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See detailLa discussion philosophique en classe : une pratique de l'émancipation ?
Herla, Anne ULg

in Tracés (2013), 25

This paper presents a recent pedagogical practice in the field of philosophy in school: Discussion with Democratic and Philosophical Aim (DDPA). According to the author, this practice differs from a more ... [more ▼]

This paper presents a recent pedagogical practice in the field of philosophy in school: Discussion with Democratic and Philosophical Aim (DDPA). According to the author, this practice differs from a more traditional conception of philosophy teaching by upsetting three key aspects of the pedagogical relationship: the relationship to knowledge, the relationship to the master, the relationship to the group. For each of these aspects, it is to show, on the one hand how authority is questioned and reworked, and secondly how the power relations relayed by the school system are revealed and transformed. More broadly, the author argues that the DDPA in its very practice questions in a new light the nature of the philosophical act and undermines the established partitions between teacher and student, philosopher and non-philosopher, scientist and ignorant. It is in this paper to highlight the concept of emancipation - inseparably intellectual and political - that underlies such a learning device of philosophy. L’article présente une pratique pédagogique récente dans le domaine de la philosophie à l’école : la Discussion à Visée Démocratique et Philosophique. D’après l’auteure, cette pratique se distingue d’une conception plus traditionnelle de l’enseignement de la philosophie en bouleversant trois aspects essentiels de la relation pédagogique : le rapport au savoir, la relation au maître, le rapport au collectif. Pour chacun de ces aspects, il s’agit de montrer, d’une part comment l’autorité est remise en question et réélaborée, et d’autre part comment les rapports de domination relayés par le système scolaire sont dévoilés et transformés. Plus largement, l’auteure avance que la DVDP, dans sa pratique même, interroge sous un angle nouveau la nature de l’acte philosophique et ébranle les partages établis entre maître et élève, philosophe et non-philosophe, savant et ignorant. Il s’agit dans cet article de mettre en lumière la conception de l’émancipation – indissociablement intellectuelle et politique – qui sous-tend un tel dispositif d’apprentissage de la philosophie. [less ▲]

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See detailDiscussion summary
Schoenen, Jean ULg

in Olesen, J. (Ed.) Headache classification and epidemiology (1994)

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See detailDiscussions about the Bp-d diagrams in polynomial for marine propeller series
Marchal, Jean ULg; Shen, Yide ULg; Kicheva, D.

in RINA (1995), volume 137

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See detailDiscutant de la Session Mainstreaming Migrant Integration Policies
Martiniello, Marco ULg

Scientific conference (2014, August 27)

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See detailDiscutant, Séminaire du programme thématique « Migrations et Diversité Culturelle »
Martiniello, Marco ULg

Scientific conference (2008, April 03)

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See detailDisease characteristics of patients with X-linked acrogigantism (X-LAG) syndrome
Daly, Adrian ULg; Lodish, MB; Trivellin, G et al

in Abstract book - ENDO 2015 (2015, March)

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See detailDisease management patterns for postmenopausal women in Europe with hormone-receptor-positive, human epidermal growth factor receptor-2 negative advanced breast cancer.
Andre, Fabrice; Neven, Patrick; Marinsek, Nina et al

in Current medical research and opinion (2014)

Abstract Background: International guidelines for hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer (BC) recommend sequential lines of ... [more ▼]

Abstract Background: International guidelines for hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer (BC) recommend sequential lines of hormonal therapy (HT), and only recommend chemotherapy for patients with extensive visceral involvement or rapidly progressive disease. This study evaluated actual physician-reported treatments for advanced BC in Europe. Methods: We conducted a retrospective chart review of 355 postmenopausal women with HR+, HER2- advanced BC who progressed on >/=1 line of HT (adjuvant or advanced) and completed >/=1 line of chemotherapy (advanced). Treatment choice was evaluated for each line of therapy. Results: Of 355 patients, 111 (31%) received first-line chemotherapy, whereas 218 (61%) and 26 (7%) switched from HT to chemotherapy in second and third line, respectively. More patients receiving first-line HT had bone metastases (73% vs 27% chemotherapy). Patients treated with first-line chemotherapy had more brain (12% vs 3% HT) or extensive liver (13% vs 6% HT) metastases. Subgroup analysis of 188 patients who received first-line HT and had de novo advanced BC or relapsed/recurrent disease more than 1 year after adjuvant therapy found that the majority (89%; n = 167) of these patients switched to chemotherapy in second line. However, among these 167 patients, 27% had no significant changes in metastases between first and second line. Among the 73% of patients who had significant changes in metastases, 20% had no brain metastases or extensive visceral disease. Conclusions: Our study suggests that the guideline-recommended use of multiple HT lines is open to interpretation and that optimal treatment for European postmenopausal women with HR+, HER2- advanced BC who responded to HT may not be achieved. [less ▲]

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See detailDisease severity assessment in epidemiological studies: accuracy and reliability of visual estimates of Septoria leaf blotch (SLB) in winter wheat.
El Jarroudi, Moussa ULg; Kouadio, Louis; Mackels, Christophe et al

in Phytopathology (2014), 104(11), 37

The accuracy and reliability of visual assessments of SLB severity by raters (i.e. one plant pathologist with extensive experience and three other raters trained prior to field observations using standard ... [more ▼]

The accuracy and reliability of visual assessments of SLB severity by raters (i.e. one plant pathologist with extensive experience and three other raters trained prior to field observations using standard area diagrams and DISTRAIN) was determined by comparison with assumed actual values obtained by digital image analysis. Initially analyses were performed using SLB severity over the full 0-100% range; then, to explore error over short ranges of the 0-100% scale, the scale was divided into sequential 10%-increments based on the actual values. Lin’s concordance correlation (LCC) analysis demonstrated that all raters were accurate when compared over the whole severity range (LCC coefficient (ρc)= 0.92-0.99). However, agreement between actual and visual SLB severities was less good when compared over the short intervals of the 10×10% classes (ρc= -0.12-0.99), demonstrating that agreement will vary depending on the actual disease range over which it is compared. Inter-rater reliability between each pair of raters over the full 0-100% range (correlation analysis r= 0.970-0.992, P<0.0001), and inter-class correlation coefficient (ρ≥ 0.927) were very high. This study provides new insight into using a full range of actual disease severity vs limited ranges to ensure a realistic measure of rater accuracy and reliability, in addition to contributing to the ongoing debate on the use of visual disease estimates based on the 0-100% ratio scale for epidemiological research. [less ▲]

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See detailDisease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster
Kumita, Janet R.; Helmfors, Linda; Williams, Jocy et al

in FASEB Journal (2012)

We have created a Drosophila model of lysozyme amyloidosis to investigate the in vivo behavior of disease-associated variants. To achieve this objective, wild-type (WT) protein and the amyloidogenic ... [more ▼]

We have created a Drosophila model of lysozyme amyloidosis to investigate the in vivo behavior of disease-associated variants. To achieve this objective, wild-type (WT) protein and the amyloidogenic variants F57I and D67H were expressed in Drosophila melanogaster using the UAS-gal4 system and both the ubiquitous and retinal expression drivers Act5C-gal4 and gmr-gal4. The nontransgenic w(1118) Drosophila line was used as a control throughout. We utilized ELISA experiments to probe lysozyme protein levels, scanning electron microscopy for eye phenotype classification, and immunohistochemistry to detect the unfolded protein response (UPR) activation. We observed that expressing the destabilized F57I and D67H lysozymes triggers UPR activation, resulting in degradation of these variants, whereas the WT lysozyme is secreted into the fly hemolymph. Indeed, the level of WT was up to 17 times more abundant than the variant proteins. In addition, the F57I variant gave rise to a significant disruption of the eye development, and this correlated to pronounced UPR activation. These results support the concept that the onset of familial amyloid disease is linked to an inability of the UPR to degrade completely the amyloidogenic lysozymes prior to secretion, resulting in secretion of these destabilized variants, thereby leading to deposition and associated organ damage.-Kumita, J. R., Helmfors, L., Williams, J., Luheshi, L. M., Menzer, L., Dumoulin, M., Lomas, D. A., Crowther, D. C., Dobson, C. M., Brorsson, A.-C. Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster. [less ▲]

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See detailDiselenide Derivative, Potential Successor of Ebselen with High Antioxidant Activity: Assessment on in vitro Models
Mareque-Faez, Juan; Deby, Carol; Lamy, Maurice ULg et al

in Resource-Full Chemistry (2008, May 24)

Oxidative stress plays a key role in several pathophysiological events, including the attack of DNA, cell membrane damage and signaling pathways disruption. The harmful effect of oxidant stress has been ... [more ▼]

Oxidative stress plays a key role in several pathophysiological events, including the attack of DNA, cell membrane damage and signaling pathways disruption. The harmful effect of oxidant stress has been attributed to a high production of reactive oxygen species (ROS) followed by a depletion of antioxidant enzymes, glutathione peroxidase (GPx), a mammalian selenoenzyme which functions as a catalytic antioxidant, has been described to protect various organisms against oxidative stress. In the past two decades, the design of small weight molecules such as ebselen (PZ 51, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one), has renewed the interest of synthetic analogues able to mimic the GPx activity. From four in vitro in vitro models, we previously showed that ebselen and some of its analogues (compounds 1, 2, 3 and 4) not only behaved at various degrees as GPx-like mimics but also as antioxidants especially for diselenide derivative (3). The present study deals with the antioxidant effect of diselenide derivative (3) versus ebselen on cellular model and the enzyme myeloperoxidase (MPO) activity using the in vitro systems. Derivative (3) has been chosen because of its interesting antioxidant profile in cell-free systems. [less ▲]

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See detailDisentanglement of magnetic field mixing reveals the spontaneous M2 decay rate for a metastable level in Xe+
Schef, P.; Lundin, P.; Biémont, Emile ULg et al

in Physical Review A (2005), 72(2),

We have investigated the radiative decay of the metastable level 5d(4)D(7/2) in Xe+. Theoretically we find the decay to be heavily dominated by an M2 transition and not by M1/E2 transitions. Lifetime ... [more ▼]

We have investigated the radiative decay of the metastable level 5d(4)D(7/2) in Xe+. Theoretically we find the decay to be heavily dominated by an M2 transition and not by M1/E2 transitions. Lifetime measurements of 5d(4)D(7/2) in a storage ring are difficult since magnetic mixing of the metastable with a short-lived level quenches its population. Decay rates were determined at different magnetic field strengths (B) in order to allow a nonlinear extrapolation to B=0. The experimental lifetime of 2.4 +/- 0.8 s was in agreement with the calculated value, but much smaller than previously estimated. [less ▲]

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See detailDisentangling component spectra of κ Scorpii, a spectroscopic binary with a pulsating primary. II. Interpretation of the line-profile variability
Uytterhoeven, K.; Briquet, Maryline ULg; Aerts, C. et al

in Astronomy and Astrophysics (2005), 432

We analyse the complex short-term SiIII line-profile variability of the spectroscopic binary β Cep star κ Scorpii after orbit subtraction, before and after spectral disentangling. We refine the known ... [more ▼]

We analyse the complex short-term SiIII line-profile variability of the spectroscopic binary β Cep star κ Scorpii after orbit subtraction, before and after spectral disentangling. We refine the known oscillation frequency of the star: f[SUB]1[/SUB]=4.99922 c d[SUP]-1[/SUP] and detect 2f[SUB]1[/SUB]. Variability is also found at frequencies near f[SUB]2[/SUB]≃ 4.85 c d[SUP]-1[/SUP] and f[SUB]3[/SUB]≃ 5.69 c d[SUP]-1[/SUP] or their aliases. These frequencies are not significant if we consider the spectra alone, but they survive our selection after the consideration that they were derived previously from independent ground-based and space photometry by different teams. Moreover, we find dominant variability in the equivalent width with a frequency in the interval [0.22,0.30] c d[SUP]-1[/SUP] which we interpret as the rotational frequency f[SUB]rot[/SUB] of the star. The complex window function does not allow us to determine definite values for f[SUB]2[/SUB], f[SUB]3[/SUB], f[SUB]rot[/SUB]. The variability with f[SUB]1[/SUB] is interpreted as a prograde non-radial oscillation mode with spherical wavenumbers (ℓ,m)=(2,-1) or (1,-1). The additional frequencies are explained in terms of rotational modulation superposed to the main oscillation. We also point out that we cannot disprove the variability in κ Scorpii to originate from co-rotating structures. KOREL disentangling preserves the large-amplitude line-profile variability but its performance for complex low-amplitude variability remains to be studied in detail. Based on observations obtained with the Coudé Échelle Spectrograph on the ESO CAT telescope and with the CORALIE échelle spectrograph on the 1.2-m Euler Swiss telescope, both situated at La Silla, Chile. [less ▲]

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