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See detailEarly neuropsychological detection of Alzheimer's disease
Bastin, Christine ULg

Conference (2014, March 06)

Considering that brain pathology due to Alzheimer’s disease starts many years before the clinical symptoms become evident, subtle cognitive changes may exist already in the predementia phase. Different ... [more ▼]

Considering that brain pathology due to Alzheimer’s disease starts many years before the clinical symptoms become evident, subtle cognitive changes may exist already in the predementia phase. Different approaches have been used to detect initial cognitive impairments indicative of Alzheimer’s disease. One approach is the assessment of the predictive power of neuropsychological tools in characterizing patients with stable mild cognitive impairment (MCI) versus MCI patients who subsequently develop Alzheimer’s disease. Another approach is the longitudinal evaluation of large cohorts of older adults in population-based studies. Findings from several studies suggest that a memory test that ensures deep encoding of information and assesses retrieval with free as well as cued recall is a useful tool to distinguish patients at an early stage of Alzheimer disease from MCI non-converters. Impaired semantic memory has also been proposed as a neuropsychological marker of predementia Alzheimer’s disease. Beyond the memory domain, category verbal fluency has been shown to predict progression to Alzheimer’s disease. Moreover, combining neuropsychological scores of memory and executive functions and neuroimaging data allows a better discrimination between stable MCI and converters than neuroimaging data alone. Altogether, it is possible to detect cognitive changes that are predictive of the typical form of probable Alzheimer’s disease already in the predementia stage. Such at risk people are thought to be the best target for therapeutic interventions. [less ▲]

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See detailEarly neuropsychological detection of Alzheimer's disease
Bastin, Christine ULg; Salmon, Eric ULg

in European Journal of Clinical Nutrition (2014), 68

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See detailEarly normalization of luteinizing hormone pulsatility after successful transsphenoidal surgery in women with microprolactinomas
Stevenaert, Achille ULg; Beckers, Albert ULg; Vandalem, J. L. et al

in Journal of Clinical Endocrinology and Metabolism (1986), 62(5), 1044-1047

In eight hyperprolactinemic amenorrheic women who had a microprolactinoma, LH secretion was examined by measuring its concentration in blood samples collected every 15 min for 6 h before and 8 days after ... [more ▼]

In eight hyperprolactinemic amenorrheic women who had a microprolactinoma, LH secretion was examined by measuring its concentration in blood samples collected every 15 min for 6 h before and 8 days after successful selective adenomectomy. Computer analysis was used for LH peak evaluation. In both circumstances, serum PRL and basal estradiol (E2) levels were also determined. Before operation, the number of LH peaks ranged from zero to one per 6 h in seven patients and was two per 6 h in the eighth patient. In all patients, serum PRL was normal on the eighth postoperative day, while E2 levels remained low, similar to the values usually found in the early follicular phase of the cycle in normal women. Postoperatively, mean LH levels were similar to preoperative levels, but there was a dramatic increase in the number of LH peaks (three to five per 6 h) in five of the eight patients. These observations confirm the impairment of LH pulsatility in hyperprolactinemiaand demonstrate that normalization of PRL levels by surgery can restore LH pulsatile secretion in certain women as early as the eighth day after operation in the absence of a significant change in serum E2 levels. Thus, the preoperative impaired pulsatility of LH secretion was probably a central effect of hyperprolactinemia. [less ▲]

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See detailEarly onset neonatal sepsis and meningitis in Belgium: a decade review
MELIN, Pierrette ULg; Maquet, Julie; Ducoffre, Geneviève et al

in American Society of Microbiology (Ed.) Program and Abstracts of the 43rd Intersciences Conference on Antimicrobial Agents and Chemotherapy (2003, September)

Background: In the late 1990s, Belgium has reached the era of “group B streptococcal (GBS) prevention” and after 1996, some institutions, but not the majority, had implemented intrapartum ... [more ▼]

Background: In the late 1990s, Belgium has reached the era of “group B streptococcal (GBS) prevention” and after 1996, some institutions, but not the majority, had implemented intrapartum antibioprophylaxis for GBS prevention. Concern exists that one unintended consequence of GBS prevention efforts through chemoprophylaxis may be an increase in the rate of serious neonatal infections due to Gram negative bacteria (GNB). To monitor trends, continued surveillance of neonatal sepsis is needed. Methods: On a weekly basis, laboratories of the Belgian sentinel network notified each case of neonatal bacteremia or meningitis occurring within 28 days after birth. We reviewed on a year-base data collected from 1991-2001 for early–onset diseases (EOD; < 5 days). Results: A yearly mean of 47 cases (24-90) were notified by 28 (16-35) laboratories. Overall GBS remained the leading cause and represented annually 37.9% (25-54.7%) of EOD and did not show significant change. It was followed by E.coli 11.4%, coagulase negative staphylococci (CNS) 11.9%, S.aureus 9.9%, Listeria sp 3.9%, S.pyogenes (GAS) 2.5%, S.pneumoniae 2.7%, H.influenzae 2.7% and others. During the decade, whereas a significant reduction in the rate of E.coli and other GNB EOD occurred (p <0.01), significant increases in the rate of EOD due to GAS (p <0.001), S.aureus (p <0.001), and CNS (p <0.01), were found. For CNS, we did not have data to distinguish definite or possible infections from contaminations. Conclusions: 1) During the last decade, GBS has remained the leading cause of neonatal EOD. 2) A decline in the rate of E.coli and other GNB infections occurred. 3) In the late 1990s, S.aureus and CNS were more frequently reported. 4) An increase in GAS occurrence was found 5) Potential change in pathogens overtime requires confirmation by ongoing surveillance. [less ▲]

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See detailEarly onset neonatal sepsis or meningitis, in Belgium, in the era of prevention for perinatal group B streptococcal diseases
MELIN, Pierrette ULg; Hayette, Marie-Pierre; Ducoffre, Geneviève et al

in ASM (Ed.) Program and Abstracts of the 46th Intersciences Conference on Antimicrobial Agents and Chemotherapy (2006, September)

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See detailEarly onset of puberty: Tracking genetic and environmental factors
Parent, Anne-Simone ULg; Rasier, Gregory; Gerard, Arlette ULg et al

in Hormone Research (2005), 64(Suppl. 2), 41-47

Under physiological conditions, factors affecting the genetic control of hypothalamic functions are predominant in determining the individual variations in timing of pubertal onset. In pathological ... [more ▼]

Under physiological conditions, factors affecting the genetic control of hypothalamic functions are predominant in determining the individual variations in timing of pubertal onset. In pathological conditions, however, these variations can involve different genetic susceptibility and the interaction of environmental factors. The high incidence of precocious puberty in foreign children migrating to Belgium and the detection in their plasma of a long-lasting 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT) residue suggest the potential role of environmental endocrine disrupting chemicals in the early onset of puberty. This hypothesis was confirmed by experimental data showing thattemporary exposure of immature female rats to DDT in vivo results in early onset of puberty. We compared the gene expression profile of hypothalamic hamartoma associated or not with precocious puberty in order to identify gene networks responsible for both hamartoma-dependent sexual precocity and the onset of normal human puberty. In conclusion, pathological variations in the timing of puberty may provide unique information about the interactions of either environmental conditions or genetic susceptibility with the hypothalamic mechanism controlling the onset of sexual maturation, as shown by examples of precocious puberty following exposure to endocrine disrupters or due to hypothalamic hamartoma. Copyright (c) 2005 S. Karger AG, Basel. [less ▲]

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See detailEarly ontogenesis od sensitization to the behavioral effects of cocaine in rats.
Tirelli, Ezio ULg; Adam, Eric; Ferrara, Maurizio

in Behavioural Pharmacology (1994), 5

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See detailAn early origin of plastids within the cyanobacterial divergence is suggested by evolutionary trees based on complete 16S rRNA sequences
Nelissen, Bart; Van De Peer, Yves; Wilmotte, Annick ULg et al

in Molecular Biology and Evolution (1995), 12

It is generally accepted that the plastids arose from a cyanobacterial ancestor, but the exact phylogenetic relationships between cyanobacteria and plastids are still controversial. Most studies based on ... [more ▼]

It is generally accepted that the plastids arose from a cyanobacterial ancestor, but the exact phylogenetic relationships between cyanobacteria and plastids are still controversial. Most studies based on partial 16S rRNA sequences suggested a relatively late origin of plastids within the cyanobacterial divergence. In order to clarify the exact relationship and divergence order of cyanobacteria and plastids, we studied their phylogeny on the basis of nearly complete 16S rRNA gene sequences. The data set comprised 15 strains of cyanobacteria from different morphological groups, 1 prochlorophyte, and plastids belonging to 8 species of plants and 12 species of diverse algae. This set included three cyanobacterial sequences determined in this study. This is the most comprehensive set of complete cyanobacterial and plastidial 16S rRNA sequences used so far. Phylogenetic trees were constructed using neighbor joining and maximum parsimony, and the reliability of the tree topologies was tested by different methods. Our results suggest an early origin of plastids within the cyanobacterial divergence, preceded only by the divergence of two cyanobacterial genera, Gloeobacter and Pseudanabaena. [less ▲]

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See detailThe early Paleozoic carbon cycle
Godderis, Y.; François, Louis ULg; Veizer, J.

in Earth And Planetary Science Letters (2001), 190(3-4), 181-196

A review of O, C, Sr and S isotope trends for the entire Phanerozoic shows that the present-day values of isotope signals are similar to those at the Proterozoic termination. The sharp rise in Sr-87/Sr-86 ... [more ▼]

A review of O, C, Sr and S isotope trends for the entire Phanerozoic shows that the present-day values of isotope signals are similar to those at the Proterozoic termination. The sharp rise in Sr-87/Sr-86 since similar to 65 Ma has been attributed to an uplift and subsequent metamorphism and erosion associated with the Himalayas and Tibet. This orogenic evolution has been postulated to have influenced the global organic and inorganic carbon cycles and climate as well. A similar large-scale orogeny, the Pan-African event, also dominated the Neoproterozoic (Vendian) times, and the similarity of modern and Neoproterozoic isotope values for seawater may therefore have had a comparable tectonic cause. In this contribution, we present the results of a numerical model of the coupled C-alkalinity-S-Sr cycles suggesting that the early Paleozoic (from early Cambrian to late Devonian) evolution of Sr, O, C and S seawater isotope signals could have been the consequence of progressive oxidation of a large reduced carbon reservoir exhumed during the Pan-African orogeny. The delta O-18 measured in brachiopod shells is used as a forcing of the model, postulating that any change in the oxygen isotopic composition of seawater is the result of a disequilibrium in the organic carbon subcycle through the coupling of the oxygen isotopic and carbon cycles. The calculated delta C-13, Sr-87/Sr-86 and delta S-34 are in good agreement with the data, as is the reasonable calculated history for atmospheric pCO(2) and its relation to global climate. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailEarly postmenopausal women have high prevalence of inadequate serum vitamin D levels. Results of a European study
Bruyère, Olivier ULg; Malaise, Olivier; Neuprez, Audrey ULg et al

in Osteoporosis International (2006, March), 17(Suppl.1), 85-86

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See detailEarly prediction of electric power system blackouts by temporal machine learning
Geurts, Pierre ULg; Wehenkel, Louis ULg

in Proceedings of ICML-AAAI 98 Workshop on "Predicting the future: AI approaches to time series analysis" (1998)

This paper discusses the application of machine learning to the design of power system blackout prediction criteria, using a large database of random power system scenarios generated by Monte-Carlo ... [more ▼]

This paper discusses the application of machine learning to the design of power system blackout prediction criteria, using a large database of random power system scenarios generated by Monte-Carlo simulation. Each scenario is described by temporal variables and sequences of events describing the dynamics of the system as it might be observed from real-time measurements. The aime is to exploit the data base in order to derive as simple as possible rules which would allow to detect an incipient blackout early enough to prevent or mitigate it. We propose a novel "temporal tree induction" algorithm in order to exploit temporal attributes and reach a compromise between the degree of anticipation and selectivity of detection rules. Tests are carried out on a a data base related to voltage collapse of an existing large scale power system. [less ▲]

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See detailEarly prediction of response to recombinant human erythropoietin in patients with the anemia of renal failure by serum transferrin receptor and fibrinogen.
Beguin, Yves ULg; Loo, Martine; R'Zik, Samir ULg et al

in Blood (1993), 82(7), 2010-6

Recombinant human erythropoietin (rHuEpo) has been shown to be effective in correcting the anemia of chronic renal failure, but the dose needed may be variable. The reason for this variation is not known ... [more ▼]

Recombinant human erythropoietin (rHuEpo) has been shown to be effective in correcting the anemia of chronic renal failure, but the dose needed may be variable. The reason for this variation is not known, but several factors could be involved, such as iron deficiency, inflammation, aluminum intoxication, hyperparathyroidism, blood losses, or marrow dysfunction. Treatment with rHuEpo was given intravenously thrice weekly after hemodialysis to 64 consecutive unselected patients with the anemia of chronic renal failure. The starting dose was 50 U/kg/dose, which was increased to 75 and 100 U/kg/dose if no response was observed after 1 and 2 months of treatment. After a minimum follow-up of 6 months, response was evaluated as early (hematocrit [Hct] > or = 30% before 3 months) or late (Hct > or = 30% after 3 months) response, or failure (target Hct not attained). We examined the value of various laboratory parameters (baseline values and early changes) as predictors of response to rHuEpo. The best prediction by pretreatment parameters only was obtained with baseline serum transferrin receptor (TfR) (< or > or = 3,500 ng/mL) and fibrinogen (< or > or = 4 g/L): 100% response rate when both parameters were low, versus only 29% when they were both high, and versus 67% when one was low and the other high. When the 2-week TfR increment was greater than 20%, the response rate was 96%. When TfR increment was less than 20%, the response rate was 100% when baseline TfR and fibrinogen were low, 12% when fibrinogen was elevated, and 62% when fibrinogen was low but baseline TfR high. The predictive value of baseline TfR and fibrinogen and of the 2-week increment of TfR was confirmed by life table analysis and stepwise discriminant analysis. Major reasons for failure or late response were identified and included subclinical inflammation, iron deficiency, functional iron deficiency, marrow disorders, hemolysis, bleeding, and low Epo dose. We conclude that response to rHuEpo can be predicted early by pretreatment fibrinogen and TfR, together with early changes of TfR levels. These prognostic factors illustrate the importance of the early erythropoietic response, subclinical inflammation, and functional iron deficiency. Early recognition of a low probability of response in a given patient could help identify and correct specific causes of treatment failure to hasten clinical improvement and avoid prolonged ineffective use of an expensive medication. [less ▲]

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See detailEarly Prediction of Transient Voltage Sags caused by Rotor Swings
Weckesser, Tilman; Johannsson, Hjortur; Van Cutsem, Thierry ULg

in Proc. IEEE PES general meeting (2014, July)

The paper investigates various methods to predict voltage sags at load buses caused by large generator rotor swings and following a transient disturbance. Three different prediction methods are proposed ... [more ▼]

The paper investigates various methods to predict voltage sags at load buses caused by large generator rotor swings and following a transient disturbance. Three different prediction methods are proposed, which all use real-time measurements from PMUs. One of the methods uses a slightly extended version of the E-SIME method. The other two methods use measurements and process them by recursive least square estimation. It is shown that the prediction method employing E-SIME allows the earliest detection of a critical voltage sag with satisfactory accuracy. [less ▲]

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See detailEarly pregnancy detection in sheep. Secondary communication
Karen, Aly; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

Poster (2005)

A szerzők a juhok vemhességének korai megállapítására összehasonlították a progeszteron- (P4) és a vemhességi fehérje (PAG) RIA-tesztek megbízhatóságát. A PAG-teszttel a nem vemhes állatok nagyobb ... [more ▼]

A szerzők a juhok vemhességének korai megállapítására összehasonlították a progeszteron- (P4) és a vemhességi fehérje (PAG) RIA-tesztek megbízhatóságát. A PAG-teszttel a nem vemhes állatok nagyobb biztonsággal voltak felismerhetők. Nagyszámú állaton (n=949 és 764) végzett rectalis ultrahangvizsgálattal a vemhességet pontosabban tudták megállapítani, ha az állatokat 12 óráig koplaltatták és vizsgálat közben a hasfalat a tőgy előtt felemelték. Az ultrahangvizsgálat és a PAG-teszt eredményeinek összehasonlításával megállapították, hogy az utóbbi megbízhatóbb eredményt ad. [less ▲]

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See detailEarly pregnancy diagnosis in sheep by progesterone and pregnancy-associated glycoprotein tests
Karen, A.; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

in Theriogenology (2003), 59(9), 1941-1948

The aim of this study was to compare the accuracy of the progesterone (P4) and pregnancy associated glycoprotein (PAG) tests for determination of early pregnancy in sheep. Estrus was synchronized in 182 ... [more ▼]

The aim of this study was to compare the accuracy of the progesterone (P4) and pregnancy associated glycoprotein (PAG) tests for determination of early pregnancy in sheep. Estrus was synchronized in 182 Awassi x Merino ewes and blood samples were collected at Days 0 (day of the insemination), 18, 22, 29, 36, and 50 after artificial insemination (AI). Plasma P4 concentrations at Days 0 and 18 were determined by double antibody radioimmunoassay, while PAG concentrations at Days 22, 29, 36 and 50 were determined by a heterologous, double-antibody radioimmunoassay (RIA) using the bovine PAG 67 kDa subunit as tracer and standard and rabbit antiserum raised against a mixture of caprine 55 and 59 kDa PAG subunits as the first antibody. The discriminatory value for diagnosis of pregnancy by the P4 and the PAG-RIA tests was greater than or equal to1 ng/ml. Based on lambing data, the accuracy for diagnosing pregnant (sensitivity) and non-pregnant ewes (specificity) and predictivity of both tests were calculated. The sensitivity, specificity, positive and negative predictive values for P4 and PAG tests were 100, 95.4, 81.6, and 100% at Day 18 (P4) and 93.5, 100, 100 and 98.7% at Day 22 (PAG), respectively. For diagnosis of non-pregnant ewes the PAG test had significantly higher specificity than the P4 test (P < 0.05). It is concluded that ovine pregnancy can be reliably diagnosed at Day 22 after AI by using a heterologous radioimmunoassay of PAG. [less ▲]

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See detailEarly pregnancy diagnosis in sheep by progesterone and pregnancy-associated glycoprotein tests.
Karen, A.; Beckers, Jean-François ULg; Sulon, J. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(1), 8

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