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See detailDevelopment and characterization of SSR markers for pomegranate (Punica granatum L.) using an enriched library
Hasnaoui, Nejib ULg; Buonamici, Anna; Sebastiani, Federico et al

in Conservation Genetics Resources (2010), 2

In the present work, we report the development of 11 microstallite markers (SSR) for Punica granatum. Evaluated on a set of 27 pomegranate accessions sampled in Tunisia, they displayed 25 alleles, with ... [more ▼]

In the present work, we report the development of 11 microstallite markers (SSR) for Punica granatum. Evaluated on a set of 27 pomegranate accessions sampled in Tunisia, they displayed 25 alleles, with number of alleles per locus ranging between 1 and 4, and an observed heterozygosity from 0.037 and 0.592. This set of SSR markers can be very useful for studies dealing with genetic diversity assessment of germplasm, with cultivars/varieties fingerprinting and pedigree analysis of this economically important fruit species. [less ▲]

Detailed reference viewed: 53 (3 ULg)
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See detailDevelopment and epidemiological evaluation of a monoclonal ELISA detecting Bovine Viral Diarrhœa Pestivirus antigens in field blood samples of persistently infected cattle
Mignon, Bernard ULg; Dubuisson, J.; Waxweiler, S. et al

in Steven, Edwards (Ed.) ESVV-Proceedings of the second symposium on pestiviruses (1993)

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See detailDevelopment and evaluation in vitro and in vivo of injectable hydrolipidic gels with sustained-release properties for the management of articular pathologies such as osteoarthritis.
Réeff, Jonathan; Oprenyeszk, Frédéric ULg; Franck, Thierry ULg et al

in International Journal of Pharmaceutics (2015), 490

This study aimed to evaluate glycerol monooleate (GMO) as a carrier to develop viscoelastic and injectable sustained-release drug delivery systems. The potential pro- and antioxidant activity of the ... [more ▼]

This study aimed to evaluate glycerol monooleate (GMO) as a carrier to develop viscoelastic and injectable sustained-release drug delivery systems. The potential pro- and antioxidant activity of the developed hydrolipidic gels were evaluated by measuring the production of ROS by polymorphonuclear leukocytes (PMNs). In addition, the biocompatibility and effectiveness of two selected gel candidates were evaluated in vivo by evaluating the benefit of a single intraarticular injection of these new treatments in a model of osteoarthritis in rabbits. The in vitro study demonstrated that the carrier F1 did not have a pro-oxidative effect and even protected PMNs against natural auto-activation, regardless of the incorporation of either clonidine chlorhydrate or betamethasone dipropionate. The in vivo study demonstrated that F1 and F1-BDP induced a loss of cartilage quality in comparison to the control and reference groups but that the lesions of cartilage observed were generally mild, with not much full-depth erosion. Moreover, no exacerbating inflammation was observed when considering the synovial membranes and the PGE2 and CRP levels. These results seemed to demonstrate that the sustained-release formulation based on GMO could be well-tolerated after intraarticular injection. Moreover, it could have the potential to prevent inflammatory conditions while sustaining drug activity locally over weeks. [less ▲]

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See detailDevelopment and Evaluation of a VTOL Observation Platform
Buysschaert, F.; Yacoubi, M.; Alami, A. et al

in Proceedings of the 27th International Congress of the Aerospace Sciences (2010, September)

An aerodynamic study of the ULB-developed ducted rotor MAV using the results of full-scale wind tunnel tests allowed the determination of the platform’s positive speed envelope, power requirements and ... [more ▼]

An aerodynamic study of the ULB-developed ducted rotor MAV using the results of full-scale wind tunnel tests allowed the determination of the platform’s positive speed envelope, power requirements and endurance characteristics for ISA sea level conditions. In this study, the power consumption appears to be majorly depending on the rotor rotational speed, while an increase in horizontal speed results in a duct operating more as a circular wing, also unveiling a power bucket as is the case with conventional helicopters. A positive influence of the ground proximity on the total thrust has been monitored. [less ▲]

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See detailDevelopment and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain.
Rubins, Daniel J.; Melega, William P.; Lacan, Goran et al

in NeuroImage (2003), 20(4), 2100-18

An automated method for placement of 3D rat brain atlas-derived volumes of interest (VOIs) onto PET studies has been designed and evaluated. VOIs representing major structures of the rat brain were ... [more ▼]

An automated method for placement of 3D rat brain atlas-derived volumes of interest (VOIs) onto PET studies has been designed and evaluated. VOIs representing major structures of the rat brain were defined on a set of digitized cryosectioned images of the rat brain. For VOI placement, each PET study was registered with a synthetic PET target constructed from the VOI template. Registration was accomplished with an automated algorithm that maximized the mutual information content of the image volumes. The accuracy and precision of this method for VOI placement was determined using datasets from PET studies of the striatal dopamine and hippocampal serotonin systems. Each evaluated PET study could be registered to at least one synthetic PET target without obvious failure. Registration was critically dependent upon the initial position of the PET study relative to the synthetic PET target, but not dependent on the amount of synthetic PET target smoothing. An evaluation algorithm showed that resultant radioactivity concentration measurements of selected brain structures had errors=2% due to misalignment with the corresponding VOI. Further, radioligand binding values calculated from these measurements were found to be more precise than those calculated from measurements obtained with manually drawn regions of interest (ROIs). Overall, evaluation results demonstrated that this atlas-derived VOI method can be used to obtain unbiased measurements of radioactivity concentration from PET studies. Its automated features, and applicability to different radioligands and brain regions, will facilitate quantitative rat brain PET assessment procedures. [less ▲]

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See detailThe development and experimental validation of a reduced ternary kinetic mechanism for the auto-ignition at HCCI conditions, proposing a global reaction path for ternary gasoline surrogates
Machrafi, Hatim ULg; Cavadias, Simeon; Amouroux, Jacques

in Fuel Processing Technology (2009), 90(2), 247-263

To acquire a high amount of information of the behaviour of the Homogeneous Charge Compression Ignition (HCCI) auto-ignition process, a reduced surrogate mechanism has been composed out of reduced n ... [more ▼]

To acquire a high amount of information of the behaviour of the Homogeneous Charge Compression Ignition (HCCI) auto-ignition process, a reduced surrogate mechanism has been composed out of reduced n-heptane, iso-octane and toluene mechanisms, containing 62 reactions and 49 species. This mechanism has been validated numerically in a OD HCCI engine code against more detailed mechanisms (inlet temperature varying from 290 to 500 K, the equivalence ratio from 0.2 to 0.7 and the compression ratio from 8 to 18) and experimentally against experimental shock tube and rapid compression machine data from the literature at pressures between 9 and 55 bar and temperatures between 700 and 1400 K for several fuels: the pure compounds n-heptane, iso-octane and toluene as well as binary and ternary mixtures of these compounds. For this validation, stoichiometric mixtures and mixtures with an equivalence ratio of 0.5 are used. The experimental validation is extended by comparing the surrogate mechanism to experimental data from an HCCI engine. A global reaction pathway is proposed for the auto-ignition of a surrogate gasoline, using the surrogate mechanism, in order to show the interactions that the three compounds can have with one another during the auto-ignition of a ternary mixture. (C) 2008 Elsevier B.V. All rights reserved. [less ▲]

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See detailDevelopment and experimental validation of an Organic Rankine cycle model
Lemort, Vincent ULg; Quoilin, Sylvain ULg; Cuevas, Critian et al

(2007)

This paper presents both a numerical model of an Organic Rankine Cycle (ORC) and an experimental study carried out on a prototype of such a cycle working with refrigerant HCFC-123, and whose heat sources ... [more ▼]

This paper presents both a numerical model of an Organic Rankine Cycle (ORC) and an experimental study carried out on a prototype of such a cycle working with refrigerant HCFC-123, and whose heat sources consist in two hot air flows. The ORC model s built by connecting different sub-models: the heat exchanger models, a volumetric pump model and a scroll expander model. Measured performances of the ORC prototype are presented and allow the validation of the ORC model. This model is finally used to investigate potential improvements of the prototype. [less ▲]

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See detailDevelopment and Identification of a Closed-Loop Model of the Cardiovascular System Including the Atria
Pironet, Antoine ULg; Revie, James A.; Paeme, Sabine ULg et al

Conference (2012, August 31)

Detailed reference viewed: 54 (6 ULg)
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See detailDevelopment and Identification of a Closed-Loop Model of the Cardiovascular System Including the Atria
Pironet, Antoine ULg; Revie, James A.; Paeme, Sabine ULg et al

in Proceedings of the 8th IFAC Symposium on Biological and Medical Systems (2012, August)

Detailed reference viewed: 45 (10 ULg)
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See detailDevelopment and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass (R) for tissue engineering applications
Roether, J. A.; Boccaccini, Aldo R.; Hench, L. L. et al

in Biomaterials (2002), 23(18), 3871-3878

Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and ... [more ▼]

Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and homogeneous Bioglasss coatings on the surface of PDLLA foams as well as infiltration of Bioglass® particles throughout the porous network were achieved using a slurry-dipping technique in conjunction with pre-treatment of the foams in ethanol. The quality of the bioactive glass coatings was reproducible in terms of thickness and microstructure. Additionally, electrophoretic deposition was investigated as an alternative method for the fabrication of PDLLA foam/Bioglass® composite materials. In vitro studies in simulated body fluid (SBF) were performed to study the formation of hydroxyapatite (HA) on the surface of PDLLA/Bioglass® composites. SEM analysis showed that the HA layer thickness rapidly increased with increasing time in SBF. The high bioactivity of the PDLLA foam/Bioglasss composites indicates the potential of the materials for use as bioactive, resorbable scaffolds in bone tissue engineering. [less ▲]

Detailed reference viewed: 101 (3 ULg)
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See detailDevelopment and Layout of a ACC-System by means of Evolutionary Algorithms
Christen, Fréderic ULg

Scientific conference (2007, August 22)

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See detailDevelopment and numerical validation of a 2-scale computational model to study the mechanical behavior of nanocrystalline metals
Péron, Vincent ULg

Doctoral thesis (2014)

This work aims at predicting the mechanical behavior of nanocrystalline structure using a 2-scale approach. Molecular simulations using the quasicontinuum method (QC) are performed to obtain the ... [more ▼]

This work aims at predicting the mechanical behavior of nanocrystalline structure using a 2-scale approach. Molecular simulations using the quasicontinuum method (QC) are performed to obtain the mechanical responses of the grain-boundaries and grains at the nanoscale. A finite element model is then calibrated using these atomistic results. This 2-scale model accounts for intergranular and intragranular plasticity, can predict the intergranular failure, and is able to study large structures. [less ▲]

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See detailDevelopment and optimisation of methods to synthesise sol-gel nanoparticles and sol-gel core-shell nanoparticles to produce nanosensors
De Bleye, Charlotte ULg

Master's dissertation (2011)

The aim of this project was to synthesise nanosensors. It can be defined as an inert, biofriendly matrix in which sensing molecules are entrapped, allowing determination of analytes concentration. Two ... [more ▼]

The aim of this project was to synthesise nanosensors. It can be defined as an inert, biofriendly matrix in which sensing molecules are entrapped, allowing determination of analytes concentration. Two types of nanosensors were synthesised according to the Stöber method and characterised by a scanning electron microscope and a CPS disc centrifuge. The nanosensors were calibrated with succes using a fluorimeter. [less ▲]

Detailed reference viewed: 45 (13 ULg)
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See detailDevelopment and optimization of pegylated lipoplexes for vaginal application
Lechanteur, Anna ULg; Furst, Tania ULg; Kanber, Erdem et al

Conference (2014, October 04)

Detailed reference viewed: 33 (8 ULg)