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See detailDefective Epo production contributes to anemia persistent after ARF in nephropathia epidemica (NE)
Clement, J.; De Bock, R.; Beguin, Yves ULg

in Papadimitriou & Alexopoulos (Ed.) Proceedings of the 3rd International Satellite Symposium on Acute Renal Failure (1994)

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See detailDefective in vitro gamma-interferon production in rheumatoid arthritis
Malaise, Michel ULg; Franchimont, P.

in Arthritis and Rheumatism (1987), 30(2), 230-231

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See detailDefective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis.
Cazzola, M.; Ponchio, L.; de Benedetti, F. et al

in Blood (1996), 87(11), 4824-30

Systemic-onset juvenile chronic arthritis (SoJCA) is associated with high levels of circulating interleukin-6 (IL-6) and is frequently complicated by severe microcytic anemia whose pathogenesis is unclear ... [more ▼]

Systemic-onset juvenile chronic arthritis (SoJCA) is associated with high levels of circulating interleukin-6 (IL-6) and is frequently complicated by severe microcytic anemia whose pathogenesis is unclear. Therefore, we studied 20 consecutive SoJCA patients with hemoglobin (Hb) levels <12 g/dL, evaluating erythroid progenitor proliferation, endogenous erythropoietin production, body iron status, and iron supply for erythropoiesis. Hb concentrations ranged from 6.5 to 11.9 g/dL. Hb level was directly related to mean corpuscular volume (r = .82, P < .001) and inversely related to circulating transferrin receptor (r = -.81, P < .001) suggesting that the severity of anemia was directly proportional to the degree of iron-deficient erythropoiesis. Serum ferritin ranged from 18 to 1,660 microgram/L and was unrelated to Hb level. Bone marrow iron stores wore markedly reduced in the three children investigated, and they also showed increased serum transferrin receptor and normal-to-high serum ferritin. All 20 patients had elevated IL-6 levels and normal in vitro growth of erythroid progenitors. Endogenous erythropoietin (epo) production was appropriate for the degree of anemia as judged by both the observed to predicted log (serum epo) ratio 10.95 +/- 0.12) and a comparison of the serum epo-Hb regression found in these subjects with that of thalassemia patients. Multiple regression analysis showed that serum transferrin receptor was the parameter most closely related to hemoglobin concentration: variation in circulating transferrin receptor explained 61% of the variation in Hb level (P < .001). In 10 severely anemic patients, amelioration of anemia following intravenous iron administration resulted in normalization of serum transferrin receptor. Defective iron supply to the erythron rather than blunted epo production is the major cause of the microcytic anemia associated with SoJCA. A true body-iron deficiency caused by decreased iron absorption likely complicates long-lasting inflammation in the most anemic children, and this can be recognized by high serum transferrin receptor levels. Although oral iron is of no benefit, intravenous iron saccharate is a safe and effective means for improving iron availability for erythropoiesis and correcting this anemia. Thus, while chronically high endogenous IL-6 levels do not appear to blunt epo production, they are probably responsible for the observed abnormalities in iron metabolism. Anemia of chronic disease encompasses a variety of anemic conditions whose peculiar features may specifically correlate with the type of cytokine(s) predominantly released. [less ▲]

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See detailDefective proteolytic processing of fibrillar procollagens and prodecorin due to biallelic BMP1 mutations results in a severe, progressive form of osteogenesis imperfecta
Six, Delfien; Brecht, Guillemyn; Symoens, Sofie et al

in Journal of Bone and Mineral Research (2015)

Whereas the vast majority of osteogenesis imperfecta (OI) is caused by autosomal dominant defects in the genes encoding type I procollagen, mutations in a myriad of genes affecting type I procollagen ... [more ▼]

Whereas the vast majority of osteogenesis imperfecta (OI) is caused by autosomal dominant defects in the genes encoding type I procollagen, mutations in a myriad of genes affecting type I procollagen biosynthesis or bone formation and homeostasis have now been associated with rare autosomal recessive OI forms. Recently, homozygous or compound heterozygous mutations in BMP1, encoding the metalloproteases bone morphogenetic protein-1 (BMP1) and its longer isoform mammalian Tolloid (mTLD), were identified in 5 children with a severe autosomal recessive form of OI and in 4 individuals with mild to moderate bone fragility. BMP1/ mTLD functions as the procollagen carboxy-(C)-proteinase for types I to III procollagen but was also suggested to participate in amino-(N)-propeptide cleavage of types V and XI procollagens and in proteolytic trimming of other extracellular matrix (ECM) substrates. We report the phenotypic characteristics and natural history of 4 adults with severe, progressive OI characterized by numerous fractures, short stature with rhizomelic shortening, and deformity of the limbs and variable kyphoscoliosis, in whom we identified novel biallelic missense and frameshift mutations in BMP1. We show that BMP1/mTLD-deficiency in humans not only results in delayed cleavage of the type I procollagen C-propeptide but also hampers the processing of the small leucine-rich proteoglycan prodecorin, a regulator of collagen fibrillogenesis. Immunofluorescent staining of types I and V collagen and transmission electron microscopy of the dermis show impaired assembly of heterotypic type I/V collagen fibrils in the ECM. Our study thus highlights the severe and progressive nature of BMP1-associated OI in adults and broadens insights into the functional consequences of BMP1/mTLD-deficiency on ECM organization. [less ▲]

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See detailDefective regulation of cerebral oxygen transport after severe birth asphyxia
RAMAEKERS, Vincent ULg; Casaer, P.

in Developmental medicine and child neurology (1990), 32(1), 56-62

Cerebral artery Doppler ultrasonography was used to study the cerebral blood-flow velocity and cerebral oxygen transport of infants requiring a blood transfusion to correct anaemia. Mean flow velocity ... [more ▼]

Cerebral artery Doppler ultrasonography was used to study the cerebral blood-flow velocity and cerebral oxygen transport of infants requiring a blood transfusion to correct anaemia. Mean flow velocity, pulsatility index and haemoglobin concentration were determined before and after transfusion. 11 stable preterm infants demonstrated an inverse relationship between haemoglobin concentration (or estimated arterial oxygen content) and mean flow velocity, indicating the presence of a homeostatic mechanism keeping brain oxygen transport within certain limits. Three infants with severe post-asphyxial encepalopathy had relatively high mean flow velocities and low pulsatility indices both before and after transfusion. There were no circulatory adjustments in response to an increase in haemoglobin concentration. Thus severe asphyxia at birth disrupted the homeostatic mechanism responsible for keeping brain oxygen transport constant. These findings stress the importance of close monitoring of arterial oxygen content, particularly for infants with severe post-asphyxial encephalopathy. [less ▲]

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See detailDefects do Catalysis: CO Monolayer Oxidation and Oxygen Reduction Reaction on Hollow PtNi/C Nanoparticles
Dubau, Laetitia; Nelayah, Jaysen; Moldovan, Simona et al

in ACS Catalysis (2016)

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See detailDefects segmentation on 'Golden Delicious' apples by using colour machine vision
Leemans, Vincent ULg; Magein, Hugo ULg; Destain, Marie-France ULg

in Computers & Electronics in Agriculture (1998), 20(2), 117-130

A method based on colour information is proposed to detect defects on 'Golden Delicious' apples. In a first step, a colour model based on the variability of the normal colour is described. To segment the ... [more ▼]

A method based on colour information is proposed to detect defects on 'Golden Delicious' apples. In a first step, a colour model based on the variability of the normal colour is described. To segment the defects, each pixel of ail apple image is compared with the model. If it matches the pixel, it is considered as belonging to healthy tissue, otherwise as a defect. Two other steps refine the segmentation, using either parameters computed on the whole fruit, or values computed locally. Some results are shown and discussed. The algorithm is able to segment a wide range of defects. (C) 1998 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailDefeminising Keats
Steyaert, Kris ULg

Conference (1996, July)

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See detailDefence Mechanisms and Coping Strategies among Caregivers in Palliative Care Units
Timmermann, Marie ULg; Naziri, Despina ULg; Etienne, Anne-Marie ULg

in Journal of Palliative Care (2009), 25(3), 181-190

This article focuses on the relationship between defence mechanisms, coping strategies, palliative attitude, and the well-being of caregivers in palliative care units, who are confronted with death ... [more ▼]

This article focuses on the relationship between defence mechanisms, coping strategies, palliative attitude, and the well-being of caregivers in palliative care units, who are confronted with death, suffering, and pain. They use many different defence mechanisms; however, studies linking their coping strategies and defence mechanisms are rare. This study uses a quantitative and qualitative design and is based on 18 caregivers (nurses) in 2 palliative care units in Belgium. Defence mechanisms are tested through a semi-structured interview, TAT, and DSQ-60. Coping strategies are evaluated through a semistructured interview, COPE, and WCQ. To maximize our global approach, coping strategies and defence mechanisms are associated with measures of wellbeing and palliative attitude. We determined that defence mechanisms and coping strategies should not be seen as obstacles to professional practices. Palliative caregivers are more likely to adopt “mature” and “mental inhibition and compromise formation” defence mechanisms, as well as “emotion-focused” and “problem-focused” coping strategies. Defence mechanisms are more unconscious and constitute appropriate answers in extreme emotional situations. Coping strategies allow for more conscious processes of adaptation to the environment of palliative care units. This study shows positive relationships between different defence mechanisms and coping strategies, palliative attitudes, and caregivers’ well-being. Institutions should improve the conditions for group exchange and for caregivers’ individual introspection so that caregivers develop adapted capacities to cope with anxiety. [less ▲]

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See detailDefence responses induced in tobacco cells by Bacillus lipopeptides acting as elicitors of systemic resistance in plants
Henry, G.; Jourdan, E.; Thonart, Philippe ULg et al

in Journal of Plant Pathology [=JPP] (2008), 90

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See detailDéfense anti-missile et dissuasion nucléaire : un jeu contradictoire, exclusif ou complémentaire ?
Dumoulin, André ULg

in Revue Défense Nationale (2011), (2),

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See detailLa défense belge dans le futur
Dumoulin, André ULg

in Revue de Défense nationale (2015), (4),

Analyse de l'évolution récente de l'armée belge avec quelques propositions relatives à son avenir dans le cadre de la préparation d'un nouveau plan stratégique à l'horizon 2030

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See detailLa défense chimique chez les insectes
Laurent, Pascal ULg

Article for general public (2002)

Dans la nature, la survie d’une population animale est étroitement liée aux possibilités qu’elle a de se nourrir, de se reproduire et de se défendre vis-à-vis des prédateurs. Chez les insectes, cette ... [more ▼]

Dans la nature, la survie d’une population animale est étroitement liée aux possibilités qu’elle a de se nourrir, de se reproduire et de se défendre vis-à-vis des prédateurs. Chez les insectes, cette dernière nécessité est à l’origine de l’apparition, au cours de l’évolution, de mécanismes de défense plus ou moins sophistiqués chez de nombreuses espèces. Cet article discute des différents mécanismes de défense chez les insectes et présente plus particulièrement les défenses chimiques chez les chrysomèles, les coccinelles et les fourmis. [less ▲]

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See detailLa défense de Liège (1914)
Bechet, Christophe ULg

in Maréchal, Christine; Schloss, Claudine (Eds.) 1914-1918 : Vivre la guerre à Liège et en Wallonie (2014)

Christophe Bechet explique aux lecteurs le système de défense mis en place autour de Liège et la manière dont les Allemands vont s’en emparer. Il rappelle ainsi fort à propos que le point faible de cette ... [more ▼]

Christophe Bechet explique aux lecteurs le système de défense mis en place autour de Liège et la manière dont les Allemands vont s’en emparer. Il rappelle ainsi fort à propos que le point faible de cette défense est l’intervalle entre les forts. Et que Moltke, le chef d’état-major allemand qui a succédé à Schlieffen, conçoit dès lors l’idée de prendre Liège rapidement, par un coup de main, spéculant sur le fait qu’une fois la ville prise, les forts se rendraient. Mais les forts eux-mêmes ne sont pas exempts de défauts (à dire vrai plutôt nombreux !) sans compter la démoralisation des troupes qui se sentaient prises au piège. L’agonie des forts, que raconte Christophe Bechet par le détail, allait durer jusqu’au 16 août. [less ▲]

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See detailLa défense des libertés à l’épreuve des extrémismes politiques et religieux !
Jamin, Jérôme ULg

Article for general public (2008)

Detailed reference viewed: 16 (5 ULg)