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See detailDeep Reinforcement Learning Solutions for Energy Microgrids Management
François-Lavet, Vincent ULg; Taralla, David; Ernst, Damien ULg et al

in European Workshop on Reinforcement Learning (EWRL 2016) (2016, December)

This paper addresses the problem of efficiently operating the storage devices in an electricity microgrid featuring photovoltaic (PV) panels with both short- and long-term storage capacities. The problem ... [more ▼]

This paper addresses the problem of efficiently operating the storage devices in an electricity microgrid featuring photovoltaic (PV) panels with both short- and long-term storage capacities. The problem of optimally activating the storage devices is formulated as a sequential decision making problem under uncertainty where, at every time-step, the uncertainty comes from the lack of knowledge about future electricity consumption and weather dependent PV production. This paper proposes to address this problem using deep reinforcement learning. To this purpose, a specific deep learning architecture has been designed in order to extract knowledge from past consumption and production time series as well as any available forecasts. The approach is empirically illustrated in the case of a residential customer located in Belgium. [less ▲]

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See detailDeep remission: A new concept?
Colombel, Jean-Frédéric; Louis, Edouard ULg; Peyrin-Biroulet, Laurent et al

in Digestive Diseases (2012)

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See detailDeep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Rivas, Manuel A.; Beaudoin, Melissa; Gardet, Agnes et al

in Nature Genetics (2012), 43(11), 1066-73

More than 1,000 susceptibility loci have been identified through genome-wide association studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of causal variants ... [more ▼]

More than 1,000 susceptibility loci have been identified through genome-wide association studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of causal variants underlying these findings have not yet been defined. Here we used pooled next-generation sequencing to study 56 genes from regions associated with Crohn's disease in 350 cases and 350 controls. Through follow-up genotyping of 70 rare and low-frequency protein-altering variants in nine independent case-control series (16,054 Crohn's disease cases, 12,153 ulcerative colitis cases and 17,575 healthy controls), we identified four additional independent risk factors in NOD2, two additional protective variants in IL23R, a highly significant association with a protective splice variant in CARD9 (P < 1 x 10(-16), odds ratio approximately 0.29) and additional associations with coding variants in IL18RAP, CUL2, C1orf106, PTPN22 and MUC19. We extend the results of successful GWAS by identifying new, rare and probably functional variants that could aid functional experiments and predictive models. [less ▲]

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See detailDeep sequencing reveals abundant non-canonical retroviral microRNAs in B-cell leukemia/lymphoma
Durkin, Keith ULg

Scientific conference (2013, January 28)

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See detailDeep sequencing reveals abundant non-canonical retroviral microRNAs in B-cell leukemia/lymphoma
Rosewick, Nicolas; Momont, Mélanie ULg; Durkin, Keith ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2013)

Viral tumor models have significantly contributed to our understanding of oncogenic mechanisms. How transforming delta-retroviruses induce malignancy however remains poorly understood, especially as viral ... [more ▼]

Viral tumor models have significantly contributed to our understanding of oncogenic mechanisms. How transforming delta-retroviruses induce malignancy however remains poorly understood, especially as viral mRNA/protein are tightly silenced in tumors. Here, using deep sequencing of broad windows of small RNA sizes in the Bovine Leukemia Virus ovine model of leukemia/lymphoma, we provide in vivo evidence of the production of non-canonical Pol IIItranscribed viral microRNAs in leukemic B-cells in the complete absence of Pol II 5’ LTR-driven transcriptional activity. Processed from a cluster of five independent self-sufficient transcriptional units located in a proviral region dispensable for in vivo infectivity, BLV microRNAs represent ~ 40 % of all microRNAs in both experimental and natural malignancy. They are subject to strong purifying selection and associate with Argonautes, consistent with a critical function in silencing of important cellular and/or viral targets. BLV microRNAs are strongly expressed in preleukemic and malignant cells in which structural and regulatory gene expression is repressed, suggesting a key role in tumor onset and progression. Understanding how Pol III-dependent microRNAs subvert cellular and viral pathways will contribute in deciphering the intricate perturbations that underlie malignant transformation. [less ▲]

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See detailDeep structure of Southern Tian Shan (China) and its neotectonic expression
Hubert, Aurelia ULg; Suppe, J.; Wang, X et al

Conference (1999, April)

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See detailDeep Water Formation in the North Pacific during the Last Glacial Termination
Okazaki, Y.; Timmermann, A.; Menviel, L. et al

in Science (2010), 329

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See detailDeep-Sky Observing with Small Telescopes -- David J. Eicher
Manfroid, Jean ULg

in Ciel et Terre (1990), 106

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See detailDeepening a precautionary european policy
Deblonde, M.; du Jardin, Patrick ULg

in Journal of Agricultural & Environmental Ethics (2005), 18

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See detailLa défaillance des PME : processus et (auto)diagnostic
Crutzen, Nathalie ULg; Van Caillie, Didier ULg

Conference (2007, June 11)

This presentation provides both a large overview of the different processes leading to business failure in SMEs and a proposal of a structured tool organized as a self-diagnosis mechanism to prevent ... [more ▼]

This presentation provides both a large overview of the different processes leading to business failure in SMEs and a proposal of a structured tool organized as a self-diagnosis mechanism to prevent bankruptcy in a particular SME. [less ▲]

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See detailDéfaillance neurologique au cours de l'insuffisance hépatique aigüe
DETRY, Olivier ULg

Conference (2011, June 16)

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See detailDéfaire le discours d'autorité. Les 'Physiologies' à la limite de l'essai
Stienon, Valérie ULg

in Glaudes, Pierre; Lyon-Caen, Boris (Eds.) Essai et essayisme en France au XIXe siècle (2014)

Les Physiologies déferlent sous la Monarchie de juillet, alimentant les dépôts de pittoresques et prolongeant les caricatures en vitrine des passages parisiens. Si, presqu’un siècle plus tard, l’emprunt ... [more ▼]

Les Physiologies déferlent sous la Monarchie de juillet, alimentant les dépôts de pittoresques et prolongeant les caricatures en vitrine des passages parisiens. Si, presqu’un siècle plus tard, l’emprunt littéraire à la «physiologie» compose encore un effet de titre pour un essai théorique tel que la Physiologie de la critique d’Albert Thibaudet (1920), le petit genre du même nom, qui présente d’autres caractéristiques formelles et thématiques, n’est pas nettement défini par rapport à une conception et une pratique de l’essai. Au mieux peut-on lui trouver certaines parentés avec la chronique sous la forme de la notation des faits-Paris et avec une fiction d’actualité féconde en savoirs culturels et sociaux. Cette indétermination générique est particulièrement intéressante en raison de la diversité des paramètres poétiques et contextuels sur lesquels elle repose. Ce sont ces aspects qui font l’objet du présent parcours synthétique dans un corpus foisonnant, en préalable à une étude plus spécifiquement dédiée aux infinies nuances qui caractérisent ces textes. [less ▲]

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See detailDéfaire le discours d'autorité. Les Physiologies à la limite de l'essai
Stienon, Valérie ULg

Conference (2013, May 23)

Un siècle après l’essoufflement de la mode panoramique des années 1830-1840, l’emprunt littéraire à la « physiologie » constitue encore un effet de titre pour un essai théorique tel que Physiologie de la ... [more ▼]

Un siècle après l’essoufflement de la mode panoramique des années 1830-1840, l’emprunt littéraire à la « physiologie » constitue encore un effet de titre pour un essai théorique tel que Physiologie de la critique d’Albert Thibaudet. Pourtant, sous la Monarchie de Juillet, le petit genre du même nom, qui présente d’autres caractéristiques formelles et thématiques, n’est pas nettement défini par rapport à une conception et une pratique de l’essai. Au mieux peut-on lui découvrir des parentés significatives avec une certaine écriture journalistique. Les Physiologies se rapprochent en effet de la chronique sous la forme de la notation des faits-Paris et développent une fiction d’actualité féconde en savoir culturel et social. Leur engagement satirique contre le gouvernement en place et leur inscription dans un contexte de vulgarisation scientifique accrue sous l’influence londonienne de la « connaissance utile » ne suffisent pas à apparenter ces Physiologies à de la prose d’idées. Au contraire, elles contournent volontiers les conventions d’écriture du texte d’idées à travers des formes parodiques et déceptives. Il s’agit, de la sorte, d’empêcher le dogmatisme de prendre consistance en oeuvrant contre le discours d’autorité, en particulier scientifique, et contre l’assertivité qui lui est inhérente. Les informations traitées sont non seulement modelées par la distanciation humoristique et la saturation polyphonique, mais elles se trouvent également travaillées en profondeur par la contamination volontaire avec la rhétorique publicitaire dans un contexte de prolifération journalistique de la « réclame ». Le genre physiologique résiste de la sorte aux structures textuelles normatives et assertives d’exposition du savoir. Il ne se les approprie que pour mieux les disqualifier par l’humour et le raisonnement paralogique. Cette caractéristique se traduit par certaines postures discursives récurrentes, en particulier celle du faux spécialiste exhibé comme tel, posture qui consiste à feindre de se rendre ponctuellement expert d’une fraction réduite et caricaturalement recréée de la société, tout en opérant des décrochages réguliers par rapport à cette position énonciative investie d’une autorité. L’étude discursive et générique de tels modes d’expression biaisée du discours d’autorité doit permettre d’éclairer la dynamique d’écriture de l’essai dans les Physiologies parisiennes des années 1830-1840. Cet examen sera orienté par la question des redistributions qui sont ainsi rendues possibles à propos de la frontière entre l’essai-cognitif, caractérisé par une structuration théorique à vocation objectivante, et l’essai-méditation, centré sur une expressivité individualisante de l’instance énonciative. [less ▲]

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See detailThe default mode network and EEG regional spectral power: a simultaneous fMRI-EEG study.
Neuner, Irene; Arrubla Martinez, Jorge Andres ULg; Werner, Cornelius J. et al

in PLoS ONE (2014), 9(2), 88214

Electroencephalography (EEG) frequencies have been linked to specific functions as an "electrophysiological signature" of a function. A combination of oscillatory rhythms has also been described for ... [more ▼]

Electroencephalography (EEG) frequencies have been linked to specific functions as an "electrophysiological signature" of a function. A combination of oscillatory rhythms has also been described for specific functions, with or without predominance of one specific frequency-band. In a simultaneous fMRI-EEG study at 3 T we studied the relationship between the default mode network (DMN) and the power of EEG frequency bands. As a methodological approach, we applied Multivariate Exploratory Linear Optimized Decomposition into Independent Components (MELODIC) and dual regression analysis for fMRI resting state data. EEG power for the alpha, beta, delta and theta-bands were extracted from the structures forming the DMN in a region-of-interest approach by applying Low Resolution Electromagnetic Tomography (LORETA). A strong link between the spontaneous BOLD response of the left parahippocampal gyrus and the delta-band extracted from the anterior cingulate cortex was found. A positive correlation between the beta-1 frequency power extracted from the posterior cingulate cortex (PCC) and the spontaneous BOLD response of the right supplementary motor cortex was also established. The beta-2 frequency power extracted from the PCC and the precuneus showed a positive correlation with the BOLD response of the right frontal cortex. Our results support the notion of beta-band activity governing the "status quo" in cognitive and motor setup. The highly significant correlation found between the delta power within the DMN and the parahippocampal gyrus is in line with the association of delta frequencies with memory processes. We assumed "ongoing activity" during "resting state" in bringing events from the past to the mind, in which the parahippocampal gyrus is a relevant structure. Our data demonstrate that spontaneous BOLD fluctuations within the DMN are associated with different EEG-bands and strengthen the conclusion that this network is characterized by a specific electrophysiological signature created by combination of different brain rhythms subserving different putative functions. [less ▲]

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See detailA default mode of brain function in altered states of consciousness.
Guldenmund, Justus Pieter; Vanhaudenhuyse, Audrey ULg; Boly, Mélanie ULg et al

in Archives Italiennes de Biologie (2012), 150(2-3), 107-21

Using modern brain imaging techniques, new discoveries are being made concerning the spontaneous activity of the brain when it is devoid of attention-demanding tasks. Spatially separated patches of ... [more ▼]

Using modern brain imaging techniques, new discoveries are being made concerning the spontaneous activity of the brain when it is devoid of attention-demanding tasks. Spatially separated patches of neuronal assemblies have been found to show synchronized oscillatory activity behavior and are said to be functionally connected. One of the most robust of these is the default mode network, which is associated with intrinsic processes like mind wandering and self-projection. Furthermore, activity in this network is anticorrelated with activity in a network that is linked to attention to external stimuli. The integrity of both networks is disturbed in altered states of consciousness, like sleep, general anesthesia and hypnosis. In coma and related disorders of consciousness, encompassing the vegetative state (unresponsive wakefulness syndrome) and minimally conscious state, default mode network integrity correlates with the level of remaining consciousness, offering the possibility of using this information for diagnostic and prognostic purposes. Functional brain imaging is currently being validated as a valuable addition to the standardized behavioral assessments that are already in use. [less ▲]

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See detailDefault network connectivity reflects the level of consciousness in non-communicative brain-damaged patients.
Vanhaudenhuyse, Audrey ULg; Noirhomme, Quentin ULg; Tshibanda, Luaba ULg et al

in Brain : A Journal of Neurology (2010), 133(Pt 1), 161-71

The 'default network' is defined as a set of areas, encompassing posterior-cingulate/precuneus, anterior cingulate/mesiofrontal cortex and temporo-parietal junctions, that show more activity at rest than ... [more ▼]

The 'default network' is defined as a set of areas, encompassing posterior-cingulate/precuneus, anterior cingulate/mesiofrontal cortex and temporo-parietal junctions, that show more activity at rest than during attention-demanding tasks. Recent studies have shown that it is possible to reliably identify this network in the absence of any task, by resting state functional magnetic resonance imaging connectivity analyses in healthy volunteers. However, the functional significance of these spontaneous brain activity fluctuations remains unclear. The aim of this study was to test if the integrity of this resting-state connectivity pattern in the default network would differ in different pathological alterations of consciousness. Fourteen non-communicative brain-damaged patients and 14 healthy controls participated in the study. Connectivity was investigated using probabilistic independent component analysis, and an automated template-matching component selection approach. Connectivity in all default network areas was found to be negatively correlated with the degree of clinical consciousness impairment, ranging from healthy controls and locked-in syndrome to minimally conscious, vegetative then coma patients. Furthermore, precuneus connectivity was found to be significantly stronger in minimally conscious patients as compared with unconscious patients. Locked-in syndrome patient's default network connectivity was not significantly different from controls. Our results show that default network connectivity is decreased in severely brain-damaged patients, in proportion to their degree of consciousness impairment. Future prospective studies in a larger patient population are needed in order to evaluate the prognostic value of the presented methodology. [less ▲]

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See detailDéfaut d'observance et inertie therapeutique en obstétrique.
Masson, Véronique ULg; Petit, Philippe ULg; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (2010), 65(5-6), 395-8

Observance around pregnancy includes two parts: what can be done before conception and what must be done during pregnancy. Preconception care, if efficaciously performed, offerss real benefits for foetal ... [more ▼]

Observance around pregnancy includes two parts: what can be done before conception and what must be done during pregnancy. Preconception care, if efficaciously performed, offerss real benefits for foetal and child development. Its efficacy will depends on the involvement and motivation of physicians and particularly also on the patient's observance. In this article we summarize essential pieces of advice to be given to each patient before pregnancy. Therapeutic inertia in obstetrics presents two differents aspects: on the one hand, the delay to initiate a therapeutic strategy when a complication arises such as a postpartum hemorrhage; on the other hand, the continuation of obsolete practices, such as the therapy of uterine hypersystolia. [less ▲]

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