Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Peer Reviewed
See detailDesign and synthesis of aromatic esters and amides of 6-chloromethyl-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of α-chymotrypsin
Pochet, L.; Doucet, C.; Schynts, M. et al

Conference (1996, May)

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailDesign and synthesis of aromatic esters and amides of 6-chloromethyl-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of α-chymotrypsin
Pochet, L.; Doucet, C.; Schynts, M. et al

in Journal de Pharmacie de Belgique (1996), 51

Detailed reference viewed: 24 (3 ULg)
See detailDesign and synthesis of D,D-peptidase inhibitors
Ghosez, Léon; Dive, Georges ULg; Dumas, Stéphane et al

in Antibiotics and antiviral compounds: chemical synthesis and modification (1993)

Detailed reference viewed: 21 (3 ULg)
Full Text
See detailDesign and synthesis of high-affinity ligands of AMPA receptors and study of their Fluorine-18 radiolabeling
Deverdenne, François ULg; Goffin, Eric ULg; Plenevaux, Alain ULg et al

Poster (2014, June 05)

The AMPA subtype of glutamatergic receptors is the main actor in the excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the ... [more ▼]

The AMPA subtype of glutamatergic receptors is the main actor in the excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the maintenance of the long-term potentiation, a phenomenon closely linked to cognitive and memorization processes. Based on experimental data collected in recent years, the use of AMPA potentiators seems to be an interesting approach in the treatment of cognitive deficits (e.g. Alzheimer disease), schizophrenia or depression. Such AMPA signal potentiation could be mediated by positive allosteric modulators (PAMs) of the AMPA receptors, a class of compounds able to produce a fine signal tuning in the presence of the endogenous ligand in the synapse, providing less toxicity than direct agonists. With this approach, the laboratory of Medicinal Chemistry of Liège university developed many series of AMPA potentiators , among which 1,2,4-benzothiadiazine 1,1-dioxides (BTDs). In order to better understand the in vivo mapping of AMPA receptors and its evolution in neurological diseases, the present work aims at developing the design and the synthesis of BTDs positive allosteric modulators radiolabeled with a fluorine-18 atom. Based on previously synthesized series in this field, we investigate the synthesis of a new class of high-affinity AMPA potentiators characterized by the presence of a fluorine atom at selected positions on the structure of the AMPA potentiators. Thanks to in vitro pharmacological evaluations, we will further determine the best candidates for their fluorine-18 radiolabeling. [less ▲]

Detailed reference viewed: 67 (8 ULg)
Full Text
Peer Reviewed
See detailDesign and synthesis of novel DOTA(Gd3+)–polymer conjugates as potential MRI contrast agents
Grogna, Mathurin ULg; Cloots, Rudi ULg; Luxen, André ULg et al

in Journal of Materials Chemistry (2011), 21(34), 12917-12926

Conventional low molecular weight gadolinium based Magnetic Resonance Imaging (MRI) contrast agents such as Magnevist® are very useful for imaging tissues. However, at the high magnetic fields used in ... [more ▼]

Conventional low molecular weight gadolinium based Magnetic Resonance Imaging (MRI) contrast agents such as Magnevist® are very useful for imaging tissues. However, at the high magnetic fields used in modern MRI equipments, their relaxivity (contrasting efficiency) is rather poor. The grafting of the gadolinium complex onto macromolecules is a way to enhance their relaxivity provided that the rotational motion of the complex is decreased significantly. Here we report the design of novel Gd3+ based MRI contrast agents with improved relaxivity and potential long blood circulation life-time. We investigate the grafting of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester (DO3AtBu-NH2; a precursor of Gd3+ ligand) onto well-defined functional copolymers bearing activated esters (succinimidyl esters) and poly(ethylene oxide) (PEO) chains required for stealthiness. The tert-butyl groups of grafted DO3AtBu-NH2 are then deprotected by trifluoroacetic acid followed by complexation of Gd3+. Addition of free DOTA at the end of the reaction is necessary to leave the pure and stable water soluble macrocontrast agent. Importantly it shows a relaxivity at high frequencies that is 300% higher than that of the ungrafted gadolinium complex. These novel functional copolymers are therefore promising candidates as macromolecular contrast agents for MRI applications. [less ▲]

Detailed reference viewed: 41 (11 ULg)
Full Text
See detailDesign and synthesis of PET-probes targeting AMPA subtype receptors
Deverdenne, François ULg; Claes, Giselle ULg; Goffin, Eric ULg et al

Poster (2015, May 13)

The AMPA subtype of glutamatergic receptors is the main actor in the fast excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the ... [more ▼]

The AMPA subtype of glutamatergic receptors is the main actor in the fast excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the maintenance of the long-term potentiation, a phenomenon closely linked to cognitive and memorization processes. Based on experimental data, it also appears that glutamatergic systems are involved in several pathological diseases. For instance, a lack of glutamatergic neurotransmission is observed in cognitive disorders or schizophrenia and an excessive activity is observed in Parkinson or Huntington diseases. The in vivo study of glutamate receptors mapping and its evolution appears to be an essential step for a better understanding of its implications. However, according to the literature, design of such a probe remains difficult due to the lack of specificity of the probes. Taking into account the potential in vitro and in vivo activity and specificity of benzothiadizine dioxides (BTDs) acting as AMPA positive allosteric modulators, we are investing the development of new compounds of this class radiolabeled with a fluorine-18 atom. Hence, we are currently developing new series of BTDs characterized by the presence of a fluorine atom and a 7-phenoxy-substituent that are expected to be more active and more specific. Finally, pharmacological tests to evaluate the best candidates for the radiochemical synthesis and in vivo evaluations are currently in progress. [less ▲]

Detailed reference viewed: 39 (6 ULg)
Full Text
See detailDesign and synthesis of PET-probes targeting AMPA-subtype receptors
Deverdenne, François ULg; Claes, Giselle ULg; Goffin, Eric ULg et al

Poster (2015, June 05)

The AMPA subtype of glutamatergic receptors is the main actor in the excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the ... [more ▼]

The AMPA subtype of glutamatergic receptors is the main actor in the excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the maintenance of the long-term potentiation, a phenomenon closely linked to cognitive and memorization processes. Based on experimental data collected in recent years, the use of AMPA potentiators seems to be an interesting approach in the treatment of cognitive deficits (e.g. Alzheimer disease), schizophrenia or depression. Such AMPA signal potentiation could be mediated by positive allosteric modulators (PAMs) of the AMPA receptors, a class of compounds able to produce a fine signal tuning in the presence of the endogenous ligand in the synapse, providing less toxicity than direct agonists. With this approach, the laboratory of Medicinal Chemistry of Liège university developed many series of AMPA potentiators , among which 1,2,4-benzothiadiazine 1,1-dioxides (BTDs). In order to better understand the in vivo mapping of AMPA receptors and its evolution in neurological diseases, the present work aims at developing the design and the synthesis of BTDs positive allosteric modulators radiolabeled with a fluorine-18 atom. Based on previously synthesized series in this field, we investigate the synthesis of a new class of high-affinity AMPA potentiators characterized by the presence of a fluorine atom at selected positions on the structure of the AMPA potentiators. Thanks to in vitro pharmacological evaluations, we will further determine the best candidates for their fluorine-18 radiolabeling. [less ▲]

Detailed reference viewed: 75 (7 ULg)
Full Text
Peer Reviewed
See detailDesign and test of a circular notch hinge
Merken, Patrick; Smal, Olivier; Debongnie, Jean-François ULg et al

in Proceedings of the International Precision Assembly Seminar (2004, February)

At the microscale, classical bearings such as ball bearings, sliding bearings and other pivots may be difficult to manufacture. Among all possible solutions to replace them, the notch hing seems to be ... [more ▼]

At the microscale, classical bearings such as ball bearings, sliding bearings and other pivots may be difficult to manufacture. Among all possible solutions to replace them, the notch hing seems to be very attractive through its many advantages. The major limitation is on the rotation angle. This paper presents a new simplified analytical model for the prediction of the maximum angular displacement and the angular stiffness of a notch hinge. To validate our model, an experimental set-up has been developed. [less ▲]

Detailed reference viewed: 92 (5 ULg)
Full Text
See detailDesign and tests for the heliospheric imager of the STEREO mission
Defise, Jean-Marc ULg; Halain, Jean-Philippe ULg; Mazy, Emmanuel ULg et al

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (2002)

The Heliospheric Imager (HI) is part of the SECCHI suite of instruments on-board the two STEREO spacecrafts to be launched in 2005. The two HI instruments will provide stereographic image pairs of solar ... [more ▼]

The Heliospheric Imager (HI) is part of the SECCHI suite of instruments on-board the two STEREO spacecrafts to be launched in 2005. The two HI instruments will provide stereographic image pairs of solar coronal plasma and coronal mass ejections (CME) over a wide field of view (~90°), ranging from 13 to 330 R[SUB]0[/SUB]. These observations compliment the 15 R[SUB]0[/SUB] field of view of the solar corona obtained by the other SECCHI instruments (2 coronagraphs and an EUV imager). The key challenge of the instrument design is the rejection of the solar disk light, with total straylight attenuation of the order of 10[SUP]-13 [/SUP]to 10[SUP]-15[/SUP]. A multi-vane diffractive baffle system has been theoretically optimized to achieve the lower requirement (10[SUP]-13[/SUP] for HI-1) and is combined with a secondary baffling system to reach the 10[SUP]-15[/SUP] rejection performance in the second camera system (HI-2). This paper presents the last updates of the SECCHI/HI design concept, with the expected performance. A verification program is currently in progress. The on-going stray-light verification tests are discussed. A set of tests has been conducted in air, and under vacuum. The results are presented and compared with the expected theoretical data. [less ▲]

Detailed reference viewed: 45 (4 ULg)
Full Text
See detailDesign and tests for the heliospheric imager of the STEREO mission
Defise, Jean-Marc ULg; Halain, Jean-Philippe ULg; Mazy, Emmanuel ULg et al

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (2003, February 01)

The Heliospheric Imager (HI) is part of the SECCHI suite of instruments on-board the two STEREO spacecrafts to be launched in 2005. The two HI instruments will provide stereographic image pairs of solar ... [more ▼]

The Heliospheric Imager (HI) is part of the SECCHI suite of instruments on-board the two STEREO spacecrafts to be launched in 2005. The two HI instruments will provide stereographic image pairs of solar coronal plasma and coronal mass ejections (CME) over a wide field of view (~90°), ranging from 13 to 330 R[SUB]0[/SUB]. These observations compliment the 15 R[SUB]0[/SUB] field of view of the solar corona obtained by the other SECCHI instruments (2 coronagraphs and an EUV imager). The key challenge of the instrument design is the rejection of the solar disk light, with total straylight attenuation of the order of 10[SUP]-13 [/SUP]to 10[SUP]-15[/SUP]. A multi-vane diffractive baffle system has been theoretically optimized to achieve the lower requirement (10[SUP]-13[/SUP] for HI-1) and is combined with a secondary baffling system to reach the 10[SUP]-15[/SUP] rejection performance in the second camera system (HI-2). This paper presents the last updates of the SECCHI/HI design concept, with the expected performance. A verification program is currently in progress. The on-going stray-light verification tests are discussed. A set of tests has been conducted in air, and under vacuum. The results are presented and compared with the expected theoretical data. [less ▲]

Detailed reference viewed: 16 (7 ULg)
Full Text
Peer Reviewed
See detailDesign and Tests of Prestressed Concrete Beams
Franssen, Jean-Marc ULg; Brüls, Aloïs

in Hasemi (Ed.) Proc. 5th Int. Symp. on Fire Safety Science (1997)

Detailed reference viewed: 33 (3 ULg)
Full Text
Peer Reviewed
See detailDesign and validation of a real-time spiking-neural-network decoder for brain–machine interfaces
Dethier, Julie ULg; Nuyujukian, Paul; Ryu, Stephen I et al

in Journal of Neural Engineering (2013), 10(3),

Objective. Cortically-controlled motor prostheses aim to restore functions lost to neurological disease and injury. Several proof of concept demonstrations have shown encouraging results, but barriers to ... [more ▼]

Objective. Cortically-controlled motor prostheses aim to restore functions lost to neurological disease and injury. Several proof of concept demonstrations have shown encouraging results, but barriers to clinical translation still remain. In particular, intracortical prostheses must satisfy stringent power dissipation constraints so as not to damage cortex. Approach. One possible solution is to use ultra-low power neuromorphic chips to decode neural signals for these intracortical implants. The first step is to explore in simulation the feasibility of translating decoding algorithms for brain–machine interface (BMI) applications into spiking neural networks (SNNs). Main results. Here we demonstrate the validity of the approach by implementing an existing Kalman-filter-based decoder in a simulated SNN using the Neural Engineering Framework (NEF), a general method for mapping control algorithms onto SNNs. To measure this system's robustness and generalization, we tested it online in closed-loop BMI experiments with two rhesus monkeys. Across both monkeys, a Kalman filter implemented using a 2000-neuron SNN has comparable performance to that of a Kalman filter implemented using standard floating point techniques. Significance. These results demonstrate the tractability of SNN implementations of statistical signal processing algorithms on different monkeys and for several tasks, suggesting that a SNN decoder, implemented on a neuromorphic chip, may be a feasible computational platform for low-power fully-implanted prostheses. The validation of this closed-loop decoder system and the demonstration of its robustness and generalization hold promise for SNN implementations on an ultra-low power neuromorphic chip using the NEF. [less ▲]

Detailed reference viewed: 62 (12 ULg)
Full Text
Peer Reviewed
See detailDesign and verification of the Far Ultraviolet Spectrographic Imager (FUV-SI) for the IMAGE mission
Renotte, Etienne ULg; Habraken, Serge ULg; Rochus, Pierre ULg et al

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (1998, November 01)

The IMAGE FUV-SI is simultaneously imaging auroras at 121.8 nm and 135.8 nm. The spectrograph design challenge is the efficient rejection of the intense Lyman-alpha emission at 121.6 nm while passing its ... [more ▼]

The IMAGE FUV-SI is simultaneously imaging auroras at 121.8 nm and 135.8 nm. The spectrograph design challenge is the efficient rejection of the intense Lyman-alpha emission at 121.6 nm while passing its Doppler-shifted component at 121.8 nm. The FUV-SI opto-mechanical design, analysis integration, and verification of performances against environment are discussed in this paper. In absence of STM environmental constraints at subsystem levels are derived analytically from F.E.M. and used for pre-qualifying optical subsystems. [less ▲]

Detailed reference viewed: 60 (9 ULg)
Peer Reviewed
See detailDesign as conceptual research and political instrument: role and legacy of the Italian Radical movement
Prina, Daniela ULg

in Glynne, Jonathan; Hackney, Fiona; Minton, Viv (Eds.) Proceedings of the 2008 Annual International Conference of the Design History Society (UK) University College Falmouth, 3-6 September (2010, June 01)

Detailed reference viewed: 17 (1 ULg)
Peer Reviewed
See detailIl design come strumento di lotta politica : il contributo del movimento Radical tra Firenze e Torino (1965-1975)
Prina, Daniela ULg

in Balicco, Daniele (Ed.) Made in Italy e cultura - Indagine sull'identità italiana contemporanea (2015)

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailIl design come strumento politico e ideologico, tra Firenze e Torino (1965-1975)
Prina, Daniela ULg

in Allegoria (2014), 68(2), 76-86

Detailed reference viewed: 47 (12 ULg)