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See detailEffect of the transversus abdominis plane block on pain after laparoscopic inguinal hernia repair
Adedjoumo, Moibi; Amabili, P.; Detry, Olivier ULg et al

in Acta Anaesthesiologica Belgica (2009, September 19), 60(3), 205

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See detailEffect of the type and number of prostaglandin treatments on corpus luteum, the largest follicle and progesterone concentration in dairy cows
Repasi, A.; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

in Reproduction in Domestic Animals (2005), 40(5), 436-442

Lactating dairy cows (n = 72) with a mature corpus luteum (CL) (diameter of >= 17 mm) determined by ultrasonography and having a follicle with a diameter of >= 10 min were randomly assigned to four groups ... [more ▼]

Lactating dairy cows (n = 72) with a mature corpus luteum (CL) (diameter of >= 17 mm) determined by ultrasonography and having a follicle with a diameter of >= 10 min were randomly assigned to four groups. Cows were treated with cloprostenol i.m. once or twice, or with dinoprost i.m. once or twice with an 8-h interval. The ovaries of each cow were scanned daily by transrectal ultrasonography to measure the changes in the areas of CL and the largest follicle and to determine the occurrence of ovulation. Oestrus was verified twice daily. In addition, blood sample was withdrawn from each cow daily for measuring progesterone (P4) concentrations. Significant decreases in the percentage changes relative to areas of CL and P4 concentrations or increases in the percentage changes in the area of the largest follicle on day 0 were detected in each group during the experiment. However, the type of the drug and the number of the treatments had no significant effect on those parameters. Cows ovulated with or without showing oestrus (group A) and cows exhibiting no oestrus and ovulation (group 13) were also evaluated. In contrast to the mean area of the CL and the mean concentration of P4 on day 0, the mean area of the largest follicles between, the two groups on day 0 differed significantly Significant decreases in the percentage changes relative to the area of the CL and P4 concentration or increases in the percentage changes relative to the area of the largest follicle during the experiment were detected in both groups; however, there were no group differences. Treatment of dairy cows with two injections of prostaglandins (cloprostenol or dinoprost) at an 8-h interval resulted in more cows being, observed in oestrus within 5 days after treatment and having significantly higher pregnancy rate than those treated with a single prostaglandin injection. [less ▲]

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See detailEffect of the use of dilute alkaline prior to Bacillus subtilis-based biocontrol steeping and germination conditions on red sorghum malt β-glucanase activities and residual β-glucans
Bwanganga Tawaba, Jean-Claude ULg; Destain, Jacqueline ULg; Malumba Kamba, Paul ULg et al

in Journal of Cereal Science (2013)

Malting is the ideal stage to deal with β-glucans. Their hydrolysis is very important as the diffusion of both hormones and hydrolytic enzymes in the endosperm of germinated grain depend on it. A high ... [more ▼]

Malting is the ideal stage to deal with β-glucans. Their hydrolysis is very important as the diffusion of both hormones and hydrolytic enzymes in the endosperm of germinated grain depend on it. A high malt β-glucanase activity is not a guarantee of an extensive hydrolysis of β-glucans. When Bacillus subtilis is used to control mould growth, red sorghum malt β-glucanase activity (measured using carboxymethylcellulose as the substrate) was improved without significantly affecting the hydrolysis of malt β-glucans. Thus, in order to reduce the residual β-glucans content, soaking in 0.2% NaOH was combined with a biocontrol. Soaking in 0.2% NaOH is recognized as capable of improving grain hydration by opening-up the endosperm cell walls. The combined use of 0.2% NaOH with Bacillus subtilis-based biocontrol treatments during red sorghum malting, leads to malt with increased β-glucanase activity and a significant reduction of residual β-glucans when compared with the 16 h biocontrol steeping without prior steeping in 0.2% NaOH. β-glucanase activity increases with increased germination temperature and time while, conversely, the residual β-glucans content of the malts decreases. Indeed, while the level of β-glucanase was not vastly different between the malts obtained after steeping in distilled water and those obtained after 8 h steeping in 0.2% NaOH followed by 8 h resteeping in distilled water (NaOH+H2O treatment), their residual β-glucans levels differ significantly. Bacillus subtilis-based treatment leads to malt with improved β-(1-3)- and β-(1-4)-glucanase activities without significantly improved malt β-(1-3),(1-4)-glucanase activity. While malts obtained after 84 h germination weren’t significantly different in terms of malt β-(1-3),(1-4)-glucanase activities for all steeping treatments, the use of 0.2% NaOH steeping prior to resteeping led to malts with improved β-glucans content. Combining the steeping in dilute alkaline and biocontrol enables taking advantage of the dilute alkaline effect on residual β-glucans content, due probably to the opening-up the cell walls and the improvement of water uptake, and that of the biocontrol (improvement of β-glucanase synthesis). [less ▲]

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See detailEffect of the vector-axial-vector coupling on the vector-meson modes
Jaminon, Martine ULg; Mendez Galain, Ramon

in Nuclear Physics A (1993), 564

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See detailThe effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice
Hills, Judith I.; Golub, Mari S.; Bettendorff, Lucien ULg et al

in Neurotoxicology & Teratology (2012), 34

Due to genetic defects or illness some individuals require higher amounts of thiamin than are typically provided by the diet. Lipid-soluble thiamin precursors can achieve high blood levels of thiamin and ... [more ▼]

Due to genetic defects or illness some individuals require higher amounts of thiamin than are typically provided by the diet. Lipid-soluble thiamin precursors can achieve high blood levels of thiamin and result in increased concentrations in the central nervous system. High intakes of thiamin have been reported as beneficial in children with autism and attention deficit/hyperactivity disorder. The current study examined the effect of thiamin tetrahydrofurfuryl disulfide (TTFD), a lipophilic precursor, on behavior in the juvenile male DBA/2J mouse. Mice given by oral gavage deionized water or deionized water providing 100mg or 340mg TTFD/kg body weight daily for 17days, starting at postnatal day 18, were tested for effects on operant learning, social interaction, general activity level, and prepulse inhibition of acoustic startle, as well as effects on growth and select organ weights. Results indicate lower activity and altered social interaction at both treatment levels and decreased acoustic startle at the 100mg/kg level. Compared to controls, percent weight gain was lower in the TTFD-treatment groups, but percent body length increase was not affected by TTFD treatment. TTFD treatment did not influence percent organ weights as percentage of body weights. TTFD treatment resulted in increased whole brain thiamin concentrations. These results support the concept that lipophilic thiamin precursors provided during early development can affect a number of behavioral parameters. In clinical trials with children with behavior disorders, attention should be given to preventing possible adverse gastrointestinal irritant effects associated with TTFD therapy. [less ▲]

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See detailEffect of three resuscitation procedures on respiratory and metabolic adaptation to extra uterine life in newborn calves
Uystepruyst, Christophe; Coghe, Joost; Dorts, Thierry et al

in Veterinary Journal (2002), 163(1), 30-44

The purpose of this study was to evaluate the effects of three resuscitation procedures on respiratory and metabolic adaptation to extra-uterine life during the first 24 h after birth in healthy newborn ... [more ▼]

The purpose of this study was to evaluate the effects of three resuscitation procedures on respiratory and metabolic adaptation to extra-uterine life during the first 24 h after birth in healthy newborn calves. Twenty-four newborn calves were randomly grouped into four categories: six calves did not receive any specific resuscitation procedure and were considered as controls (C); six received pharyngeal and nasal suctioning immediately after birth by use of a hand-powered vacuum pump (SUC); six received five litres of cold water poured over their heads immediately after birth (CW) and six were housed in a calf pen with an infrared radiant heater for 24 h after birth (IR). Calves were examined at birth, 5, 15, 30, 45 and 60 min, 2, 3, 6, 12 and 24 h after birth and the following measurements were recorded: physical and clinical examination, arterial blood gas analysis, pulmonary function tests using the oesophageal balloon catheter technique, arterial and venous blood acid-base balance analysis, jugular venous blood sampling for determination of metabolic, haematological and passive immune transfer variables. SUC was accompanied by improved pulmonary function efficiency and by a less pronounced decrease in body temperature. The "head shaking movement" and the subsequent temporary increase in total pulmonary resistance as well as the greater lactic acidosis due to CW were accompanied by more efficient, but statistically non-significant, pulmonary gas exchanges. IR allowed maintenance of higher body temperature without requiring increased catabolism of energetic stores. IR also caused a change in breathing pattern which contributed to better distribution of the ventilation and to slightly improved gas exchange. The results indicate that use of SUC, CW and IR modified respiratory and metabolic adaptation during the first 24 h after birth without side-effects. These resuscitation procedures should be recommended for their specific indication, i.e. cleansing of fetal fluid from upper airways, hypothermal stimulation of breathing and prevention of heat losses. [less ▲]

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See detailThe effect of tibolone in postmenopausal women receiving tamoxifen after surgery for breast cancer: a randomised, double-blind, placebo-controlled trial
Kroiss, R.; Fentiman, I. S.; Helmond, F. A. et al

in BJOG : An International Journal of Obstetrics & Gynaecology (2005), 112(2), 228-233

Objective To assess the effects of tibolone on climacteric symptoms, endometrium and serum lipid/lipoproteins in postmenopausal women receiving tamoxifen after surgery for breast cancer. Design Double ... [more ▼]

Objective To assess the effects of tibolone on climacteric symptoms, endometrium and serum lipid/lipoproteins in postmenopausal women receiving tamoxifen after surgery for breast cancer. Design Double-blind, randomised, placebo-controlled, multicentre pilot study. Setting Hospital outpatient clinic. Sample Seventy postmenopausal women receiving tamoxifen following surgery for early breast cancer. Methods Women received 20 mg/day oral tamoxifen plus either 2.5 mg/day oral tibolone or placebo for 12 months. Main outcome measures Frequency and severity of hot flushes (diary cards); intensity of hot flushes and sweats (Landgren scale); interference of hot flushes and sweats with normal life; frequency and intensity of other climacteric symptoms; endometrial thickness and histology; vaginal bleeding; breast cancer recurrence and serum lipid/lipoproteins. Results Daily card data showed no change in the daily number of hot flushes with either tibolone or placebo (P= 0.219) after three months. There was a significant reduction in the severity of flushes with tibolone compared with placebo (-0.4 vs 0.2, P= 0.031). The Landgren scale showed a mean change in the number of hot flushes of -0.6 with tibolone and +1.1 with placebo after 12 months (P= 0.022). Endometrial biopsies were normal and vaginal bleeding was similar in both groups. A significant decrease in triglycerides (-23%vs 1.4%) and HDL (-12%vs 19%) was seen with tibolone compared with placebo after 12 months. Conclusion Tibolone prevented an increase in hot flushes in postmenopausal women given tamoxifen following surgery for breast cancer without untoward effects on the endometrium. Beneficial effects on serum lipid profile were noted. [less ▲]

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See detailEffect of tibolone on breast cancer cell proliferation in postmenopausal ER+ patients: Results from STEM trial
Kubista, E.; Gomez, JVMP; Dowsett, M. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2007), 13(14), 4185-4190

Purpose: Tibolone is a selective tissue estrogenic activity regulator, approved for the treatment of vasomotor symptoms in postmenopausal women. We have done an exploratory, double-blind, randomized ... [more ▼]

Purpose: Tibolone is a selective tissue estrogenic activity regulator, approved for the treatment of vasomotor symptoms in postmenopausal women. We have done an exploratory, double-blind, randomized, placebo-controlled pilot trial to investigate the tissue-specific effects of 2.5 mg tibolone on breast cancer in postmenopausal women, in particular on tissue proliferation (STEM, Study of Tibolone Effects on Mamma carcinoma tissue). Experimental Design: Postmenopausal women with initially stage I/II, estrogen receptor-positive (ER+) primary breast cancer, were randomly assigned to 14 days of placebo or 2.5 mg/d tibolone. Core biopsies of the primary tumor were obtained before and after treatment. Ki-67 and apoptosis index were analyzed in baseline and corresponding posttreatment specimen. Results: Of 102 enrolled patients, 95 had evaluable data. Baseline characteristics were comparable between both treatment groups. Breast cancer cases are mainly invasive (99%), stage I or II (42% and 50% respectively), and ER+ (99%). Median intratumoral Ki-67 expression at baseline was 13.0%, in the tibolone group and 17.8% in the placebo group, and decreased to 12.0% after 14 days of tibolone while increasing to 19.0% in the placebo group. This change from baseline was not significantly different between tibolone and placebo (Wilcoxon test; P = 0.17). A significant difference was observed between the treatment groups when the median change from baseline apoptosis index was compared between the treatment groups (tibolone, 0.0%; placebo, +0.3%; Wilcoxon test; P = 0.031). The incidence of adverse effects was comparable. Conclusions: In ER+ breast tumors, 2.5 mg/d tibolone given for 14 days has no significant effect on tumor cell proliferation. [less ▲]

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See detailEffect of tidal overwash on the embryonic development of leatherback turtles in French Guiana
Guirlet, Elodie ULg; Caut, Stéphane; Girondot, Marc

in Marine Environmental Research (2010), 69

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See detailEffect of timing of surgery on survival after preoperative hyperfractionated accelerated radiotherapy (HART) for locally advanced rectal cancer (LARC): Is it a matter of days?
Coucke, Philippe ULg; Notter, Markus; Matter, Maurice et al

in Acta Oncologica (2006), 45(8), 1086-1093

We intend to analyse retrospectively whether the time interval ("gap duration" = GD) between preoperative radiotherapy and surgery in locally advanced rectal cancer (LARC) has an impact on overall ... [more ▼]

We intend to analyse retrospectively whether the time interval ("gap duration" = GD) between preoperative radiotherapy and surgery in locally advanced rectal cancer (LARC) has an impact on overall survival (OS), cancer specific survival (CSS), disease free survival (DFS) and local control (LC). Two hundred seventy nine patients with LARC were entered in Trial 93-01 (hyperfractionated accelerated radiotherapy 41.6 Gy/26 Fx BID) shortly followed by surgery. From these 250 patients are fully assessable. The median GD of 5 days was used as a discriminator. The median follow-up for all patients was 39 months. GD > 5 days was a significant discriminator for actuarial 5-years OS (69% vs 47%, p = 0.002), CSS (82% vs 57%, p = 0.0007), DFS (62% vs 41%, p = 0.0003) but not for LC (93% vs 90%, p = non-significant). In multivariate analysis, the following factors independently predict outcome; for OS: age, GD, circumferential margin (CM) and nodal stage (ypN); for CSS: GD, ypN and vascular invasion (VI); for DFS: CEA, distance to anal verge, GD, ypN and VI; for LC: CM only. Gap duration predicts survival outcome but not local control. The patients submitted to surgery after a median delay of more than 5 days had a significantly better outcome. [less ▲]

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See detailEffect of topographic stress on circulation in the Western Mediterranean
Alvarez, A.; Tintore, J.; Holloway, G. et al

in Journal of Geophysical Research (1994), 99(C8), 16053-16064

The interaction of eddies with seafloor topography can exert large systematic forces on ocean circulation. Using a statistical mechanics approach it is possible to obtain a parametrization of this effect ... [more ▼]

The interaction of eddies with seafloor topography can exert large systematic forces on ocean circulation. Using a statistical mechanics approach it is possible to obtain a parametrization of this effect (the Neptune effect) for application in large-scale ocean circulation models. Circulation of the western Mediterranean has been observed to follow a definite cyclonic path. Numerical models usually show good qualitative agreement for the large-scale circulation but show systematic deficiencies at a subbasin scale. We have tested the importance of the Neptune effect on the circulation of the western Mediterranean Sea. To perform this test, different numerical experiments on western Mediterranean circulation were done with and without eddy-topography interaction. As a first step we analyze the influence of the Neptune effect in an ideal western Mediterranean with closed straits. After these experiments the more realistic case of open straits is studied. All the experiments show that the Neptune effect may be a significant factor in the basin and subbasin scale circulation in the western Mediterranean Sea. [less ▲]

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See detailThe effect of topography-enhanced diapycnal mixing on ocean and atmospheric circulation and marine biogeochemistry
Friedrich, T.; Timmermann, A.; Decloedt, T. et al

in Ocean Modelling (2011), 3-4

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See detailEffect of total treatment time on event-free survival in carcinoma of the cervix
Delaloye, J-F; COUCKE, Philippe ULg; Pampallona, S et al

in Gynecologic Oncology (1996), 60

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See detailThe effect of training on the calcified zone of equine middle carpal articular cartilage
Murray, R. C.; Whitton, R. C.; Vedi, S. et al

in Equine Veterinary Journal. Supplement (1999), 30

Carpal osteochondral injury is frequently observed in strenuously trained horses. It is clear that the integrity of articular cartilage and subchondral bone are intimately related, although there is ... [more ▼]

Carpal osteochondral injury is frequently observed in strenuously trained horses. It is clear that the integrity of articular cartilage and subchondral bone are intimately related, although there is controversy about which component is the most important. Calcified cartilage provides the mechanical link between soft hyaline cartilage and stiff subchondral bone so it is essential to understand the tissue's response to exercise. Middle carpal calcified and uncalcified (hyaline) cartilage thickness was investigated in horses undergoing high- and low-intensity exercise. Twelve untrained horses (18-21 months) were paired, and randomly assigned to an exercise group. Group 1 underwent 19 weeks progressive high-intensity training on a high-speed treadmill. Group 2 underwent walking exercise only. Osteochondral specimens were obtained from 8 test sites per carpus immediately after euthanasia. Histomorphometric measurements of total cartilage, hyaline layer, and calcified zone thickness were obtained from decalcified and undecalcified samples. Mean +/- s.d. (micron) calcified cartilage thickness for dorsal cartilage from Group 1 was 271 +/- 73 and from Group 2 was 163 +/- 49; for palmar cartilage from Group 1 was 195 +/- 42 and Group 2 was 150 +/- 52. Group 1 horses had significantly thicker total cartilage (P < 0.0001) and calcified zone (P < 0.0001) than Group 2, but there was no difference in hyaline layer. Within each group all dorsal sites had thicker calcified cartilage (P < 0.003) than palmar sites, but no difference in hyaline or total cartilage. These findings indicate that high-intensity exercise leads to greater calcified zone depth without alteration in hyaline cartilage thickness, and that this response is maximal at sites that withstand high, intermittent loads. Increasing calcified cartilage thickness with exercise may maintain the articular surface stiffness gradient in the face of alterations in hyaline cartilage and/or subchondral bone stiffness [less ▲]

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See detailEffect of Transdermal 17 Beta-Estradiol and Oral Conjugated Equine Estrogens on Biochemical Parameters of Bone Resorption in Natural Menopause
Reginster, Jean-Yves ULg; Christiansen, C.; Dequinze, B. et al

in Calcified Tissue International (1993), 53

OBJECTIVE: To evaluate and compare the effects or oral and transdermal estrogen replacement therapy on biochemical markers of bone resorption in early postmenopausal women. DESIGN: Controlled, randomized ... [more ▼]

OBJECTIVE: To evaluate and compare the effects or oral and transdermal estrogen replacement therapy on biochemical markers of bone resorption in early postmenopausal women. DESIGN: Controlled, randomized group comparison. SETTING: Outpatient clinic for menopausal women and research into osteoporosis. SUBJECTS: Sixty healthy women menopausal for less than 5 years and who had never received any medications interfering with bone metabolism. INTERVENTIONS: The 60 women were randomly allocated to 3 months therapy with either oral conjugated estrogens (0.625 mg/day) (n = 28) or transdermal estradiol (50 micrograms/day) (n = 32) in cyclical combination with medroxyprogesterone acetate (5 mg/day). MAIN OUTCOME MEASURES: Traditional (urinary calcium/creatinine and hydroxyproline/creatinine) and the new specific (urinary pyridinoline/creatinine and deoxypyridinoline/creatinine) markers of bone resorption were determined before and after 3 months of treatment. RESULTS: In both groups, circulating levels of estrone and estradiol were significantly (P < 0.001) increased during treatment. In women treated with oral conjugated equine estrogens, urinary calcium/creatinine and hydroxyproline/creatinine ratios were significantly (P < 0.05) reduced. Pyridinoline/creatinine ratio fell from 69.1 (4) [mean (SEM)] to 50 (4) mumol/mumol (P < 0.01) and deoxypyridinoline/creatinine ratio fell from 10.8 (1) [mean (SEM)] to 8.3 (0.8) mumol/mumol (P < 0.01). In the group treated with transdermal estradiol, urinary hydroxyproline/creatinine ratio was significantly (P < 0.05) reduced. Pyridinoline/creatinine ratio fell from 66.3 (4) [mean (SEM)] to 46.2 (3) mumol/mumol (P < 0.01) and deoxypyridinoline/creatinine ratio fell from 11.5 (1.5) [mean (SEM)] to 7.7 (0.6) mumol/mumol (P < 0.01). There were no differences between the evolution of the biochemical variables in the two groups. CONCLUSION: These results suggest that oral conjugated equine estrogens and transdermal estradiol, in the given doses, are equally effective in reducing postmenopausal bone resorption. [less ▲]

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See detailEffect of Transient Creep Strain Model on the Behavior of Concrete Columns Subjected to Heating and Cooling
Gernay, Thomas ULg

in Fire Technology (2012), 48(2), 313-329

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when ... [more ▼]

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when subjected to high temperatures: the transient creep strain. Models integrating explicitly a term for transient creep strain have been proposed in the literature but, in the current Eurocode 2 model, there is no explicit term for transient creep strain. This phenomenon is included in the Eurocode 2 model, but it is implicitly considered in the mechanical strain term. A series of experimental fire tests on axially restrained concrete columns subjected to heating and cooling has been recently performed at South China University of Technology and described by Wu et al. (Fire Technol 46:231–249). In the original paper, it was shown that using the implicit model of Eurocode 2, the behavior of the columns cannot be simulated properly, especially during the cooling phase. The objective of the present paper is to perform again the fire tests simulations using a new formulation of the Eurocode 2 model that contains an explicit term for transient creep. In the first part of the paper, the explicit formulation of the Eurocode 2 model is presented. In the second part, the fire tests are modeled with the software SAFIR using, on the one hand, the implicit Eurocode model and, on the other hand, the new explicit model. It is shown that the transient creep model has significant implications on the global behavior of structural concrete members, as the residual axial load sustained by the columns at the end of the fire can differ by up to 25% of the initial applied load depending on the transient creep strain model that is used for the calculation. The experimental behavior is better matched with the new explicit model than with the current Eurocode model. Particularly, the results given by the Eurocode model during the cooling phase are unconservative as the residual axial load is overestimated. Finally, it is explained why, on the basis of an example, in a performance-based approach, these results can have important implications on the global fire resistance of a structure. [less ▲]

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See detailEffect of transphenoidal surgery on the LH pulsatility in women with microprolactinomas
Stevenaert, Achille ULg; Beckers, Albert ULg; vandalem, jl et al

in Journal of Endocrinological Investigation (1985)

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See detailEffect of transplantation on Posidonia oceanica shoots
Vangeluwe, Denis; Lepoint, Gilles ULg; Bouquegneau, Jean-Marie ULg et al

in Vie et Milieu-Life and Environment (2004), 54(4), 223-230

Posidonia oceanica shoots sampled from the healthy meadow in the bay of Revelatta (Corsica, France) were transplanted on metallic grids at 10 m depth. Transplanted shoots have been regularly monitored by ... [more ▼]

Posidonia oceanica shoots sampled from the healthy meadow in the bay of Revelatta (Corsica, France) were transplanted on metallic grids at 10 m depth. Transplanted shoots have been regularly monitored by the measurement of growth, biomass and C, N and P contents in the leaves and the belowground parts. After six months of experiment, the survival rates varied from 14 to 84 % on the different transplantation sites. Leaf biomass on the transplanted cuttings was lower than biomass in the control shoots but root biomass raised from December 2000 to May 2001 on the transplanted shoots. Transplant growth (8,3 +/- 2,3 mm.d(-1).shoot(-1)) after six months was similar to control growth (8,2 +/- 2,8 mm.d(-1). shoot(-1)). The C, N and P contents in transplants were significatively lower than in control shoots suggesting that transplanted cuttings are unable to meet their nutrient requirements. The modifications of the C, N, P contents in the belowground parts of the transplanted shoots indicate a mobilization of these nutrients in those compartments to produce new roots and restore a normal nutrients absorption. [less ▲]

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See detailEffect of transsphenoidal surgery on the LH pulsatility in women with microprolactinomas.
Beckers, Albert ULg; Stevenaert, Achille ULg; Vandalem, J. L. et al

in Journal of Endocrinological Investigation (1985)

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