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See detailDeciphering Mars lower atmosphere: Nitric Oxide nightglow seasonal variations as observed by IUVS
Stiepen, Arnaud ULg

Scientific conference (2016, February 02)

Detailed reference viewed: 23 (1 ULg)
See detailDeciphering mechanisms of cancer adaptation to targeted therapy
Sounni, Nor Eddine ULg

Conference (2015, May 12)

Targeted therapies designed towards specific molecules such as the receptor tyrosine kinase inhibitors (TKRIs) emerged in recent years and are currently in clinical use for multiple tumor types ... [more ▼]

Targeted therapies designed towards specific molecules such as the receptor tyrosine kinase inhibitors (TKRIs) emerged in recent years and are currently in clinical use for multiple tumor types. Unfortunately, their efficacy is limited, in part due to the development of resistance to treatment. The first part of my talk will be focused on mechanisms of adaptation to antiangiogenic therapy using RTKIs in preclinical studies. Our recent data suggest that RTKIs withdrawal results in accelerated tumor progression and metastasis. We found that antiangiogenic therapy induced a metabolic shift in cancer and stromal cells to a glycolytic and hypoxic state during treatment, which was reversed upon therapy withdrawal, resulting in a shift to de novo lipogenesis and increased TCA cycle activity to promote tumor regrowth. Targeting lipid metabolism using pharmacological inhibition or specific knockdown of FASN suppressed the RTKIs withdrawal–associated tumor regrowth and metastasis. The second part of my talk will shed light on EGFR signaling in triple negative breast carcinomas (TNBC) and difficulties in targeting EGFR signaling. Although anti-EGFR treatments have shown promise in some cancers, single agent therapy is ineffective in unselected TNBC and response of patients is often limited due to the acquisition of resistance. Accumulating data have appreciated the importance of the cooperation of EGFR with other cell surface proteins to induce cell transformation, growth and survival. In this context, we recently reported that MT4-MMP, a membrane-type matrix metalloproteinase (MMP17) interacts with EGFR and enhances EGFR signaling and TNBC cell proliferation. I will also talk about our preclinical models and the opportunity to identify novel potential combination of treatment regimens that would increase the clinical benefit of targeted therapy against VEGF and EGFR. [less ▲]

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See detailDeciphering supportive treatment strategies for toxic epidermal necrolysis.
Jennes, Serge; PIERARD, Gérald ULg; Paquet, Philippe

in Current Drug Safety (2012), 7(5), 361-6

Toxic epidermal necrolysis (TEN) is a dreadful life-threatening syndrome typically induced by an adverse drug reaction. This condition is characterized by the sudden and extensive destruction of the ... [more ▼]

Toxic epidermal necrolysis (TEN) is a dreadful life-threatening syndrome typically induced by an adverse drug reaction. This condition is characterized by the sudden and extensive destruction of the epidermis. The patient should be promptly addressed to a burn unit where three types of treatment should be administered, namely, (a) specific topical care of the bullous/eroded skin areas, (b) systemic anti-apoptotic/necrotic treatments, and (c) supportive care preventing secondary internal organ failures. This latter aspect is covered by the present review and focuses on (a) early withdrawal of the causative drug, (b) airway management, (c) hydro-electrolytic control, (d) nutritional support, (e) antibiotherapy, (f) prevention of venous thrombosis and gastroduodenal ulcers, and (g) analgesia and anesthesia. [less ▲]

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See detailDeciphering the factors defining the pH-dependence of a commercial glycoside hydrolase family 8 enzyme
Barroca, M.; Santos, G.; Johansson, B. et al

in Enzyme and Microbial Technology (2017), 96

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See detailDeciphering the impaired cytokine cascades in chronic leg ulcers (review).
Quatresooz, Pascale ULg; Henry, Frédérique ULg; Paquet, Philippe ULg et al

in International Journal of Molecular Medicine (2003), 11(4), 411-8

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis ... [more ▼]

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis. The various cytokines identified in experimental wounds are also present in leg ulcers. VEGF is strongly implicated as a promoter of blood vessel growth in patients with venous disease. In addition, there is good evidence of increased expression of bFGF, TGF-beta1, and PDGF in lipodermatosclerosis. All of these growth factors are involved in wound healing. Upregulated TGF-beta1 is probably one of the main causes of the fibrosis observed in lipodermatosclerosis. In leg ulcers, cytokines appear to be trapped in the perivascular fibrinoid deposits. It is not the nature and amount of cytokines that are inadequate in leg ulcers, but rather their spatial distribution. Dermal dendrocytes (DD) are resident factor XIIIa-enriched macrophages. They likely play a role in tissue repair when boosted adequately. New therapies aiming at helping the release of cytokines by DD apparently promote and improve the healing phase. [less ▲]

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See detailDeciphering the metabolism of polyprenyl-phosphate: The universal glycan lipid carrier at the membrane frontier
Manat, Guillaume; Roure, Sophie; El Ghachi, Meriem ULg et al

Poster (2015, June)

Detailed reference viewed: 19 (3 ULg)
See detailDeciphering the molecular mechanisms underlying NLRP3 inflammasome activation by saturated fatty acids
Gianfrancesco, Marco ULg; Bloch, Katarzyna; Dehairs, Jonas et al

Poster (2015, September)

Detailed reference viewed: 41 (18 ULg)
See detailDeciphering the record of early life in Precambrian oceans
Javaux, Emmanuelle ULg

Scientific conference (2008)

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See detailDeciphering the record of early life in Precambrian oceans using combined microscopy and microchemistry of organic-walled microfossils.
Javaux, Emmanuelle ULg; Marshall, C. P.

in Geochimica et Cosmochimica Acta (2007), 71(15), 442

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See detailDeciphering the role of 75KDA SIRT1 fragment in osteoarthritis
Dvir-Ginzberg, M; Oppenheimer, H; Meir, H et al

in Osteoarthritis and Cartilage (2013), 21

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See detailDecision algorithms for the re-treatment with viscosupplementation in patients suffering from knee osteoarthritis
Henrotin, Yves ULg; Richette, Pascal; Raman, R et al

in Osteoarthritis and Cartilage (2017), 25

Detailed reference viewed: 10 (1 ULg)
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See detailA decision analyst's views on the nuclear debate. From a nightmare to a daydream.
Leclercq, Dieudonné ULg

in THILL, Georges; FOUREZ, Gérard (Eds.) Le débat nucléaire (1977)

After having described the model (maximization of expected utility) on which is based the modern decision making theory, the author lists a series of obstacles that make difficult its application ... [more ▼]

After having described the model (maximization of expected utility) on which is based the modern decision making theory, the author lists a series of obstacles that make difficult its application (nightmare), in particular in the nuclear debate. Then, he mentions in which respect one can be inspired by an on going real project managed according to these principles : Ward Edwards' contribution to a desegregation project in Los angeles. Then the author imagines (daydream) the eight steps of a solution to the nuclear debate via decision making with a strong democratic commitment (To will, perchance to win). Then he indicates ongoing real works (with similar theoretical inspirations) on the nuclear debate. [less ▲]

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See detailLa décision de traitement des risques dans l’entreprise sociale : le rôle de la perception des dirigeants à l’égard du risque, de l’incertitude et de la sécurité
Kamto Kenmogne, Marius ULg; Van Caillie, Didier ULg

Conference (2013, July 04)

Recent developments in the fields of research focused on risk management plea for moving from a silo-perspective (focused on a separate and cross-sectional management of risks) to an holistic and ... [more ▼]

Recent developments in the fields of research focused on risk management plea for moving from a silo-perspective (focused on a separate and cross-sectional management of risks) to an holistic and integrated view of the risk management function (called Enterprise Risk Management or ERM), in which risks, uncertainties and resources are considered globally as a whole. Despite the numerous papers focused on risks and risk management in firms, no specific study appears to be devoted to the strategies implemented in order to manage risks in social enterprises. Our paper aims to fulfill this absence and discusses the results of an empirical study that analyses the impact of the perception of the concepts of risk, uncertainty and security on the decision for managing risks in social enterprises. [less ▲]

Detailed reference viewed: 193 (43 ULg)
See detailDecision making for teeth replacement in the esthetic area
LAMBERT, France ULg

Scientific conference (2013)

Esthetic results in dentistry are determined by the harmony between the dental prostheses and the soft tissues. To reach an optimal result, each single step of the treatment has a great importance, from ... [more ▼]

Esthetic results in dentistry are determined by the harmony between the dental prostheses and the soft tissues. To reach an optimal result, each single step of the treatment has a great importance, from the smile analyses to the final restoration delivery. The goal of this lecture is to describe how to elaborate a treatment planning for single and multiple tooth replacement in the aesthetic zone. A decision tree for the surgical protocols will be proposed according to our clinical experience at the university of Liège and, the current scientific evidences. The overall objective is, from an initial clinical situation, to determine the appropriate treatment approach and timing. The following scientific aspects will be developed: - The biological concept of extraction socket preservation. The use of biomaterials for alveolar bone augmentation or socket preservation. The goal is to clarify properties of the mostly used biomaterial in dentistry, as well as determine their clinical indications and limitations. Soft tissue management around teeth and implant [less ▲]

Detailed reference viewed: 27 (0 ULg)
See detailDecision making for tooth replacement in the esthetic zone
LAMBERT, France ULg

Conference (2012, October 06)

Aesthetic results in implantology are determined by the harmony between the dental prostheses and the soft tissues. To reach an optimal result, each single step of the treatment has a great importance ... [more ▼]

Aesthetic results in implantology are determined by the harmony between the dental prostheses and the soft tissues. To reach an optimal result, each single step of the treatment has a great importance, from the smile analyses to the final restoration delivery. The goal of this lecture is to describe how to elaborate a treatment planning for single and multiple tooth replacement in the aesthetic zone. A decision tree for the surgical protocols will be proposed according to our clinical experience at the university of Liège and, the current scientific evidences. The biological concept of the use of biomaterial in extraction socket preservation and bone regeneration will be also discussed. The overall objective is, from an initial clinical situation, to determine the appropriate treatment approach. [less ▲]

Detailed reference viewed: 18 (2 ULg)
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See detailDecision Making from Confidence Measurement on the Reward Growth using Supervised Learning: A Study Intended for Large-Scale Video Games
Taralla, David ULg; Qiu, Zixiao ULg; Sutera, Antonio ULg et al

in Proceedings of the 8th International Conference on Agents and Artificial Intelligence (ICAART 2016) - Volume 2 (2016, February)

Video games have become more and more complex over the past decades. Today, players wander in visually and option- rich environments, and each choice they make, at any given time, can have a combinatorial ... [more ▼]

Video games have become more and more complex over the past decades. Today, players wander in visually and option- rich environments, and each choice they make, at any given time, can have a combinatorial number of consequences. However, modern artificial intelligence is still usually hard-coded, and as the game environments become increasingly complex, this hard-coding becomes exponentially difficult. Recent research works started to let video game autonomous agents learn instead of being taught, which makes them more intelligent. This contribution falls under this very perspective, as it aims to develop a framework for the generic design of autonomous agents for large-scale video games. We consider a class of games for which expert knowledge is available to define a state quality function that gives how close an agent is from its objective. The decision making policy is based on a confidence measurement on the growth of the state quality function, computed by a supervised learning classification model. Additionally, no stratagems aiming to reduce the action space are used. As a proof of concept, we tested this simple approach on the collectible card game Hearthstone and obtained encouraging results. [less ▲]

Detailed reference viewed: 492 (27 ULg)
See detailDecision making in noisy bistable switches A local analysis for non local predictions
Trotta, Laura ULg; Bullinger, Eric ULg; Sepulchre, Rodolphe ULg

Conference (2012, March)

In this paper, we try to estimate some statistics about the decision making process in a bistable model submitted to noise by studying the local properties of the system around an hyperbolic saddle point ... [more ▼]

In this paper, we try to estimate some statistics about the decision making process in a bistable model submitted to noise by studying the local properties of the system around an hyperbolic saddle point. Despite the fact that the saddle is not an equilibrium point of the stochastic system, we show that a local approach is still instructive. Under appropriate assumptions, the system can be reduced to an Orsntein-Uhlenbeck process whose dynamics depend on the properties of the saddle point. Yet, Orstein-Uhlenbeck processes have been used to study decision making under uncertainty in a broad variety of fields including statistics and cognitive neurosciences . [less ▲]

Detailed reference viewed: 47 (3 ULg)