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See detailDetermination of the Expansion Rate and Incidence of Rupture of Abdominal Aortic Aneurysms
Limet, Raymond ULg; Sakalihasan, Natzi ULg; Albert, Adelin ULg

in Journal of Vascular Surgery : Official Publication, the Society for Vascular Surgery and International Society For Cardiovascular Surgery, North American Chapter (1991), 14(4), 540-8

Expansion rate and incidence of rupture of abdominal aortic aneurysms in relation to their size is a source of debate. We studied 114 patients (out of a cohort of 752 consecutive patients admitted with ... [more ▼]

Expansion rate and incidence of rupture of abdominal aortic aneurysms in relation to their size is a source of debate. We studied 114 patients (out of a cohort of 752 consecutive patients admitted with abdominal aortic aneurysms) who were denied any immediate operation because of patient's refusal, high surgical risk, or small transverse diameter as assessed by CT scanning and ultrasonography. All patients not operated on underwent from two to six repeated examinations during an average follow-up period of 26.8 months (range, 3 to 132). Forty-seven patients (41.2%) were subsequently operated on electively because of marked increase of transverse diameter of the aneurysm (n = 44) or for other reasons (n = 3), with a death rate of 0%. Eighteen other patients underwent emergency operation for leaking or ruptured aneurysms, and there were five deaths. The incidence of rupture was clearly related to the final diameter value, rising from 0% in aneurysms less than 40 mm to 22% in large size aneurysms (greater than or equal to 50 mm). Among the 49 patients not operated on, one died of rupture before operation and five of causes unrelated to the disease. Using individual serial measurements, we determined the linear expansion rate of the aneurysm, which proved to be related to initial diameter values: 5.3 mm/year for diameters less than 40 mm (n = 49), 6.9 mm/year in the 40 to 49 mm group (n = 41), and 7.4 mm/year for diameters of 50 mm or more (n = 24).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailDetermination of the free/included piroxicam ratio in cyclodextrin complexes: comparison between UV spectrophotometry and differential scanning calorimetry
Van Hees, Thierry ULg; Piel, Géraldine ULg; Henry de Hassonville, Sandrine et al

in European Journal of Pharmaceutical Sciences (2002), 15(4), 347-353

Few analytical techniques allow to evaluate the inclusion yield of cyclodextrin-drug complexes, because most manufacturing processes give amorphous products, In this study we have developed an alternative ... [more ▼]

Few analytical techniques allow to evaluate the inclusion yield of cyclodextrin-drug complexes, because most manufacturing processes give amorphous products, In this study we have developed an alternative method to differential scanning calorimetry, to accurately determine the free/complexed piroxicam ratio by UV spectroscopy. This method is based on the differential solubility of the piroxicam-beta-cyclodextrin 1:2.5 mol/mol complex in water-acetonitrile (1:1 v/v) (Solvent A) or in anhydrous acetonitrile (Solvent B). both containing 0.05 M HCl. In anhydrous acetonitrile, beta-cyclodextrin is insoluble and the included drug remains entrapped, allowing the free piroxicam determination, while with 50% of water, the complex is totally dissolved, allowing the determination of the total guest content. This method was validated for linearity, precision and accuracy. The presence of cyclodextrin does not influence the assays, but more than 0.5% of water in Solvent B significantly affects the determination of the free piroxicam content. In comparison with differential scanning calorimetry, both delectability and precision were improved. It is now possible to analyse complexes with an inclusion purity greater than 99%. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailDetermination Of The Functionality Of Common Apoa5 Polymorphisms
Talmud, Pj.; Palmen, J.; Putt, W. et al

in Journal of Biological Chemistry (2005), 280(31), 28215-20

Common variants of APOA5 have consistently shown association with differences in plasma triglyceride (TG) levels. These single nucleotide polymorphisms (SNPs) fall into three common haplotypes: APOA5*1 ... [more ▼]

Common variants of APOA5 have consistently shown association with differences in plasma triglyceride (TG) levels. These single nucleotide polymorphisms (SNPs) fall into three common haplotypes: APOA5*1, with common alleles at all sites; APOA5*2, with rare alleles of -1131T--> C, -3A--> G, 751G--> T, and 1891T--> C; and APOA5*3, distinguished by the c56C--> G (S19W). Molecular modeling of the apoAV signal peptide (SP) showed an increased angle of insertion (65 degrees ) at the lipid/water interface of Trp-19 SP compared with Ser-19 SP (40 degrees ), predicting reduced translocation. This was confirmed by 50% reduction of Trp-19-encoded SP.secretory alkaline phosphatase (SEAP) fusion protein secreted into the medium from HepG2 cells compared with the Ser-19.SEAP fusion protein (p < 0.002). Considering APOA5*2 SNPs, there was no significant difference in the relative luciferase expression in Huh7 cells transiently transfected with a -1131T construct compared with the -1131C (fragments -1177 to -516 or -1177 to -3). Similarly, for the -3A--> G in the Kozak sequence, in vitro transcription/translation assays and primer extension inhibition assays showed no alternate AUG initiation codon usage, demonstrating that -3A--> G did not influence translation efficiency. Although 1891T--> C in the 3'-untranslated region disrupts a putative Oct-1 transcription factor binding site, when inserted 3' of the luciferase gene the T--> C change demonstrated no significant difference in luciferase expression. Thus, association of APOA5*2 SNPs with TG levels is not due to the individual effects of any of these SNPs, although cooperativity between the SNPs cannot be excluded. Alternatively, the effect on TG levels may reflect the strong linkage disequilibrium with the functional APOC3 SNPs. [less ▲]

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See detailDetermination of the high strain rate forming properties of steel sheet
Verleysen, Patricia; Peirs, Jan; Duchene, Laurent ULg

in Complas XI (2011)

The strain rate dependence of the plastic yield and failure properties displayed by most metals affects energies, forces and forming limits involved in high speed forming processes. In this contribution a ... [more ▼]

The strain rate dependence of the plastic yield and failure properties displayed by most metals affects energies, forces and forming limits involved in high speed forming processes. In this contribution a technique is presented to assess the influence of the strain rate on the forming properties of steel sheets. In a first step, static and high strain rate tensile experiments are carried out in order to characterize the materials strain rate dependent behaviour. In a second step, the phenomenological Johnson-Cook model and physically-based Voce model are used to describe the constitutive material behaviour. The test results are subsequently used to calculate the forming limit diagrams by a technique based on the Marciniak-Kuczynski model. With the developed technique, static and dynamic forming limit diagrams are obtained for a commercial DC04 steel and a laboratory made CMnAl TRIP steel. The results clearly indicate that increasing the strain rate during a forming process can have a positive or negative effect. [less ▲]

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See detailDetermination of the Influence of Alloying Elements on Solidification Parameters for the Study of the Thixoformability of a Chromium Steel
Fraipont, Céline; Lecomte-Beckers, Jacqueline ULg

in Proceedings of The 10th Esaform Conference on Material Forming (2007)

This paper deals with the examination of the influence of alloying elements on the thixoformability of a chromium steel. It focuses on the liquid fraction curves of different chromium steel with and ... [more ▼]

This paper deals with the examination of the influence of alloying elements on the thixoformability of a chromium steel. It focuses on the liquid fraction curves of different chromium steel with and without modification of composition. The liquid fraction versus temperature has been obtained experimentally by differential thermal analysis (DTA), limited to low heating rates. The correlation between liquid fraction and temperature has been studied. The effect of modifications of composition was observed. [less ▲]

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See detailDetermination of the lower critical field Hc1(T) in FeSe single crystals by magnetization measurements
Abdel-Hafiez, M; Vasiliev, A.N.; Chareev, D.A. et al

in Physica C: Superconductivity (2014), 503

In a recent work, Abdel-Hafiez et al. we have determined the temperature dependence of the lower critical field Hc1(T) of a FeSe single crystal under static magnetic fields H parallel to the ... [more ▼]

In a recent work, Abdel-Hafiez et al. we have determined the temperature dependence of the lower critical field Hc1(T) of a FeSe single crystal under static magnetic fields H parallel to the crystallographic c axis. The temperature dependence of the first vortex penetration field has been experimentally obtained by two independent methods and the corresponding Hc1(T) was deduced by taking into account demagnetization factors. In general, the first vortex penetration field may not reflect the true Hc1(T) due to the presence of surface barriers. In this work we show that magnetic hysteresis loops are very symmetric close to the critical temperature Tc = 9 K evidencing the absence of surface barriers and thus validating the previously reported determination of Hc1(T) and the main observations that the superconducting energy gap in FeSe is nodeless. [less ▲]

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See detailDetermination of the magnetic penetration depth in a superconducting Pb film
Brisbois, Jérémy ULg

Conference (2014, May 01)

By means of scanning Hall probe microscopy technique we accurately map the magnetic field pattern produced by Meissner screening currents in a thin superconducting Pb stripe. The obtained field profile ... [more ▼]

By means of scanning Hall probe microscopy technique we accurately map the magnetic field pattern produced by Meissner screening currents in a thin superconducting Pb stripe. The obtained field profile allows us to quantitatively estimate the Pearl length Λ without the need of pre-calibrating the Hall sensor. This fact contrasts with the information acquired through the spatial field dependence of an individual flux quantum where the scanning height and the magnetic penetration depth combine in a single inseparable parameter. The derived London penetration depth λL coincides with the values previously reported for bulk Pb once the kinetic suppression of the order parameter is properly taken into account. [less ▲]

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See detailDetermination of the magnetic penetration depth in a superconducting Pb film
Brisbois, Jérémy ULg; Raes, Bart; Van de Vondel, Joris et al

in Journal of Applied Physics (2014), 115(10), 103906

By means of scanning Hall probe microscopy technique we accurately map the magnetic field pattern produced by Meissner screening currents in a thin superconducting Pb stripe. The obtained field profile ... [more ▼]

By means of scanning Hall probe microscopy technique we accurately map the magnetic field pattern produced by Meissner screening currents in a thin superconducting Pb stripe. The obtained field profile allows us to quantitatively estimate the Pearl length Λ without the need of pre-calibrating the Hall sensor. This fact contrasts with the information acquired through the spatial field dependence of an individual flux quantum where the scanning height and the magnetic penetration depth combine in a single inseparable parameter. The derived London penetration depth λL coincides with the values previously reported for bulk Pb once the kinetic suppression of the order parameter is properly taken into account. [less ▲]

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See detailDetermination of the mass of nearby stars from astrometric microlensing observations
Dib, S.; Claeskens, Jean-François ULg; Surdej, Jean ULg

in Surdej, Jean; Swings, J.-P.; Caro, D. (Eds.) et al Proceedings of the LIAC “From optical to millimetric interferometry, scientific and technological challenges” (2001)

The possibility of determining, with a precision of 10%, the mass of bright, nearby stars by means of astrometric microlensing observations is investigated in the context of the future ground-based and ... [more ▼]

The possibility of determining, with a precision of 10%, the mass of bright, nearby stars by means of astrometric microlensing observations is investigated in the context of the future ground-based and spaceborne high precision astrometric instruments, such as the VLT interferometer, GAIA and SIM. [less ▲]

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See detailDetermination Of The Methionine Requirement Of Finishing Double-Muscled Belgian Blue Bulls With A Three-Step Method
Froidmont, Eric; Beckers, Yves ULg; Thewis, André ULg

in Canadian Journal of Animal Science (2002), 82(1), 95-102

A three-step technique was used to determine total amino acids (AA) and the first limiting AA requirements in finishing double-muscled Belgian Blue (dmBB) bulls. In a first experiment, three dmBB bulls ... [more ▼]

A three-step technique was used to determine total amino acids (AA) and the first limiting AA requirements in finishing double-muscled Belgian Blue (dmBB) bulls. In a first experiment, three dmBB bulls (505 ± 21 kg) received a low metabolizable protein diet containing 25% meadow hay and 75% concentrate. Net energy supply was adequate for maximizing daily gains because of continuous infusion of dextrose into the duodenum. The intestinal apparent disappearance of essential AA (EAA) averaged 70.8% and was the lowest for histidine (61.3%) and the highest for arginine (79.9%). In a second experiment, four dmBB bulls (517 ± 16 kg) received the same diet supplemented with duodenal infusion of dextrose and four doses of Na-caseinate (17, 33, 50 and 66% of metabolizable dietary AA) in a 4 × 4 Latin square design. Nitrogen retention for the basal diet alone and the four increasing supplements of Na-caseinate averaged 61, 64, 74, 75 and 78 g d–1, respectively. A supply of 720 g d–1 of metabolizable AA was defined as optimising the N utilization for animal growth. Based on patterns of plasma concentrations, methionine and phenylalanine were probably the limiting AA. In a third experiment, five dmBB bulls (513 ± 60 kg) fed the basal diet received duodenal infusion of dextrose and AA, equivalent to the second dose in exp. 2 except for the supply of metabolizable methionine (12.8, 15.1, 17.6, 20.1, 22.6 and 25.1 g d–1) that varied in a 6 × 6 Latin square design with one missing animal. On the basis of N retention, the metabolizable methionine requirement was estimated to 22.8 g d–1 and corresponded to 360 mg of metabolizable methionine per gram of N retained. [less ▲]

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See detailDetermination Of The Methionine Requirement Of Growing Double-Muscled Belgian Blue Bulls With A Three-Step Method
Froidmont, Eric; Beckers, Yves ULg; Thewis, André ULg

in Journal of Animal Science (2000), 78(1), 233-241

The three-step technique was used to determine the requirements of total amino acids (TAA) and the first-limiting amino acid (AA) in growing double- muscled Belgian Blue bulls (BBb). In Exp. 1, three ... [more ▼]

The three-step technique was used to determine the requirements of total amino acids (TAA) and the first-limiting amino acid (AA) in growing double- muscled Belgian Blue bulls (BBb). In Exp. 1, three double-muscled BBb weighing initially 306 ± 28 kg received a basal diet consisting of 30% meadow hay and 70% concentrate that was poor in digestible protein but had adequate NE because of continuous infusion of dextrose into the duodenum. The intestinal apparent digestibility of essential AA (EAA) was defined according to their duodenal and ileal flows. It averaged 72% but varied between 60% for Met and 79% for Arg. In Exp. 2, five double-muscled BBb (334 ± 22 kg) received the same diet supplemented with duodenal infusions of dextrose and four doses of Na-caseinate (28, 56, 84, and 112% of intestinal digestible dietary AA) in a 4 × 4 Latin square design with one additional animal. Nitrogen retention for the basal diet alone and the four increasing supplements of Na-caseinate reached 49, 61, 70, 80, and 86 g/d, respectively. Nitrogen utilization improved from 34.3% without Na-caseinate supplementation to a maximum of 40.6%, with the third dose supplying 788 g/d of apparently digestible AA. Based on patterns of plasma concentrations, Met, Phe, and Arg were probably the limiting AA when animals optimized N utilization. In Exp. 3, six double-muscled BBb (315 ± 25 kg) fed the basal diet received duodenal infusions of dextrose and AA, equivalent to the third dose in Exp. 2, except for digestible Met (9.3, 14.4, 18.4, 22.4, 26.4, and 30.4 g/d) in a 6 × 6 Latin square design. The Met requirement was close to 26.4 g/d on the basis of N retention. [less ▲]

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See detailDetermination Of The Minimal Fusion Peptide Of Bovine Leukemia Virus Gp30
Lorin, A.; Lins, Laurence ULg; Stroobant, V. et al

in Biochemical and Biophysical Research Communications (2007), 355(3), 649-53

In this study, we determined the minimal N-terminal fusion peptide of the gp30 of the bovine leukemia virus on the basis of the tilted peptide theory. We first used molecular modelling to predict that the ... [more ▼]

In this study, we determined the minimal N-terminal fusion peptide of the gp30 of the bovine leukemia virus on the basis of the tilted peptide theory. We first used molecular modelling to predict that the gp30 minimal fusion peptide corresponds to the 15 first residues. Liposome lipid-mixing and leakage assays confirmed that the 15-residue long peptide induces fusion in vitro and that it is the shortest peptide inducing optimal fusion since longer peptides destabilize liposomes to the same extent but not shorter ones. The 15-residue long peptide can thus be considered as the minimal fusion peptide. The effect of mutations reported in the literature was also investigated. Interestingly, mutations related to glycoproteins unable to induce syncytia in cell-cell fusion assays correspond to peptides predicted as non-tilted. The relationship between obliquity and fusogenicity was also confirmed in vitro for one tilted and one non-tilted mutant peptide. [less ▲]

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See detailDetermination Of The Minimal Fusion Peptide Of Hiv, Siv And Blv Fusion Glycoproteins
Lorin, A.; Charloteaux, Benoît ULg; Lins, Laurence ULg et al

in Peptides For Youth - the Proceedings of the 20th American Peptidesymposium (2009), 611

The entry of enveloped viruses into target cells requires the fusion between the viral envelope and the target cell membrane. In the case of many viruses like HIV, SIV and BLV, the fusion is mediated by ... [more ▼]

The entry of enveloped viruses into target cells requires the fusion between the viral envelope and the target cell membrane. In the case of many viruses like HIV, SIV and BLV, the fusion is mediated by class 1 fusion glycoproteins located on the viral envelope. These fusion glycoproteins contain a region at their N-terminal extremity called the “fusion peptide”, which interact with the target membrane. Many mutagenesis studies showed that this region is required for mediating membrane fusion [1]. Moreover, synthetic peptides corresponding to the fusion peptide of many glycoproteins induce membrane fusion in vitro. Despite the large number of studies on synthetic fusion peptides, the region necessary and sufficient to induce optimal membrane fusion is not known. To determine this minimal fusion peptide, we used the “tilted peptide” theory. According to this theory, a helical peptide inserting obliquely into membranes induces fusion [2]. Moreover, the more tilted the peptide is, the more important the fusion is. Then, we postulate that the minimal fusion peptide corresponds to the shortest helical fragment able to insert into the membrane with an angle close to 45°. This peptide was predicted using the IMPALA algorithm, which allow to predict peptide-membrane interactions [3]. Fusogenicity of this peptide was then assessed in liposome lipid-mixing and leakage assays and compared to the fusogenicity of smaller and longer peptides to check the validity of the prediction. This methodology was used to determine successfully the minimal fusion peptide of three viruses, HIV, SIV and BLV. [less ▲]

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See detailDetermination of the molecular players of adaptation to anti-angiogenic therapy in breast cancer by quantitative proteomic and high molecular MALDI Imaging.
Cimino, Jonathan ULg; Sounni, Nor Eddine ULg; Calligaris, David ULg et al

Poster (2012, October 13)

Breast carcinoma is the most common and second leading cause of cancer mortality in women. The recognition of the “angiogenic switch” as a rate-limiting secondary step in tumorigenesis led to extensive ... [more ▼]

Breast carcinoma is the most common and second leading cause of cancer mortality in women. The recognition of the “angiogenic switch” as a rate-limiting secondary step in tumorigenesis led to extensive pre-clinical researches on angiogenesis and finally the approval of VEGF-neutralizing antibodies (bevacizumab) and VEGF receptor tyrosine kinase inhibitors (RTKs:Sunitinib). The Sunitinib has been used clinically in patients with breast cancer refractory to other therapeutic agents. Unfortunately, like the cytotoxic therapies, these drugs do not produce lasting effects and resistance to treatment appeared clinically. Questions have emerged about the failure of anti-angiogenic therapy in clinic and the limitations of predictive preclinical models, and also about the molecular assessment of all stages of tumor adaptation and me<x>tastatic disease. To this end, we applied quantitative proteomics and imaging mass spectrometry tools to visualize and study the profiles of proteins and small molecules associated with tumor treated or not with Sunitinib using a novel preclinical model of breast carcinoma cells. In this project, we first developed a reproducible model of resistance to Sunitinib of human triple negative breast cancer MDA-MB-231 cells expressing luciferase gene. Cells were subcutaneously injected into mice RAG1-/- and divided into four experimental groups including, control mice treated with vehicle or Sunitinib for 30 days and sacrificed 1 days after treatment withdrawal or when tumor reached a volume of 300 mm3. In the second step. Tumors were analyzed using a nanoAcquity UPLC Synapt TM HDMS TM G1 (Waters, Manchester,UK) and Mass Spectrometry Imaging. For quantitative proteomic analyses of tumors, a bioinformatics analysis was used with the Protein lynx global server 2.2.5 software. Imaging mass spectrometry was performed on tissue sections of tumors and organs subsequently colonized by me<x>tastases. Matrix sublimation was used to coat tumor sections (14 µm-tick) with 1.5 Diaminonaphthalene for lipids analysis and Sinapinic acid for entire proteins analysis. Ion cartographies were recorded with a Solarix 9.4T FTMS instrument for lipids and with an Ultraflex II TOF-TOF instrument for entire proteins (Bruker Daltonics, Germany) with a spatial resolution of 100 µm. Global protemic revealed different protein profiles between tumor treated or not with Sunitinib. The Mass Spectrometry Imaging detected differences in intensity and location of some proteins and lipids are also associated with some histological features including inflammatory, necrotic and angiogenic areas. Bioinformatics analysis will be applied to ensure the integration of all data in order to provide the basis for identifying molecular pathways activated during the acquisition of refractoriness to drug treatments. [less ▲]

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See detailDetermination of the optimal forging conditions of a Cr-Mo-V high alloy steel through a microstructural, thermophysical and mechanical study
Bouffioux, Chantal ULg; Carton, Marc ULg; Lecomte-Beckers, Jacqueline ULg et al

in Banabic, D. (Ed.) Proceedings of the 8th ESAFORM Conference on Material Forming (Vol. 1) (2005)

The forging process of cylinders requires the knowledge of material recrystallisation conditions to prevent crack appearance. Due to the continuous recrystallisation during forging, very large ... [more ▼]

The forging process of cylinders requires the knowledge of material recrystallisation conditions to prevent crack appearance. Due to the continuous recrystallisation during forging, very large deformations can be applied as the generated dislocations do not yield to hardening but to recrystallisation phenomenon. This paper summarizes the data identification of a FEM recrystallisation model and defines the optimal forging process for one roll. [less ▲]

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See detailDetermination of the performance characteristics of enzyme immunoassays using the photon era automatic analyszer
Chapelle, Jean-Paul ULg; El Allaf, M.

in Annals of Clinical Biochemistry (1987), 24(suppl. 2), 116

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See detailDetermination of the pole orientation of an asteroid - The amplitude-aspect relation revisited
Pospieszalska-Surdej, Anna ULg; Surdej, Jean ULg

in Astronomy and Astrophysics (1985), 149

Near the opposition of a minor planet the geometrical approximation essentially constitutes a good representation of the Hapke-Irvine relation for describing the scattering properties of a surface layer ... [more ▼]

Near the opposition of a minor planet the geometrical approximation essentially constitutes a good representation of the Hapke-Irvine relation for describing the scattering properties of a surface layer, and the authors show that the normalized light curve of a three-axes ellipsoid model reduces to a straight line whose slope depends only on the aspect angle A and on the semi-axes ratios a/b, b/c of the ellipsoid. A set of non-linear equations is then solved by a least squares method in order to derive the four unknown parameters lambda[SUB]0[/SUB], beta[SUB]0[/SUB] (ecliptic coordinates of the pole) and a/b, b/c. The authors have applied this technique to published observations of two asteroids: For (624) Hektor two possible solutions are found; and for the case of (44) Nysa, they show that additional observations are needed in order to derive a self-consistent pole orientation. [less ▲]

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