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See detailEffects of 4-Hydroxy-2-Nonenal, a Major Lipid Peroxidation-Derived Aldehyde, and N-Acetylcysteine on the Cyclooxygenase-2 Expression in Human Uterine Myometrium.
Temma-Asano, K.; Tskitishvili, Ekaterine ULg; Kanagawa, T. et al

in Gynecologic & Obstetric Investigation (2011)

Background: Chorioamnionitis is one of the important causes of preterm labor. Preterm labor with chorioamnionitis is associated with oxidative stress. We reported that 4-hydroxy-2-nonenal (4-HNE), a major ... [more ▼]

Background: Chorioamnionitis is one of the important causes of preterm labor. Preterm labor with chorioamnionitis is associated with oxidative stress. We reported that 4-hydroxy-2-nonenal (4-HNE), a major end product of oxidative fatty acid metabolism, is accumulated in the placenta with chorioamnionitis. The aim of this study was to confirm the effect of 4-HNE on cyclooxygenase-2 (COX-2) and prostaglandin (PG) induction in the uterine myometrial tissues. We also examined the effect of N-acetylcysteine (NAC) on 4-HNE-induced COX-2 expression. Methods: Uterine myometrial tissues were obtained from 5 patients. One of them underwent elective cesarean section without labor, and 4 of them underwent hysterectomy because of placental previa or atonic bleeding. We stimulated the uterine myometrial tissues with 4-HNE. In addition, the tissues were pretreated with NAC before 4-HNE treatment. The expression of COX-2 mRNA was observed by real-time PCR. PGE2 and prostacyclin release into the supernatants of the tissue cultures was measured by ELISA. Results: 4-HNE induced the COX-2 mRNA expression and PGE2 production in the uterine myometrial tissue culture in a dose-dependent and time-dependent manner. NAC inhibited 4-HNE-induced COX-2 expression. Conclusion: 4-HNE may play an important role in preterm labor. NAC might be protective against preterm labor under oxidative stress. [less ▲]

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See detailEffects of 6-substituted 2-oxo-2H-1-benzopyran-3-carbowylic acide derivatives on cellular invasion in vitro
Kempen, I.; Frankenne, F.; Noël, Agnès ULg et al

Poster (2002, November 15)

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See detailEffects of 8-epi-Pgf2alpha on isolated bronchial smooth muscle of healthy and heaves-affected horses
Kirschvink, Nathalie; Art, Tatiana ULg; Lekeux, Pierre ULg et al

in Journal of Veterinary Pharmacology & Therapeutics (2001), 24(3), 215-221

8-Epi-PGF2alpha, a prostaglandin-like compound generated by oxidative stress, has been shown to be an in vitro bronchoconstrictor in airways from healthy laboratory animals and healthy humans, but it has ... [more ▼]

8-Epi-PGF2alpha, a prostaglandin-like compound generated by oxidative stress, has been shown to be an in vitro bronchoconstrictor in airways from healthy laboratory animals and healthy humans, but it has never been studied in diseased airways. Here, the bronchoconstrictive capacity of 8-epi-PGF2alpha on isolated bronchial rings (BR) of healthy and heaves-affected horses was evaluated by comparing the maximal effect and the potency of 8-epi-PGF2alpha to those of (1) acetylcholine (ACh), (2) its stereoisomer PGF2alpha and (3) its synthetic receptor agonist, U46619. Furthermore, the potential capacity of 8-epi-PGF2alpha to enhance the cholinergic (ACh) responsiveness of bronchial smooth muscle was investigated. 8-Epi-PGF2alpha contracted BR with a rank order of efficacy of Ach > U44619 > PGF2alpha > 8-epi-PGF2alpha in both healthy and heaves-affected horses. The contractile maximal response elicited by 8-epi-PGF2alpha was significantly smaller than that elicited by the other drugs, but was significantly higher in BR from heaves-affected horses than in those sampled in healthy horses, whilst pD2 values were similar. A subthreshold concentration of 8-epi-PGF2alpha (10-7 M) did not induce in vitro cholinergic hyper-responsiveness in BR of either healthy or heaves-affected horses. In conclusion, it has been demonstrated that 8-epi-PGF2alpha is an in vitro bronchoconstrictor of minor importance in healthy horses, but whose efficacy is significantly increased in heaves-affected horses. [less ▲]

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See detailEffects of a 1-year treatment with a low-dose combined oral contraceptive containing ethinyl estradiol and cyproterone acetate on glucose and insulin metabolism.
Scheen, André ULg; Jandrain, Bernard ULg; Humblet, Dominique ULg et al

in Fertility and Sterility (1993), 59(4), 797-802

OBJECTIVE: To study the effects of the slightly estrogen-dominant monophasic low-dose oral contraceptive (OC) Diane-35 (Schering AG, Berlin, Germany) (35 micrograms ethinyl estradiol [EE2] + 2 mg ... [more ▼]

OBJECTIVE: To study the effects of the slightly estrogen-dominant monophasic low-dose oral contraceptive (OC) Diane-35 (Schering AG, Berlin, Germany) (35 micrograms ethinyl estradiol [EE2] + 2 mg cyproterone acetate, a 17 alpha-hydroxyprogesterone derivative [17-OHP]) on glucose and insulin metabolism. DESIGN: Seven healthy young women were investigated by using the euglycemic hyperinsulinemic glucose clamp technique (insulin delivery rate = 100 mU/kg per hour for 120 minutes). This test was performed, after an overnight fast, during the last 7 days of a spontaneous cycle and within the last 5 days of pill intake during the sixth and twelfth cycle of a continuous treatment with Diane-35 in each subject. RESULTS: The three indexes measuring the insulin-induced glucose disposal during the clamp (glucose infusion rate, glucose metabolic clearance rate, and glucose infusion rate divided by plasma insulin plateau levels) were not significantly affected by Diane-35. In contrast, the metabolic clearance rate of the exogenous insulin infused during the clamp tended to be slightly increased with Diane-35 (significant after 6 but not after 12 cycles). CONCLUSION: These results suggest that a 1-year treatment with the OC Diane-35, which contains EE2 + a 17-OHP rather than a 19-nortestosterone derivative as the progestogen compound, does not significantly alter peripheral (presumably muscular) insulin sensitivity but slightly increases insulin (presumably hepatic) clearance. [less ▲]

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See detailThe effects of a cadmium exposure on poplar plants: A combined proteomic, physiological and biochemical approach to unravel stress-responses in poplar.
Kieffer, Pol ULg

Doctoral thesis (2012)

The industrial revolution in the 1800s and the subsequent industrialization had the consequence of an anthropogenic release of many organic and inorganic pollutants. Among these pollutants, cadmium is ... [more ▼]

The industrial revolution in the 1800s and the subsequent industrialization had the consequence of an anthropogenic release of many organic and inorganic pollutants. Among these pollutants, cadmium is very problematic due to its high toxicity. It can induce significant damage to the vegetation and an accumulation in farmland introduces the pollutant into the food chain. This creates a possible major health risk for humans. Poplar plants, as a member of the Salicaceae family, seem to possess a certain tolerance to this toxic metal and accumulate significant amount in their aerial parts, making poplar a possible candidate for phytoremedation. The metabolic and physiological impact of cadmium have been studied as well in field trials as in controlled laboratory conditions, but mostly in clearly targeted studies focusing on a few key aspects. The recent advent of more global techniques such as transcriptomics and proteomics, make it possible to obtain new results. In the thesis presented here, a proteomic study of the short-term and long-term effects of cadmium on poplar leaf and roots metabolic processes in controlled laboratory conditions was carried out. With the help of this technique, complemented with biochemical and physiological approaches and with morphological observations, it was possible to obtain results on the stress-coping mechanisms underlying an acute first response, but also on the more general adaptation mechanism which make it possible for the poplar plants to tolerate significant amounts of cadmium. Results showed a negative impact on important cell processes like photosynthesis and ATP synthesis and the antioxidant system, explaining the impaired growth. Similar results could be obtained in roots, although the stress seemed much more acute, as evidenced by the stronger accumulation of typical stress proteins (i.e. heat shock proteins). In a final set of experiments a controlled combination of two stresses (cadmium and nonlethal chilling stress; 4°C) allowed separating specific cadmium responses from a more general stress response. Cadmium had a much more severe impact on plant survival when combined with an additional constraints. In this present work, the procedures, results and conclusions obtained are presented in detail. [less ▲]

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See detailEffects of a daily physical education programme on the attitude of elementary school pupils
Piéron, Maurice ULg; Delfosse, Catherine; Cloes, Marc ULg

in University of Victoria (Ed.) Proceedings of the 10th Commonwealth & International Scientific Congress. Access to Active Living (1994)

A daily physical educationprogramme (one 40 minute session) lasting for three years was implemented in 14 schools (kindergarten and primary levels). These schools were located in the whole territory of ... [more ▼]

A daily physical educationprogramme (one 40 minute session) lasting for three years was implemented in 14 schools (kindergarten and primary levels). These schools were located in the whole territory of the French Community in Belgium. More than 3.500 children were involved in the experimental programme. Its implementation demanded a close cooperation between classroom teachers and physical education specialists. The evaluation of the effects of the daily physical education programme was copleted on the basis of a multidimensional data collection. This paper deals essentially with the children's attitudes in the comparison of experimental aned control schools and the longitudinal aspect of the study. A progressive deterioration of the pupils' attitude towards school was evidenced. However, children from the experimental classes maintained a significantly more favourable attitude towareds school and towards classroom and specialists teachers than pupils from control classes at each investigated level. [less ▲]

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See detailEffects of a dietary vitamin E supplementation on performance and meat characteristics in fattening bulls from the Belgian Blue breed
Dufrasne, Isabelle ULg; Marche, Christian; Clinquart, Antoine ULg et al

in Livestock Production Science (1998), 65(1/2), 197-201

An experiment was conducted to study effects of dietary vitamin E supplementation on animal performance, slaughter characteristics and meat quality traits in Belgian Blue double-muscled bulls. Two groups ... [more ▼]

An experiment was conducted to study effects of dietary vitamin E supplementation on animal performance, slaughter characteristics and meat quality traits in Belgian Blue double-muscled bulls. Two groups of six bulls each (404 kg) were offered (close to ad libitum) a fattening diet based on sugar beet pulp for 154 days, at which time they were slaughtered. The diet given to the control group (CG) contained 12.5 mg vitamin E/kg concentrate. The vitamin E-treated group (VG) received the same concentrate plus a supplement of 1000 mg vitamin E per bull daily. Steaks from m. longissimus thoracis were used to determine meat quality characteristics, α tocopherol concentration and thiobarbituric acid reactive substances content (TBARS), an indicator of oxidation rancidity. Supplementation had no influence on performance or carcass characteristics. The main findings were that vitamin E doubled the muscle alpha tocopherol level (1.9 vs. 0.9 mg/kg; P<0.001), lipid oxidation was suppressed as indicated by TBARS values (P<0.01 at days 7, 9, 11 and 14 after slaughter), but muscle colour was not significantly affected although a* (redness) tended to be higher for VG. [less ▲]

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See detailEffects of a dust storm on the coupled Mars thermosphere ionosphere
Witasse, Olivier; Bougher, S. W.; Cerisier, Jean-Claude et al

Conference (2003)

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See detailEffects of a long-term low-polyamine diet on biochemical parameters and polyamine content in different organs of the germ-free rat
Deloyer, Patricia; Peulen, Olivier ULg; Klimek, Monique ULg et al

in Bardocz, S.; White, A.; Hajos, G. (Eds.) COST 917 Biogenically active amines in food. Volume II : Metabolic effects of biologically active amines in food (1998)

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See detailEffects of a micro hydroelectric power plant upon population abundance, mobility and reproduction behaviour of European grayling T. thymallus and brown trout S. trutta in a salmonid river
Ovidio, Michaël ULg; Paquer, Frédéric ULg; Capra, Hervé et al

in Garcia de Jalon, Diego; Vizcaino Martinez, Pilar (Eds.) International Symposium on Ecohydraulics. Aquatic habitat: Analysis & Restoration (2004)

This study examines the potential effects of a new micro hydroelectric power plant (MHPP) on the behaviour (habitat use, movements) and population abundance of European grayling (T. thymallus) and brown ... [more ▼]

This study examines the potential effects of a new micro hydroelectric power plant (MHPP) on the behaviour (habitat use, movements) and population abundance of European grayling (T. thymallus) and brown trout (S. trutta) in the Lhomme (Belgian Ardennes). Thirteen grayling and five brown trout were captured before their spawning period and were manually radio-tracked up to 6 times a week. Population density and biomass were estimated into two different sampling sectors with electric fishing, before and after the MHPP started up. The mobility patterns of grayling and trout in the reach of the river Lhomme influenced by the MHPP strongly contrasted with results obtained in an undisturbed river of the same type in the Belgian Ardennes. Movements were mostly restricted and rarely increased during the spawning period. Spawning took place, but was disturbed by hydropeakings. The population biomass of grayling and trout decreased by 61 % and 23 % respectively, five months after the start-up of the MHPP exploitation. [less ▲]

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See detailEffects of a new impeller on oxygen transfer rates in 5L-bioreactors
Bakri, Y.; Jacques, Ph.; Shi, K. et al

Poster (2001, May)

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See detailEffects of a new oral contraceptive containing an antimineralocorticoid progestogen, drospirenone, on the renin-aldosterone system, body weight, blood pressure, glucose tolerance, and lipid metabolism.
Oelkers, W.; Foidart, Jean-Michel ULg; Dombrovicz, N. et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(6), 1816-21

Combined hormonal oral contraceptives (OCs) may lead to a mild rise in blood pressure and body weight. In rare instances, large increments in blood pressure are measured. We investigated the effect of a ... [more ▼]

Combined hormonal oral contraceptives (OCs) may lead to a mild rise in blood pressure and body weight. In rare instances, large increments in blood pressure are measured. We investigated the effect of a combination of ethinyl estradiol (EE) plus a progestogen with antimineralocorticoid, i.e. natriuretic, properties [Drospirenone (DRSP)] on body weight, blood pressure, the renin-aldosterone system, atrial natriuretic factor, plasma lipids, and glucose tolerance. It is anticipated that this will lead to the development of an OC that does not raise body weight or blood pressure. Four groups of 20 women each received 30 micrograms EE plus 3 mg DRSP (group A), 20 micrograms EE plus 3 mg DRSP (group B), 15 micrograms EE plus 3 mg DRSP (group C), and, as a control OC, 30 micrograms EE plus 150 micrograms levonorgestrel (Microgynon, Schering; group D) for 6 months. During the OC-free control cycles before and after treatment and throughout treatment, the target parameters were measured. Between the pretreatment cycle and the sixth treatment cycle, mean body weight fell by 0.8 to 1.7 kg in groups A, B, and C (P < 0.05 vs. D), whereas it rose by 0.7 kg in group D. Systolic and diastolic blood pressures fell by 1-4 mm Hg in groups A, B, and C (significant for A and C vs. D) and increased by 1-2 mm Hg in group D. Renin substrate rose equally in all groups (P < 0.05), whereas PRA and plasma aldosterone rose significantly only in the DRSP groups, presumably due to sodium loss. In the DRSP groups, high density lipoprotein cholesterol rose (P < 0.05), in contrast to group D. Low density lipoprotein cholesterol fell slightly (P > 0.05), whereas triglyceride levels showed a stronger increase in the DRSP groups (P < 0.05) than in group D. All groups attained good cycle control; group A had the best. Side-effects were minimal. To our knowledge, this is the first report on a combined OC that leads to a small decrease in body weight and blood pressure. It may be especially beneficial for women susceptible for a gain in weight and a rise in blood pressure. The potential of a new oral contraceptive (OC) containing drospirenone (DRSP) to avert the moderate increases in body weight and blood pressure often associated with use of existing combined OCs was investigated in a study of four groups of 20 German women each. Group A received 30 mcg of ethinyl estradiol (EE) and 3 mg of DRSP, Group B was administered 20 mcg of EE and 3 mg of DRSP, Group C received 15 mcg of EE and 3 mg of DRSP, and Group D was given a standard OC containing 30 mcg of EE and 150 mcg of levonorgestrel. Between the pretreatment cycle and the last (sixth) treatment cycle, mean body weight fell by 0.8-1.7 kg in Groups A, B, and C, but rose by 0.7 kg in Group D. Systolic and diastolic blood pressures fell by 1-4 mm Hg in Groups A, B, and C and rose by 1-2 mm Hg in Group D. Renin substrate rose equally in all four groups, while plasma renin activity, plasma aldosterone, and high density lipoprotein cholesterol rose significantly only in the three DRSP groups and serum triglyceride levels were significantly higher in Group D than in the three DRSP groups. Glucose tolerance increases were similar in all four groups. Finally, all groups--but especially Group A--experienced good cycle control and there were no serious side effects. These findings suggest that a combined OC containing DRSP may be especially beneficial for women who have a tendency to gain weight or experience a rise in blood pressure while taking OCs. [less ▲]

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See detailEffects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivo
Desreux, Joëlle ULg; Kebers, F.; Noël, Agnès ULg et al

in Breast (Edinburgh, Scotland ) (2003), 12(2), 142-149

Many investigators have reported cyclic proliferation of normal human breast epithelial cells. A delicate balance between proliferation and apoptosis (programmed cell death) ensures breast homeostasis ... [more ▼]

Many investigators have reported cyclic proliferation of normal human breast epithelial cells. A delicate balance between proliferation and apoptosis (programmed cell death) ensures breast homeostasis. Both the follicular and luteal phases of the menstrual cycle are characterized by proliferation, whereas apoptosis occurs only at the end of the latter phase. In this study, we observed that the withdrawal of a synthetic progestin (nomegestrol acetate or NOMAC), but not continuous treatment with it, induced apoptosis of normal human breast epithelial cells in vitro and in women who applied NOMAC gel to their breasts. Furthermore, this apoptotic response was specific to normal breast cells, since withdrawal of NOMAC did not induce apoptosis of tumoral T47D cells in vitro or of fibroadenoma cells in women. These observations open up new perspectives in the prevention of hyperplasia and breast cancer. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailEffects of a quantitative trait locus for muscle hypertrophy from Belgian Texel sheep on carcass conformation and muscularity
Laville, E.; Bouix, J.; Sayd, T. et al

in Journal of Animal Science (2004), 82(11), 3128-3137

A QTL for muscle hypertrophy has been identified in the Belgian Texel breed. A population of F-2 and backcross lambs created from crosses of Belgian Texel rams with Romanov ewes was studied. Effects on ... [more ▼]

A QTL for muscle hypertrophy has been identified in the Belgian Texel breed. A population of F-2 and backcross lambs created from crosses of Belgian Texel rams with Romanov ewes was studied. Effects on carcass traits and muscle development of the Belgian Texel breed polygenes and Belgian Texel single QTL were compared. In both cases, carcass conformation and muscularity were improved. The Texel polygenic environment improved conformation mainly through changes in skeletal frame shape. Segments were shorter and bone weight lower. Muscles were more compact, shorter, and thicker. The single QTL affected muscle development. Thickness and weight of muscles were increased. Composition in myosin changed toward an increase of fast contractile type. The relative contribution of hind limb joint to carcass weight was increased. Differences in skeletal frame morphology among the three genotypes of the single QTL were small. Conformation scoring was mainly influenced by leg muscularity. Back and shoulder muscle development, which largely contributed to variability of muscularity, were less involved in the conformation scoring. Lastly, the QTL explains a small part of differences between these Belgian Texel and Romanov breeds for conformation or muscle development. A large part of genetic variability remains to be explored. [less ▲]

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See detailEffects of a reduction of diet crude protein content on gaseous emissions from deep-litter pens for fattening pigs
Philippe, François-Xavier ULg; Laitat, Martine ULg; Canart, Bernard et al

in Animal Research (2006), 55(5), 397-407

Two successive batches of 32 fattening pigs per batch were each divided into 2 homogenous groups of 16 pigs fed either a high crude protein (CP) level diet (HP-groups) or a low crude protein level diet ... [more ▼]

Two successive batches of 32 fattening pigs per batch were each divided into 2 homogenous groups of 16 pigs fed either a high crude protein (CP) level diet (HP-groups) or a low crude protein level diet balanced with synthetic amino acids (LP-groups). Pigs were raised on straw-based deep litters in separate rooms according to diets. Once a month, the emissions of ammonia (NH3), nitrous oxide (N2O), methane (CH4), carbon dioxide (CO2) and water vapour (H2O) were measured continuously for 6 days consecutively. The mean nitrogen (N) intakes of pigs from HP-groups and LP-groups were 6.83 kg and 5.78 kg per pig respectively with mean initial and final pig body weights of 26.6 and 111.4 kg. There was no significant difference between the daily weight gains with regards to the diet CP content. At the end of the fattening periods, the N-contents of the litters were on average 1.84 kg per pig for the HP-groups and 1.56 kg per pig for the LP-groups. Gaseous emissions in the room with LP-groups were, compared with the emissions in the room with HP-groups, 26.1% lower for NH3 (10.60 vs. 14.35 g per pig per day), 12.8% lower for CH4 (13.12 vs. 15.04 g per pig per day) and 2 times higher for N2O (1.02 vs. 0.52 g per pig per day). The emissions of CO2 and H2O were not significantly different according to the diet CP level. [less ▲]

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See detailEffects of a reduction of nitrogen fertilizer on sward characteristics and dairy cows performances
Dufrasne, Isabelle ULg; Limbourg, Pierre; Hornick, Jean-Luc ULg et al

in Proceedings of the 16th General Meeting of the European Grassland Federation (1996)

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See detailEffects of a rice hydrolysate on growth of CHO cells and production of human interferon-g in a serum-free medium
Bare, G.; Charlier, H.; De Nijs, L. et al

in Animal Cell Technology : from target to market (2001)

Detailed reference viewed: 12 (1 ULg)