129 α-syn showed a preferential membrane association compared with WT Ser(P)-129 α-syn. Collectively, these data suggest that phosphorylation at Ser-129 is dynamic and that the subcellular distribution of α-syn bearing PD-linked mutations, A30P or A53T, is influenced by the phosphorylation state of Ser-129. [less ▲]

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See detailEffect of serotonergic blockade on calf pulmonary function after the intravenous administration of 3-methylindole
Linden, Annick ULg; Desmecht, Daniel ULg; Vandenput, Sandrina ULg et al

in Journal of Comparative Pathology (1996), 114(4), 361-371

This study was designed to investigate whether 3-methylindole (3-Mi), a tryptamine analogue, could cause pulmonary injury in calves other than by cytotoxicity. Injection of 3-Mi resulted in a marked ... [more ▼]

This study was designed to investigate whether 3-methylindole (3-Mi), a tryptamine analogue, could cause pulmonary injury in calves other than by cytotoxicity. Injection of 3-Mi resulted in a marked increase of respiratory rate, decrease of tidal volume and increase in minute ventilation. Pulmonary mechanics values were also profoundly affected, lung dynamic compliance being reduced to approximately one-third of its baseline value and total pulmonary resistance being increased two-fold. Arterial oxygen partial pressure was dramatically reduced. Successive challenges with 3-Mi after physiological saline pretreatment resulted in quantitatively identical alterations of pulmonary function values. Conversely, all these ventilatory, mechanical and gas exchange changes were abolished by pretreatment with serotonergic antagonists. It was concluded that intravenous administration of 3-Mi to healthy calves induced immediate and reversible bronchoconstriction which affected both central and peripheral airways. Because the effect was abolished by pretreatment with antiserotonin drugs, it is suggested that 3-Mi acts either directly by stimulating serotonergic receptors or indirectly through the release of serotonin from platelets. Current concepts of the physiopathological cascade underlying the toxicity of 3-Mi should, therefore, be re-evaluated in the light of this pharmacological mechanism. [less ▲]

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See detailEffect of serum dilution on binding of cortisol to thermolabile and thermostable serum proteins
Demey-Ponsart, E.; Foidart, Jean-Michel ULg; Hendrickx, J. C. et al

in Journal of Steroid Biochemistry (1977), 8(10), 1091-5

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