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See detailDecreased number and defect of the internalization process of corticotropin-releasing hormone receptors in adenomatous corticotrophs
verhelst, j; Abs, R.; Beckers, Albert ULg et al

in Acta Clinica Belgica (1993), 48

Detailed reference viewed: 4 (0 ULg)
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See detailDecreased Protein Levels of the C-Cbl Protooncogene in Murine Aids
Trebak, Mohamed; Lambert, Charles A; Rahmouni, Souad ULg et al

in Cellular Immunology (1998), 188(2), 151-7

Murine acquired immunodeficiency syndrome (MAIDS) can be viewed as a lymphoproliferative disease which involves B cells as well as T cells from spleen and lymph nodes while thymus and Peyer's patches do ... [more ▼]

Murine acquired immunodeficiency syndrome (MAIDS) can be viewed as a lymphoproliferative disease which involves B cells as well as T cells from spleen and lymph nodes while thymus and Peyer's patches do not participate in the process. The 120-kDa protooncogene product c-Cbl was initially cloned from the murine Cas NS-1 B cell lymphoma. It is a main target of immunoreceptor (TCR and BCR)-mediated protein tyrosine kinase activity. Moreover, recent data suggest that c-Cbl might play a crucial role in the regulation of cell proliferation through regulation of GTP-binding proteins. Therefore, the involvement of c-Cbl was evaluated in the lymphoproliferative disease induced by the MAIDS virus. The expression of the c-Cbl protein was dramatically reduced in the lymph node of infected mice while it remained normal in the thymus. In contrast, the expression of actin, TCR-zeta chain, ZAP-70, and p59(fyn) remained similar in controls and infected mice. Identical results were obtained with sorted B cells and T cells. Surprisingly, a B cell lymphoma line derived from late stage MAIDS mice displayed a normal level of c-Cbl. [less ▲]

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See detailDecreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent's disease.
Raggi, Claudia; Fujiwara, Kunio; Leal, Teresinha et al

in Pflügers Archiv : European Journal of Physiology (2011), 462(6), 851-60

The clinical use of aminoglycoside (AG) antibiotics is limited by their renal toxicity, which is caused by drug accumulation in proximal tubule (PT) cells. Clinical studies reported that renal clearance ... [more ▼]

The clinical use of aminoglycoside (AG) antibiotics is limited by their renal toxicity, which is caused by drug accumulation in proximal tubule (PT) cells. Clinical studies reported that renal clearance of AG is enhanced in cystic fibrosis (CF) patients, which might reflect the role of CFTR in PT cell endocytosis. In order to assess the role of chloride transporters on the renal handling of AG, we investigated gentamicin uptake and renal accumulation in mice lacking functional CFTR (Cftr ( F/F)) or knock-out for the Cl(-)/H(+) exchanger ClC-5 (Clcn5 ( Y/- )). The latter represent a paradigm of PT dysfunction and defective receptor-mediated endocytosis. As compared with controls, Cftr ( F/F) and Clcn5 ( Y/- ) mice showed a 15% to 85% decrease in gentamicin accumulation in the kidney, respectively, in absence of renal failure. Studies on primary cultures of Cftr ( F/F) and Clcn5 ( Y/- ) mouse PT cells confirmed the reduction in gentamicin uptake, although colocalization with endosomes and lysosomes was maintained. Quantification of endocytosis in PT cells revealed that gentamicin, similar to albumin, preferentially binds to megalin. The functional loss of ClC-5 or CFTR was reflected by a decrease of the endocytic uptake of gentamicin, with a more pronounced effect in cells lacking ClC-5. These results support the concept that CFTR, as well as ClC-5, plays a relevant role in PT cell endocytosis. They also demonstrate that the functional loss of these two chloride transporters is associated with impaired uptake of AG in PT cells, reflected by a decreased renal accumulation of the drug. [less ▲]

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See detailDecreased responsiveness of GH3 cells to the dopaminergic inhibition of prolactin
Faure, Nacia; Cronin, Michaël J; Martial, Joseph ULg et al

in Endocrinology (1980), 107(4), 1022-1026

The inhibitory regulation of PRL secretion by dopamine (DA) or the dopaminergic agonists bromergocryptine (CB-154) and apomorphine was studied in cultured GH3 cells, an established rat anterior pituitary ... [more ▼]

The inhibitory regulation of PRL secretion by dopamine (DA) or the dopaminergic agonists bromergocryptine (CB-154) and apomorphine was studied in cultured GH3 cells, an established rat anterior pituitary cell line which produces both PRL and GH. The basal release of PRL from GH3 cells was unaffected when incubated for 6 h with DA concentrations as high as 10(-4) M. The inability of DA to suppress PRL secretion could not be explained by the catabolism of DA or the presence of unknown inhibitors (e.g. estradiol) in the fetal calf serum present in the incubation media. Apomorphine and CB-154 were only partially effective in suppressing PRL release at high concentrations of 10(-4) and 10(-5) M, respectively. Various concentrations of the dopaminergic antagonist d-butaclamol did not reverse the inhibitory action of 10(-5) M CB-154, while equal concentrations (10(-5) M) of both d- and l-butaclamol significantly suppressed PRL release. The greatly lowered responsiveness of GH3 cells to dopaminergic inhibition of PRL is suggestive of some impairment of DA receptors. This hypothesis is supported by radioligand binding studies in which high affinity dopaminergic binding sites are absent in the same cell line used in this study. [less ▲]

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See detailDecreased Thymosin Beta 4 Expression Results in Poor Prognosis and Decreased Survival in Multiple Myeloma
CAERS, Jo ULg; Hose, Dirk; Kuipers, Ine et al

Poster (2008)

Detailed reference viewed: 19 (1 ULg)
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See detailDécret d'optimalisation du CWATUP
Delnoy, Michel ULg

in Immobilier (2002), 16

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See detailLe décret décumul : Quels impacts pour le mandat local ?
Grandjean, Geoffrey ULg

Scientific conference (2015, October 17)

A l’heure où la relation entre ministre et bourgmestre empêché pose question et contribue à renforcer un sentiment de méfiance de la part de la population à l’égard des mandataires, les débats sur le ... [more ▼]

A l’heure où la relation entre ministre et bourgmestre empêché pose question et contribue à renforcer un sentiment de méfiance de la part de la population à l’égard des mandataires, les débats sur le cumul ou plutôt le décumul des mandats fait la une de l’actualité de manière récurrente. Aujourd’hui, les représentants politiques belges cumulent en moyenne entre cinq et huit mandats. En 2010, sous le gouvernement PS/CDH/Ecolo, était adopté le décret décumul, traduisant certaines préoccupations évoquées plus haut. Depuis lors, un député wallon ne peut plus cumuler son mandat avec une fonction de bourgmestre, d’échevin ou de président d’un CPAS. Toutefois, un quart des membres de chaque groupe politique est autorisé à cumuler. Pour ce faire, ils sont désignés sur la base de leur taux de pénétration. La communication se propose de retracer brièvement le processus législatif du décret, tout en analysant le jeu des multiples acteurs. A travers une analyse politico-juridique, il se penchera sur les effets du décret pour les mandataires liégeois. Enfin, il dressera des pistes de réflexion concernant la notion de bourgmestre empêché. [less ▲]

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See detailLe décret décumul et le Parlement wallon
Grandjean, Geoffrey ULg; Janssens, Frédéric

in Administration Publique: Revue du Droit Public et des Sciences Administratives (2016), 2

Detailed reference viewed: 22 (6 ULg)
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See detailLe décret du 31 mai 2007 relatif à la participation du public en matière d'environnement : avancées et questions
Delnoy, Michel ULg; Jadot, Benoît

in Delnoy, Michel (Ed.) Actualités du droit de l'aménagement du territoire et de l'environnement - plans et permis (2009)

Detailed reference viewed: 58 (10 ULg)
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See detailLe décret du parlement wallon du 5 décembre 2008 relatif à la gestion des sols
Delnoy, Michel ULg

in Chroniques notariales n°49 (2009)

Detailed reference viewed: 87 (3 ULg)
See detailLe décret mémoire. Exemple d’un projet
Grandjean, Geoffrey ULg

Conference given outside the academic context (2011)

Detailed reference viewed: 27 (0 ULg)
See detailLe décret relatif au permis d'environnement
Delnoy, Michel ULg

Book published by edi.pro (2003)

Detailed reference viewed: 28 (5 ULg)
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See detailLe décret relatif aux implantations commerciales: une logique juridique à l'encontre de celle du marché intérieur européen?
Van Cleynenbreugel, Pieter ULg; Zians, Audrey ULg

in Vanhuffel, Annabelle; Haumont, Francis (Eds.) Les implantations commerciales - État des lieux deux ans après la régionalisation (2016)

This chapter analyses the applicability of the services directive to the Walloon commercial implantation decree. It also considers to what extent the decree is compatible with EU internal market law.

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See detailDécret Robin des Bois, La réfutation du recours en annulation de l’article 17, §1, 10° et 11°
Souply-Pierard, Fernand ULg

Learning material (2011)

Dans ce travail, nous résumons les deux moyens du requérant ainsi que les deux « contre- » moyens. On notera également que les deux points de vue se justifient chacun en droit et que sur quelques points ... [more ▼]

Dans ce travail, nous résumons les deux moyens du requérant ainsi que les deux « contre- » moyens. On notera également que les deux points de vue se justifient chacun en droit et que sur quelques points, il n’est question que d’affrontement intellectuel et d’interprétation plus ou moins appuyée par la doctrine et la jurisprudence. [less ▲]

Detailed reference viewed: 31 (5 ULg)
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See detailLe décret wallon de gestion des sols : après l'entrée en vigueur, l'opérationnalité ?
Delnoy, Michel ULg

Article for general public (2013)

Detailed reference viewed: 27 (4 ULg)
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See detailLe décret wallon du 22 novembre 2007 sur la prévention et la réparation des dommages environnementaux (II)
Delnoy, Michel ULg; Born, Charles-Hubert

in Aménagement - Environnement (2009), 3

Detailed reference viewed: 71 (11 ULg)