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See detailEffect of 5 different types of exercise, transportation and ACTH administration on plasma cortisol concentration in sports horses.
Linden, Annick ULg; Art, Tatiana ULg; Amory, Hélène ULg et al

in Persson, S. G. B.; Jeffcott, L. B.; Lindholm, A. (Eds.) Equine Exercise Physiology III (1991)

This study was carried out to compare the changes in plasma cortisol concentration produced by 5 different types of exercise, transportation and ACTH administration. Venous blood was analysed for cortisol ... [more ▼]

This study was carried out to compare the changes in plasma cortisol concentration produced by 5 different types of exercise, transportation and ACTH administration. Venous blood was analysed for cortisol concentration before and after each stimulus. The types of exercise were show jumping (n=28), cross country phase of a three-day event (n=32), trot race (n=9), gallop race (n = 10) and endurance ride (n=8). The response following the intravenous injection of synthetic ACTH (200 µg) in 6 of the event horses was determined. The ACTH test was carried out one week after competition. In 5 horses, the response to road transport of one hour was studied. All stimuli, except transportation produced a significant increase in plasma cortisol concentration. The endurance ride produced the largest increase and the show jumping the smallest. ACTH administration resulted in a 164% rire in plasma cortisol. Il was concluded that I) the degree of increase in plasma cortisol concentration appeared to reflect both intensity and dotation of workload; endurance ride appeared to be the most exhaustive and show jumping the least; 2) there was a correlation (r2=0.82) between the individual cortisol response to cross country exercise and to exogenous ACTH in the saure horses and 3) there was an important individual effect on transport-induced cortisol changes. [less ▲]

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See detailEffect of 5-year risedronate therapy on fracture reduction and bone histology and histomorphometry
Watts, NB; Sorensen, O; Eriksen, E et al

in Arthritis and Rheumatism (2001), 44(1220), 256

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See detailEffect of a 30-minute infusion of dobutamine hydrochloride on hind limb blood flow and hemodynamics in halothane-anesthetized horses
Raisis, Anthea L; Young, Lesley E; Blissitt, Karen J et al

in American Journal of Veterinary Research (2000), 61(10), 1282-1288

OBJECTIVE: To evaluate the hemodynamic effects of dobutamine hydrochloride (0.5 microg/kg of body weight/min) in halothane-anesthetized horses. ANIMALS: 6 adult Thoroughbred horses. PROCEDURE: Anesthesia ... [more ▼]

OBJECTIVE: To evaluate the hemodynamic effects of dobutamine hydrochloride (0.5 microg/kg of body weight/min) in halothane-anesthetized horses. ANIMALS: 6 adult Thoroughbred horses. PROCEDURE: Anesthesia was induced by use of romifidine (100 microg/kg) and ketamine (2.2 mg/kg), IV. Anesthesia was maintained by halothane (end-tidal concentration 0.9 to 1.0%). Aortic, left ventricular, and right atrial pressures were measured, using catheter-mounted strain gauge transducers. Cardiac output (CO), velocity time integral, maximal aortic blood flow velocity and acceleration, and left ventricular preejection period and ejection time were measured from aortic velocity waveforms obtained by transesophageal Doppler echocardiography. Velocity waveforms were recorded from the femoral vessels, using Doppler ultrasonography. The time-averaged mean velocity and early diastolic deceleration slope (EDDS) were measured. Pulsatility index (PI) and volumetric flow were calculated. Microvascular perfusion was measured in the semimembranosus muscles by laser Doppler flowmetry. Data were recorded 60 minutes after induction of anesthesia (control) and at 15 and 30 minutes after start of an infusion of dobutamine (0.5 microg/kg/min). RESULTS: Aortic pressures were significantly increased during the infusion of dobutamine. No change was observed in the indices of left ventricular systolic function including CO. Femoral arterial flow significantly increased, and the PI and EDDS decreased. No change was observed in the femoral venous flow or in microvascular perfusion. CONCLUSIONS AND CLINICAL RELEVANCE: At this dosage, dobutamine did not alter left ventricular systolic function. Femoral blood flow was preferentially increased as the result of local vasodilatation. The lack of effect of dobutamine on microvascular perfusion suggests that increased femoral flow is not necessarily associated with improved perfusion of skeletal muscles [less ▲]

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See detailEffect of a 4-Week Treatment with Theophylline on Sputum Eosinophilia and Sputum Eosinophil Chemotactic Activity in Steroid-Naive Asthmatics
Louis, Renaud ULg; Bettiol, J.; Cataldo, Didier ULg et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (2000), 30(8), 1151-60

BACKGROUND: The precise mechanism of action of theophylline in asthma is not fully understood but recent data have drawn attention to its potential anti-inflammatory effect. OBJECTIVE: The purpose of this ... [more ▼]

BACKGROUND: The precise mechanism of action of theophylline in asthma is not fully understood but recent data have drawn attention to its potential anti-inflammatory effect. OBJECTIVE: The purpose of this study was to assess the effect of theophylline on sputum eosinophilia and sputum eosinophil chemotactic activity in steroid-naive asthmatics. METHOD: We performed a 4-week randomized double-blind, placebo-controlled, parallel group study in 21 mild to moderate steroid-naive asthmatics whose sputum eosinophilia was found twice > 5% during the run in period. Eleven subjects received 600 mg/24 h theophylline for the first 2 weeks and 900 mg/24 h for the last 2 weeks while 10 subjects took a placebo for 4 weeks. Sputum was induced after 2 and 4 weeks of treatment and 1 week after stopping the treatment. The sputum samples were compared for their cell counts, eosinophil cationic protein (ECP) levels and eosinophil chemotactic activity using micro-Boyden chambers. RESULTS: Serum theophylline concentrations reached 7 and 11 microg/mL at V3 and V4, respectively. Intragroup comparisons showed that theophylline, but not placebo, caused a significant reduction in sputum eosinophil counts at V3 (62 +/- 10% from baseline, P < 0.01) and a strong trend at V4 (67 +/- 16% from baseline, P = 0.07) when compared to baseline. The intergroup difference obtained after comparing the area under the curve over the 4 week treatment period only approached the statistical significance (P = 0.08). At baseline the fluid phase of the sputum contained a significant eosinophil chemotactic activity which was inhibited after a 4-week treatment by theophylline (P < 0. 01) but not by placebo. The mean sputum theophylline levels after 4 weeks of treament (1.7 microg/mL) was lower than that required to cause significant inhibition of eosinophil chemotaxis in vitro. CONCLUSION: Theophylline decreases the natural sputum eosinophil chemotactic activity present in asthmatics. However, when using a small sample size, the 35% reduction in sputum eosinophilia achieved by theophylline failed to reach statistical significance when compared to that seen after placebo. [less ▲]

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See detailEffect of a Booster Vaccination against Influenza and Equine Herpes Virus on Cardio-Respiratory Adjustments to Strenuous Exercise and Training in Thoroughbred Horses
Art, Tatiana ULg; Lekeux, Pierre ULg

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1993), 40(7), 481-491

This study was conducted in order to assess whether exercise- and training-induced cardio-respiratory adjustments are modified during the 10-day period which follows a booster vaccination with an oily ... [more ▼]

This study was conducted in order to assess whether exercise- and training-induced cardio-respiratory adjustments are modified during the 10-day period which follows a booster vaccination with an oily adjuvanted inactivated vaccine against influenza and equine herpesvirus-1 (Equiffa). Nine healthy vaccinated thoroughbred horses were used. Six were revaccinated and three were kept as control. All the horses completed a standardised exercise test (SET) that was repeated 4 times, i.e. 10 (SET1) and 2 (SET2) days before revaccination, and 2 (SET3) and 10 (SET4) days after revaccination. During the whole experimental period the horses were trained 6 days per week according to an interval training schedule. Respiratory airflow, tidal volume, respiratory rate and expired minute volume (VE) were measured using a face mask and 2 ultra-sonic pneumotachographs. The oxygen uptake (VO2) and carbon dioxide production (VCO2) were obtained on a breath-by-breath basis, using a mass spectrometer. Heart rate (HR) was continuously measured with a polar horse tester. Venous blood was sampled before and after the test and analysed for biochemical determinations. Blood was also sampled before and 21 days after the booster vaccination for circulating antibody titration. The peak VO2, VCO2, ventilatory equivalent (VE/VO2) and oxygen pulse (VO2/HR) were significantly improved by the 3-week training period. The other cardio-respiratory parameters as well as most of the blood parameters remained unchanged throughout the 4 SETs. The revaccination did not impair any of the parameters measured before, during, or after the SETs. All revaccinated horses showed a rise in antibodies against influenza virus type A1 and A2 and EVH-1 compared to the control horses. It was concluded that, in our horses, revaccination with an oily adjuvanted inactivated vaccine against influenza and EVH-1 did not impair their cardiorespiratory and metabolic adjustments to strenuous exercise and intense training, and that the seroconversion due to revaccination was unaffected by the intense daily exercise experienced by the animals in the post-vaccination period [less ▲]

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See detailEffect of a bovine colostrum supplementation in piglet diet at weaning on growth performances, food ingestion and faecal E. coli concentrations.
Boudry, Christelle ULg; Didderen, Isabelle; Wavreille, José et al

in Proceedings of the British Society of Animal Science (2005, April)

Bovine colostrum supplementation in piglets diet stimulates food intake and reduces the faecal E. coli population during the first week after weaning, inducing a liveweight gain increase. A reduction of ... [more ▼]

Bovine colostrum supplementation in piglets diet stimulates food intake and reduces the faecal E. coli population during the first week after weaning, inducing a liveweight gain increase. A reduction of the food conversion ratio was also observed, suggesting a better nutrient assimilation by the piglets. [less ▲]

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See detailEffect Of A Bovine Colostrum Whey Supplementation On Growth Performance, Faecal Escherichia Coli Population And Systemic Immune Response Of Piglets At Weaning
Boudry, Christelle ULg; Dehoux, Jean-Paul; Wavreille, José et al

in Animal (2008), 2(5), 730-737

This study examined the effect of a bovine colsotrum whey supplementation on growth performance, feed intake, faecal Escherichia coli population and systemic immune response of piglets.

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See detailEffect of a capillary meniscus on the Faraday instability threshold
Caps, Hervé ULg; NGUYN THU LAM, Khanh Dang

in European Physical Journal E -- Soft Matter (2011), 34

Threshold for Faraday instability has been experimentally measured for slightly viscous liquids. Changing the size of the container containing the fluid allows us to emphasize the role played by the ... [more ▼]

Threshold for Faraday instability has been experimentally measured for slightly viscous liquids. Changing the size of the container containing the fluid allows us to emphasize the role played by the capillary meniscus on the onset for instability. As the container is getting smaller, an upset of the critical acceleration is observed. Below a given container diameter, eigen-modes are observed along the stability curve. A dissipation terms is proposed for considering the viscous dissipation against the walls of the container. [less ▲]

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See detailEffect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized controlled trial
Spinewine, A.; Swine, C.; Dhillon, S. et al

in Journal of the American Geriatrics Society (2007), 55(5), 658-665

OBJECTIVES: To evaluate the effect of pharmaceutical care provided in addition to acute Geriatric Evaluation and Management (GEM) care on the appropriateness of prescribing. DESIGN: Randomized, controlled ... [more ▼]

OBJECTIVES: To evaluate the effect of pharmaceutical care provided in addition to acute Geriatric Evaluation and Management (GEM) care on the appropriateness of prescribing. DESIGN: Randomized, controlled trial, with the patient as unit of randomization. SETTING: Acute GEM unit. PARTICIPANTS: Two hundred three patients aged 70 and older. INTERVENTION: Pharmaceutical care provided from admission to discharge by a specialist clinical pharmacist who had direct contacts with the GEM team and patients. MEASUREMENTS: Appropriateness of prescribing on admission, at discharge, and 3 months after discharge, using the Medication Appropriateness Index (MAI), Beers criteria, and Assessing Care of Vulnerable Elders (ACOVE) underuse criteria and mortality, readmission, and emergency visits up to 12 months after discharge. RESULTS: Intervention patients were significantly more likely than control patients to have an improvement in the MAI and in the ACOVE underuse criteria from admission to discharge (odds ratio (OR)=9.1, 95% confidence interval (CI)=4.2-21.6 and OR=6.1, 95% CI=2.2-17.0, respectively). The control and intervention groups had comparable improvements in the Beers criteria. CONCLUSION: Pharmaceutical care provided in the context of acute GEM care improved the appropriate use of medicines during the hospital stay and after discharge. This is an important finding, because only limited data exist on the effect of various strategies to improve medication use in elderly inpatients. The present approach has the potential to minimize risk and improve patient outcomes. [less ▲]

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See detailEffect of a combined iodine and selenium supplementation on I and Se status of cows and their calves
Guyot, Hugues ULg; Alves de Oliveira, Laurent; Ramery, Eve ULg et al

in Journal of Trace Elements in Medicine and Biology (2011), 25(2), 118-124

Iodine (I) and selenium (Se) deficiencies are commonly reported in cattle, however, there are also studies regarding a very high iodine supply. The aim of the study was to determine the long-term effect ... [more ▼]

Iodine (I) and selenium (Se) deficiencies are commonly reported in cattle, however, there are also studies regarding a very high iodine supply. The aim of the study was to determine the long-term effect of I and Se supplementation on non-pregnant cows, pregnant cows and their calves. The hypothalamus pituitary axis was investigated (TSH, T4, T3 assays) during a TRH challenge on non-pregnant cows. Twenty-four cows, half of them pregnant, were assigned into 2 diet-groups, one group with a low I (0.45 ppm) and Se (0.15 ppm) diet (LISe), the other with a high I (5.45 ppm) and Se (0.45 ppm) diet (HISe), for a period of 120 days. Nutritional (plasma iodide, urinary I, plasma Se, I content in colostrum and foetal fluids) and functional (thyrotropin, thyroid hormones, glutathione-peroxidase activity in erythrocytes) markers of I and Se status were assayed in dams at regular intervals for 120 days and in their calves at birth. A TRH challenge was performed on 8 non-pregnant cows at day 110 of the trial. At the end of the study, I and Se nutritional markers were higher in dams in the HISe group, compared to the LISe group, except for plasma Se. At birth, I nutritional markers in calves in the HISe group were higher compared to the LISe group. Reactivity of the pituitary–thyroid-axis was not influenced by I and Se supplementation. I and Se supplementation is efficient in improving newborn status. [less ▲]

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See detailEffect of a corpus luteum with or without a cavity on fertility in dairy cows after prostaglandin treatment
Repasi, A.; Melo de Sousa, Noelita ULg; Beckers, Jean-François ULg et al

in Proceedings of the Hungarian Association for Buiatrics (2010, October)

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See detailEffect of a decrease in sample dimensions on plasticity: application to the micro-forming of nickel
Keller, Clément ULg; Afteni, Mitica; Banu, M. et al

in Steel Research International (2010), 81(9), 1173-1177

The mechanical behavior of polycrystalline nickel is investigated in tension as a function of the dimensions. Experimental tests and finite element simulations with a crystalline plasticity code are ... [more ▼]

The mechanical behavior of polycrystalline nickel is investigated in tension as a function of the dimensions. Experimental tests and finite element simulations with a crystalline plasticity code are carried out for samples with thicknesses ranging between 12.5 μm and 3.2 mm and grain size around 100 μm. Results show three different kinds of behavior depending on the number of grains across the thickness due to the apparition of stress and dislocation density gradients. Bulge tests are then used to study the formability of nickel polycrystals with thickness lower than 400 μm. [less ▲]

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See detailEffect of a decreased gas density on the machanics of breathing in running ponies
Lekeux, Pierre ULg; Art, Tatiana ULg

in Proceedings of the Seventh Veterinary Respiratory Symposium (1988, November 12)

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