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See detailDynamic assessment of the floc morphology, bacterial diversity and integron content of an activated sludge reactor processing hospital effluent
Stalder, Thibault; Alrhmoun, Moussab; Louvet, Jean-Noël ULg et al

in Environmental Science & Technology (2013)

The treatment of hospital effluents (HE) is a major concern, as they are suspected of disseminating drugs and antibiotic resistance determinants in the environment. In order to assess HE influence on ... [more ▼]

The treatment of hospital effluents (HE) is a major concern, as they are suspected of disseminating drugs and antibiotic resistance determinants in the environment. In order to assess HE influence on wastewater treatment plant biomass, lab scale conventional activated sludge systems (CAS) were continuously fed with real HE or urban effluent as a control. To gain insights into the main hurdles linked to HE treatment, we conducted a multiparameter study using classical physicochemical characterization, phase contrast and confocal laser 35 scaning microscopy, and molecular biology (i.e. pyrosequencing) tools. HE caused erosion of floc structure and the production of extracellular polymeric substances attributed to the development of floc forming bacteria. Adaptation of the sludge bacterial community to the HE characteristics, thus maintaining the purification performance of the biomass, was observed. Finally, the comparative metagenomic analysis of the CAS showed that HE 40 treatment resulted in an increase of class 1 resistance integrons (RIs) and the introduction of Pseudomonas spp. into the bacterial community. HE treatment did not reduce the CAS process performance; nevertheless it increases the risk of dissemination into the environment of bacterial species and genetic determinants (RIs) involved in antibiotic resistance acquisition. [less ▲]

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See detailDynamic auroral storms on Saturn as observed by the Hubble Space Telescope
Nichols, J. D.; Badman, S. V.; Baines, K. H. et al

in Geophysical Research Letters (2014), 41

We present observations of significant dynamics within two UV auroral storms observed on Saturn using the Hubble Space Telescope in April/May 2013. Specifically, we discuss bursts of auroral emission ... [more ▼]

We present observations of significant dynamics within two UV auroral storms observed on Saturn using the Hubble Space Telescope in April/May 2013. Specifically, we discuss bursts of auroral emission observed at the poleward boundary of a solar wind-induced auroral storm, propagating at ˜330% rigid corotation from near ˜01 h LT toward ˜08 h LT. We suggest that these are indicative of ongoing, bursty reconnection of lobe flux in the magnetotail, providing strong evidence that Saturn's auroral storms are caused by large-scale flux closure. We also discuss the later evolution of a similar storm and show that the emission maps to the trailing region of an energetic neutral atom enhancement. We thus identify the auroral form with the upward field-aligned continuity currents flowing into the associated partial ring current. [less ▲]

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See detailDynamic calibration of Flexiforce sensors for ballistic measurements
Robbe, Cyril ULg; Papy, Alexandre; Nsiampa Ndompetelo, ULg

in Binetruy, Christophe; Boussu, François (Eds.) Recent Advances in TExtile Composites (2010, October 26)

In the field of terminal ballistics, non-invasive force measurements are sometimes needed. The cheap and thin Flexiforce sensors can be used for this purpose with low collateral effects. This paper works ... [more ▼]

In the field of terminal ballistics, non-invasive force measurements are sometimes needed. The cheap and thin Flexiforce sensors can be used for this purpose with low collateral effects. This paper works on the development of a method designed to dynamically calibrate the Flexiforce sensor. The objective is to find a calibration parameter that correlates the Flexiforce output signal, in terms of conductance, to the applied force. The process used to achieve this dynamic calibration is based on a drop test. The principle is to impact the sensor with the falling of a specified mass. The force signal delivered by the Flexiforce sensor is afterwards compared to the signal measured by a reference force sensor that measures the same impact. To further validate this measurement, the impact is applied on a spring, placed directly between the falling mass and the Flexiforce. The deflection of that spring is measured with a high-speed camera. Knowing the spring properties, we can determine the force produced by the spring on the two sensors, and consequently validate the reference measurement. The calibration factor seems independent of the applied force, and follows a normal distribution. Both the frequency of the impact and the contact surface have an influence on the output of the Flexiforce sensor. For that reason the calibration process should use a frequency and a contact surface similar to the considered application. [less ▲]

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See detailDynamic change of global and local information processing in Propofol-induced loss and recovery of consciousness
Monti, Martin; Lutkenoff, Evan; Rubinov, Mikail et al

in PLoS Computational Biology (2013), 9

Detailed reference viewed: 72 (8 ULg)
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See detailDynamic changes in brain aromatase activity following sexual interactions in males: Where, when and why?
de Bournonville, Catherine ULg; Dickens, Molly J.; Ball, Gregory F. et al

in Psychoneuroendocrinology (2013), 38(6), 789-99

It is increasingly recognized that estrogens produce rapid and transient effects at many neural sites ultimately impacting physiological and behavioral endpoints. The ability of estrogens to acutely ... [more ▼]

It is increasingly recognized that estrogens produce rapid and transient effects at many neural sites ultimately impacting physiological and behavioral endpoints. The ability of estrogens to acutely regulate cellular processes implies that their concentration should also be rapidly fine-tuned. Accordingly, rapid changes in the catalytic activity of aromatase, the limiting enzyme for estrogen synthesis, have been identified that could serve as a regulatory mechanism of local estrogen concentrations. However, the precise anatomical localization, time-course, triggering stimuli and functional significance of these enzymatic changes in vivo are not well understood. To address these issues as to where, when and why aromatase activity (AA) rapidly changes after sexual interactions, AA was assayed in six populations of aromatase-expressing cells microdissected from the brain of male quail that experienced varying durations of visual exposure to or copulation with a female. Sexual interactions resulted in a rapid AA inhibition. This inhibition occurred in specific brain regions (including the medial preoptic nucleus), in a context-dependent fashion and time-scale suggestive of post-translational modifications of the enzyme. Interestingly, the enzymatic fluctuations occurring in the preoptic area followed rather than preceded copulation and were tied specifically to the female's presence. This pattern of enzymatic changes suggests that rapid estrogen effects are important during the motivational phase of the behavior to trigger physiological events essential to activate mate search and copulation. [less ▲]

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See detailDynamic changes in the density of radial glial fibres of the developing murine cerebral wall: A quantitative immunohistochemical analysis
Gadisseux, Jean-François; Evrard, Phlippe; Misson, Jean-Paul ULg et al

in Journal of Comparative Neurology (The) (1992), 321

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See detailDynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.
Lienard, Benoit M. R.; Huting, Rebekka; Lassaux, Patricia ULg et al

in Journal of medicinal chemistry (2008), 51(3), 684-8

The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid ... [more ▼]

The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid identification of an inhibitor with a K(i) of < 1 microM. The study exemplifies the utility of protein-MS for screening dynamic mixtures of potential enzyme-inhibitors. [less ▲]

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See detailDynamic Computation and Design of a World’s Record Death-Ride
Denoël, Vincent ULg; Canor, Thomas ULg; Demanet, Johan

in Proceedings of the 4th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering (2013)

A death-ride is a long cable anchored between two dead ends, allowing the crossing of wide valleys. Besides these mobility purposes, it is also operated in rescue operations, or simply for leisure. From a ... [more ▼]

A death-ride is a long cable anchored between two dead ends, allowing the crossing of wide valleys. Besides these mobility purposes, it is also operated in rescue operations, or simply for leisure. From a serviceability viewpoint, a death-ride design should offer a comfortable and/or enjoyable journey to the riders, which is typically expressed in terms of maximum velocity. From a strength viewpoint, a death-ride should be designed in order to safely withstand the cable self-weight, wind forces, the rider’s load and at last but not least, the initial tension in the cable. Actually, the tensioning operation is usually subtle. Indeed, in case of a loose cable, the rider may be stopped in the in-span sagging area. Conversely a too tight cable will generate large stresses but also large outlet velocity at the end of the ride. The design of a death-ride is a tradeoff between all these aspects. The paper presents the dynamic model that was used for the design of a 1.2km long death-ride, with an only 10-mm diameter, a constraint fixed in the very first stages of this project for compatibility reasons, with the existing equipment. This death-ride, built and used in May 2010 in a Grimp competition [1], has a world record of the longest death-ride in urban area. The structural part of the dynamic model is rather common, with a co-rotational description of the cable by means of a chain-like model [2]. An interesting feature, however, concerns the interaction between the rider and the cable. In fact, because the pulley is rolling on the cable, the position of the force acting on the cable, resulting from the ride, depends on the rider’s velocity, which itself depends on the cable inclination. This coupling is solved in a staggered manner, and the details of the algorithm are given in the full paper. In some limiting cases, a comparison with analytical solutions is also provided, where these analytical solutions are available [3]. Experimental validation and observation of the operated death-ride will also be presented. [less ▲]

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See detailDynamic Effect of Solvation on the Optical Properties of a CdTe Nanocrystal
Malcioǧlu, O. B.; Raty, Jean-Yves ULg

in Advanced Optical Materials (2013), 1(3), 239-243

Changes in the optical response of a CdTe quantum dot (QD) due to dynamic and surface effects are investigated using ab initio methods. The model successfully captures experimentally reported non-linear ... [more ▼]

Changes in the optical response of a CdTe quantum dot (QD) due to dynamic and surface effects are investigated using ab initio methods. The model successfully captures experimentally reported non-linear trends in the optical spectra. The combination of ab initio molecular dynamics, time-dependent DFT, and optical spectroscopy provides a very effective method to investigate various dynamic effects on very small QDs, and to explore generalizable trends for similar structures. Using TDDFT and ab-initio molecular dynamics, a correlation is established between the time evolution of spectral features with various structural components of a ligand-stabilized CdTe quantum dot. The localization of charge oscillations due to light absorption is investigated before and after embedding the quantum dot in an explicit solvent environment. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. [less ▲]

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See detailDynamic extended equal area criterion. Part 1. Basic formulation
Xue, Yusheng; Rousseaux, Patricia ULg; Gao, Z. et al

in Proceedings of the IEEE Athens Power Tech Conference (1993)

Detailed reference viewed: 56 (4 ULg)
See detailDynamic extended equal area criterion. Part 2. Embedding fast valving and automatic voltage regulation
Xue, Yusheng; Zhang, Y.; Gao, Z. et al

in Procedings of the IEEE Athens Power Tech Conference (1993)

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See detailDynamic generalized linear models and repeated measurements
Lindsey, James ULg; Lambert, Philippe ULg

in Journal of Statistical Planning & Inference (1995), 47

The dynamic generalized linear model for non-normal data is extended for use in repeated measurements, when series of observations are available for more than one individual. Examples are given for count ... [more ▼]

The dynamic generalized linear model for non-normal data is extended for use in repeated measurements, when series of observations are available for more than one individual. Examples are given for count and duration data. [less ▲]

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See detailA Dynamic Graph Model of Endochondral Ossification can assess the Importance of Biological Actors in Differentiation
Kerkhofs, Johan ULg; Van Oosterwyck, Hans; Geris, Liesbet ULg

Conference (2012, September 18)

Cell-based tissue engineering constructs are a promising avenue for the treatment of long bone defects since they provide the primordial ingredients for bone regeneration. The construct provides the ... [more ▼]

Cell-based tissue engineering constructs are a promising avenue for the treatment of long bone defects since they provide the primordial ingredients for bone regeneration. The construct provides the appropriate micro-environment through the carrier, cells to form tissue and chemical cues to kick start the natural bone forming process. Clearly this approach will benefit from a more comprehensive appreciation of how cell populations and the microenvironment provided by the carrier can impact on bone formation in all its complexities. A cornucopia of studies of developmental biology have revealed many biological actors that together form a central network that orchestrates cell behaviour during this process and assures its robustness. This knowledge can be brought to bear specifically in the form of a mathematical model of endochondral ossification, the dominant type of ossification. This model can facilitate the understanding of how growth factors and transcription factors influence cell fate decisions and consequently answer the question whether they can boost bone healing. The model formalism accommodates the qualitative information that is typically available in developmental studies. The network comprises 46 nodes and 161 interactions, shown to be important in endochondral ossification. To simulate network dynamics in discrete time the normalized value of each gene is determined by additive functions where all interactions are assumed to be equally powerful. Furthermore, each species is represented by a fast variable (activity level, as determined by post translation modifications) which is assumed to be in equilibrium with a slow variable (mRNA) at all times. Through a Monte Carlo approach the importance of each node in the stability of chondrocytic phenotypes (proliferating, hypertrophic) is assessed. The hypertrophic state, driven by Runx2, is more stable than the proliferating chondrocyte. This higher stability seems to be conferred by faster reactions that favor the hypertrophic phenotype. In addition, the results point out that some transcription factors are necessary for the induction of a certain phenotype, whereas other transcription factors are required to maintain the phenotype, but are not necessary capable of inducing it. Overall, the model allows the importance of several important factors in the fate decision of mesenchymal cells to be quantitatively assessed based mainly on topological information. [less ▲]

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See detailDynamic Hedge Fund Style Analysis with Errors-in-Variables
Bodson, Laurent ULg

Conference (2009, May)

This paper revisits the traditional return-based style analysis (RBSA) in presence of time-varying exposures and errors-in-variables (EIV). We first apply a selection algorithm using the Kalman filter to ... [more ▼]

This paper revisits the traditional return-based style analysis (RBSA) in presence of time-varying exposures and errors-in-variables (EIV). We first apply a selection algorithm using the Kalman filter to identify the more appropriate benchmarks for the analyzed fund return. Then, we compute their corresponding higher moment estimated errors-in-variables, i.e. the measurement error series introducing the (cross) moments of order three and four. We adjust the selected benchmarks by subtracting their higher moments estimated EIV from the initial return series, to obtain an estimate of the true uncontaminated benchmarks. We finally run the Kalman filter on these adjusted regressors. Analyzing EDHEC alternative indexes styles, we show that this technique improves the factor loadings and permits to identify more precisely the return sources of the considered hedge fund strategy. [less ▲]

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See detailDynamic Hedge Fund Style Analysis with Errors-in-Variables
Bodson, Laurent ULg; Hübner, Georges ULg; Coën, Alain

Conference (2008, July)

This paper revisits the traditional return-based style analysis (RBSA) in presence of time-varying exposures and errors-in-variables (EIV). We first apply a selection algorithm using the Kalman filter to ... [more ▼]

This paper revisits the traditional return-based style analysis (RBSA) in presence of time-varying exposures and errors-in-variables (EIV). We first apply a selection algorithm using the Kalman filter to identify the more appropriate benchmarks for the analyzed fund return. Then, we compute their corresponding higher moment estimated errors-in-variables, i.e. the measurement error series introducing the (cross) moments of order three and four. We adjust the selected benchmarks by subtracting their higher moments estimated EIV from the initial return series, to obtain an estimate of the true uncontaminated benchmarks. We finally run the Kalman filter on these adjusted regressors. Analyzing EDHEC alternative indexes styles, we show that this technique improves the factor loadings and permits to identify more precisely the return sources of the considered hedge fund strategy. [less ▲]

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See detailDynamic Hedge Fund Style Analysis with Errors-in-Variables
Bodson, Laurent ULg; Hübner, Georges ULg; Coën, Alain

Conference (2008, April)

This paper revisits the traditional return-based style analysis (RBSA) in presence of time-varying exposures and errors-in-variables (EIV). We first apply a selection algorithm using the Kalman filter to ... [more ▼]

This paper revisits the traditional return-based style analysis (RBSA) in presence of time-varying exposures and errors-in-variables (EIV). We first apply a selection algorithm using the Kalman filter to identify the more appropriate benchmarks for the analyzed fund return. Then, we compute their corresponding higher moment estimated errors-in-variables, i.e. the measurement error series introducing the (cross) moments of order three and four. We adjust the selected benchmarks by subtracting their higher moments estimated EIV from the initial return series, to obtain an estimate of the true uncontaminated benchmarks. We finally run the Kalman filter on these adjusted regressors. Analyzing EDHEC alternative indexes styles, we show that this technique improves the factor loadings and permits to identify more precisely the return sources of the considered hedge fund strategy. [less ▲]

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See detailDynamic Hedge Fund Style Analysis with Errors-in-Variables
Bodson, Laurent ULg; Hübner, Georges ULg; Coën, Alain

Conference (2008, June)

This paper revisits the traditional return-based style analysis (RBSA) in presence of time-varying exposures and errors-in-variables (EIV). We first apply a selection algorithm using the Kalman filter to ... [more ▼]

This paper revisits the traditional return-based style analysis (RBSA) in presence of time-varying exposures and errors-in-variables (EIV). We first apply a selection algorithm using the Kalman filter to identify the more appropriate benchmarks for the analyzed fund return. Then, we compute their corresponding higher moment estimated errors-in-variables, i.e. the measurement error series introducing the (cross) moments of order three and four. We adjust the selected benchmarks by subtracting their higher moments estimated EIV from the initial return series, to obtain an estimate of the true uncontaminated benchmarks. We finally run the Kalman filter on these adjusted regressors. Analyzing EDHEC alternative indexes styles, we show that this technique improves the factor loadings and permits to identify more precisely the return sources of the considered hedge fund strategy. [less ▲]

Detailed reference viewed: 54 (21 ULg)
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See detailDynamic Hedge Fund Style Analysis with Errors-in-Variables
Bodson, Laurent ULg; Coën, Alain ULg; Hübner, Georges ULg

Conference (2008, July)

This paper revisits the traditional return-based style analysis (RBSA) in presence of time-varying exposures and errors-in-variables (EIV). We first apply a selection algorithm using the Kalman filter to ... [more ▼]

This paper revisits the traditional return-based style analysis (RBSA) in presence of time-varying exposures and errors-in-variables (EIV). We first apply a selection algorithm using the Kalman filter to identify the more appropriate benchmarks for the analyzed fund return. Then, we compute their corresponding higher moment estimated errors-in-variables, i.e. the measurement error series introducing the (cross) moments of order three and four. We adjust the selected benchmarks by subtracting their higher moments estimated EIV from the initial return series, to obtain an estimate of the true uncontaminated benchmarks. We finally run the Kalman filter on these adjusted regressors. Analyzing EDHEC alternative indexes styles, we show that this technique improves the factor loadings and permits to identify more precisely the return sources of the considered hedge fund strategy. [less ▲]

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See detailDynamic Hedge Fund Style Analysis with Errors-in-Variables
Bodson, Laurent ULg; Coën, Alain; Hübner, Georges ULg

in Journal of Financial Research (2010), 33(3), 201-221

We revisit the traditional return-based style analysis in the presence of time varying exposures and errors-in-variables (EIV). We apply a benchmark selection algorithm using the Kalman filter and compute ... [more ▼]

We revisit the traditional return-based style analysis in the presence of time varying exposures and errors-in-variables (EIV). We apply a benchmark selection algorithm using the Kalman filter and compute the estimated EIV of the selected benchmarks. We adjust them by subtracting their EIV from the initial return series to obtain an estimate of the true uncontaminated benchmarks. Finally, we run the Kalman filter on these adjusted regressors. Analyzing EDHEC alternative index styles, we show that this technique improves the factor loadings and allows more precise identification of the return sources of the considered hedge fund strategy. [less ▲]

Detailed reference viewed: 58 (14 ULg)