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See detailDevelopment of techniques for rapid production of rattan seedlings
Kouakou, K. L.; Zoro Bi, I. A.; Baudoin, Jean-Pierre ULg

Conference given outside the academic context (2008)

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See detailDevelopment of the Abilities to Acquire New Orthographic Representations from Grades 2 to 6
Binamé, Florence ULg; Poncelet, Martine ULg

Conference (2014, May 27)

Unlike English, little attention has been accorded to orthographic learning in French which has a challenging spelling due to its high level of inconsistency. There is evidence that the mastery of ... [more ▼]

Unlike English, little attention has been accorded to orthographic learning in French which has a challenging spelling due to its high level of inconsistency. There is evidence that the mastery of alphabetic decoding is critical to acquire word-specific orthographic representations (Share 1995). It is also generally admitted that orthographic processing skills are involved in orthographic learning beyond the core phonological component. Even if these skills still remain underspecified, research particularly focuses on the sensitivity to orthographic constraints. While Pacton et al. (2013) have shown that graphotactic knowledge influences the learning of new spellings, little is known about the development of this knowledge over time. Our aim was to determine the developmental trajectory of orthographic word form acquisition abilities within the French orthography by assessing the speed of acquisition of new orthographic forms as well as the sensitivity to orthographic regularities. Five groups of forty French-speaking children from grades 2 to 6 took part in the study. We proposed two experimental tasks. The first consisted of an orthographic learning of 10 new orthographic forms (inconsistent in spelling) by using a repeated spelling paradigm. In practice, children were firstly asked to read aloud each item once. Then, the experimenter dictated each item ten times in a mixed order. The capacity of retention of the new representations was assessed one week later with a dictation task. The second task aimed at determining the sensitivity to different French orthographic regularities by means of an orthographic choice task containing 62 pairs of non-words homophones. Moreover, general reading and spelling abilities were also assessed. Results show that the speed of orthographic learning and the capacity of long-term retention significantly increase during the first years but do not differ anymore between grades 4-5 and 5-6, suggesting that older children have reached a nearly maximal potential in their learning capacities. Nevertheless, the general orthographic abilities, which are more dependent on scholar knowledge, continue to develop significantly during school years. Furthermore, sensitivity to orthographic regularities increases significantly only from grade 2 to 3, indicating that children as soon as 9 years-old are already able to extract different graphotactic patterns of their writing system. Pacton, S., Sobaco, A., Fayol, M., & Treiman, R. (2013). How does graphotactic knowledge influence children’s learning of new spellings? Frontiers in Psychology, 4, 1-10. Share, D. (1995). Phonological recoding and self-teaching: sine qua non of reading acquisition. Cognition 55, 151-218. [less ▲]

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See detailThe development of the abilities to acquire novel detailed orthographic representations and maintain them in long-term memory
Binamé, Florence ULg; Poncelet, Martine ULg

in Journal of Experimental Child Psychology (2016), 143

Previous studies have clearly demonstrated that the development of orthographic representations relies on phonological recoding. However, substantial questions persist about the remaining unexplained ... [more ▼]

Previous studies have clearly demonstrated that the development of orthographic representations relies on phonological recoding. However, substantial questions persist about the remaining unexplained variance in the acquisition of word-specific orthographic knowledge that is still underspecified. The main aim of this study was to explore whether two cognitive factors—sensitivity to orthographic regularities and short-term memory (STM) for serial order—make independent contributions to the acquisition of novel orthographic representations beyond that of the phonological core component and the level of preexisting word-specific orthographic knowledge. To this end, we had children from second to sixth grades learn novel written word forms using a repeated spelling practice paradigm. The speed at which children learned the word forms and their long-term retention (1 week and 1 month later) were assessed. Hierarchical regression analyses revealed that phonological recoding, preexisting word-specific orthographic knowledge, and order STM explained a portion of the variance in orthographic learning speed, whereas phonological recoding, preexisting word-specific orthographic knowledge, and orthographic sensitivity each explained a portion of variance in the long-term retention of the newly created orthographic representations. A secondary aim of the study was to determine the developmental trajectory of the abilities to acquire novel orthographic word forms over the course of primary schooling. As expected, results showedan effect of age on both learning speed and long-term retention. The specific roles of orthographic sensitivity and order STM as independent factors involved in different steps of orthographic learning are discussed. [less ▲]

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See detailDevelopment of the Crohn's disease digestive damage score, the Lemann score.
Pariente, Benjamin; Cosnes, Jacques; Danese, Silvio et al

in Inflammatory Bowel Diseases (2011), 17(6), 1415-22

Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural ... [more ▼]

Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural damage to the bowel, which may predict long-term disability, is needed. The aim of this article is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lemann score), should take into account damage location, severity, extent, progression, and reversibility, as measured by diagnostic imaging modalities and the history of surgical resection. It should not be "diagnostic modality driven": for each lesion and location, a modality appropriate for the anatomic site (for example: computed tomography or magnetic resonance imaging enterography, and colonoscopy) will be used. A total of 24 centers from 15 countries will be involved in a cross-sectional study, which will include up to 240 patients with stratification according to disease location and duration. At least 120 additional patients will be included in the study to validate the score. The Lemann score is expected to be able to portray a patient's disease course on a double-axis graph, with time as the x-axis, bowel damage severity as the y-axis, and the slope of the line connecting data points as a measure of disease progression. This instrument could be used to assess the effect of various medical therapies on the progression of bowel damage. [less ▲]

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See detailDevelopment of the Geer basin Hydrological model for climatic scenarios and first results about impacts evaluation
Goderniaux, Pascal ULg; Brouyère, Serge ULg; Orban, Philippe ULg et al

Report (2008)

A surface – subsurface flow numerical model of the Geer basin (465 km²) has been implemented to assess the possible impacts of climate change on the groundwater resources. This model is physically-based ... [more ▼]

A surface – subsurface flow numerical model of the Geer basin (465 km²) has been implemented to assess the possible impacts of climate change on the groundwater resources. This model is physically-based, spatially-distributed and it integrates totally the groundwater and surface water. Simulations were performed using 6 climate change scenarios generated by the University of Newcastle-Upon-Tyne. These scenarios simulate changes in the amplitude, but also in the frequency and persistence of some meteorological events. First results show that, according the implemented flow model and the used climatic scenarios, significant decreases are expected in the groundwater levels (up to 12 meters) and in the surface water flow rates (reduction between 16% and 32%) [less ▲]

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See detailDevelopment of the lemann index to assess digestive tract damage in patients with Crohn's disease.
Pariente, Benjamin; Mary, Jean-Yves; Danese, Silvio et al

in Gastroenterology (2015), 148(1), 52-63

BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for ... [more ▼]

BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for measuring disease progression. We developed the Lemann Index and assessed its ability to measure cumulative structural bowel damage in patients with Crohn's disease (CD). METHODS: We performed a prospective, multicenter, international, cross-sectional study of patients with CD evaluated at 24 centers in 15 countries. Inclusions were stratified based on CD location and duration. All patients underwent clinical examination and abdominal magnetic resonance imaging analyses. Upper endoscopy, colonoscopy, and pelvic magnetic resonance imaging analyses were performed according to suspected disease locations. The digestive tract was divided into 4 organs and subsequently into segments. For each segment, investigators collected information on previous operations, predefined strictures, and/or penetrating lesions of maximal severity (grades 1-3), and then provided damage evaluations ranging from 0.0 (no lesion) to 10.0 (complete resection). Overall level of organ damage was calculated from the average of segmental damage. Investigators provided a global damage evaluation (from 0.0 to 10.0) using calculated organ damage evaluations. Predicted organ indexes and Lemann Index were constructed using a multiple linear mixed model, showing the best fit with investigator organ and global damage evaluations, respectively. An internal cross-validation was performed using bootstrap methods. RESULTS: Data from 138 patients (24, 115, 92, and 59 with upper tract, small bowel, colon/rectum, and anus CD location, respectively) were analyzed. According to validation, the unbiased correlation coefficients between predicted indexes and investigator damage evaluations were 0.85, 0.98, 0.90, 0.82 for upper tract, small bowel, colon/rectum, anus, respectively, and 0.84 overall. CONCLUSIONS: In a cross-sectional study, we assessed the ability of the Lemann Index to measure cumulative structural bowel damage in patients with CD. Provided further successful validation and good sensitivity to change, the index should be used to evaluate progression of CD and efficacy of treatment. [less ▲]

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See detailDevelopment of the National Forest Inventory in Luxembourg
Rondeux, Jacques ULg; Wagner, Marc

in Tomppo, Erkki; Gschwantner, Thomas; Lawrence, Mark (Eds.) et al National Forest Inventories - Pathways for common reporting (2010)

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See detailDevelopment of the Osteoporosis Risk Assessment by Composite Linear Essay (ORACLE)
Richy, Florent; Uhoda, Emmanuelle ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2002, November), 13(Suppl.3), 11

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See detailDevelopment of the paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.
Peyrin-Biroulet, Laurent; Billioud, Vincent; D'Haens, Geert et al

in American Journal of Gastroenterology (2012), 107(12), 1770-6

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen ... [more ▼]

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD. [less ▲]

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See detailDevelopment of the Regional Forest Inventory (RFI) in Wallonia
Rondeux, Jacques ULg; Sanchez, Christine; Latte, Nicolas ULg

in Tomppo, Erkki; Gschwantner, Thomas; Lawrence, Mark (Eds.) et al National Forest Inventories. Pathways for Common Reporting (2010)

Detailed reference viewed: 38 (10 ULg)
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See detailDevelopment of the surface structure of TRIP steels prior to hot-dip galvanizing
Bellhouse, Erika M.; Mertens, Anne ULg; McDermid, Joe R.

in Materials Science & Engineering : A (2007), 463

Focusing on improving the reactive wetting of transformation-induced plasticity (TRIP) steels during hot-dip galvanizing, the effect of the alloying elements manganese, silicon and aluminum on the surface ... [more ▼]

Focusing on improving the reactive wetting of transformation-induced plasticity (TRIP) steels during hot-dip galvanizing, the effect of the alloying elements manganese, silicon and aluminum on the surface structure prior to galvanizing was studied. A C-Mn steel and two TRIP steels with aluminum either completely or partially replacing silicon were investigated. [less ▲]

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See detailDevelopment of the surface structure of TRIP steels prior to hot-dip galvanizing
Bellhouse, Erika M.; Mertens, Anne ULg; McDermid, Joe R.

Conference (2006, March)

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See detailDevelopment of the ultrastructure of sonic muscles: a kind of neoteny?
Millot, Sandie; Parmentier, Eric ULg

in BMC Evolutionary Biology (2014), 14

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See detailDevelopment of thermal comfort models for various climatic zones of North-East India
Singh, Manoj Kumar ULg; Mahapatra, Sadhan; Teller, Jacques ULg

in Sustainable Cities and Society (2015), 14

Thermal comfort study provides crucial information about thermal performance of naturally ventilated buildings. Humphreys and Auliciems comfort model uses indoor and outdoor temperatures to predict ... [more ▼]

Thermal comfort study provides crucial information about thermal performance of naturally ventilated buildings. Humphreys and Auliciems comfort model uses indoor and outdoor temperatures to predict comfort temperatures. It is found that the comfort temperatures obtained by using these methods do not take into account the occupant behavioral adaptability to a particular climatic zone. This demands development of new set of comfort models based on local environmental parameters, socio-cultural setup and behavioral action. Analysis shows that four major variables like indoor and outdoor temperature, relative humidity and clothing pattern plays an important role in defining comfort and greatly influence the occupant’s perception and acceptance on thermal comfort. In this study, comfort models are developed based on these variables. The computed neutral temperatures based on the models are compared with the comfort temperatures obtained through comfort survey. The models are developed using the measured data of January and July months and validated with the measured data of April and October months. This study also concludes that it is not possible to obtain a generalized thermal comfort model for all climatic zone because adaptation process, expectation and perception of people are region specific and governed by local socio-cultural requirement. [less ▲]

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See detailDevelopment of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors
Francotte, Pierre ULg; Goffin, Eric ULg; Fraikin, Pierre et al

in Journal of Medicinal Chemistry (2013), 56(20), 7838-7850

On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the ... [more ▼]

On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the design of original isosteric 3,4-dihydro-2H-thieno-1,2,4-thiadiazine 1,1-dioxides. Owing to the sulfur position, three series of compounds were developed and their activity as AMPA potentiators was characterized. In each of the developed series, potent compounds were discovered. After screening the selected active compounds on a safety in vivo test, 6-chloro-4-ethyl-3,4-dihydro-2H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide (24) appeared as the most promising compound and was further evaluated. Its effects on long-term potentiation in vivo and on AMPA-mediated noradrenaline release were measured to predict its potential cognitive enhancing properties. Finally, an object recognition test performed in mice revealed that 24 was able to significantly enhance cognition, after oral administration, at doses as low as 0.3 mg/kg. This study validates the interest of the isosteric replacement of the benzene or pyridine nuclei by the thiophene nucleus in the ring-fused thiadiazine dioxides class of AMPA potentiators. [less ▲]

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