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See detailDefense of the bovine mammary gland by polymorphonuclear neutrophil leukocytes
Paape, Max; Mehrzad, Jalil; Zhao, Xin et al

in Journal of Mammary Gland Biology and Neoplasia (2002), 7(2), 109-121

The primary phagocytic cells of the bovine mammary gland, polymorphonuclear neutrophil leukocytes (PMN), and macrophages, comprise the first line of defense against invading pathogens. In the normal ... [more ▼]

The primary phagocytic cells of the bovine mammary gland, polymorphonuclear neutrophil leukocytes (PMN), and macrophages, comprise the first line of defense against invading pathogens. In the normal healthy mammary gland, macrophages predominate and act as sentinels to invading mastitis-causing pathogens. Once invaders are detected, macrophages, and possibly mammary epithelial cells, release chemoattractants that direct migration of PMN into the area. In the mammary gland, protection is only effective if rapid influx of PMN from the circulation and subsequent phagocytosis and killing of bacteria occur. The second line of defense against infection consists of a network of memory cells and immunoglobulins that interact with the first line of defense. To minimize mammary tissue damage caused by bacterial toxins and oxidative products released by PMN, elimination of invading bacteria must proceed quickly. Therefore, the inflammatory response needs to be regulated. Hormones, metabolites, and acute phase proteins act to influence the outcome of mastitis, especially around parturition. The number of circulating PMN in cows during early lactation is highly heritable and closely related to susceptibility to clinical mastitis at this time. Advances in molecular biology are making available the tools, techniques, and products to study and modulate host-pathogen interactions. For example, the cloning and expression of proteins such as recombinant bovine soluble (rbos) CD (cluster of differentiation) 14 antigens, may provide ways of minimizing damaging effects of endotoxin during acute coliform mastitis. Soluble CD14 binds and neutralizes lipopolysacharide (LPS) and causes local recruitment of PMN after binding of CD14-LPS complexes to mammary epithelial cells. Development of transgenic animals that express rbosCD14 in their milk could prevent infection by Gram-negative pathogens. [less ▲]

Detailed reference viewed: 52 (4 ULg)
See detailLa défense sociale : réinventée ou moins paradoxale ?
Garcet, Serge ULg

Scientific conference (2014, April 29)

Detailed reference viewed: 35 (13 ULg)
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See detailDéfense végétale, biotechnologies et développement de bio-insecticides
Francis, Frédéric ULg; Blecker, Christophe ULg; Deroanne, Claude et al

in Abstract book (2006)

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See detailDefensins in (lymph)angiogenesis
Herfs, Michael ULg

Conference (2014, May)

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See detailDefensins: « simple » antimicrobial peptides or broad-spectrum molecules ?
Suarez-Carmona, Meggy ULg; Hubert, Pascale ULg; Delvenne, Philippe ULg et al

in Cytokine & Growth Factor Reviews (2015), 26

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See detailDefensis induce the recruitment of dendritic cells in cervical human papillomavirus-associated (pre)neoplastic lesions formed in vitro and transplanted in vivo
Hubert, Pascale ULg; Herman, Ludivine ULg; Maillard, Catherine ULg et al

in FASEB Journal (2007), 21(11), 2765-75

In addition to their direct antimicrobial activity, defensins might also influence adaptive immunity by attracting immature dendritic cells (DC). As these cells have been shown to be deficient in uterine ... [more ▼]

In addition to their direct antimicrobial activity, defensins might also influence adaptive immunity by attracting immature dendritic cells (DC). As these cells have been shown to be deficient in uterine cervix carcinogenesis, we evaluated the ability of -defensin (HNP-2, human neutrophil defensin 2) and ß-defensin (HßD2, human beta defensin 2) to stimulate their migration in human papillomavirus (HPV)-associated (pre)cancers. We first observed, using RT-PCR and immunohistology, that HßD2 is absent in HPV-transformed keratinocytes and that it is weakly expressed in cervical (pre)neoplastic lesions in comparison with normal keratinocytes. We next demonstrated that defensins exert a chemotactic activity for DC in a Boyden Chamber assay and stimulate their infiltration in an in vitro-formed (pre)neoplastic epithelium (organotypic culture of HPV-transformed keratinocytes). To evaluate the ability of defensins also to recruit DC in vivo, we developed a model of immunodeficient mice grafted with organotypic cultures of HPV+ keratinocytes, which form an epithelium similar to a high-grade neoplastic lesion, with tumoral invasion and neovascularization. Intravenously injected human DC were able to infiltrate grafts of HPV+ keratinocytes after administration of HNP-2 in the transplantation chamber. Taken together, these results suggest that defensins could reverse a frequent immune alteration observed in cancer development. [less ▲]

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See detailLa défensse sociale en Belgique, une matière complexe qui mérite un vaste débat
Englebert, Jérôme ULg; Aberghaz, Sabah; Follet, Valérie et al

Article for general public (2015)

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See detailDeferral vs. performance of percutaneous coronary intervention of functionally non-significant coronary stenosis: 15-year follow-up of the DEFER trial
Zimmermann, Frederik M.; Ferrara, Angela; Johnson, Nils P. et al

in European Heart Journal (2015), 36

Deferral of PCI of a functionally non-significant stenosis is associated with a favourable very long-term follow-up without signs of late ‘catch-up’ phenomenon.

Detailed reference viewed: 36 (9 ULg)
See detailDeffand, Marie de Vichy-Chamrond, marquise du
Tilkin, Françoise ULg

in Voir barré (1996), 12-13

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See detailLe défi climatique, être citoyen co-responsable pour la société de demain? L’expérience du Parlement Citoyen Climat en province de Luxembourg
Stassart, Pierre M ULg

Conference given outside the academic context (2016)

Présentation de l'expérience de parlement climat citoyen en province de Luxembourg qui s'est déroulée de septembre à novembre 2015. La triple innovation sociale autour du tirage au sort, du choix des ... [more ▼]

Présentation de l'expérience de parlement climat citoyen en province de Luxembourg qui s'est déroulée de septembre à novembre 2015. La triple innovation sociale autour du tirage au sort, du choix des experts et de la remise de l'avis au conseil provincial. Bilan provisoire [less ▲]

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See detailDéfi climatique: l'état et le marché
Gautier, Axel ULg

Conference given outside the academic context (2016)

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See detailLe défi de la diversité linguistique des apprenants pour l’apprentissage de la lecture et de l’écriture
Lucchini, Silvia ULg; Flamini, F.; Campolini, L.

in Langues Modernes (2001), (1), 34-41

Detailed reference viewed: 39 (4 ULg)
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See detailLe défi de la santé publique au Rwanda et en République démocratique du Congo.
Porignon, Denis ULg

in Porignon, Denis; et al (Eds.) L’art de la paix : approche transdisciplinaire (2003)

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See detailLE DÉFI DU CONTRÔLE LOCAL DANS LE CANCER PULMONAIRE NON A PETITES CELLULES, LOCALEMENT AVANCE, NON OPERABLE
BARTHELEMY, Nicole ULg; LENNERTS, Evelyne ULg; MEYNS, Mia ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 75-80

Le cancer broncho-pulmonaire non à petites cellules (CBNPC) est fréquent. Pour près d’un patient sur cinq, au moment du diagnostic, la maladie est déjà localement avancée et inopérable. A ce stade, le ... [more ▼]

Le cancer broncho-pulmonaire non à petites cellules (CBNPC) est fréquent. Pour près d’un patient sur cinq, au moment du diagnostic, la maladie est déjà localement avancée et inopérable. A ce stade, le pronostic de cette affection est mauvais, caractérisé, entre autres, par un taux élevé de réci - dive locale, malgré la chimiothérapie et la radiothérapie. Le but de cette revue est de décrire l’hétérogénéité de ce groupe de patients, de clarifier les modalités de traitement combinant la chimiothérapie et la radiothérapie et de préciser l’intérêt des techniques modernes de radiothérapie pour améliorer le contrôle local [less ▲]

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See detailLe défi du pluralisme culturel en Europe : le cas de Bruxelles
Martiniello, Marco ULg

Scientific conference (1991, April 05)

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See detailLe défi wallon du FDF
Counet, Maxime ULg; Matagne, Geoffroy ULg; Verjans, Pierre ULg

Learning material (2016)

Detailed reference viewed: 17 (1 ULg)