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See detailThe efficacy of a communication skills training program : is it possible to predict assessment and supportive skills learning among residents?
Bragard, Isabelle ULg; Merckaert, I.; Libert, Y. et al

in Psycho-oncology (2010, May), 19(Suppl.2)(1-313), 248

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See detailThe efficacy of a communication skills training program on successive sequences of breaking bad news simulated consultation : A randomized controlled study
Gibon, A.-S.; Merckaert, I.; Libert, Y. et al

in Psycho-oncology (2009, June), 18 (Suppl. 2)

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See detailThe efficacy of a phyto-aromatic ear gel against auricular mange in rabbits and carnivores
Mignon, Bernard ULg; Losson, Bertrand ULg

in Veterinary Record : Journal of the British Veterinary Association (1996), 138

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See detailEfficacy of a strontium ranelate 2 G/vitamin D3 1000 UI combination on the correction of vitamin D insufficiency
Rizzoli, R; Dawson-Hughes, B; Kaufman, JM et al

in Osteoporosis International (2012, May), 23(S2), 225

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See detailEfficacy of alphacalcidol and calcitriol in primary and corticosteroid-induced osteoporosis: a meta-analysis of their effects on bone mineral density and fracture rate
Richy, Florent Y; Reginster, Jean-Yves ULg

in Arthritis and Rheumatism (2003, September), 48(number 9 (suppl.)), 214

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See detailEfficacy of alphacalcidol and calcitriol in primary and corticosteroid-induced osteoporosis: a meta-analysis of their effects on bone mineral density and fracture rate
Richy, F.; Ethgen, Olivier ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2004), 15(4), 301-310

Vitamin D metabolites alphacalcidol and calcitriol (D-hormones) have been investigated for two decades, but few and conflicting results are available from high-quality randomized controlled trials. Our ... [more ▼]

Vitamin D metabolites alphacalcidol and calcitriol (D-hormones) have been investigated for two decades, but few and conflicting results are available from high-quality randomized controlled trials. Our objectives were to provide an evidence-based update quantitatively summarizing their efficacy on bone mineral density (BMD) and fracture rate. We performed a systematic research of any randomized controlled trial containing relevant data, peer review, data extraction and quality scoring blinded for authors and data sources, and comprehensive meta-analyses of the relevant data. Inclusion criteria were: randomized controlled study, calcitriol or alphacalcidol, BMD or fractures in healthy/osteopenic/osteoporotic patients exposed or not to corticosteroids (CS). Analyses were performed in a conservative fashion using professional dedicated softwares and stratified by outcome, target patients, study quality, and control-group type. Results were expressed as effect size (ES) for bone loss or relative risk (RR) for fracture while allocated to D-hormones vs control. Publication bias and robustness were investigated. Of the trials that were retrieved and subsequently reviewed, 17 papers fitted the inclusion criteria and were assessed. Quality scores ranged from 20 to 100%, the mean (standard deviation) being 72 (22)%. Calcitriol and alphacalcidol were found to have the same efficacy on all outcomes at p>0.13. We globally assessed D-hormones effects in preventing bone loss in patients not exposed to CS, and found positive effect: ES=0.39 (p<0.001). For lumbar spine, this particular effect was 0.43 (p<0.001). D-hormones significantly reduced the overall fracture rates: RR=0.52 (0.46; 0.59) and both vertebral and non-vertebral fractures: RR=0.53 (0.47; 0.60) and RR=0.34 (0.16; 0.71), respectively. No statistical difference in response was observed between results from studies on healthy and osteoporotic patients or depending on the fact that controls were allowed to calcium supplementation. Treatment with D-hormones was evaluated for maintaining spinal bone mass in five trials of patients with CS-induced osteoporosis, and provided ES=0.43 at p<0.001. Only two studies specifically addressed the effects of calcitriol on spinal fracture rate. None of them provided significant results, and the global RR did not reach the significance level as well: RR=0.33 (0.07; 1.51). Our data demonstrated efficacy for DH on bone loss and fracture prevention in patients not exposed to CS and on bone loss in patients exposed to CS, in the light of the most reliable scientific evidence. Their efficacy in reducing the number of fractures in patients exposed to CS remains to be determined. [less ▲]

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See detailEfficacy of ceftiofur and flunixin in the early treatment of bronchopneumonia in weaners
Halloy, D. J.; Cambier, Carole ULg; Gustin, Pascal ULg

in Veterinary Record : Journal of the British Veterinary Association (2006), 158(9), 291-296

Three groups of five pigs were inoculated intratracheally with Escherichia coli lipopolysaccharides, and 24 hours later with 10 x 10(9) colony-forming units of a non-toxigenic strain of Pasteurella ... [more ▼]

Three groups of five pigs were inoculated intratracheally with Escherichia coli lipopolysaccharides, and 24 hours later with 10 x 10(9) colony-forming units of a non-toxigenic strain of Pasteurella multocida type A; a fourth group was left uninoculated as controls. The three inoculated groups received either no treatment (positive controls), or were treated with 3 mg/kg ceftiofur intramuscularly once a day for five consecutive days, either alone or combined with 2 mg/kg flunixin intramuscularly once a day for three consecutive days. The sustained coughing and hyperthermia recorded in the positive controls disappeared after two days and three days of treatments, respectively, in the treated animals, and the reductions in daily weight gain and changes in breathing pattern observed in the controls were not observed in the treated animals. There were no significant differences between the pigs treated with ceftiofur alone or ceftiofur combined with flunixin. In the positive controls, the number of inflammatory cells in samples of bronchoalveolar lavage fluid continued to increase up to 15 days after inoculation, whereas in the treated animals there were similar increases at six days but the numbers had decreased to baseline levels after 15 days. Similarly, in the treated animals the volume of the lung lesions was significantly less than in the control animals, but the inclusion of flunixin in the treatment regimen had no significant additional effect [less ▲]

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See detailEfficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial
Sandor, P. S.; Di Clemente, L.; Coppola, G. et al

in Neurology (2005), 64(4), 713-715

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double ... [more ▼]

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated. [less ▲]

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See detailEfficacy of D-Hormones in primary and corticosteroid-induced osteoporosis: a meta-analysis of their effects on bone mineral density and fracture rate
Richy, Florent; Reginster, Jean-Yves ULg

in Osteoporosis International (2002, November), 13(Suppl.3), 21

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See detailEfficacy of diatomaceous earth formulations admixed with grain against populations of Tribolium castaneum
Arnaud, Ludovic; Lan, H. Tran Thi; Brostaux, Yves ULg et al

in Journal of Stored Products Research (2005), 41(2), 121-130

The efficacy of diatomaceous earth (DE) to control stored-products Coleoptera on stored grain was examined against several populations of the red flour beetle, Tribolium castaneum (Herbst). Four ... [more ▼]

The efficacy of diatomaceous earth (DE) to control stored-products Coleoptera on stored grain was examined against several populations of the red flour beetle, Tribolium castaneum (Herbst). Four commercially available DE formulations were tested: INSECTO(R), Perma-Guard(TM), Protect-It(R) and the diatomite used for the production of Dryacide(R), each at six concentrations (100-1000ppm). A great variation of efficacy was observed among the DE formulations tested. Protect-It at concentrations up to 400 ppm was found to be the most effective formulation to control red flour beetle populations. However, a concentration of 1000 ppm of Protect-It was necessary to control all adults of all populations. Most T castaneum populations, except one from Ivory Coast (Asm), were more than 90% controlled with INSECTO and Dryacide DE at 600 ppm. At this concentration, about 88% and 22% Asm adults died with INSECTO and Dryacide DE, respectively. Perma-Guard was the least efficient DE formulation to control T castaneum adults with three populations exhibiting some survival at 1000 ppm. Reduced susceptibility to DE was observed in two populations, Asm and Lab susceptible from Kansas (Lab-S). As neither population had been previously exposed to DE, it is suggested that red flour beetles may naturally vary in susceptibility to DE. In addition, it was found that some populations can be satisfactorily controlled with some DE formulations but not with others. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailEfficacy of Erlotinib in patients (PTS) with advanced non-small-cell lung cancer (NSCLC) relative to clinical charesteristics : subset analyses from the trust study
Allan, S.; BOSQUEE, Léon ULg; Franke, A. et al

in American Journal of Clinical Oncology (2008), 26(20),

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See detailEfficacy of errorless learning in the acquisition of a new procedural skill in Alzheimer's disease
Schmitz, Xavier ULg; Lejeune, Caroline ULg; Vervecken, Nancy et al

Poster (2011, May 27)

In Alzheimer’s disease (AD), implicit or procedural rehabilitation techniques would be more effective to train new skills than explicit or declarative learning methods (van Halteren-van Tilborg, 2007 ... [more ▼]

In Alzheimer’s disease (AD), implicit or procedural rehabilitation techniques would be more effective to train new skills than explicit or declarative learning methods (van Halteren-van Tilborg, 2007). Following Baddeley and Wilson (1994)’s assumption, Maxwell et al. (2001) showed that reducing errors during motor learning minimizes the building of declarative knowledge and would allow implicit knowledge accumulation. However, most studies on errorless learning focused on learning of face-name associations (Clare et al., , 2001), and very few studies have investigated errorless learning in procedural learning situations, even though some data suggest that errorless learning would be efficient for learning instrumental activities of daily living (e.g., Thivierge et al., 2008). The aim of this study was to examine the efficacy of an error-reducing versus an errorfull method in motor skill learning. We examined the acquisition of a new motor skill in 24 patients with AD and 24 healthy older adults matched for age, sex, and education. In this task, subjects had to follow with a reversed mouse the contour of a form (a star) displayed on a computer screen. Half the subjects learned in an error-reducing condition, and the others in an errorfull condition. After the learning phase, all the subjects had to complete a novel form. Results show an advantage for the error-reducing condition in the AD group, whereas the performance of the healthy participants did not differ between the two conditions, confirming the efficiency of errorless learning principles in AD for procedural learning situations. [less ▲]

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See detailThe efficacy of glucosamine sulfate in osteoarthritis: Financial and nonfinancial conflict of interest
Reginster, Jean-Yves ULg

in Arthritis and Rheumatism (2007), 56(7), 2105-2110

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See detailEfficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes.
Puig, Juan Garcia; Marre, Michel; Kokot, Franciszek et al

in American Journal of Hypertension : Journal of the American Society of Hypertension (2007), 20(1), 90-7

BACKGROUND: Blood pressure control is the main influential variable in reducing microalbuminuria in patients with type 2 diabetes. In this subanalysis of the Natrilix SR versus Enalapril Study in ... [more ▼]

BACKGROUND: Blood pressure control is the main influential variable in reducing microalbuminuria in patients with type 2 diabetes. In this subanalysis of the Natrilix SR versus Enalapril Study in hypertensive Type 2 diabetics with micrOalbuminuRia (NESTOR) study, we have compared the effectiveness of indapamide sustained release (SR) and enalapril in reducing blood pressure and microalbuminuria in patients > or =65 years of age. METHODS: Of the 570 hypertensive patients with type 2 diabetes and persistent microalbuminuria in the NESTOR study, 187 (33%) individuals > or =65 years of age were included in this analysis. Of these, 95 patients received indapamide SR 1.5 mg and 92 patients received enalapril 10 mg, taken once daily in both cases. Adjunctive amlodipine and/or atenolol was added if required. RESULTS: The urinary albumin-to-creatinine ratio decreased by 46% in the indapamide SR group and 47% in the enalapril group. Noninferiority of indapamide SR over enalapril was demonstrated (P = .0236; 35% limit of noninferiority) with a ratio of 0.95 (95% CI: 0.68, 1.34). Mean arterial pressure decreased by 18 mm Hg and 15 mm Hg in the indapamide SR and the enalapril groups, respectively (P = .1136). The effects of both treatments seen in these elderly patients were similar to those observed in the main population, although the extent of the reduction in microalbuminuria was slightly higher. Both treatments were well tolerated, and no difference between groups was observed regarding glucose or lipid profiles. CONCLUSION: Indapamide SR is not less effective than enalapril in reducing microalbuminuria and blood pressure in patients aged >65 years of age with type 2 diabetes and hypertension. [less ▲]

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See detailEfficacy of interferon-based antiviral therapy in patients with chonic hepatitis C infected HCV genotype 5: a meta-analysis of two large prospective clinical trials
D'Heygere, F.; George, C.; Van Vlierberghe, H. et al

in Journal of Medical Virology (2011), 83(5), 815-819

The characteristics and response rate to pegylated interferon and ribavirin (PEG-INF + RBV) of patients with chronic hepatitis C infected with genotype 5 are poorly documented. A meta-analysis of two ... [more ▼]

The characteristics and response rate to pegylated interferon and ribavirin (PEG-INF + RBV) of patients with chronic hepatitis C infected with genotype 5 are poorly documented. A meta-analysis of two large phase III/IV prospective randomized clinical trials conducted in Belgium in patients with chronic hepatitis C (n = 1,073 patients) was performed in order to compare the response to antiviral therapy of hepatitis C virus (HCV) genotype 5 with that of other HCV genotypes. A subset of HCV-1 infected patients selected from within the study database were selected to match the HCV-5 sample for known prognostic factors. In Belgium HCV-5 is responsible for a significant minority of cases of chronic hepatitis C CHC (4.5%) and is characterized by a more advanced age (58.4 years), a high frequency of cirrhosis (27.7%), a specific mode of HCV acquisition, and a particular geographic origin (66.7% of patients from West Flanders). The primary comparative analysis showed that response to treatment with PEG-INF + RBV of HCV-5 is similar to HCV-1 and lower compared to HCV-2/3. The analysis of the matched patient subgroup demonstrates that the HCV-5 "intrinsic sensitivity" to PEG-IFN + RBV therapy is identical to HCV-1, with a sustained virological response of 55% in both groups. In contrast to previous publications, this meta-analysis suggests that HCV-5 response to treatment is closer to HCV-1 than to HCV-2/3 and suggests that in Belgium HCV-5 infection should be treated with the same antiviral regimen as HCV-1. [less ▲]

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See detailEfficacy of intrasinusal administration of bifonazole cream alone or in combination with enilconazole irrigation in canine sino-nasal aspergillosis: 17 cases.
Billen, Frédéric ULg; Guieu, L. V.; Bernaerts, F. et al

in Canadian Veterinary Journal = Revue Vétérinaire Canadienne (2010), 51

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See detailEfficacy of ivermectin and levamisole against immature Dictyocaulus viviparus in cattle
Pouplard, L.; Lekeux, Pierre ULg; Detry, M.

in Veterinary Record : Journal of the British Veterinary Association (1986), 118

Eighteen calves aged approximately three months were each infected with Dictyocaulus viviparus larvae at a rate of 30/kg bodyweight. Seven days later they were randomly allocated to three groups of six ... [more ▼]

Eighteen calves aged approximately three months were each infected with Dictyocaulus viviparus larvae at a rate of 30/kg bodyweight. Seven days later they were randomly allocated to three groups of six animals. Calves of group 1 were controls. Calves of group 2 were given levamisole at a dose rate of 10 mg/kg and calves of group 3 were given ivermectin at a dose rate of 200 micrograms/kg. The anthelmintic activity of these two drugs was compared using clinical, functional, parasitological and pathological parameters. The results showed that the efficacy of ivermectin, given at a therapeutic dose, against immature D viviparus was higher than that of levamisole, given at double the recommended dose [less ▲]

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