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See detailDurability of mortar and concretes containing slag with low hydraulic activity
Hadj Sadok, Ahmed; Kenaï, Saïd; Courard, Luc ULg et al

in Cement & Concrete Composites (2012), 34(5), 671677

Granulated blast furnace slag has been widely used as a partial substitute for Portland cement in many applications because of advantages which include cost reduction, reduction in heat evolution and ... [more ▼]

Granulated blast furnace slag has been widely used as a partial substitute for Portland cement in many applications because of advantages which include cost reduction, reduction in heat evolution and improvement of durability properties. However, the effectiveness of slag depends on its hydraulic reactivity. In this paper, the results of an experimental study on the effect of slag with low hydraulicity on the mechanical and durability properties of concrete and the performance of mortar under sulfate attack are discussed. Special attention is given to gas permeability and water absorption of slag concrete. The durability of slag concrete is improved at long term at low Water/Binder ratio. Sulfate resistance of mortar is improved by slag replacement up to 30%. [less ▲]

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See detailDurability of mortars modified with metakaolin
Courard, Luc ULg; Darimont, Anne ULg; Schouterden, M. et al

in Cement & Concrete Research (2003), 33(9), 1473-1479

Results of an investigation to determine the effects of metakaolin additions on transport properties of mortars are reported. Comparisons are made to ordinary Portland cement (OPC) to determine the ... [more ▼]

Results of an investigation to determine the effects of metakaolin additions on transport properties of mortars are reported. Comparisons are made to ordinary Portland cement (OPC) to determine the influence of addition and replacement percentage. Cement is replaced on a mass basis of 5-20% for metakaolin. A mixture with natural kaolin is also studied. The transport properties and chemical behaviors are analyzed by means of chloride diffusion tests and sulfate immersion. Obserdvations after more than 100 days are used to prescribe mixtures that reduce the rate of chloride diffusion and sulfate degradation. For metakaolin, the optimum seems to be between 10% and 15% with regard to inhibition effect on chloride diffusion and sulfate attack. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailDural artery from the anterior cerebral artery to the planum sphenoidale.
Signorelli, Francesco; Scholtes, Félix ULg; Kauffmann, C. et al

in Acta Neurochirurgica (2010)

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See detailDuration of corneal anaesthesia following multiple doses and two concentrations of tetracaine hydrochloride eyedrops on the normal equine cornea
Monclin, Sébastien ULg; Farnir, Frédéric ULg; Grauwels, Magda ULg

in Equine Veterinary Journal (2011), 43(1), 69-73

REASONS FOR PERFORMING STUDY: There is a clinical impression that tetracaine hydrochloride (THCl) eyedrops is a suitable topical anaesthetic in horses. OBJECTIVE: To determine the duration of corneal ... [more ▼]

REASONS FOR PERFORMING STUDY: There is a clinical impression that tetracaine hydrochloride (THCl) eyedrops is a suitable topical anaesthetic in horses. OBJECTIVE: To determine the duration of corneal anaesthesia following instillation of multiple doses and 2 concentrations of THCl in 10 healthy horses. METHODS: The corneal touch threshold (CTT) was determined, in both eyes, before (basal CTT) and after application of one drop of 0.5% THCl, 2 drops at a 1 min interval of 0.5% THCl or one drop of 1% THCl. CTT was measured in mm every 5 min until complete recovery of the basal CTT. Treatments were separated by an interval of at least one week. RESULTS: Corneal sensitivity was significantly reduced from baseline values for 30, 60 and 50 min after application of one drop of 0.5% THCl, 2 drops of 0.5% THCl and one drop of 1% THCl, respectively. Mean maximal anaesthetic effects, corresponding to a CTT of 0 mm, lasted 5.5, 16 and 15.25 min and maximal anaesthetic effect was present in 55, 90 and 80% of eyes, 5 min after application of one drop of 0.5% THCl, 2 drops of 0.5% THCl and one drop of 1% THCl, respectively. CONCLUSIONS: The application of a second drop or the use of more concentrated eyedrops significantly increases duration of both anaesthesia and maximal anaesthetic effect. POTENTIAL RELEVANCE: Duration of corneal anaesthesia following tetracaine instillation was established enabling a better use when performing diagnostic and therapeutic procedures. Comparison of tetracaine with other ocular anaesthetics needs to be published in the future. [less ▲]

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See detailDuration perception: A Developmental Semiology from 2:6 to 13 Years, General Population versus Atypical, Assessment by Parental Questionnaire
SCHOLL, Jean-Marc ULg; Philippe, Paule; Gérard, Paul ULg et al

Conference (2012, December 20)

Introduction Perception of duration has a major impact on the child’s ability to manage everyday life. Usually, the perception of time is considered in its sequential component. To our knowledge, possible ... [more ▼]

Introduction Perception of duration has a major impact on the child’s ability to manage everyday life. Usually, the perception of time is considered in its sequential component. To our knowledge, possible semiological markers for the capacity to apprehend temporal duration have not yet been explored. There are thus no existing tools either for its evaluation (in everyday life) or for the description of its development during childhood. We are thus largely in the dark about how the perception of duration develops during childhood. Hypothesis 1) It is possible to track perception of duration using semiological markers in everyday life; 2) Children with developmental disorders can be expected to develop difficulties in this domain. Method We designed a questionnaire for parents using a Likert scale. The questionnaire was administered to 2 samples from 2:6 to 13 years: 827 in a general population and 297 in a mixed-psychopathological population recruited from the Mental Health Services network. We carried out a multinomial logistic regression and used percentiles curves (P5,50,95). Results In the general population, perception of duration is gradually acquired and full competence is attained by 9 years. The apprehension of sequential time is achieved by 4 years. In the psychopathological sample, mean perception of temporal duration is delayed by 18 months and significant difficulties remain even at 13 years. The apprehension of sequential time is also delayed: even at 13 years it remains low (at percentile 95). We have found no sex-related differences. Discussion Perception of duration is an important developmental feature which has not been taken into account until now. Semiological markers can be used to differentiate typically developing children from clinical populations as to their respective capacities to perceive temporal duration. [less ▲]

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See detailLa durée de validité de l'arrêt de maintien de la détention préventive encas de requalification des faits
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (2014)

Selon la gravité des faits, la décision de maintien de la détention préventive prise par les juridictions d'instruction vaut pour un ou trois mois. Qu'en est-il en cas de requalification des faits par ... [more ▼]

Selon la gravité des faits, la décision de maintien de la détention préventive prise par les juridictions d'instruction vaut pour un ou trois mois. Qu'en est-il en cas de requalification des faits par celles-ci ? [less ▲]

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See detailDurée, fréquence et répartition des temps de repos de taurillons culards de race Blanc-Bleu-Belge en stabulation entravée
Dechamps, P.; Nicks, Baudouin ULg; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1988), 132

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See detailDurée, fréquence et répartition des temps de repos de taurillons Pie-Noirs en stabulation entravée
Nicks, Baudouin ULg; Dechamps, Pierre; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1988), 132

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See detailDurée, fréquence et répartition des temps de repos de vaches primipares en stabulation mixte, avant et après vêlage
Dechamps, P.; Nicks, Baudouin ULg; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1988), 132(2), 131-139

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See detailDurito, een cyber-ridder op pantoffels
Vanden Berghe, Kristine ULg

in Lie, Nadia; D'haen, Theo (Eds.) Zorro & co. Populaire personages en het koloniale verleden (2002)

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See detailDurkheim et la littérature
Ledent, David ULg

Scientific conference (2014, October 09)

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See detailDUSP3 Phosphatase Deficiency or Inhibition Limit Platelet Activation and Arterial Thrombosis
Musumeci, Lucia ULg; Kuijpers, Marijke; Gilio, Karen et al

in Circulation (in press)

Background A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. Better understanding of the molecular mechanisms leading to platelet ... [more ▼]

Background A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. Better understanding of the molecular mechanisms leading to platelet activation is of importance for the development of improved therapies. Recently, protein tyrosine phosphatases (PTPs) have emerged as critical regulators of platelet function. Methods and Results This is the first report implicating the dual-specificity phosphatase 3 (DUSP3) in platelet signaling and thrombosis. This phosphatase is highly expressed in human and mouse platelets. Platelets from DUSP3-deficient mice displayed a selective impairment of aggregation and granule secretion mediated through the collagen receptor glycoprotein VI (GPVI) and the C-type lectin-like receptor 2 (CLEC-2). DUSP3-deficient mice were more resistant to collagen- and epinephrine-induced thromboembolism, compared to wild-type mice, and showed severely impaired thrombus formation upon ferric chloride-induced carotid artery injury. Intriguingly, bleeding times were not altered in DUSP3-deficient mice. At the molecular level, DUSP3 deficiency impaired Syk tyrosine phosphorylation, subsequently reducing phosphorylation of PLCγ2 and calcium fluxes. To investigate DUSP3 function in human platelets, a novel small-molecule inhibitor of DUSP3 was developed. This compound specifically inhibited collagen and CLEC-2-induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine cells. Conclusions DUSP3 plays a selective and essential role in collagen- and CLEC-2-mediated platelet activation and thrombus formation in vivo. Inhibition of DUSP3 may prove therapeutic for arterial thrombosis. This is the first time a PTP, implicated in platelet signaling, has been targeted with a small-molecule drug. [less ▲]

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See detailDUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase
Amand, Mathieu ULg; Erpicum, Charlotte ULg; BAJOU, Khalid ULg et al

in Molecular Cancer (2014)

Background DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies ... [more ▼]

Background DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies showed that DUSP3 is a negative regulator of ERK and JNK pathways in several cell lines. On the other hand, DUSP3 is implicated in human cancer. It has been alternatively described as having tumor suppressive and oncogenic properties. Thus, the available data suggest that DUSP3 plays complex and contradictory roles in tumorigenesis that could be cell type-dependent. Since most of these studies were performed using recombinant proteins or in cell-transfection based assays, the physiological function of DUSP3 has remained elusive. Results Using immunohistochemistry on human cervical sections, we observed a strong expression of DUSP3 in endothelial cells (EC) suggesting a contribution for this phosphatase to EC functions. DUSP3 downregulation, using RNA interference, in human EC reduced significantly in vitro tube formation on Matrigel and spheroid angiogenic sprouting. However, this defect was not associated with an altered phosphorylation of the documented in vitro DUSP3 substrates, ERK1/2, JNK1/2 and EGFR but was associated with an increased PKC phosphorylation. To investigate the physiological function of DUSP3, we generated Dusp3-deficient mice by homologous recombination. The obtained DUSP3-/- mice were healthy, fertile, with no spontaneous phenotype and no vascular defect. However, DUSP3 deficiency prevented neo-vascularization of transplanted b-FGF containing Matrigel and LLC xenograft tumors as evidenced by hemoglobin (Hb) and FITC-dextran quantifications. Furthermore, we found that DUSP3 is required for b-FGF-induced microvessel outgrowth in the aortic ring assay. Conclusions All together, our data identify DUSP3 as a new important player in angiogenesis. [less ▲]

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See detailDUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase
Amand, Mathieu ULg; Erpicum, Charlotte ULg; BAJOU, Khalid ULg et al

Poster (2014, January 27)

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See detailDussart Frans
Merenne-Schoumaker, Bernadette ULg

in Nouvelle biographie nationale (2010)

Courte biographie du Prof F. Dussart de l'Université de Liège

Detailed reference viewed: 12 (3 ULg)