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See detailEffectiveness of High-Dose Riboflavin in Migraine Prophylaxis. A Randomized Controlled Trial
Schoenen, Jean ULg; Jacquy, J.; Lenaerts, M.

in Neurology (1998), 50(2), 466-70

A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis. We now compared ... [more ▼]

A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis. We now compared riboflavin (400 mg) and placebo in 55 patients with migraine in a randomized trial of 3 months duration. Using an intention-to-treat analysis, riboflavin was superior to placebo in reducing attack frequency (p = 0.005) and headache days (p = 0.012). Regarding the latter, the proportion of patients who improved by at least 50%, i.e. "responders," was 15% for placebo and 59% for riboflavin (p = 0.002) and the number-needed-to-treat for effectiveness was 2.3. Three minor adverse events occurred, two in the riboflavin group (diarrhea and polyuria) and one in the placebo group (abdominal cramps). None was serious. Because of its high efficacy, excellent tolerability, and low cost, riboflavin is an interesting option for migraine prophylaxis and a candidate for a comparative trial with an established prophylactic drug. [less ▲]

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See detailThe effectiveness of inpatient geriatric evaluation and management units: a systematic review and meta-analysis.
Van Craen, Katleen; Braes, Tom; Wellens, Nathalie et al

in Journal of the American Geriatrics Society (2010), 58(1), 83-92

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on ... [more ▼]

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on literature search of multiple databases and the references lists of all identified articles and by contacting authors. SETTING: GEMUs. PARTICIPANTS: Elderly people admitted to a GEMU. MEASUREMENTS: Quality of the studies was assessed on 10 criteria. The outcome parameters were mortality, institutionalization, functional decline, readmission, and length of stay at different follow-up points. A random-effects meta-analysis was performed using Hedges' gu and variance of relative risk (RR). RESULTS: GEMUs are organized in a heterogeneous way and the included studies gave no thorough description of comprehensive geriatric assessment (CGA). Involvement of a multidisciplinary team was a key element in all GEMUs. The individual trials showed that admission to a GEMU has one or more favorable effects on the outcomes of interest, with two significant effects in the meta-analysis: less functional decline at discharge from the GEMU (RR=0.87, 95% confidence interval (CI)=0.77-0.99; P=.04) and a lower rate of institutionalization 1 year after discharge (RR=0.78, CI=0.66-0.92; P=.003). For the other outcomes in the meta-analysis, a GEMU did not induce significantly different outcomes than usual care. CONCLUSION: This meta-analysis shows a significant effect in favor of the GEMU group on functional decline at discharge and on institutionalization after 1 year. There is heterogeneity between the studies, poor quality of some randomized controlled trials, and shortage of information about CGA. Multidisciplinary CGA offered in a GEMU may add value to the care for frail older persons admitted to the hospital, but the limitations confirm the need for well-designed studies using explicit CGA and more-structured and -coherent assessment instruments such as the Minimum Data Set Resident Assessment Instrument. [less ▲]

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See detailEffectiveness of Moringa oleifera defatted cake versus seed in the treatment of unsafe drinking water : case study of surface and well waters in Burkina Faso.
Kabore, Aminata; Savadogo, Boubacar; Rosillon, Francis ULg et al

in Journal of Water Resource and Protection [=JWARP] (2013), 5(11),

Safe drinking water access for rural populations in developing countries remains a challenge for a sustainable develop-ment, particularly in rural and periurban areas of Burkina Faso. The study aims to ... [more ▼]

Safe drinking water access for rural populations in developing countries remains a challenge for a sustainable develop-ment, particularly in rural and periurban areas of Burkina Faso. The study aims to investigate the purifying capacity of Moringa oleifera defatted cake as compared to Moringa oleifera seed in the treatment of surface and well waters used for populations alimentation. A total of 90 water samples were collected in sterile glass bottles from 3 dams’ water reservoirs, a river, and a large diameter well, respectively. The water samples were treated in triplicate with Moringa oleifera seed and defatted cake coagulants. At different settling time and coagulant concentration, turbidity and pH were measured to determine the optimal conditions and factors influencing treatment with regard to sampling source. Nine physicochemical parameters (turbidity, pH, nitrates, nitrites, calcium, magnesium, total hardness, organic matter and sulfates), three bacterial fecal pollution indicators (Escherichia coli, fecal Coliforms and fecal Streptococcus) and parasite cysts were monitored based on laboratory standard methods. Data were analyzed using the Student’ t test and XLSTAT 7.5.2 statistical software. From the results obtained, for the same concentration of coagulant, settling times providing the lowest turbidity were significantly shorter (p<0.0001) with Moringa oleifera cake than seed. Optimum settling time with Moringa oleifera cake was between 15-60 min versus 60-120 min, with Moringa oleifera seed. Both treatments reduced significantly minerals concentration in water excepted sulfates for which the concentration reversely increased. However, only Moringa oleifera cake treatment reduced organic matter content in all the water samples, while it increased with Moringa oleifera seed one (p<0.0001). The reduction of microbial pollution indicators was 92-100% with M. oleifera cake treatment and 84-100% with M. oleifera seed one. Overall, for all water samples, Moringa oleifera cake treatment appeared more efficient in improving drinking water quality than the M. oleifera seed treatment. [less ▲]

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See detailThe effectiveness of oil bioremediation processes in marine sediments under sub-Antarctic conditions
Pelletier; Delille, Bruno ULg; Delille, D.

Conference (2001, September)

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See detailEffectiveness of pharmaceutical care for patients with COPD (PHARMACOP) : A randomized controlled trial
Tommelein, E; Mehuys, E; Van Hees, Thierry ULg et al

Conference (2012, September)

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See detailEffectiveness of PHARMAceutical care for patients with COPD (PHARMACOP): a randomized controlled trial
Tommelein, Eline; Mehuys, Els; Van Hees, Thierry ULg et al

in British Journal of Clinical Pharmacology (2014), 77(5), 756-766

AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary ... [more ▼]

AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary Disease (COPD) have been conducted. We assessed the effectiveness of a pharmaceutical care program for patients with COPD. METHODS: The PHARMACOP-trial is a single-blind 3-month RCT, conducted in 170 community pharmacies in Belgium, enrolling patients prescribed daily COPD medication, aged >/=50 years, and with a smoking history >/=10 pack-years. A computer-generated randomization sequence allocated patients to intervention (n=371), receiving protocol-defined pharmacist care, or control group (n=363), receiving usual pharmacist care (1:1 ratio, stratified by center). Interventions, focusing on inhalation technique and adherence to maintenance therapy, were carried out at start of the trial and at one month follow-up. Primary outcomes were inhalation technique and medication adherence. Secondary outcomes were exacerbation rate, dyspnea, COPD specific and generic health status and smoking behavior. RESULTS: From December 2010 to April 2011, 734 patients were enrolled. 42 patients (5.7%) were lost to follow-up. At the end of the trial, inhalation score (Mean estimated difference [Delta],13.5%; 95% Confidence Interval [CI], 10.8-16.1; P<.0001) and medication adherence (Delta, 8.51%; 95%CI, 4.63-12.4; P<.0001) were significantly higher in the intervention group compared to the control group. In the intervention group, a significantly lower hospitalization rate was observed (9 vs 35; Rate Ratio, 0.28; 95%CI, 0.12-0.64; P=.003). No other significant between-group differences were observed. CONCLUSION: Pragmatic pharmacist care programs improve the pharmacotherapeutic regime in patients with COPD and could reduce hospitalization rates. [less ▲]

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See detailEffectiveness of poly(vinylpyridine) block copolymers as stabilizers of aqueous titanium dioxide dispersions of a high solid content
Creutz, Serge; Jérôme, Robert ULg

in Langmuir (1999), 15(21), 7145-7156

Diblock copolymers of 4-vinylpyridine (4VP) and sodium methacrylate (MANa) have been synthesized and tested as dispersants for aqueous dispersions (80 wt % solid) of alumina-coated titanium dioxide. P4VP ... [more ▼]

Diblock copolymers of 4-vinylpyridine (4VP) and sodium methacrylate (MANa) have been synthesized and tested as dispersants for aqueous dispersions (80 wt % solid) of alumina-coated titanium dioxide. P4VP is strongly anchored onto the pigment surface. The molecular composition of the block copolymers has an effect on the amount of copolymer required for imparting good stability to the slurry. Where the two parent triblock copolymers are concerned, triblocks consisting of PMANa outer blocks have a stabilizing efficiency comparable to the diblock copolymers, whereas the reverse structure is much less efficient. In the case of a nonblock distribution of 4VP and MANa in the copolymer chains, the stabilization effect is lost. Finally, the comparison of different stabilizing blocks attached to the same anchoring block confirms that the electrosteric stabilization mechanism is superior to the steric stabilization mechanism. A decrease in the anchoring strength of the diblocks has a deleterious effect on the dispersion stability. [less ▲]

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See detailEffectiveness of preventive back educational interventions for low back pain: a critical review of randomized controlled clinical trials
Demoulin, Christophe ULg; Marty, M.; Genevay, S. et al

in European Spine Journal (2012), 21

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See detailThe effectiveness of tailor made care: the example of cross border care between Belgium and the Netherlands
Fecher-Bourgeois, Fabienne ULg; Paulus, Aggie; van der Made, Jan et al

Report (2000)

The provision of tailor made care, the search for cost containment and European harmonisation and unification have stimulated insurers, providers, patients and governments throughout Europe to seek for ... [more ▼]

The provision of tailor made care, the search for cost containment and European harmonisation and unification have stimulated insurers, providers, patients and governments throughout Europe to seek for opportunities to establish new health care markets. The opening up of cross border care markets presents a good example. These markets offer health care services and products to patients in other countries than the nation which covers their residency or insurance. Although there are clear economic motives for cross border care, the number of patients which actually (can) cross borders is relatively limited: practice proves that current institutional frameworks can block patient flows. This raises the question how and which institutional frameworks have to be present or (re)designed in order to develop and establish an effectively functioning cross border health care market. This paper analyses this question in order to derive lessons and recommendations for future European harmonisation with regard to health care. Using a theoretical framework, which displays the economic motives, obstacles and possible institutional alternatives for cross border care, the conditions for the development and establishment of an effectively functioning health care market between the Netherlands and Belgium is explored. Using cross border care for rheumatological patients as a point of reference, it is shown that current regulations can hinder patients as well as care givers to engage in cross border care. On the basis of our framework, the consumption of Belgians consuming cross border care in the Netherlands is expected to be higher in comparison to the number of Dutch patients who consume care in Belgium. Conflicting interests among private and public specialists, general and academic hospitals, insurance companies and national government policies are also important stumbling blocks for cross border care. Our analysis shows that the most effective institutional frameworks include those that have a functional regional design: they offer the best opportunity to minimize on transaction costs and maximize the degree of tailor made care. [less ▲]

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See detailThe effectiveness of the Attention Training Technique in reducing intrusive thoughts in schizophrenia: A case study
Levaux, Marie-Noëlle ULg; Laroi, Frank ULg; Offerlin-Meyer, Isabelle et al

in Clinical Case Studies (2011), 10(6), 466-484

The aim of this study was to investigate the effectiveness of the attention training technique (ATT) on the frequency of intrusive thoughts experienced by a person with schizophrenia in her daily life ... [more ▼]

The aim of this study was to investigate the effectiveness of the attention training technique (ATT) on the frequency of intrusive thoughts experienced by a person with schizophrenia in her daily life. The attentional procedure was designed to attenuate self-focused attention and to reinforce attentional control and consisted of auditory external exercises. Homework practice was included to promote transfer to everyday life. The efficacy and specificity of the ATT were assessed with cognitive, functional, and control measures. The impact of ATT on symptomatology, work functioning, and self-esteem was also measured. Postrehabilitation results showed that, after nine training sessions, there was a reduction in intrusive thoughts for the cognitive and ecological outcome measures. Selective attention, attention switching, and resistance to distractive interference specifically improved. The person reported a reduction in intrusive thoughts in her daily life. In addition, positive symptoms decreased. Finally, a 6-month follow-up assessment revealed the maintenance of most of the beneficial effects in daily life. [less ▲]

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See detailEffectiveness of the review of individual applications before the European court of Human Rights
Behrendt, Christian ULg

Conference (2011, November 24)

Paper presented at the Round Table Meeting held at the Constitutional Court of Turkey and organized by the Council of Europe, as part of the "Joint Project of the European Union and the Council of Europe ... [more ▼]

Paper presented at the Round Table Meeting held at the Constitutional Court of Turkey and organized by the Council of Europe, as part of the "Joint Project of the European Union and the Council of Europe on Enhancing the Role of the Supreme Judicial Authorities of Turkey in respect of European standards". [less ▲]

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See detailEFFECTIVENESS OF VOICE THERAPY RELYING ON THE USE OF EUTONY IN THE TRAITEMENT OF DYSPHONIC PATIENTS.
Martinot, Gisèle; Caner, Jessie; Morsomme, Dominique ULg

Poster (2010, July 15)

Twenty six patients with dysphonia (different etiologies) were submitted to a voice therapy program involving the use of Eutony. In order to assess its efficacy, pre and post-treatment audio recordings ... [more ▼]

Twenty six patients with dysphonia (different etiologies) were submitted to a voice therapy program involving the use of Eutony. In order to assess its efficacy, pre and post-treatment audio recordings were analysed and submitted to perceptual rating using GRBAS-I scale and acoustical analysis of fundamental frequency, jitter and shimmer. Aerodynamic data (Maximum Phonation Time & Estimated Subglottic Pressure) were also included in the voice quality assessment protocol. In addition , a questionnaire was sent to all patients to collect self-evaluation of voice quality and therapy outcomes. The study revealed a significant improvement lasting in time for two acoustic parameters : Jitter and Shimmer and five perceptual parameters : Grade, Roughness, Breath, Asthenia and Strain. Aerodynamic data showed slight improvements but no significant changes. Self evaluation questionnaires also tend to strengthen positive effects of therapy. Thus, this study supports the use of Eutony in vocal therapy for dysphonia. Its effects were shown to be measurable with both acoustical analysis and perceptual rating of voice quality. [less ▲]

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See detailEffectiveness of zoledronic acid in the prevention and treatment of glucocorticoid-induced osteoporosis in men and premenopausal women
Saag, k; Roux, C.; Devogelaer, J. P. et al

in Arthritis and Rheumatism (2010, October), 62(10), 902-903

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See detailEffectors of Inflammation in Actinic Prurigo
Arrese, J. E.; Dominguez-Soto, L.; Hojyo-Tomoka, M. T. et al

in Journal of the American Academy of Dermatology (2001), 44(6), 957-61

BACKGROUND: Actinic prurigo is a specific familial photodermatosis of uncertain pathogenesis. OBJECTIVE: Our purpose was to investigate the immunohistologic presentation of actinic prurigo to explore the ... [more ▼]

BACKGROUND: Actinic prurigo is a specific familial photodermatosis of uncertain pathogenesis. OBJECTIVE: Our purpose was to investigate the immunohistologic presentation of actinic prurigo to explore the involved pathomechanisms. METHODS: The present immunohistochemical study was performed on biopsy specimens from 20 Mexican patients presenting with a severe and perennial form of the disease. RESULTS: The dense inflammatory infiltrate was composed predominantly of helper T type 1 lymphocytes admixed with scattered B-cell lymphoid follicles and numerous dermal dendrocytes. Keratinocytes contained abundant tumor necrosis factor-alpha and calprotectin. CONCLUSION: In subjects genetically predisposed to actinic prurigo, ultraviolet light may trigger excessive tumor necrosis factor-alpha production by keratinocytes whose sustained release in turn exerts its proinflammatory activity and deleterious epidermal effects. Such a cascade of events is in line with the therapeutic benefit already reported when thalidomide is used to treat actinic prurigo. [less ▲]

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See detailEffects caused on the structure by localised fires in large compartments
Franssen, Jean-Marc ULg; Cajot, Louis-Guy; Schleich, Jean-Baptiste

Conference (1998)

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See detailEffects de l'entraînement sur la fonction cardio-respiratoire et sur la température rectale chez le poney
Amory, Hélène ULg; Art, Tatiana ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1988), 132

The influence of training on cardiorespiratory and thermoregulatory adaptations to exercise was studied in 2 healthy race ponies (age : 3.5 and 5 years; weight : 270 and 295 kg). Respiratory airflow (V ... [more ▼]

The influence of training on cardiorespiratory and thermoregulatory adaptations to exercise was studied in 2 healthy race ponies (age : 3.5 and 5 years; weight : 270 and 295 kg). Respiratory airflow (V), tidal volume (VT), electrocardiogram and rectal temperature were simultaneously recorded before, during and alter a standardized exercise which consisted of 3 min walking (1.5 m.sec -1), 3 min slow trotting (3.0 m.sec-1) and 3 min fast trotting (3.5 m.sec-1). These parameters were recorded 4 times, i.e. before (test 1), during (test 2 and 3) and 2 weeks alter (test 4) a 4 week-period of training. Respiratory frequency (f), VT, peak inspiratory and expiratory V, minute volume (Ve), heart rate (H.R.) and rectal temperature changes were calculated on the basis of the collected data. For a given workload, Ve was increased and H.R. decreased during test 2 and 3. These adaptations to training persisted alter the 2 week-period of detraining. Neither Ve nor H.R. recoveries were changed during the whole experimental period. On the other hand, f measured both during exercise and recovery was subject to great variations, obviously independent of the state of training. Lastly, the exercise-induced hyperthermia was reduced alter the training period. This thermoregulatory changes was reversed alter detraining. The results of this preliminary study must be taken with cautions because of the small number of animals used. Nevertheless, they suggested that (1) f is a poor indication of the ventilation, (2) measurements of Ve and HR during a standardized exercise may give a good estimation of the fitness of a horse, (3) on the opposite both parameters measured during recovery seemed to be poorly correlated with the state of training. [less ▲]

Detailed reference viewed: 144 (3 ULg)