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See detailDesign Sensitivity Analysis for Shape Optimization of Nonlinear Magnetostatic Systems
Kuci, Erin ULg; Duysinx, Pierre ULg; Dular, Patrick ULg et al

in Proceedings of COMPUMAG 2015 (2015, June)

In this paper, a direct and an adjoint analytic sensitivity analysis for a nonlinear magnetostatic system is obtained, in the context of shape optimization for any design function. The calculations are ... [more ▼]

In this paper, a direct and an adjoint analytic sensitivity analysis for a nonlinear magnetostatic system is obtained, in the context of shape optimization for any design function. The calculations are based on the material derivative concept of continuum mechanics. The resulting sensitivity formula can be expressed as either a volume integral or as a boundary integral along the interface where shape modification occurs. A method for the calculation of the design velocity field and mesh updating scheme is introduced as well. The accuracy of the methodology is analysed on an inductor system, suggesting that the volume integration technique should be preferred. All methods are freely available for further testing in the open source environment GetDP/Gmsh. [less ▲]

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See detailDesign Sensitivity Analysis for Shape Optimization of Nonlinear Magnetostatic Systems
Kuci, Erin ULg; Henrotte, François; Duysinx, Pierre ULg et al

in IEEE Transactions on Magnetics (2016), 52(3),

The paper discusses the sensitivity analysis for the shape optimization of a nonlinear magnetostatic system, evaluated both by direct and adjoint approaches. The calculations rely on the Lie derivative ... [more ▼]

The paper discusses the sensitivity analysis for the shape optimization of a nonlinear magnetostatic system, evaluated both by direct and adjoint approaches. The calculations rely on the Lie derivative concept of differential geometry where the flow is the velocity field associated with the modification of a geometrical parameter in the model. The resulting sensitivity formulas can be expressed naturally in a finite element setting through a volume integral in the layer of elements connected to the surface undergoing shape modification. The accuracy of the methodology is analyzed on a 2D model of an interior permanent magnet motor (IPM), and on a 3D model of a permanent magnet system. [less ▲]

Detailed reference viewed: 45 (11 ULg)
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See detailDesign Space and desirability index. A Bayesian predictive risk-based approach to flexibly achieve multi-criteria decision methods.
Lebrun, Pierre ULg; Boulanger, Bruno; Hubert, Philippe ULg et al

Conference (2011, March 02)

The Design Space (DS) is defined as the set of factors settings (input conditions) that will provide results at least better than pre-defined acceptance limits. The proposed methodology aims at ... [more ▼]

The Design Space (DS) is defined as the set of factors settings (input conditions) that will provide results at least better than pre-defined acceptance limits. The proposed methodology aims at identifying a region in the space of factors that will likely provide satisfactory results during the future use of an analytical method or process in routine, through an optimization process. In a Bayesian framework, the responses are modelled using a multivariate multiple regression model allowing deriving their joint predictive posterior distribution. On the basis of this consequent distribution, a multi-criteria risk-based decision is taken with respect to the pre-defined acceptance limits. This aims to identify the DS. In this context, desirability methodologies are also applied to take the risk-based decision in a more flexible way. An example based on high-performance liquid chromatography illustrates the applicability of the methodology with highly correlated and constrained responses. [less ▲]

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See detailDesign space approach in the optimization of the spray-drying process
Lebrun, Pierre ULg; Krier, Fabrice ULg; Mantanus, Jérôme ULg et al

in European Journal of Pharmaceutics & Biopharmaceutics (2012), 80(1), 226-234

From a quality by design perspective, the aim of the present study was to demonstrate the applicability of a Bayesian statistical methodology to identify the design space (DS) of a spray-drying process ... [more ▼]

From a quality by design perspective, the aim of the present study was to demonstrate the applicability of a Bayesian statistical methodology to identify the design space (DS) of a spray-drying process. Following the ICH Q8 guideline, the DS is defined as the “multidimensional combination and interaction of input variables (e.g., materials attributes) and process parameters that have been demonstrated to provide assurance of quality”. Thus, a predictive risk-based approach was set up in order to account for the uncertainties and correlations found in the process and in the derived critical quality attributes such as the yield, the moisture content, the inhalable fraction of powder, the compressibility index and the Hausner ratio. This allowed quantifying the guarantees and the risks to observe whether the process shall run according to specifications. These specifications describe satisfactory quality outputs and were defined a priori given safety, efficiency and economical reasons. Within the identified DS, validation of the optimal condition was effectuated. The optimized process was shown to perform as expected, providing a product for which the quality is built in by the design and controlled set-up of the equipment, regarding identified critical process parameters: the inlet temperature, the feed rate and the spray flow rate. [less ▲]

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See detailA DESIGN SPACE APPROACH TO DEVELOP A GENERIC CE METHOD FOR THE SEPARATION OF 19 ANTIMALARIAL DRUGS
Lamalle, Caroline ULg; Marini Djang'Eing'A, Roland ULg; Debrus, Benjamin ULg et al

Poster (2010, September)

This project consists in analysing different molecules used against malaria by capillary electrophoresis (CE).

Detailed reference viewed: 77 (20 ULg)
Peer Reviewed
See detailDesign Space for analytical methods. A Bayesian perspective based on multivariate models and prediction
Lebrun, Pierre ULg; Boulanger, Bruno ULg; Jullion, Astrid et al

Conference (2008, September)

Detailed reference viewed: 35 (13 ULg)
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See detailDesign Space for Analytical Methods: Why ? What ? How ?
Rozet, Eric ULg; Debrus, Benjamin ULg; Lebrun, Pierre ULg et al

Conference (2015, January 22)

Detailed reference viewed: 28 (2 ULg)
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See detailDesign Space ou Espace de Conception
Boulanger, B.; Lebrun, Pierre ULg; Rozet, Eric ULg et al

Scientific conference (2011, November 29)

Detailed reference viewed: 35 (7 ULg)
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See detailDesign Spaces for Analytical Methods
Rozet, Eric ULg; Lebrun, Pierre ULg; Debrus, Benjamin ULg et al

in Trends in Analytical Chemistry (2013), 42

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a Quality by Design (QbD) approach, there have been many discussions on the opportunity for ... [more ▼]

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a Quality by Design (QbD) approach, there have been many discussions on the opportunity for analytical method developments to follow a similar approach. A key component of the QbD paradigm is the definition of the Design Space of analytical methods where assurance of quality is provided. Several Design Spaces for analytical methods have been published, stressing the importance of this concept. This paper aims at explaining what is an analytical method Design Space, why it is useful for the robust development and optimization of analytical methods and how to build such a Design Space. A strong emphasis is made by distinguishing the usual mean response surface approach, overlapping mean response surfaces and the desirability function one to other probabilistic approaches as only these last ones correctly define a Design Space. In addition, recent publications assessing the Design Space of analytical methods are reviewed and discussed. [less ▲]

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See detailDesign status of ASPIICS, an externally occulted coronagraph for PROBA-3
Renotte, Etienne ULg; Alia, A.; Bemporad, A. et al

in Proc. SPIE Volume 9604 Solar Physics and Space Weather Instrumentation VI (2015, September 21)

The “sonic region” of the Sun corona remains extremely difficult to observe with spatial resolution and sensitivity sufficient to understand the fine scale phenomena that govern the quiescent solar corona ... [more ▼]

The “sonic region” of the Sun corona remains extremely difficult to observe with spatial resolution and sensitivity sufficient to understand the fine scale phenomena that govern the quiescent solar corona, as well as phenomena that lead to coronal mass ejections (CMEs), which influence space weather. Improvement on this front requires eclipse-like conditions over long observation times. The space-borne coronagraphs flown so far provided a continuous coverage of the external parts of the corona but their over-occulting system did not permit to analyse the part of the white-light corona where the main coronal mass is concentrated. The proposed PROBA-3 Coronagraph System, also known as ASPIICS (Association of Spacecraft for Polarimetric and Imaging Investigation of the Corona of the Sun), with its novel design, will be the first space coronagraph to cover the range of radial distances between ~1.15 and 3 solar radii where the magnetic field plays a crucial role in the coronal dynamics, thus providing continuous observational conditions very close to those during a total solar eclipse. PROBA-3 is first a mission devoted to the in-orbit demonstration of precise formation flying techniques and technologies for future European missions, which will fly ASPIICS as primary payload. The instrument is distributed over two satellites flying in formation (approx. 150m apart) to form a giant coronagraph capable of producing a nearly perfect eclipse allowing observing the sun corona closer to the rim than ever before. The coronagraph instrument is developed by a large European consortium including about 20 partners from 7 countries under the auspices of the European Space Agency. This paper is reviewing the recent improvements and design updates of the ASPIICS instrument as it is stepping into the detailed design phase. [less ▲]

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See detailDesign Synthesis and Use of Polypeptides as Biosynthetic Nanomachines
Asano, Marie ULg

Conference (2014, March)

Detailed reference viewed: 3 (2 ULg)
See detailDesign Synthesis and Use of Polypeptides as Biosynthetic Nanomachines
Asano, Marie ULg

Conference (2013, March)

Detailed reference viewed: 2 (2 ULg)
See detailDesign Synthesis and Use of Polypeptides as Biosynthetic Nanomachines
Asano, Marie ULg

Conference (2015, March)

Detailed reference viewed: 3 (2 ULg)
See detailDesign Synthesis and Use of Polypeptides as Biosynthetic Nanomachines
Asano, Marie ULg

Scientific conference (2015)

Detailed reference viewed: 5 (3 ULg)
See detailDesign Synthesis and Use of Polypeptides as Model Systems for SMFS
Asano, Marie ULg

Scientific conference (2014, April)

Detailed reference viewed: 5 (3 ULg)
See detailLe "Design Thinking" ou comment décomplex(ifi)er l'accès à la créativité et augmenter votre efficacité
Elsen, Catherine ULg

Conference given outside the academic context (2012)

La pensée créative est à l’innovation ce que les méthodes sont à la recherche scientifique: une base essentielle. Longtemps associés à une certaine part de mystère, les mécanismes intrinsèques de la ... [more ▼]

La pensée créative est à l’innovation ce que les méthodes sont à la recherche scientifique: une base essentielle. Longtemps associés à une certaine part de mystère, les mécanismes intrinsèques de la créativité sont aujourd’hui peu à peu décryptés par les communautés de chercheurs actifs en ingénierie de la conception, en sciences sociales ou en psychologie. Un consensus semble se dégager quant à l’étendue de son application: la véritable valeur ajoutée de la créativité apparaît lorsqu’elle est appliquée, telle une culture d’entreprise, à toutes les strates d’un projet et lorsqu’elle est mise en oeuvre, sans distinction, par tout un chacun. Forts de ce constat, des entrepreneurs et inventeurs tels que David Kelley (fondateur d’IDEO, directeur de la d.school, Université de Stanford) ou Tim Brown (CEO actuel d’IDEO) ont activement développé une approche appelée le "Design Thinking". Celle-ci vise à démystifier et «décomplex(ifi)er» certains procédés favorisant la créativité et ainsi parvenir à décomplexer les acteurs généralement considérés comme «non créatifs». L’intervention abordera, au travers d’une vingtaine de «success stories», les concepts de base de la démarche. Elle se voudra avant tout à la portée de ceux et celles qui désirent ré-intégrer la créativité au sein de leur pratique professionnelle et, en finalité, augmenter leur potentiel innovant. [less ▲]

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See detailLe Design Thinking: de la "boîte noire" du designer à la boîte à outil de l'innnovateur
Elsen, Catherine ULg; Cornet, Adeline ULg

Article for general public (2012)

Ce premier article du blog d'ID Campus révèle au grand public les facettes du Design Thinking.

Detailed reference viewed: 133 (12 ULg)
See detailDesign Thinking: l'approche empathique, clé de voûte de l'entreprise créative ?
Elsen, Catherine ULg

Conference given outside the academic context (2014)

La posture créative est à l’innovation ce que l’excellence opérationnelle est à l’entreprise: une démarche désormais incontournable. Et pourtant les plus sceptiques poussent nos communautés, avec raison ... [more ▼]

La posture créative est à l’innovation ce que l’excellence opérationnelle est à l’entreprise: une démarche désormais incontournable. Et pourtant les plus sceptiques poussent nos communautés, avec raison, à poursuivre la réflexion: que reste-t-il à apprendre des méthodes créatives divergentes, comme le brainstorming par exemple ? Comment éviter à l’avenir la mise en œuvre répétitive et décontextualisée de recettes « toutes faites » qui dénaturent la créativité et nuisent à sa crédibilité ? Ces inquiétudes seront analysées par Catherine Elsen à la lumière du Design Thinking, cette approche méthodologique qui pourrait bien faire favorablement évoluer les représentations et accompagner chaque entreprise dans la mise en œuvre d’un modèle créatif qui lui correspond réellement. Esquissée dès la fin des années 80 aux Etats-Unis par des entrepreneurs et innovateurs tels que David Kelley (fondateur d’IDEO, directeur de la d.school, Université de Stanford) ou Tim Brown (CEO actuel d’IDEO), la méthode repose sur deux piliers fondamentaux: l’approche empathique (du marché, des utilisateurs, mais aussi de l’entreprise elle-même) et le « quick and rough prototyping » (ou « protocept »), soit une matérialisation itérative précoce des idées, que certains qualifient d’agile. L’intervention abordera ces fondamentaux théoriques et leur mise en œuvre pratique au travers d’exemples d’applications et d’outils ré-appropriables. [less ▲]

Detailed reference viewed: 164 (17 ULg)
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See detailDesign Thinking: une approche à intégrer à nos pratiques pour renforcer le potentiel d'innovation technologique en Wallonie ?
Elsen, Catherine ULg; Réseau Easynove

Conference given outside the academic context (2015)

Detailed reference viewed: 37 (0 ULg)
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See detailDesign tools for outdoor comfort assessment
Teller, Jacques ULg

Scientific conference (1998)

Detailed reference viewed: 33 (4 ULg)