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See detailEctopic Expression of Bone Sialoprotein in Human Thyroid Cancer
Bellahcene, Akeila ULg; Albert, V.; Pollina, L. et al

in Thyroid (1998), 8(8), 637-41

Bone sialoprotein (BSP) is a small, highly posttranslationally modified integrin binding protein found in the mineral compartment of developing bone. The recent discovery that BSP can be detected in a ... [more ▼]

Bone sialoprotein (BSP) is a small, highly posttranslationally modified integrin binding protein found in the mineral compartment of developing bone. The recent discovery that BSP can be detected in a variety of human cancers, particularly those that metastasize preferentially to the skeleton, shed light on potential new biological functions for this protein. The demonstration of a positive association between BSP expression in primary breast tumors and the development of bone metastases suggests that this glycoprotein could play a role in the selective implantation of breast cancer cells in bone. BSP is also expressed in most lung and prostate cancers as well as in multiple myeloma, three other osteotropic malignancies. Because thyroid carcinoma also metastasizes preferentially to the skeleton, we decided to look at the expression of BSP in a collection of 145 thyroid malignant lesions including 24 follicular thyroid carcinomas (FTCs), 55 papillary thyroid carcinomas (PTCs), 19 medullary thyroid carcinomas (MTCs), 23 anaplastic carcinomas (ACs), and 24 poorly differentiated carcinomas (PDCs). BSP expression was evaluated by immunoperoxidase technique using two specific polyclonal antibodies. Most of the thyroid carcinomas (72%) examined expressed high levels of BSP. Expression of BSP was significantly lower in FTCs and MTCs compared with PDCs, which are more aggressive (p = 0.0009 and 0.0003, respectively). Our study demonstrates for the first time that ectopic BSP expression is a common feature of thyroid cancer. The prognostic value of BSP detection in thyroid adenocarcinoma and the potential role of BSP in the propension of this type of cancer to metastasize to bone are currently under investigation. [less ▲]

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See detailEctopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype
Davis, Erica; Jensen, C.; Schroder, H. D. et al

in Current Biology (2004), 14(20), 1858-1862

The callipyge (CLPG) phenotype is an inherited skeletal muscle hypertrophy described in sheep. It is characterized by an unusual mode of inheritance ("polar overdominance") in which only heterozygous ... [more ▼]

The callipyge (CLPG) phenotype is an inherited skeletal muscle hypertrophy described in sheep. It is characterized by an unusual mode of inheritance ("polar overdominance") in which only heterozygous individuals having received the CLPG mutation from their father (+(MAT)/CLPG(PAT)) express the phenotype . +(MAT)/CLPG(PAT) individuals are born normal and develop the muscular hypertrophy at approximately 1 month of age. The CLPG mutation was identified as an A to G transition in a highly conserved dodecamer motif located between the imprinted DLK1 and GTL2 genes . This motif is thought to be part of a long-range control element (LRCE) because the CLPG mutation was shown, in postnatal skeletal muscle, to enhance the transcript levels of the DLK1, PEG11, GTL2, and MEG8 genes in cis without altering their imprinting status . As a result, the +(MAT)/CLPG(PAT) individuals have a unique expression profile thought to underlie the callipyge phenotype: an overexpression of the paternally expressed protein encoding DLK1 (Figure 1A) and PEG11 transcripts in the absence of an overexpression of the maternally expressed noncoding GTL2 and MEG8 transcripts . However, the way in which this distinct expression profile causes the callipyge muscular hypertrophy has remained unclear. Herein, we demonstrate that the callipyge phenotype is perfectly correlated with ectopic expression of DLK1 protein in hypertrophied muscle of +(MAT)/CLPG(PAT) sheep. We demonstrate the causality of this association by inducing a generalized muscular hypertrophy in transgenic mice that express DLK1 in skeletal muscle. The absence of DLK1 protein in skeletal muscle of CLPG/CLPG animals, despite the presence of DLK1 mRNA, supports a trans inhibition mediated by noncoding RNAs expressed from the maternal allele. [less ▲]

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See detailEctopic Hormones-Secreting Pheochromocytoma: A Francophone Observational Study
KIRKBY-BOTT, James; BRUNAUD, Laurent; MATHONET, Muriel et al

in World Journal of Surgery (2012), 36

Background Ectopic hormone-secreting pheochromocytomas <br />are rare; only case reports exist in the literature. This <br />condition has been linked with increased malignancy, <br />familial syndromes ... [more ▼]

Background Ectopic hormone-secreting pheochromocytomas <br />are rare; only case reports exist in the literature. This <br />condition has been linked with increased malignancy, <br />familial syndromes, and ACTH secretion. We wanted to <br />test these hypotheses and shed light on the nature of ectopic <br />hormone-secreting pheochromocytomas. <br />Methods This is a multicenter (francophone) observational <br />study. Inclusion was based upon abnormal preoperative <br />hormone tests in patients with pheochromocytoma <br />that normalized after removal of the tumor. Where <br />possible, immunohistochemistry was performed to confirm <br />that ectopic secretion came from the tumor. <br />Results Sixteen cases were found: nine female and seven <br />male patients. Median age was 50.5 (range 31–89) years. <br />Most presented with hypertension, diabetes, or cushingoid <br />features. Ten patients had specific symptoms from the <br />ectopic hormone secretion. Two had a familial syndrome. <br />Of eight patients with excess cortisol secretion, three died <br />as a result of the tumor resection: two had pheochromocytomas[ <br />15 cm and their associated cortisol hypersecretion <br />complicated their postoperative course. The other died <br />from a torn subhepatic vein. The 13 survivors did not <br />develop any evidence of malignancy during follow-up <br />(median 50 months). Symptoms from the ectopic secretion <br />resolved after removal of the tumor. Immunohistochemistry <br />was performed and was positive in eight tumors: five <br />ACTH, three calcitonins, and one VIP. <br />Conclusions Most pheochromocytomas with ectopic <br />secretion are neither malignant nor familial. Most ectopic <br />hormone-secreting pheochromocytoma cause hypercortisolemia. <br />Patients with a pheochromocytoma should be <br />worked up for ectopic hormones, because removal of the <br />pheochromocytoma resolves those symptoms. Associated <br />cortisol secretion needs careful attention. [less ▲]

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See detailEctopic ureters
Hamaide, Annick ULg

in Proceedings du 1st Surgical Forum ECVS (2001, July)

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See detailEctopic ureters in the dog: literature review and case reports in 3 male dogs
Pollaci, Elsa; Balligand, Marc; Hamaide, Annick ULg

in Annales de Médecine Vétérinaire (2004), 148(2), 103-109

Ureteral ectopia is a congenital abnormality in which one or both ureters does not open into the bladder. This is the most common cause of urinary incontinence in the immature bitch, but is rarely ... [more ▼]

Ureteral ectopia is a congenital abnormality in which one or both ureters does not open into the bladder. This is the most common cause of urinary incontinence in the immature bitch, but is rarely diagnosed in the male dog. Some breeds are predisposed (Siberian Husky, Labrador, Golden Retriever). Typical clinical signs are a continuous (but sometimes intermittent) leakage of urine since birth, although micturition can be normal. Other associated congenital abnormalities can be present (hydronephrosis, double vagina, cryptorchidism). Diagnostic techniques include excretory urography coupled with a pneumocystography, vaginourethrography, cystoscopy, vaginoscopy, and ultrasonography. Ectopic ureters can be unilateral (most commonly) or bilateral, and they are either intramural or extramural. Surgical correction is the treatment of choice. After a successful surgery, some patients can still show some degree of incontinence, due to the presence of urethral sphincter mechanism incompetence. This residual incontinence can be resolved in the majority of the cases with the use of alpha-adrenergic agents. [less ▲]

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See detailEctopic ureters: conventional surgery
Hamaide, Annick ULg

in Proceedings of the 21th ECVS Annual Scientific Meeting (2012)

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See detailEctopic ureters: role of urodynamic investigation
Hamaide, Annick ULg

in Proceedings of the 21th ECVS Annual Scientific Meeting (2012)

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See detailEctopie cervicale du coeur chez un veau
Gabriel, Annick ULg; Vandeputte, Sébastien ULg; Rollin, Frédéric ULg et al

in Annales de Médecine Vétérinaire (1994), 138

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See detailLes écueils de l'évaluation
Vandoorne, Chantal ULg

in Prospective Jeunesse - Drogues-Santé-Prévention (2012), (61), 19-22

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See detailEcueils et chausse-trapes.
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(5), 249

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See detailEculizumab (ECU) Inhibits Thrombotic Microangiopathy (TMA) and Improves Renal Function in Adult Atypical Hemolytic Uremic Syndrome (aHUS) Patients (Pts)
Fakhouri, Fadi; Hourmant, Maryvonne; Campistol, Josep et al

Poster (2013, November 08)

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See detailEculizumab (ECU) Inhibits Thrombotic Microangiopathy (TMA) and Improves Renal Function In Adult Patients (Pts) With Atypical Hemolytic Uremic Syndrome (aHUS)
Fakhouri, Fadi; Hourmant, Maryvonne; Cataland, Spero et al

Poster (2013, December 08)

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See detailL’Ecureuil, Sciurus vulgaris
Maréchal, Corinnne; Libois, Roland ULg

Learning material (1998)

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See detailEdad de las esporas de la Formacion Los Espejos, Silurico de la Precordillera de San Juan, Argentina
Rubinstein, Claudia; Muro, V.J.; Steemans, Philippe ULg

Conference (2010)

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See detailEDDIE BURNS Portrait
Sacré, Robert ULg

Article for general public (1976)

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See detailEDDIE C. CAMPBELL live
Sacré, Robert ULg

in Soul Bag (2002), (167), 47-48

Concert au Sang-A-Klang, Luxembourg, 8 mars 2002: compte rendu + Photo WILLIE BLACK (basse)

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See detailEddy Covariance Co2 Flux Measurements In Nocturnal Conditions: An Analysis Of The Problem
Aubinet, Marc ULg

in Ecological Applications (2008), 18(6),

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See detailEddy covariance measurements over crops
Moureaux, Christine ULg; Ceschia, Eric; Arriga, Nicolas et al

in Aubinet, Marc; Vesala, Timo; Papale, Dario (Eds.) Eddy Covariance: A Practical Guide to Measurement and Data Analysis (2012)

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