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See detailEffect of seasonal acclimatization on the expression of the carp transcription factor Pit-1
Kausel, G.; Vera, M. I.; Figueroa, J. et al

in Biochemistry and Molecular Biology International (1998), 45(5), 813-21

We isolated a clone comprising four exons of the carp Pit-1 gene. Using synthetic oligonucleotide probes derived from the carp Pit-1 sequence Pit-1 expression was assessed by in situ hybridization in ... [more ▼]

We isolated a clone comprising four exons of the carp Pit-1 gene. Using synthetic oligonucleotide probes derived from the carp Pit-1 sequence Pit-1 expression was assessed by in situ hybridization in pituitary sections from summer- and winter-acclimatized carp. Semiquantitative analyses of the hybridization signals revealed a significant higher Pit-1 expression in the proximal pars distalis (PPD) and pars intermedia (PI) of the pituitary glands from summer-acclimatized carp, compared to the winter-acclimatized fish. In both adaptive states, relative to the PPD and PI, only a basal Pit-1 expression was detected in the rostral pars distalis. Thus, during seasonal acclimatization of an eurythermal fish, Pit-1 seems to be involved in the mechanisms that underlie the compensatory response. [less ▲]

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See detailEffect of seasonality and short-term light and temperature history on monoterpene emissions from European beech (Fagus sylvatica L.)
Demarcke, M.; Amelynck, Crist; Schoon, N. et al

in Hansel, Armin; Dunkl, Jürgen (Eds.) 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and its Applications (2011, January)

Branch enclosure measurements of monoterpene emision rates have been performed at different positions in the canopy of a European beech tree in natural environmental conditions. Strong and position ... [more ▼]

Branch enclosure measurements of monoterpene emision rates have been performed at different positions in the canopy of a European beech tree in natural environmental conditions. Strong and position-dependent standard emission rate variations were observed in the course of the growth season. By using the obtained dataset and a modified vesrion of the MEGAN algorithm, the response of the emissions to short-term light and temperature history was investigated [less ▲]

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See detailEffect of secondary schools on academic choices and on success in higher education
Pustjens, Heidi; Van De Gaer, Eva ULg; Van Damme, Jan et al

in School Effectiveness & School Improvement (2004)

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See detailEffect of selenium compounds on murine B16 melanoma cells and pigmented cloned pB16 cells
Siwek, Brigitte; Bahbouth, E.; Serra, M. A. et al

in Archives of Toxicology (1994), 68(4), 246-254

Seleno-DL-cysteine and sodium selenate are toxic in B16 cells and this toxicity seems to involve glutathione metabolites.

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See detailEffect of Ser-129 Phosphorylation on Interaction of Alpha-Synuclein with Synaptic and Cellular Membranes.
Wislet-Gendebien, Sabine ULg; Visanji, Naomi; Oschipok, Lauren et al

in Journal of Biological chemistry (2011), 286(41), 35863-73

In the healthy brain, less than 5% of α-synuclein (α-syn) is phosphorylated at serine 129 (Ser(P)-129). However, within Parkinson disease (PD) Lewy bodies, 89% of α-syn is Ser(P)-129. The effects of Ser(P ... [more ▼]

In the healthy brain, less than 5% of α-synuclein (α-syn) is phosphorylated at serine 129 (Ser(P)-129). However, within Parkinson disease (PD) Lewy bodies, 89% of α-syn is Ser(P)-129. The effects of Ser(P)-129 modification on α-syn distribution and solubility are poorly understood. As α-syn normally exists in both membrane-bound and cytosolic compartments, we examined the binding and dissociation of Ser(P)-129 α-syn and analyzed the effects of manipulating Ser(P)-129 levels on α-syn membrane interactions using synaptosomal membranes and neural precursor cells from α-syn-deficient mice or transgenic mice expressing human α-syn. We first evaluated the recovery of the Ser(P)-129 epitope following either α-syn membrane binding or dissociation. We demonstrate a rapid turnover of Ser(P)-129 during both binding to and dissociation from synaptic membranes. Although the membrane binding of WT α-syn was insensitive to modulation of Ser(P)-129 levels by multiple strategies (the use of phosphomimic S129D and nonphosphorylated S129A α-syn mutants; by enzymatic dephosphorylation of Ser(P)-129 or proteasome inhibitor-induced elevation in Ser(P)-129; or by inhibition or stable overexpression of PLK2), PD mutant Ser(P)-129 α-syn showed a preferential membrane association compared with WT Ser(P)-129 α-syn. Collectively, these data suggest that phosphorylation at Ser-129 is dynamic and that the subcellular distribution of α-syn bearing PD-linked mutations, A30P or A53T, is influenced by the phosphorylation state of Ser-129. [less ▲]

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See detailEffect of serotonergic blockade on calf pulmonary function after the intravenous administration of 3-methylindole
Linden, Annick ULg; Desmecht, Daniel ULg; Vandenput, Sandrina ULg et al

in Journal of Comparative Pathology (1996), 114(4), 361-371

This study was designed to investigate whether 3-methylindole (3-Mi), a tryptamine analogue, could cause pulmonary injury in calves other than by cytotoxicity. Injection of 3-Mi resulted in a marked ... [more ▼]

This study was designed to investigate whether 3-methylindole (3-Mi), a tryptamine analogue, could cause pulmonary injury in calves other than by cytotoxicity. Injection of 3-Mi resulted in a marked increase of respiratory rate, decrease of tidal volume and increase in minute ventilation. Pulmonary mechanics values were also profoundly affected, lung dynamic compliance being reduced to approximately one-third of its baseline value and total pulmonary resistance being increased two-fold. Arterial oxygen partial pressure was dramatically reduced. Successive challenges with 3-Mi after physiological saline pretreatment resulted in quantitatively identical alterations of pulmonary function values. Conversely, all these ventilatory, mechanical and gas exchange changes were abolished by pretreatment with serotonergic antagonists. It was concluded that intravenous administration of 3-Mi to healthy calves induced immediate and reversible bronchoconstriction which affected both central and peripheral airways. Because the effect was abolished by pretreatment with antiserotonin drugs, it is suggested that 3-Mi acts either directly by stimulating serotonergic receptors or indirectly through the release of serotonin from platelets. Current concepts of the physiopathological cascade underlying the toxicity of 3-Mi should, therefore, be re-evaluated in the light of this pharmacological mechanism. [less ▲]

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See detailEffect of serum dilution on binding of cortisol to thermolabile and thermostable serum proteins
Demey-Ponsart, E.; Foidart, Jean-Michel ULg; Hendrickx, J. C. et al

in Journal of Steroid Biochemistry (1977), 8(10), 1091-5

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See detailEffect of sexual genotype on the reproductive biology of the Nile tilapia, O.niloticus.
Rougeot, Carole ULg; Badiane, A. A.; Prignon, Christian ULg et al

Poster (2007, June)

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See detailThe Effect of Shape, Age and Extension on the Compliance of Equine Tracheal Segments
Art, Tatiana ULg; Lekeux, Pierre ULg

in Veterinary Research Communications (1991), 15(2), 135-146

The influence of the age and weight of the animal as well as that of the extension and the shape of the trachea on the mechanical properties of the cervical trachea was studied in 33 isolated tracheal ... [more ▼]

The influence of the age and weight of the animal as well as that of the extension and the shape of the trachea on the mechanical properties of the cervical trachea was studied in 33 isolated tracheal segments obtained from freshly slaughtered horses. The relationship between intraluminal pressure and volume was determined in the cervical tracheal segments positioned firstly under normal longitudinal tension and secondly in hyperextension. At the same time, changes in the area of the cross-section of the lumen (X-SA) at the midpoint of the segment were measured using photographs obtained by slit-lamp transillumination and endoscopy. The sagittal (DS) and transverse (DT) diameters were determined for each segment and the DT/DS ratio was calculated to give an estimate of the shape of the X-SA. The results showed that (i) neither the age nor the weight of the horses had any influence on the mechanical properties of the trachea; (ii) extension decreases the compressibility of the tracheal segment in vitro; (iii) there is a wide variation in the extrathoracic tracheal X-SA shape in horses; and (iv) the shape of the X-SA has a major influence on the mechanical properties of the trachea. It was concluded that (i) hyperextension of the neck will partly facilitate respiration at high levels of ventilation by elongating the trachea and by decreasing its collapsibility; and (ii) the tracheal collapse which may occur during high levels of ventilation will be more or less important depending on the individual X-SA shape. [less ▲]

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See detailEffect of short-chain fructooligosaccharide-enriched energy-restricted diet on weight loss and serum haptoglobin concentration in Beagle dogs.
Ricci, Rebecca; Jeusette, Isabelle; Godeau, Jean-Marie ULg et al

in British Journal of Nutrition (2011), 106

The effects of the dietary inclusion of two levels of short-chain fructooligosaccharides (sc-FOS) on weight loss, biochemical parameters and serum haptoglobin concentration were investigated in twelve ... [more ▼]

The effects of the dietary inclusion of two levels of short-chain fructooligosaccharides (sc-FOS) on weight loss, biochemical parameters and serum haptoglobin concentration were investigated in twelve experimental obese Beagle dogs. Dogs were randomised into two groups and submitted to a weight loss program (WLP): the control group (C) received a commercial energy-restricted high-protein diet containing 1 % DM sc-FOS, whereas the test group (T) received the same diet enriched with sc-FOS to attain a 3 % DM content. Body weight (BW) and body condition score were weekly assessed in each dog and blood was collected before and after WLP to measure total plasma cholesterol (CHOL), TAG, NEFA, glucose (GLUC), insulin, serum leptin and haptoglobin. Groups showed similar BW and blood parameters before treatment. When values before and after treatment of the dogs were compared, significant reductions were observed for all parameters, with the exception of NEFA and GLUC. However, when these reductions were compared between C and T groups, significant differences were detected only for haptoglobin (T before v. T after: 1545 v. 605 mg/l, P = 0.03; C before v. C after: 1635 v. 1400 mg/l, P = NS). Positive correlations between haptoglobin and CHOL and between haptoglobin and TAG were observed before but not after WLP. In conclusion, feeding obese dogs with the energy-restricted diet caused significant weight loss and reduction of blood parameters, irrespective of the sc-FOS content included. However, serum haptoglobin level, and the subclinical inflammatory condition associated with it, was significantly lowered in the T but not in the C group. [less ▲]

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See detailEffect of short-term oral and inhaled corticosteroids on airway inflammation and responsiveness in a feline acute asthma model
Leemans, Jérôme; Kirschvink, Nathalie; Clercx, Cécile ULg et al

in Veterinary Journal (2011)

The objective of this study was to investigate whether high-dose inhaled fluticasone propionate (FP), alone or in combination with salmeterol (SAL), is as effective as oral prednisolone in reducing airway ... [more ▼]

The objective of this study was to investigate whether high-dose inhaled fluticasone propionate (FP), alone or in combination with salmeterol (SAL), is as effective as oral prednisolone in reducing airway inflammation and obstruction in cats with experimentally-induced acute asthma. Six cats sensitised to Ascaris suum (AS) were enrolled in a prospective controlled therapeutic trial and underwent four aerosol challenges, at 1-month intervals with AS allergen. The allergen - stimulated animals received four consecutive days treatment with either oral prednisolone at 1mg/kg twice daily, 500μg of FP inhaled twice daily, or a combination of FP/SAL at 500μg/50μg inhaled twice daily, respectively, according to a randomised cross-over design. Treatment-related changes in lung function, airway responsiveness (AR) and bronchoalveolar lavage fluid (BALF) cytology were assessed. Barometric whole-body plethysmography (BWBP) was used for the assessment of respiratory variables and AR. No significant differences in respiratory rate or Penh (an estimate of airflow limitation measured by BWBP) were detected among treatment groups. Allergen-induced airway hyper-responsiveness was significantly inhibited by all three steroid treatments (P<0.05). The mean BALF eosinophil percentage (±SEM) was lower after oral and inhaled corticosteroid treatment and these changes were significant for groups receiving prednisolone and the FP/SAL combination. Findings suggest high-dose FP, particularly in combination with SAL, is effective in ameliorating airway inflammation and hyper-responsiveness in this model of acute feline asthma, and highlight the potential use of these drugs in cats experiencing acute exacerbations of the naturally occurring disease. [less ▲]

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See detailEffect of Show Jumping on Heart Rate, Blood Lactate and Other Plasma Biochemical Values
Art, Tatiana ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in Equine Veterinary Journal. Supplement (1990), 32(9), 78-82

This study investigated some physiological responses to exercise performed by a horse during show jumping. The effects of jumping on heart rate (HR), blood lactate (LA) and some other blood values were ... [more ▼]

This study investigated some physiological responses to exercise performed by a horse during show jumping. The effects of jumping on heart rate (HR), blood lactate (LA) and some other blood values were studied in nine normal horses participating at the Belgian Junior Championship. Venous blood was sampled before and immediately after the show jumping and was analysed for packed cell volume, LA, blood glucose (GLU), total plasma protein, bicarbonate, sodium, potassium (K+), chloride, calcium and activities of plasma lactate dehydrogenase, creatine phosphokinase (CK) aspartate amino transferase and gamma glutamyl transferase (GGT). A heart rate recorder placed under the saddle allowed the continuous recording of HR from the warm-up until 2 mins after the event. The completion of the jumping induced significant changes in all values, except in K, GLU and GGT. Resting values of LA and HR were 0.53 +/- 0.05 mmol/litre and 43.9 +/- 1.9 beats/min respectively. Post exercise LA reached a mean value of 9.04 +/- 0.9 mmol/litre, and, during the jumping, HR rose to a peak of 191.4 +/- 3.8 beats/min. The results of this study demonstrate that, although the speed and duration of such an exercise are low, show jumping represents a severe exertion which requires the use of anaerobic metabolism. This implies that the training schedule of jumpers must include power training in order to improve their anaerobic capacity. [less ▲]

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See detailEffect of sibutramine on cardiovascular outcomes in overweight and obese subjects.
James, W. P.; Caterson ID, I.D.; Coutinho, W. et al

in New England Journal of Medicine [=NEJM] (2010), 363

BACKGROUND: The long-term effects of sibutramine treatment on the rates of cardiovascular events and cardiovascular death among subjects at high cardiovascular risk have not been established. METHODS: We ... [more ▼]

BACKGROUND: The long-term effects of sibutramine treatment on the rates of cardiovascular events and cardiovascular death among subjects at high cardiovascular risk have not been established. METHODS: We enrolled in our study 10,744 overweight or obese subjects, 55 years of age or older, with preexisting cardiovascular disease, type 2 diabetes mellitus, or both to assess the cardiovascular consequences of weight management with and without sibutramine in subjects at high risk for cardiovascular events. All the subjects received sibutramine in addition to participating in a weight-management program during a 6-week, single-blind, lead-in period, after which 9804 subjects underwent random assignment in a double-blind fashion to sibutramine (4906 subjects) or placebo (4898 subjects). The primary end point was the time from randomization to the first occurrence of a primary outcome event (nonfatal myocardial infarction, nonfatal stroke, resuscitation after cardiac arrest, or cardiovascular death). RESULTS: The mean duration of treatment was 3.4 years. The mean weight loss during the lead-in period was 2.6 kg; after randomization, the subjects in the sibutramine group achieved and maintained further weight reduction (mean, 1.7 kg). The mean blood pressure decreased in both groups, with greater reductions in the placebo group than in the sibutramine group (mean difference, 1.2/1.4 mm Hg). The risk of a primary outcome event was 11.4% in the sibutramine group as compared with 10.0% in the placebo group (hazard ratio, 1.16; 95% confidence interval [CI], 1.03 to 1.31; P=0.02). The rates of nonfatal myocardial infarction and nonfatal stroke were 4.1% and 2.6% in the sibutramine group and 3.2% and 1.9% in the placebo group, respectively (hazard ratio for nonfatal myocardial infarction, 1.28; 95% CI, 1.04 to 1.57; P=0.02; hazard ratio for nonfatal stroke, 1.36; 95% CI, 1.04 to 1.77; P=0.03). The rates of cardiovascular death and death from any cause were not increased. CONCLUSIONS: Subjects with preexisting cardiovascular conditions who were receiving long-term sibutramine treatment had an increased risk of nonfatal myocardial infarction and nonfatal stroke but not of cardiovascular death or death from any cause. (Funded by Abbott; ClinicalTrials.gov number, NCT00234832.) [less ▲]

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See detailEffect of SIBX-PAX collector mixture Ore : Kansanshi (Zambia) - HG5
Bastin, David ULg; Kottgen, Axel

Report (2009)

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See detailEffect of silica-coated poly(butyl methacrylate)-block-poly(methyl methacrylate) double-shell particles on the mechanical properties of PMMA composites
Chakkalakal, G. L.; Alexandre, Michaël ULg; Boschetti-de-Fierro, Adriana et al

in Macromolecular Materials and Engineering (2012), 297(9), 887-893

Silica nanoparticles with average diameters of 12nm are grafted with PBMA-b-PMMA double shells through typical ATRP from a Si12-g-(PBMA)Br macroinitiator using 2-BriB as the initiator. A commercially ... [more ▼]

Silica nanoparticles with average diameters of 12nm are grafted with PBMA-b-PMMA double shells through typical ATRP from a Si12-g-(PBMA)Br macroinitiator using 2-BriB as the initiator. A commercially available PMMA homopolymer is used for the preparation of composites with unmodified, silane-modified and double-shell-modified silica particles. Good mechanical properties are obtained for silica double shell containing systems. The silica content in double shell particle systems is varied from 0 to 2.5 wt%. A significant improvement in impact properties is observed. The surface-modified silica particles are characterized by ATR-FTIR, NMR, GPC, and thermal analysis. TEM analysis is used to analyze the nature of dispersion of particles in the composites. [less ▲]

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See detailEffect of single annual infusion of zoledronic acid on bone turnover markers versus daily oral risedronate in patients with glucocorticoid-induced osteoporosis
Sambrook, P.; Reid, D.; Devogelaer, Jean-Pierre et al

in Osteoporosis International (2009, April), 20(Suppl.1), 128-129

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See detailEffect Of Site Location And Collecting Period On The Chemical Composition Of Hyptis Spicigera Lam. An Insecticidal Essential Oil From North-Cameroon
Noudjou, Félicité; Kouninki, Habiba; Ngamo, Léonard S.T. et al

in Journal of Essential Oil Research (2007), 19(6), 597-601

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See detailThe effect of size, weight, body compartment, sex and reproductive status on the bioaccumulation of 19 trace elements in rope-grown Mytilus galloprovincialis
Richir, Jonathan ULg; Gobert, Sylvie ULg

in Ecological Indicators (2014), 36

Numerous trace elements (TEs) can be considered as potential pollutants of the environment, their mining productions and industrial uses increasing worldwide. Their monitoring can be achieved through the ... [more ▼]

Numerous trace elements (TEs) can be considered as potential pollutants of the environment, their mining productions and industrial uses increasing worldwide. Their monitoring can be achieved through the use of bioindicator species, such as the Mediterranean mussel Mytilus galloprovincialis (Lamarck, 1819). That species has been widely used to monitor the chemical pollution of coastal ecosystems by Cr, Ni, Cu, Zn, Cd, Pb, As, Ag and V. Conversely, environmental levels of Be, Al, Fe, Mn, Co, Se, Mo, Sn, Sb and Bi have been little or not monitored so far in mussel watch programs. Bioaccumulation processes of these 19 TEs in rope-grown M. galloprovincialis purchased from a salt pond with good chemical water quality were thus investigated in the present study. Mussels efficiently accumulated the 19 studied TEs. Bioaccumulation processes were driven by numerous mutually dependent biological parameters such as the mussel size and flesh weight, the sex and the reproductive status and the body compartment considered. TE bioaccumulation was a power function of the mussel soft body dry weight; total contents linearly increased with the shell length. Small-size mussels overall concentrated more TEs, with a high inter-individual variability, consequently influencing the modelling of their bioaccumulation in the whole rope population. Although a large range of rope-grown M. galloprovincialis sizes can be used for monitoring purposes, one will thus take care not to use extreme size individuals. The influence of gametogenesis in determining female body higher TE concentrations prior to spawning could not be neglected and varied depending on the element. TEs were preferentially accumulated in the hepatopancreas, except for Zn, Se, Cd and Mo, more concentrated in gills. Gametogenesis did not influence TE distribution between body compartments, but likely diluted their concentrations as a direct consequence of massive reproductive tissue production. So, results from the present study underline the potential use of M. galloprovincialis in the biomonitoring of numerous little studied TEs and give some insights into the decisive role played by some relevant biological parameters in bioaccumulation processes of the 19 investigated TEs in rope-grown mussels. [less ▲]

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See detailEffect of SK channel blockade on the firing of dorsal raphe neurons in anaesthetized rats
Alleva, Livia ULg; Rouchet, Nathalie; Waroux, Olivier ULg et al

Poster (2006, October 17)

K channels are small conductance calcium-activated potassium channels which trigger an outward current generating an afterhyperpolarization (AHP). This AHP follows a single or a train of action potential ... [more ▼]

K channels are small conductance calcium-activated potassium channels which trigger an outward current generating an afterhyperpolarization (AHP). This AHP follows a single or a train of action potential, and therefore is important in the regulation of the firing frequency and/or pattern of many types of neurons. Serotonergic (5-HT) neurons from the raphe nuclei express SK channels and exhibit a significant AHP which can be efficiently blocked in vitro by apamin and N-methyl laudanosine (NML) (Scuvée-Moreau et al, 2004). In the later study, we found that some but not all neurons (50%) had a significantly increase in their firing rate when positive current was injected after SK channel blockade. In order to determine the physiological relevance of these channels in vivo, single unit extracellular recordings were carried out in anesthetized rats and combined with iontophoresis of the specific non-peptidic SK channel blocker, UCL1684. 5-HT neurons were tested for their inhibitory response to locally applied 5-HT and histological analysis confirmed the localization of the recording site. UCL 1684 was used at a concentration of 200 µM. Out of 11 neurons recorded, 6 showed a significant increase in the production of doublets, with no effect on their mean firing rate as compared to the control condition. The other neurons were completely unaffected. These results suggest that the responsiveness of presumed 5-HT neurons to SK channel block is variable. Although the use of 200 µM UCL allow us to be sure of a sufficient SK blockade at the recording site (Waroux et al, 2005), we can not rule out the possibility that SK channels present at the dendritic level were not completely blocked. In conclusion, SK channels in vivo might play a role in controlling the firing pattern of a subgroup of 5-HT neurons. [less ▲]

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