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See detailDentin Matrix Protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation.
Pirotte, Sophie ULg; Lamour, Virginie ULg; Lambert, Vincent ULg et al

in Blood (2011), 117(8), 2515-26

Dentin matrix protein 1 (DMP1) is a member of the Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs) family, a group of proteins initially described as mineralized extracellular matrices ... [more ▼]

Dentin matrix protein 1 (DMP1) is a member of the Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs) family, a group of proteins initially described as mineralized extracellular matrices components. More recently, SIBLINGs have been implicated in several key steps of cancer progression, including angiogenesis. Although pro-angiogenic activities have been demonstrated for two SIBLINGs, the role of DMP1 in angiogenesis has not been addressed yet. We demonstrated that this extracellular matrix protein induced the expression of VE-cadherin, a key regulator of intercellular junctions and contact inhibition of growth of endothelial cells that is also known to modulate VEGFR-2 activity, the major high affinity receptor for VEGF. DMP1 induced VE-cadherin and p27(Kip1) expression followed by cell cycle arrest in human umbilical vein endothelial cells (HUVEC) in a CD44-dependent manner. VEGF-induced proliferation, migration and tubulogenesis responses were specifically blocked upon DMP1 pre-treatment of HUVEC. Indeed, subsequently to VE-cadherin induction, DMP1 inhibited VEGFR-2 phosphorylation and Src-mediated signaling. However, DMP1 did not interfere with bFGF-induced angiogenesis. In vivo, DMP1 significantly reduced laser-induced choroidal neovascularization lesions and tumor-associated angiogenesis. These data enable us to put DMP1 on the angiogenic chessboard for the first time and to identify this protein as a new specific inhibitor of VEGF-induced angiogenesis. [less ▲]

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See detailDentin matrix protein 1 is expressed in human lung cancer
Chaplet, Michael; de Leval, Laurence ULg; Waltregny, David ULg et al

in Journal of Bone and Mineral Research (2003), 18(8), 1506-1512

We have previously shown that breast and prostate cancers express bone matrix proteins. DMPI expression was evaluated in 59 human lung cancer samples at the protein and mRNA levels. It was detectable in ... [more ▼]

We have previously shown that breast and prostate cancers express bone matrix proteins. DMPI expression was evaluated in 59 human lung cancer samples at the protein and mRNA levels. It was detectable in 80% of the cases, suggesting a potential role for DMP1 in tumor progression and bone metastasis. Introduction: Previously, we and others have shown that bone extracellular matrix proteins such as bone sialoprotein (BSP) and osteopontin (OPN) are expressed in various types of cancer that are characterized by a high affinity for bone including breast, prostate, and lung adenocarcinoma. Based on biochemical and genetic features, BSP, OPN, dentin matrix protein 1 (DMP1), and dentin sialophosphoprotein (DSPP) have been recently classified in a unique family named SIBLING (small integrin-binding ligand, N-linked glycoprotein). Therefore, we investigated whether DMPI could also be detected in osteotropic cancers. Materials and Methods: We first used a cancer array for evaluating the relative abundance of DMP1 transcript in a broad spectrum of human cancer tissues. This screening showed that DMP1 was strongly detectable in lung tumors compared with normal corresponding tissue. In a second step, we used an immunophosphatase technique and a specific polyclonal antibody directed against DMPI to examine the expression of DMP1 in 59 human non-small cell lung cancer samples, including 29 squamous carcinoma, 20 adenocarcinoma, and 10 bronchioloalveolar carcinoma. Student's t-test was used to determine the statistical significance of immunostaining scores between the lung cancer histological groups studied and between cancer and normal lung tissues. Results: Our results show that DMP1 is detectable in 90% of the adenocarcinoma and squamous carcinoma analyzed while 8 of 10 bronchioloalveolar specimens were negative. DMP1 immunostaining intensity and extent scores were significantly higher in adenocarcinoma (p = 0.0004) and squamous carcinoma (p < 0.0001) samples compared with adjacent normal lung tissue. In situ hybridization experiments confirmed that DMP1 mRNA is localized in lung cancer cells. Conclusion: In this study, we show that a third SIBLING protein is ectopically expressed in lung cancer. The role of DMPI in lung cancer is largely unknown. Further studies are required to determine the implication of this protein, next to its sisters SIBLING proteins, in tumor progression and bone metastasis development. [less ▲]

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See detailDentin sialophosphoprotein expression correlates with progression markers in human prostate cancer
Chaplet, Michael; Waltregny, David ULg; Detry, Cédric et al

Conference (2005)

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See detailDentin sialophosphoprotein expression correlates with progression markers in human prostate cancer
Chaplet, Michael; Waltregny, David ULg; Detry, Cédric ULg et al

in Journal of Bone and Mineral Research (2005), 20(Suppl. 2), 45

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See detailDentinal tubules sealing by means of diode lasers (810 and 980 nm): A preliminary in vitro study
Umana, M.; Heysselaer, D.; Compère, Philippe ULg et al

in Photomedicine and Laser Surgery (2013), 31(7), 307-314

Objective: The aim of this study was to evaluate the effect on dentinal surfaces of diode lasers (810 and 980 nm) at different parameters. Materials and methods: Twenty-four caries-free human impacted ... [more ▼]

Objective: The aim of this study was to evaluate the effect on dentinal surfaces of diode lasers (810 and 980 nm) at different parameters. Materials and methods: Twenty-four caries-free human impacted wisdom teeth were used. The crowns were sectioned transversely in order to expose the dentin. The smear layer was removed by a 1 min application of ethylenediaminetetraacetic acid (EDTA). Each surface was divided into four quadrants irradiated at a different output power setting for each kind of laser: 0.8, 1, 1.6, and 2 W (energy densities: 2547, 3184, 5092, and 6366 J/cm2, irradiation speed 1 mm/sec; optical fiber diameter: 200 μm; continuous and noncontact mode). Half of the samples were stained with a graphite paste. All specimens were sent for scanning electron microscopic (SEM) analysis. Pulp temperature increases in additional 20 teeth were measured by a thermocouple. Results: Diode laser irradiations at 0.8 and 1 W led to occlusion or narrowing of dentin tubules without provoking fissures or cracks. The application of graphite paste increased the thermal effects in dentin. Measurements of pulp temperature showed that irradiations at 0.8 and 1 W for a period of 10 sec in continuous mode increased pulp temperature (T ≤2 C). Conclusions: Diode lasers (810 and 980 nm) used at 0.8 and 1 W for 10 sec in continuous mode were able to seal the dentin tubules. These parameters can be considered harmless for pulp vitality, and may be effective in the treatment of dentinal hypersensitivity. © Copyright 2013, Mary Ann Liebert, Inc. 2013. [less ▲]

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See detailA deontologia do psicologo : una psico-etica ?
Mormont, Christian ULg

in Contato (1995), 15

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See detailDéontologie de l'information : journée d'étude
Vanesse, Marc ULg

Poster (2010, December 14)

Journée de réflexion sur la déontologie journalistique avec le bâtonnier de l'Ordre des avocats de Liège, le secrétaire général du Conseil de déontologie, un journaliste d'investigation et le secrétaire ... [more ▼]

Journée de réflexion sur la déontologie journalistique avec le bâtonnier de l'Ordre des avocats de Liège, le secrétaire général du Conseil de déontologie, un journaliste d'investigation et le secrétaire général adjoint de l'Association des journalistes. [less ▲]

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See detailDéontologie des enseignements et formateurs
Leclercq, Dieudonné ULg; Poumay, Marianne ULg; Faulx, Daniel ULg et al

Learning material (2010)

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See detailDéontologie des formateurs et des chercheurs en éducation
Leclercq, Dieudonné ULg; Poumay, Marianne ULg

Learning material (2007)

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See detailLa déontologie du psychologue en centre de santé mentale
Blavier, Adelaïde ULg

Conference (2010, February 29)

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See detailLa déontologie du psychologue
Blavier, Adelaïde ULg; Darras, B.

Conference (2010, November 29)

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See detailLa déontologie du psychologue
Blavier, Adelaïde ULg; Darras, B.

Conference (2009, November 28)

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See detailDéontologie et spécificités de l'expertise psychologique
Mormont, Christian ULg

in Ius & Actores : Revue des Acteurs de la Justice (2015), 3(2015), 11-68

Ethics considerations about psycho-legal expertise and empirical data

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See detailUne déontologie manipulée ?
Durand, Pascal ULg; Grégoire, Arnaud

Article for general public (2007)

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See detailLa déontologie, à la croisée de l'éthique et du droit
Genicot, Gilles ULg

in L'éthique en médecine bucco-dentaire (2012)

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See detailDeorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis
Ahmed, Kashan; Tunaru, Sorin; Langhans, C. D. et al

in Journal of Biological Chemistry (2009), 284(33), 21928-33

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See detailDeoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma.
Marechal, Raphael; Mackey, John R; Lai, Raymond et al

in Cancer (2010), 116(22), 5200-6

BACKGROUND: Gemcitabine (2',2'-difluorodeoxycytidine) administration after resection of pancreatic cancer improves both disease-free survival (DFS) and overall survival (OS). Deoxycytidine kinase (dCK ... [more ▼]

BACKGROUND: Gemcitabine (2',2'-difluorodeoxycytidine) administration after resection of pancreatic cancer improves both disease-free survival (DFS) and overall survival (OS). Deoxycytidine kinase (dCK) mediates the rate-limiting catabolic step in the activation of gemcitabine. The authors of this report studied patient outcomes according to the expression of dCK after a postoperative gemcitabine-based chemoradiation regimen. METHODS: Forty-five patients with resected pancreatic adenocarcinoma received adjuvant gemcitabine based-therapy in the context of multicenter phase 2 studies. Their tumors were evaluated retrospectively for dCK protein expression by immunohistochemistry. A composite score based on the percentage of dCK-positive cancer cells and the intensity of staining was generated, and the results were dichotomized at the median values. RESULTS: The median follow-up was 19.95 months (95% confident interval [CI], 3.3-107.4 months). The lymph node (LN) ratio and dCK protein expression were significant predictors of DFS and OS in univariate analysis. On multivariate analysis, dCK protein expression was the only independent prognostic variable (DFS: hazard ratio [HR], 3.48; 95% CI, 1.66-7.31; P = .001; OS: HR, 3.2; 95% CI,1.44-7.13; P = .004). CONCLUSIONS: dCK protein expression was identified as an independent and strong prognostic factor in patients with resected pancreatic adenocarcinoma who received adjuvant gemcitabine therapy. The authors concluded that it deserves prospective evaluation as a predictive biomarker for patient selection. [less ▲]

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See detailDépart à la retraite et conditions de vie parmi la population âgée de 50 à 64 ans
Compagnie, Ph.; Pestieau, Pierre ULg; Sluse, Myriam ULg et al

in Fondation Roi Baudouin (1995)

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See detailDépart à la retraite: une perspective internationale
Jousten, Alain ULg

in Revue Française d'Economie (2003), XVIII

Des différences internationales importantes persistent quant au taux d'activité des travailleurs âgés et à l'âge du départ à la retraite. Tandis que certains pays d'Europe continentale sont caractérisés ... [more ▼]

Des différences internationales importantes persistent quant au taux d'activité des travailleurs âgés et à l'âge du départ à la retraite. Tandis que certains pays d'Europe continentale sont caractérisés par des taux d'activités relativement faibles, d'autres pays développés ne connaissent pas cette tendance. Nous illustrons le rôle important joué par les décisions individuelles dans le contexte du départ à la retraite. [less ▲]

Detailed reference viewed: 18 (3 ULg)