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See detailCyprinid herpesvirus 3 : an intersting virus for applied and fundamental research
Rakus; Ouyang, Ping; Boutier, Maxime ULiege et al

in Veterinary Research (2013), 44

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See detailCyprinid Herpesvirus 3 Il10 Inhibits Inflammatory Activities of Carp Macrophages and Promotes Proliferation of Igm+ B Cells and Memory T Cells in a Manner Similar to Carp Il10.
Piazzon, M. Carla; Wentzel, Annelieke S.; Tijhaar, Edwin J. et al

in Journal of immunology (Baltimore, Md. : 1950) (2015), 195(8), 3694-704

Cyprinid herpesvirus 3 (CyHV-3) is the causative agent of a lethal disease of carp and encodes for an Il10 homolog (ORF134). Our previous studies with a recombinant ORF134-deleted strain and the derived ... [more ▼]

Cyprinid herpesvirus 3 (CyHV-3) is the causative agent of a lethal disease of carp and encodes for an Il10 homolog (ORF134). Our previous studies with a recombinant ORF134-deleted strain and the derived revertant strain suggested that cyprinid herpesvirus 3 Il10 (CyHV-3 Il10 [cyhv3Il10]) is not essential for viral replication in vitro, or virulence in vivo. In apparent contrast, cyhv3Il10 is one of the most abundant proteins of the CyHV-3 secretome and is structurally very similar to carp Il10 and also human IL10. To date, studies addressing the biological activity of cyhv3Il10 on cells of its natural host have not been performed. To address the apparent contradiction between the presence of a structurally conserved Il10 homolog in the genome of CyHV-3 and the lack of a clear phenotype in vivo using recombinant cyhv3Il10-deleted viruses, we used an in vitro approach to investigate in detail whether cyhv3Il10 exerts any biological activity on carp cells. In this study, we provide direct evidence that cyhv3Il10 is biologically active and, similarly to carp Il10, signals via a conserved Stat3 pathway modulating immune cells of its natural host, carp. In vitro, cyhv3Il10 deactivates phagocytes with a prominent effect on macrophages, while also promoting proliferation of Igm(+) B cells and memory T cells. Collectively, this study demonstrates a clear biological activity of cyhv3Il10 on cells of its natural host and indicates that cyhv3Il10 is a true viral ortholog of carp Il10. Furthermore, to our knowledge, this is the first report on biological activities of a nonmammalian viral Il10 homolog. [less ▲]

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See detailCyprinid Herpesvirus 3 ORF57 is an essential virulence factor
Boutier, Maxime ULiege; Gao, Yuan; Vancsok, Catherine et al

Poster (2017)

The genus Cyprinivirus comprises phylogenetically related viruses causing important economic losses in aquaculture. Its archetype species, the cyprinid herpesvirus 3 (CyHV 3) is the causative agent of ... [more ▼]

The genus Cyprinivirus comprises phylogenetically related viruses causing important economic losses in aquaculture. Its archetype species, the cyprinid herpesvirus 3 (CyHV 3) is the causative agent of mass mortalities in koi and common carp worldwide. Recently, we reported the development of a recombinant attenuated vaccine against CyHV 3 for mass vaccination of carp. This attenuated vaccine encodes a deletion encompassing ORF56 and ORF57. In the present study, we investigated the relative contribution of ORF56 and ORF57 in the safety observed for the ORF56-57 double deleted genotype. Single deleted recombinants were produced based on deletion-insertion of a galK cassette, inserting stop codons in frame with the sequence upstream of the deletion and disrupting the frame of the remaining sequence downstream of the deletion. Inoculation of these recombinants to carp demonstrated that the absence of ORF56 protein expression did not affect virulence; while ORF57 deletion led to an attenuation comparable to the one observed for the ORF56-57 deletion. To further demonstrate the role of ORF57 as a key virulence factor, a recombinant unable to express ORF57 protein was produced by insertion of multiple stop codons in the ORF. In vivo testing of this recombinant revealed a safety-efficacy profile comparable to the one observed for the vaccine candidate deleted for ORF56 and ORF57. Altogether, the present study demonstrates the role of ORF57 as a key virulence factor of CyHV 3 and identifies ORF57 orthologues encoded by other pathogenic cypriniviruses as gene candidates for production of attenuated recombinant vaccines. [less ▲]

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See detailCyprinid herpesvirus 3: An interesting virus for applied and fundamental research
Fournier, G; Vanderplasschen, Alain ULiege

in Bulletin de l'Académie Vétérinaire de France (2011), 164(4), 353-358

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See detailCyproterone and a comparison with its acetate ester
de Ruyck, J.; de Hassonville, S. H.; Liégeois, Jean-François ULiege et al

in Acta Crystallographica Section E-Structure Reports Online (2005), 61(Part 11), 3576-3578

The crystal structure of cyproterone (systematic name: 6-chloro-1,2-dihydro-17-hydroxy-30H-cyclopropa[a]pregna-1,4,6- triene-3,20-dione), C22H27ClO3, is compared with cyproterone acetate, a potent anti ... [more ▼]

The crystal structure of cyproterone (systematic name: 6-chloro-1,2-dihydro-17-hydroxy-30H-cyclopropa[a]pregna-1,4,6- triene-3,20-dione), C22H27ClO3, is compared with cyproterone acetate, a potent anti-androgen steroid. The two compounds adopt a similar conformation, except for the cyclopropyl ring attached to the cyclohexenone ring (ring A). Cyproterone further adopts a crystal packing distinct from that of the acetate form. These differences result from hydrogen bonding between the free hydroxy group and the carbonyl group of ring A. [less ▲]

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See detailCyrano de Bergerac et l'utopie
Torero-Ibad, Alexandra ULiege

in Utopia and Utopianism (2007), 2

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See detailCyrano de Bergerac et la matérialité de l'âme
Torero-Ibad, Alexandra ULiege

in Bargy, Hervé; Mothu, Alain (Eds.) Cyrano de Bergerac, Cyrano de Sannois (2008)

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See detailCyrano et l’éthique d’Épicure
Torero-Ibad, Alexandra ULiege

in Libertinage et philosophie au XVIIe siècle (2009), 11

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See detailCyrtodactylus sanook (Squamata: Gekkonidae), a new cave-dwelling gecko from Chumphon Province, southern Thailand
Pauwels, Olivier S.G.; Sumontha, Montri; Latinne, Alice ULiege et al

in Zootaxa (2013), 3635(3), 275-285

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See detailCyrtospiriferid brachiopods from the mid-Late Devonian of southern Belgium (Namur-Dinant Basin)
Mottequin, Bernard ULiege

in The Palaeontological Association. 54th Annual Meeting. Programme and Abstracts (2010, December 18)

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See detailCyrus Console, Brief Under Water
Delville, Michel ULiege

in Sentence: A Journal of Prose Poetics (2009), 7

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See detailCystatin C as a GFR Marker in Renal Transplantation: Promises and Challenges.
Masson, Ingrid; Mariat, Christophe; DELANAYE, Pierre ULiege

in Cohen, J. B.; Ryseck, L. P. (Eds.) Cystatins: Protease Inhibitors, Biomarkers and Immunomodulators (2011)

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See detailCystatin C blood level as a risk factor for death after heart surgery
Ledoux, Didier ULiege; Monchi, M.; Chapelle, Jean-Paul ULiege et al

in European Heart Journal (2007), 28(15), 1848-53

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See detailCystatin C in HIV Patients: More than just a GFR marker ?
Gagneux-Brunon, Amandine; Mariat, Christophe; DELANAYE, Pierre ULiege

in Cohen, J. B.; Ryseck, L. P. (Eds.) Cystatins: Protease Inhibitors, Biomarkers and Immunomodulators (2011)

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See detailCystatin C in HIV-infected patients: promising but not yet ready for prime time.
Gagneux-Brunon, Amandine; Mariat, Christophe; DELANAYE, Pierre ULiege

in Nephrology Dialysis Transplantation (2012), 27(4), 1305-1313

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See detailCystatin C is a reliable marker for estimation of glomerular filtration rate in renal transplantation: validation of a new turbidimetric assay using monospecific sheep antibodies
Bargnoux, A. S.; Cavalier, Etienne ULiege; Cristol, J. P. et al

in Clinical Chemistry & Laboratory Medicine (2011), 49(2), 265-70

Background: The potential use of Cystatin C was recently assessed in kidney transplantation. A new particle-enhanced turbidimetric immunoassay (PETIA) that uses sheep antibodies (Binding Site Human ... [more ▼]

Background: The potential use of Cystatin C was recently assessed in kidney transplantation. A new particle-enhanced turbidimetric immunoassay (PETIA) that uses sheep antibodies (Binding Site Human Cystatin C immunoassay) has been developed. Analytical performance of this new assay was evaluated. Clinical relevance was determined by comparison with a reference method in a cohort of kidney transplant patients. Patients and methods: First, the analytical performance of the Binding Site cystatin C kit was tested on SPAPLUS® and Hitachi® analyzers. Second, a comparison study was performed using SPAPLUS® analyzer against two other cystatin C methods (the Siemens-PENIA method on BNII® and the Dako-PETIA application on Olympus AU640®). Third, the glomerular filtration rate (GFR) was estimated using several predictive cystatin C- and creatinine-based equations and compared to GFR measured by an isotopic method (99mTc-DTPA). These predictive algorithms were analyzed with respect to bias, precision and accuracy. Results: Total intra-assay and inter-assay coefficients of variation were below 5%. Values obtained with the SPAPLUS® correlated with the Siemens-PENIA and the Dako-PETIA methods. The creatinine and cystatin C-based equation allowed reliable assessment of GFR in our population of renal transplantation. Conclusions: The use of algorithms based on cystatin C and creatinine could provide a reliable estimate of GFR in kidney transplantation. [less ▲]

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See detailCystatin C or Creatinine for Detection of Stage 3 Chronic Kidney Disease in Anorexia Nervosa.
Delanaye, Pierre ULiege; Cavalier, Etienne ULiege; Radermecker, Régis ULiege et al

in Nephron. Clinical Practice (2008), 110(3), 158-163

Background: Patients with anorexia nervosa (AN) are at a high risk of renal failure. Chronic kidney disease (CKD) is often missed in these patients because the serum creatinine is a poor marker of kidney ... [more ▼]

Background: Patients with anorexia nervosa (AN) are at a high risk of renal failure. Chronic kidney disease (CKD) is often missed in these patients because the serum creatinine is a poor marker of kidney function. We studied the utility of cystatin C to detect renal failure in this population. Method: Twenty-seven AN patients were studied. Glomerular filtration rates (GFR) were measured with the chromium-51- ethylenediaminetetraacetate ((51)Cr-EDTA) method. We compared the ability of creatinine and cystatin C to detect stage 3 CKD (GFR below 60 ml/min) by ROC curve analysis. Results: In this cohort, there is no correlation between GFR and serum creatinine, but there is a significant correlation between cystatin C and GFR. By ROC analysis, the cystatin C concentration is better than the serum creatinine concentration for the detection of stage 3 CKD (area under the curve of 0.86 vs. 0.61, p = 0.05). Conclusion: Plasma cystatin C is better than serum creatinine in detecting stage 3 CKD in patients with AN. [less ▲]

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See detailCystatin C standardization decreases assay variation and improves assessment of GFR
Ebert, N; DELANAYE, Pierre ULiege; Shlipak, M et al

Poster (2016)

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See detailCystatin C standardization decreases assay variation and improves assessment of glomerular filtration rate
Ebert, N; DELANAYE, Pierre ULiege; Shlipak, M et al

in Clinica Chimica Acta (2016), 456

Detailed reference viewed: 24 (0 ULiège)