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See detailDepth-integrated flow modelling taking into account bottom curvature
Dewals, Benjamin ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Journal of Hydraulic Research (2006), 44(6), 787-795

Successfully modelling flows over a spillway and on strongly vertically curved bottoms is a challenge for any depth-integrated model. This type of computation requires the use of axes properly inclined ... [more ▼]

Successfully modelling flows over a spillway and on strongly vertically curved bottoms is a challenge for any depth-integrated model. This type of computation requires the use of axes properly inclined along the mean flow direction in the vertical plane and a modelling of curvature effects. The proposed generalized model per-forms such computations by means of suitable curvilinear coordinates in the vertical plane, leading to a fully integrated approach. This means that the flows in the upstream reservoir, on the spillway, in the stilling basin and in the downstream river reach are all handled in a single simulation. The velocity profile is generalized in comparison with the uniform one usually assumed in the classical shallow water equations. The pressure dis-tribution is modified as a function of the bottom curvature and is thus not purely hydrostatic. Representative test cases, as well as the application of the extended model to the design of a large hydraulic structure in Bel-gium, lead to satisfactory validation results. [less ▲]

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See detailDepths and type of substrate influence the ability of Nasonia vitripennis Walker (Hymenoptera: Pteromalidae) to encounter host
Frederickx, Christine ULg; Dekeirsschieter, Jessica ULg; Verheggen, François ULg et al

in Journal of Insect Science [=JIS] (2014)

The foraging behaviour of a parasitoid insect species includes the host’s habitat and subsequent location of the host. Habitats-substrate, substrate moisture and light levels can affect the host location ... [more ▼]

The foraging behaviour of a parasitoid insect species includes the host’s habitat and subsequent location of the host. Habitats-substrate, substrate moisture and light levels can affect the host location made by different species of parasitoids. However, the depth at which parasitoids concentrate their search effort is an another important ecological characteristic and play an important role on the host location. Here, we have investigated the ability of a pupal parasitoid, Nasonia vitripennis Walker, to penetrate and kill fly pupae located at different depth of the substrate. Three different types of substrate were tested: loam soil, compost and vermiculite substrate. In both loam soil and compost, all of the parasitism activity was restricted to pupae placed directly on the surface. Parasitism activity in vermiculite showed that the average number of pupae parasitized was decreased with depth. These results suggest that fly pupae situated deeper in the substrate are less subjected to parasitism by N. vitripennis. [less ▲]

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See detailDer Einfluss von Rollenstress auf die Arbeitsleistung von Kundenkontaktmitarbeitern - Ein personenspezifisches Phänomen
Volz, Julian; Büttgen, Marion; Ates, Zelal ULg et al

in Schmitz, Gertrud (Ed.) Theorie und Praxis des Dienstleistungsmarketing: Aktuelle Konzepte und Entwicklungen (2013)

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See detailDer p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus
Herman, Julie ULg; Thelen, Nicolas ULg; Smargiasso, Nicolas ULg et al

in Biochimica et Biophysica Acta - General Subjects (2013), 1840

Background: The enzymatic activity of the four proteases found in the house dust mite Dermatophagoides pteronyssinus is involved in the pathogenesis of allergy. Our aim was to elucidate the activation ... [more ▼]

Background: The enzymatic activity of the four proteases found in the house dust mite Dermatophagoides pteronyssinus is involved in the pathogenesis of allergy. Our aim was to elucidate the activation cascade of their corresponding precursor forms and particularly to highlight the interconnection between proteases during this cascade. Methods: The cleavage of the four peptides corresponding to the mite zymogen activation sites was studied on the basis of the Förster Resonance Energy Transfermethod. The proDer p 6 zymogen was then produced in Pichia pastoris to elucidate its activation mechanismbymite proteases, especially Der p 1. The role of the propeptide in the inhibition of the enzymatic activity of Der p 6 was also examined. Finally, the Der p 1 and Der p 6 proteases were localised via immunolocalisation in D. pteronyssinus. Results: All peptides were specifically cleaved by Der p 1, such as proDer p 6. The propeptide of proDer p 6 inhibited the proteolytic activity of Der p 6, but once cleaved, it was degraded by the protease. The Der p 1 and Der p 6 proteases were both localised to the midgut of the mite. Conclusions: Der p 1 in either its recombinant formor in the natural context of house dustmite extracts specifically cleaves all zymogens, thus establishing its role as a major activator of both mite cysteine and serine proteases. General significance: This finding suggests that Der p 1 may be valuable target against mites. [less ▲]

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See detailDer Struwwelpeter ou le plaisir triomphant
Mormont, Christian ULg

in Théâtre du Tilleul (Ed.) Autour de Crasse-Tignasse (1996)

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See detailDe derde reus
Spinoy, Erik ULg

in Van Vaeck, Marc; De Geest, Dirk (Eds.) Brekende spiegels. Beeldveranderingen in de Nederlandse literatuur (1992)

This is a contribution to an edited volume on changing views of literary oeuvres. My article concerns the consecutive images that have been constructed of the work of Paul van Ostaijen.

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See detailDerechef Ounamon, 2,13-14
Winand, Jean ULg

in Göttinger Miszellen (1994), 139

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See detailEl derecho de propiedad, la función social del suelo y la normativa urbana
Cabrera Quispe, Juan Edson ULg

in Dimensiones (2008), 1(winter), 120-134

Cuál es el origen de la planeación urbana? del ordenamiento del territorio? de la reglamentación urbana? Sin duda desde que los derechos de propiedad se han constituido, ha sido necesario un conjunto de ... [more ▼]

Cuál es el origen de la planeación urbana? del ordenamiento del territorio? de la reglamentación urbana? Sin duda desde que los derechos de propiedad se han constituido, ha sido necesario un conjunto de herramientas diferentes, algunas llamadas planes. Las cuales tienen la función de intervenir sobre las libertades y derechos de propiedad a fin de evitar el abuso absoluto de ellos. En ese marco la posibilidad de ejercer derechos sobre la propiedad también implica responsabilidades, siendo una de las más importantes la función social. Ella es interpretada desde el urbanismo como la llave fundamental para promover instrumentos de gestión viable y eficiente, traducidos en legislaciones sobre el suelo, normas urbanas y otros. La posibilidad de reformar la normativa urbana de la ciudad de Cochabamba es una ocasión importante y fundamental para considerar la oportunidad que nos brinda la función social constituida en nuestro marco jurídico fundamental, expresado en la CPE y el Código Civil. Finalmente la función social y también la función ecológica de la propiedad inmobiliaria y su reconocimiento ontológico, permite el rediseño elemental de una nueva norma urbana sin la necesidad expresa de reformas constitucionales o marcos legales específicos como la tan demandada ley de urbanismo. [less ▲]

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See detailDeregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells.
Cornez, Isabelle ULg; Creppe, Catherine ULg; Gillard, Magali ULg et al

in Biochemical Pharmacology (2008), 75

Elongator, a multi-subunit complex assembled by the IkappaB kinase-associated protein (IKAP)/hELP1 scaffold protein is involved in transcriptional elongation in the nucleus as well as in tRNA ... [more ▼]

Elongator, a multi-subunit complex assembled by the IkappaB kinase-associated protein (IKAP)/hELP1 scaffold protein is involved in transcriptional elongation in the nucleus as well as in tRNA modifications in the cytoplasm. However, the biological processes regulated by Elongator in human cells only start to be elucidated. Here we demonstrate that IKAP/hELP1 depleted colon cancer-derived cells show enhanced basal expression of some but not all pro-apoptotic p53-dependent genes such as BAX. Moreover, Elongator deficiency causes increased basal and daunomycin-induced expression of the pro-survival serum- and glucocorticoid-induced protein kinase (SGK) gene through a p53-dependent pathway. Thus, our data collectively demonstrate that Elongator deficiency triggers the activation of p53-dependent genes harbouring opposite functions with respect to apoptosis. [less ▲]

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See detailDeregulated expression of TANK in glioblastomas triggers pro-tumorigenic ERK1/2 and AKT signaling pathways
Stellzig, J; Chariot, Alain ULg; Shostak, Kateryna ULg et al

in Oncogenesis (2013), e79

Signal transmission by the noncanonical IkappaB kinases (IKKs), TANK-binding kinase 1 (TBK1) and IKKɛ, requires interaction with adapter proteins such as TRAF associated NF-κB activator (TANK). Although ... [more ▼]

Signal transmission by the noncanonical IkappaB kinases (IKKs), TANK-binding kinase 1 (TBK1) and IKKɛ, requires interaction with adapter proteins such as TRAF associated NF-κB activator (TANK). Although increased expression or dysregulation of both kinases has been described for a variety of human cancers, this study shows that deregulated expression of the TANK protein is frequently occurring in glioblastomas (GBMs). The functional relevance of TANK was analyzed in a panel of GBM-derived cell lines and revealed that knockdown of TANK arrests cells in the S-phase and prohibits tumor cell migration. Deregulated TANK expression affects several signaling pathways controlling cell proliferation and the inflammatory response. Interference with stoichiometrically assembled signaling complexes by overexpression or silencing of TANK prevented constitutive interferon-regulatory factor 3 (IRF3) phosphorylation. Knockdown of TANK frequently prevents constitutive activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2). TANK-mediated ERK1/2 activation is independent from the canonical MAP kinase or ERK kinase (MEK) 1/2-mediated pathway and utilizes an alternative pathway that uses a TBK1/IKKɛ/Akt signaling axis, thus identifying a novel pathway suitable to block constitutive ERK1/2 activity. [less ▲]

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See detailDeregulated NF-kappa B activity in haematological malignancies
Keutgens, Aurore ULg; Robert, Isabelle ULg; Viatour, Patrick ULg et al

in Biochemical Pharmacology (2006), 72(9), 1069-1080

The NF-kappa B family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappa B activation is a common feature for most haematological ... [more ▼]

The NF-kappa B family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappa B activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-kappa B deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor. (c) 2006 Elsevier Inc. All rights reserved. [less ▲]

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See detailDerek Walcott’s The Odyssey : A Post-Colonial ‘Odd Assay’ of the Epic Genre as a Regenerative Source of ‘Latent Cross-Culturalities’.
Bada, Valérie ULg

in Bellarsi, Franca; Maufort, Marc (Eds.) Crucible of Cultures. Anglophone Drama at the Dawn of a New Millennium. (2002)

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See detailDerf Backderf, Mon ami Dahmer
Delville, Michel ULg

Article for general public (2014)

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See detailDerivation and Application of Sensitivities to Assess Transient Voltage Sags caused by Rotor Swings
Weckesser, Tilman; Johannsson, Hjortur; Ostergaard, Jacob et al

in International Journal of Electrical Power & Energy Systems (2015), 72

The paper introduces an approach to investigate voltage sags, which are caused by large generator rotor swings following a transient disturbance. Therefore, the method exploits sensitivities derived from ... [more ▼]

The paper introduces an approach to investigate voltage sags, which are caused by large generator rotor swings following a transient disturbance. Therefore, the method exploits sensitivities derived from the algebraic network equations. These provide information on the impact of a generator on the voltage magnitude at a load bus and the e ffect of load variation on the generator's power injection. It is shown that these sensitivities give valuable information to identify critical generator-load pairs and locations for applying preventive control measures. [less ▲]

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See detailDérivation des équations d'observation
Bruyninx, Carine; Warnant, René ULg

Report (1990)

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See detailDerivation of a bioclinical prognostic index in severe head injury.
Hans, Pol ULg; Albert, Adelin ULg; Born, J. D. et al

in Intensive Care Medicine (1985), 11(4), 186-91

We investigated the problem of outcome prediction from seven risk factors in 40 severely head injured patients - 13 favorable and 27 unfavorable outcomes. By applying stepwise logistic discriminant ... [more ▼]

We investigated the problem of outcome prediction from seven risk factors in 40 severely head injured patients - 13 favorable and 27 unfavorable outcomes. By applying stepwise logistic discriminant analysis to the patients' data, we selected three significant risk variables: cerebrospinal fluid (CSF) CK-BB isoenzyme activity recorded on admission, severely raised intracranial pressure (more than 40 mmHg) and age, respectively. CSF CK-BB activity, which quantifies the initial neurological damage, proved to be the best prognostic factor. The presence of severe intracranial hypertension was always associated with a bad outcome, whereas its absence was not necessarily indicative of good prognosis. Finally, we combined the three selected variables into a single risk index, which allowed correct predictions in 92% of patients with favorable outcome and in 85% of patients with unfavorable outcome (total predictive efficiency 88%). [less ▲]

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See detailDerivation of a new lamb survival trait for implementation in the New Zealand sheep industry
Vanderick, Sylvie ULg; Auvray, Benoit; Newman, Sheryl-Anne et al

Poster (2012, June)

Lambing percentage is one of the most significant factors affecting profitability on New Zealand sheep farms. Since the early 1990s, lambing percentage has increased at about 1% per year from a relatively ... [more ▼]

Lambing percentage is one of the most significant factors affecting profitability on New Zealand sheep farms. Since the early 1990s, lambing percentage has increased at about 1% per year from a relatively stable level of approximately 100%, and top performing sheep farms are now consistently achieving 150% or more. As lambing percentage increases, the proportion of ewes bearing twins and triplets increases accordingly. Lamb mortality rate in these multiples is higher than in singles, with triplets being particularly susceptible. Consequently, lamb survival has become increasingly important to the New Zealand sheep industry. Sheep Improvement Ltd (SIL, New Zealand's national sheep genetic evaluation system provided by Beef & Lamb NZ) records lamb survival to weaning but genetic improvement has been limited due to the low heritability of the trait and the current method of recording. [less ▲]

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See detailDerivation of a new lamb survival trait for the New Zealand sheep industry
Vanderick, Sylvie ULg; Auvray, Benoit; Newman, Sheryl-Anne et al

in Journal of Animal Science (2015), 93

Previous research identified that a review of the current industry New Zealand lamb survival trait was necessary as its recording accuracy was reliant on farmers notifying their Sheep Improvement Limited ... [more ▼]

Previous research identified that a review of the current industry New Zealand lamb survival trait was necessary as its recording accuracy was reliant on farmers notifying their Sheep Improvement Limited bureau of lamb deaths. This paper reports the decision rules and genetic parameters for a new lamb survival trait for the New Zealand sheep industry. These rules define the new lamb survival trait (NEWSUR) using lamb birth fate (BFATE) codes and the presence/absence of lamb weight measurements. Six univariate animal models were tested and used to estimate variance or covariance components and the resulting direct and maternal heritabilities for NEWSUR. The models differed in the way they adjust for the effect of day of birth, the exclusion or inclusion of a litter (dam/year of birth) random effect and the application or not of a logit transformation of the phenotypes. For both the linear and logistic methods, models including the random effect of litter provided the best fit for NEWSUR according to log-likelihood values. Log-likelihoods for the linear and logistic models cannot be compared, therefore a cross-validation method was used to assess whether the logit transformation was appropriate by analyzing the predictive ability of the models. The mean square errors were slightly lower for the linear compared to the logistic model and therefore the linear model was recommended for industry use. The heritability attributed to direct effects ranged from 2 to 5.5%. A direct heritability of 5.5% resulted from a linear model without litter effect and omitting the effect of day of birth on survival, whereas a direct heritability of 2% resulted from the logistic model fitting a random litter effect. The heritability attributed to maternal genetic effects ranged from 1.9 to 7.7%. A maternal genetic heritability of 7.7% resulted from the logistic model omitting the litter effect, whereas a maternal genetic heritability of 1.9% resulted from the linear model fitting a random litter effect. The addition of the litter random effect decreased the maternal heritabilities substantially in all cases and was recommended for industry use to avoid overestimation of the maternal genetic variance. SIL has implemented NEWSUR and the associated genetic evaluation model based on information described in this paper. Industry wide implementation will enable sheep breeders to produce more accurate genetic evaluations to their commercial clients. [less ▲]

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