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See detailDelayed neuroendocrine sexual maturation in female rats after a very low dose of Bisphenol A through altered GABAergic neurotransmission and opposing effects of a high dose.
Franssen, Delphine ULg; GERARD, Arlette ULg; HENNUY, Benoit ULg et al

in Endocrinology (2016)

Rat sexual maturation is preceded by a reduction of the interpulse interval (IPI) of gonadotropinreleasing hormone (GnRH) neurosecretion. This work aims at studying disruption of that neuroendocrine event ... [more ▼]

Rat sexual maturation is preceded by a reduction of the interpulse interval (IPI) of gonadotropinreleasing hormone (GnRH) neurosecretion. This work aims at studying disruption of that neuroendocrine event in females after early exposure to a very low dose of Bisphenol A (BPA), a ubiquitous endocrine disrupting chemical. Female rats were exposed to vehicle or BPA 25 ng/kg.day, 25 g/kg.day, or 5 mg/kg.day from postnatal day (PND) 1 to 5 or 15. Exposure to 25 ng/kg.day of BPA for 5 or 15 days was followed by a delay in developmental reduction of GnRH IPI studied ex vivo on PND 20. After 15 days of exposure to that low dose of BPA, vaginal opening tended to be delayed. In contrast, exposure to BPA 5 mg/kg.day for 15 days resulted in a premature reduction inGnRHIPI and a trend toward early vaginal opening. RNAseq analysis on PND20 indicated that exposure to BPA resulted in opposing dose effectsonthemRNAexpression of hypothalamic genes involved inGABAA neurotransmission. The study of GnRH secretion in vitro in the presence of GABAA receptor agonist/antagonist confirmed an increased or a reduced GABAergic tone after in vivo exposure to the very low or the high dose of BPA, respectively. Overall, we show for the first time that neonatal exposure to BPA leads to opposing dose-dependent effects on the neuroendocrine control of puberty in the female rat. A very low and environmentally relevant dose of BPA delays neuroendocrine maturation related to puberty through increased inhibitory GABAergic neurotransmission. [less ▲]

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See detailDelayed neutrophil apoptosis in bovine subclinical mastitis.
Boutet, Philippe ULg; Boulanger, D.; Gillet, Laurent ULg et al

in Journal of Dairy Science (2004), 87(12), 4104-4114

Bovine subclinical mastitis can be defined as a moderated inflammatory disease characterized by a persistent accumulation of neutrophils in milk. As GMCSF-mediated delay of neutrophil apoptosis ... [more ▼]

Bovine subclinical mastitis can be defined as a moderated inflammatory disease characterized by a persistent accumulation of neutrophils in milk. As GMCSF-mediated delay of neutrophil apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many human diseases, we sought to determine whether subclinical mastitis in cows is also associated with a GMCSF-dependent increase in milk-neutrophil survival. We first addressed the hypothesis that GMCSF delays bovine neutrophil apoptosis by activation of the signal transducer and activator of transcription (STAT) family members STAT3 and STAT5, which are critical regulators of the expression of various Bcl-2 family proteins. Granulocyte-macrophage colony-stimulating factor significantly delayed apoptosis of blood neutrophils obtained from healthy cows. In these cells, GMCSF activated STAT5, but not STAT3, and induced an increase in the mRNA of the antiapoptotic Bcl-2 member, Bcl-xL. Granulocyte-macrophage colony-stimulating factor-dependent STAT5 activation and up-regulation of Bcl-xL mRNA were blocked by the Jak inhibitor, AG-490. This inhibition was associated with abrogation of the prosurvival effect of GMCSF, demonstrating a key role for STAT5 in delayed neutrophil apoptosis. We further found that GMCSF expression was increased in milk cells from cows affected with subclinical mastitis. Neutrophils from these cows demonstrated a significant delay of apoptosis as compared with neutrophils obtained from healthy cows and were unresponsive to GMCSF. Active STAT5 complexes were detected in these neutrophils. Finally, in the presence of AG-490, apoptosis was induced and a time-dependent down-regulation of Bcl-xL mRNA was observed in milk neutrophils from mastitis-affected cows. These results indicate that neutrophil survival is enhanced in milk of subclinical mastitis-affected cows and suggest a role for a GMCSF-activated STAT5 signaling pathway in this phenomenon. This pathway could thus represent a target for the control of persistent accumulation of neutrophils in the bovine mammary gland [less ▲]

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See detailDelayed onset muscle soreness induced by eccentric isokinetic exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Forthomme, Bénédicte ULg et al

in Isokinetics & Exercise Science (2003), 11(1), 21-29

Delayed onset muscle soreness (DOMS) follows unaccustomed muscular exercise, most notably in the eccentric mode. That concept refers to a dull ache combined with tenderness, stiffness and weakness of the ... [more ▼]

Delayed onset muscle soreness (DOMS) follows unaccustomed muscular exercise, most notably in the eccentric mode. That concept refers to a dull ache combined with tenderness, stiffness and weakness of the previously active muscles. lsokinetic device constitutes a specific model in generating and investigating DOMS. Respective effects of concentric and eccentric actions have been compared, emphasizing on the variability in the response (serum activity of CK for instance). The particular sensitivity of the hamstrings was underlined although causes remained unexplained. Some treatment have been proposed in the management of DOMS. Several studies reported that anti-inflammatory agents fail to alleviate pain and discomfort even if other authors indicated a relative effectiveness. Based on the repeated-bout effect, submaximal eccentric exercise currently represent the most useful preventive strategy. [less ▲]

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See detailDelayed Paraplegia After Endovascular Treatment of a Thoracoabdominal Aortic Aneurysm Successfully Managed Using Cerebrospinal Fluid Drainage.
Azevedo Mendes, Manuel; Szecel, Delphine; Hans, Greogry A. et al

in Journal of Cardiothoracic and Vascular Anesthesia (2016)

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See detailDelayed puberty in a girl due to an inactivating mutation of the LH receptor
FUDVOYE, Julie ULg; PARENT, Anne-Simone ULg; Bourguignon, Jean-Pierre ULg

Poster (2012, March)

We report the case of a 46 XY patient with a disorder of sex differentiation (DSD) caused by an inactivating mutation of the LH receptor. Mutations of genes involved in hypothalamic-pituitary-gonadal ... [more ▼]

We report the case of a 46 XY patient with a disorder of sex differentiation (DSD) caused by an inactivating mutation of the LH receptor. Mutations of genes involved in hypothalamic-pituitary-gonadal function are rare but they provide an experience of nature for understanding the physiology and the pathophysiology of gonadotropins actions. There arise from correlation between the phenotypes and genotypes in those unique conditions. Management of this particular patient with no LH activity involves oestrogen replacement therapy to induce breast development together with a gonadectomy due to the risk of gonadoblastoma in streak gonads. [less ▲]

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See detailDelayed reepithelialization and scarring deregulation following drug-induced toxic epidermal necrolysis.
Paquet, Philippe ULg; Jacob, E.; Quatresooz, Pascale ULg et al

in Burns (2007), 33(1), 100-4

A 51-year-old Caucasian woman developed severe drug-induced toxic epidermal necrolysis (TEN) due to allopurinol. The withdrawal of the culprit drug was unfortunately delayed, and dramatic retardation of ... [more ▼]

A 51-year-old Caucasian woman developed severe drug-induced toxic epidermal necrolysis (TEN) due to allopurinol. The withdrawal of the culprit drug was unfortunately delayed, and dramatic retardation of reepithelialization was observed. At that stage of disease evolution, an inflammatory cell infiltrate was present in the dermis. Coverage of eroded lesions by frozen cultured keratinocyte allografts failed to hasten reepithelialization compared to ungrafted sites. This unusual protracted TEN evolution was followed by the development of extensive hypertrophic and keloid scars. Several biopsies were taken over 6 months. The histologic presentation of the grafted and ungrafted eroded scar tissues looked similar. Both the number and size of the Factor XIIIa-positive dermal dendrocytes, as well as the number of alpha-actin-positive myofibroblasts showed a marked increase between weeks 2 and 12 after grafting. They were reduced after 6 months when the scarring process was stabilized. alpha1 [IV] collagen was never expressed over the eroded scars. Similar to burn patients, delayed reepithelialization might be a risk factor for abnormal scarring in TEN. Cultured keratinocyte allograft apparently offered no improvement in reepithelialization and did not prevent abnormal scarring in this TEN patient. [less ▲]

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See detailDelayed-Onset Muscle Soreness : treatment or prevention ?
Hody, Stéphanie ULg

Conference (2009, March 05)

Detailed reference viewed: 50 (13 ULg)
See detailDelayed-onset profound biotinidase deficiency.
Wolf, B.; Pomponio, R. J.; Norrgard, K. J. et al

in The Journal of pediatrics (1998), 132(2), 362-5

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb ... [more ▼]

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb weakness, spastic paresis, and eye problems, such as loss of visual acuity and scotomata, rather than the more characteristic symptoms observed in young untreated children with the disorder. These older children each have different mutations, but they are the same as those of children who have exhibited symptoms at an early age. Biotinidase deficiency should be considered in older children who suddenly experience limb weakness and/or spastic paresis and eye symptoms. [less ▲]

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See detailDelayed-onset profound biotnidase deficiency
Wolf, B.; Pomponio, R.; Norrgard, K. et al

in Journal of Pediatrics (1998), 132(2), 362-365

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb ... [more ▼]

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb weakness, spastic paresis, and eye problems, such as loss of visual acuity and scotomata, rather than the more characteristic symptoms observed in young untreated children with the disorder. These older children each have different mutations, but they are the same as those of children who have exhibited symptoms at on early age. Biotinidase deficiency should be considered in older children who suddenly experience limb weakness and/or spastic paresis and eye symptoms. [less ▲]

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See detailDelays in claiming social security benefits
Jousten, Alain ULg; Diamond, P.; Coile, C. et al

in Journal of Public Economics (2002), 84

This paper focuses on Social Security benefit claiming behavior, a take-up decision that has been ignored in the previous literature. Using financial calculations and simulations based on an expected ... [more ▼]

This paper focuses on Social Security benefit claiming behavior, a take-up decision that has been ignored in the previous literature. Using financial calculations and simulations based on an expected utility maximization model, we show that delaying benefit claim for a period of time after retirement is optimal in a wide variety of cases and that gains from delay may be significant.We find that approximately 10% of men retiring before their 62nd birthday delay claiming for at least 1 year after eligibility. We estimate hazard and probit models using data from the New Beneficiary Data System to test four cross-sectional predictions. While the data suggest that too few men delay, we find that the pattern of delays by early retirees is generally consistent with the hypotheses generated by our theoretical model. [less ▲]

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See detailDelegation and Information Revelation
Gautier, Axel ULg; Paolini, Dimitri

in Journal of Institutional and Theoretical Economics = Zeitschrift für die Gesamte Staatswissenschaft (2007), 163

This paper analyzes, in a set-up where only the control over actions is contractible, the rationale for delegation. An organization must take two decisions. The payoffs are affected by a random parameter ... [more ▼]

This paper analyzes, in a set-up where only the control over actions is contractible, the rationale for delegation. An organization must take two decisions. The payoffs are affected by a random parameter and only the agent knows its realization. If the principal delegates the control over the first decision to the agent, his choice may indicate the information that he possesses. If the principal retains control over the second decision, discovering this information is valuable. Hence, this paper provides a new rationale for delegation: A transfer of control to the informed party can be used to discover the private information. (JEL: D23, D82, L22 , M41) [less ▲]

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See detailDélégation par abandon ; approche psychologique
Born, Michel ULg

in Les politiques sociales (1999), 3-4

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See detailDelegation, externalities and organizational design
Gautier, Axel ULg; Paolini, Dimitri

in Economics Bulletin (2009), 29(4),

In a repeated interaction between a principal and two agents with inter-agents externalities and asymmetric information, we show that optimal decentralization within the organization is limited to the ... [more ▼]

In a repeated interaction between a principal and two agents with inter-agents externalities and asymmetric information, we show that optimal decentralization within the organization is limited to the first period and across agents. [less ▲]

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See detailLe délégué à la gestion journalière et les délégations particulières de pouvoir
Caprasse, Olivier ULg

in L'organisation du pouvoir dans la société anonyme (2004)

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See detailDeleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity.
Lopez-Herrera, Gabriela; Tampella, Giacomo; Pan-Hammarstrom, Qiang et al

in American Journal of Human Genetics (2012), 90(6), 986-1001

Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently not well understood. Most affected individuals are simplex cases, but both autosomal-dominant and autosomal-recessive ... [more ▼]

Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently not well understood. Most affected individuals are simplex cases, but both autosomal-dominant and autosomal-recessive inheritance have been described. We performed genetic linkage analysis in consanguineous families affected by hypogammaglobulinemia. Four consanguineous families with childhood-onset humoral immune deficiency and features of autoimmunity shared genotype evidence for a linkage interval on chromosome 4q. Sequencing of positional candidate genes revealed that in each family, affected individuals had a distinct homozygous mutation in LRBA (lipopolysaccharide responsive beige-like anchor protein). All LRBA mutations segregated with the disease because homozygous individuals showed hypogammaglobulinemia and autoimmunity, whereas heterozygous individuals were healthy. These mutations were absent in healthy controls. Individuals with homozygous LRBA mutations had no LRBA, had disturbed B cell development, defective in vitro B cell activation, plasmablast formation, and immunoglobulin secretion, and had low proliferative responses. We conclude that mutations in LRBA cause an immune deficiency characterized by defects in B cell activation and autophagy and by susceptibility to apoptosis, all of which are associated with a clinical phenotype of hypogammaglobulinemia and autoimmunity. [less ▲]

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