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See detailEffect of Benchmark Misspecification on Risk-Adjusted Performance Measures
Bodson, Laurent ULg; Hübner, Georges ULg

in Gregoriou, Greg N.; Hoppe, Christian; Wehn, Carsten (Eds.) The Risk Modeling Evaluation Handbook (2010)

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See detailEffect of benzoic acid analogs on myeloperoxidase activity measured by a new technique to study their direct interaction with the enzyme.
Franck, Thierry ULg; Mazloum, Ali; Mouithys-Mickalad, Ange ULg et al

Poster (2011, May)

Myeloperoxidase (MPO) plays a key role in inflammatory response and constitutes a target for new drug development. The effects of some benzoic acid analogs were studied on the specific activity of human ... [more ▼]

Myeloperoxidase (MPO) plays a key role in inflammatory response and constitutes a target for new drug development. The effects of some benzoic acid analogs were studied on the specific activity of human MPO measured by SIEFED (“Specific Immunologic Extraction Followed by Enzymatic Detection”), an original method that consists of incubation of the compound with MPO, followed by capture of the enzyme by specific antibodies, washing (elimination of the compounds) and enzymatic detection of the immunocaptured enzyme. The compounds tested at 10-4, 10-5 and 10-6 M were studied in terms of structure activity relationship. Gallic acid (3,4,5-trihydroxybenzoic acid) with 3 hydroxyl groups had an important dose dependent inhibitory effect on MPO activity. Other molecules with less or without hydroxyl groups [3,4-dihydroxybenzoic acid, 2-hydroxybenzoic acid (salicylic acid) and benzoic acid] had rather an activator effect at 10-5 and 10-6 M. 2,4,6-Trihydroxybenzoic acid, with two hydroxyl groups adjacent to the carboxyl group, had a less efficient inhibitory effect. Caffeic acid (3,4-dihydroxycinnamic acid) with a propenoic acid group presented a dose dependent inhibitory effect on MPO activity contrary to its analog 3,4-dihydroxybenzoic acid. The esterification of the carboxyl group of gallic acid to obtain propyl gallate induced an activation of MPO at 10-5 and 10-6 M. Finally, the substitution of one or two hydroxyl groups by methoxyl ones (ferulic and syringic acids) decreased the efficiency of the molecules on the enzyme inhibition. The SIEFED technique appears as an innovative pharmacological tool to study the direct interaction of compounds with MPO. Number and position of hydroxyl groups and the extension of the carboxyl group of benzoic acid play a crucial role in the inhibition of MPO activity probably by facilitating the interaction with the active site or another elements of the enzyme structure. [less ▲]

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See detailThe effect of bequest motives on the composition and distribution of assets in France
Arrondel, L.; Pestieau, Pierre ULg; Perelman, Sergio ULg

in Tachibanaki, T. (Ed.) Saving and Bequest (1994)

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See detailTHE EFFECT OF BETA MICROPROBE IMPLANTATION ON THE BLOOD BRAIN BARRIER
Warnock, Geoffrey ULg; Dedeurwaardere, Stefanie; Bahri, Mohamed Ali ULg et al

Poster (2010, September)

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See detailEffect of BHT-920 on monoaminergic neurons of the rat brain : an electrophysiological in vivo and in vitro study
Seutin, Vincent ULg; Scuvée-Moreau, Jacqueline ULg; Giesbers, Irène ULg et al

in Mededelingen van de Faculteit Landbouwwetenschappen (Rijksuniversiteit te Gent) (1990), 342

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See detailEffect of bi-level positive airway pressure (BiPAP) nasal ventilation on the postoperative pulmonary restrictive syndrome in obese patients undergoing gastroplasty.
Joris, Jean ULg; Sottiaux, Thierry; Chiche, Jean-Daniel et al

in CHEST (1997), 111(3), 665-70

STUDY OBJECTIVE: Upper abdominal surgery results in a postoperative restrictive pulmonary syndrome. Bi-level positive airway pressure (BiPAP System; Respironics Inc; Murrysville, Pa), which combines ... [more ▼]

STUDY OBJECTIVE: Upper abdominal surgery results in a postoperative restrictive pulmonary syndrome. Bi-level positive airway pressure (BiPAP System; Respironics Inc; Murrysville, Pa), which combines pressure support ventilation and positive end-expiratory pressure via a nasal mask, could allow alveolar recruitment during inspiration and prevent expiratory alveolar collapse, and therefore limit the postoperative pulmonary restrictive syndrome. This study investigated the effect of BiPAP on postoperative pulmonary function in obese patients after gastroplasty. DESIGN: Prospective controlled randomized study. SETTING: GI surgical ward in a university hospital. PATIENTS: Thirty-three morbidly obese patients scheduled for gastroplasty were studied. INTERVENTION: The patients were assigned to one of three techniques of ventilatory support during the first 24 h postoperatively: O2 via a face mask, BiPAP System 8/4, with inspiratory and expiratory positive airway pressure set at 8 and 4 cm H2O, respectively, or BiPAP System 12/4 set at 12 and 4 cm H2O. Pulmonary function (FVC, FEV1, and peak expiratory flow rate [PEFR]) were measured the day before surgery, 24 h after surgery, and on days 2 and 3. Oxygen saturation by pulse oximeter (SpO2) was also recorded during room air breathing. RESULTS: Three patients were excluded. After surgery, FVC, FEV1, PEFR, and SpO2 significantly decreased in the three groups. On day 1, FVC and FEV1 were significantly improved in the group BiPAP System 12/4, as compared with no BiPAP; SpO2 was also significantly improved. After removal of BiPAP System 12/4, these benefits were maintained, allowing faster recovery of pulmonary function. No significant effects were observed on PEFR. BiPAP System 8/4 had no significant effect on the postoperative pulmonary restrictive syndrome. CONCLUSION: Prophylactic use of BiPAP System 12/4 during the first 24 h postoperatively significantly reduces pulmonary dysfunction after gastroplasty in obese patients and accelerates reestablishment of preoperative pulmonary function. [less ▲]

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See detailEffect of bilateral stimulation on spinal evoked potentials in dogs
Poncelet, Luc; Delauche, A.; Vinals, C. et al

in American Journal of Veterinary Research (1992)

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See detailEffect of bio-sourced compounds on activation of immune cells in the view of to improve immunotherapy of malignant pleural mesothelioma
Hamaïdia, Malik ULg

Poster (2013, July)

Glycans are macromolecules (O-glycosidic and N-glycosidic linkage of monosacharides) which can be extracted from various agricultural products (i.e. cellulose, lignin, starch, insect). Preliminary data ... [more ▼]

Glycans are macromolecules (O-glycosidic and N-glycosidic linkage of monosacharides) which can be extracted from various agricultural products (i.e. cellulose, lignin, starch, insect). Preliminary data indicate that glycans can stimulate inflammation without initiating an anti-inflammatory feedback loop. Notwithstanding, inhibition of immune response by anti-inflammatory cytokines is a major cause of cancer therapy failure in human. The goal of the project is to study the ability of glycans to modulate the functions of macrophages and dendritic cells in order to stimulate anti-tumor immune response. The project aims to assess this hypothesis in a high incidence cancer: Malignant Pleural Mesothelioma. Glycan extracts will be isolated from a variety of agroforestry resources and especially broadleaved trees of the different systems tested on the platform AgricultureIsLife (zones 1-3 : hedges, tree lines, agrisilviculture, short rotation coppice) and modified by physical, chemical, enzymatic or microbiotic approaches. [less ▲]

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See detailEffect of biologically active coating on biocompatibility of Nitinol devices designed for the closure of intra-atrial communications.
Kong, Xiangqing; Grabitz, R. G.; van Oeveren, W. et al

in Biomaterials (2002), 23(8), 1775-83

Anti-thrombogenicity and rapid endothelialisation are prerequisites for the use of closure devices of intra-atrial communications in order to reduce the risk of cerebral embolism. The purpose of this ... [more ▼]

Anti-thrombogenicity and rapid endothelialisation are prerequisites for the use of closure devices of intra-atrial communications in order to reduce the risk of cerebral embolism. The purpose of this study was therefore to assess the effect of bioactive coatings on biocompatibility of Nitinol coils designed for the closure of intra-atrial communications. Nitinol coils (n = 10, each) and flat Nitinol bands (n = 3, each) were treated by basic coating with poly(amino-p-xylylene-co-p-xylylene) and then coated with either heparin, r-hirudin or fibronectin. Anti-thrombogenicity was studied in vitro in a dynamic model with whole blood by partial thromboplastin time (PTT), platelet binding and thrombin generation, respectively, and cytotoxicity by hemolysis. Endothelialisation was studied on Nitinol bands with human umbilical venous endothelial cells (HUVEC) by 3-(4,5-dimethylthiazole-2yl)-2,5-triphenyl tetrazolium (MTT) assay and immnuofluorescence analysis of Ki67, vinculin, fibronectin and von Willebrand Factor. Uncoated or coated devices did not influence hemolysis and PTT. r-Hirudin (but not heparin) and fibronectin coating showed lower platelet binding than uncoated Nitinol (p < 0.005, respectively). Heparin and r-hirudin coating reduced thrombin formation (p < 0.05 versus Nitinol, respectively). HUVEC adhesion, proliferation, and matrix formation decreased in the order: fibronectin coating > uncoated Nitinol > r-hirudin coating > heparin coating > basic coating. MTT assay corroborated these findings. In conclusion, r-hirudin and fibronectin coating, by causing no acute cytotoxicity, decreasing thrombogenicity and increasing endothelialisation improve in vitro biocompatibility of Nitinol devices designed for the closure of intra-atrial communications. [less ▲]

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See detailEffect of blend levels on composite wheat doughs performance made from yam and cassava native starches and bread quality
Nindjin, Charlemagne; Amani, G. N.; Sindic, Marianne ULg

in Carbohydrate Polymers (2011), 86

The effects of refined wheat flour substitution with two native starches from yam tuber and cassava root, and two commercial products, a specialty starch, C*Actistar and a wheat bran flour, at 10%, 20 ... [more ▼]

The effects of refined wheat flour substitution with two native starches from yam tuber and cassava root, and two commercial products, a specialty starch, C*Actistar and a wheat bran flour, at 10%, 20%, 30%, 40% and 60% dry basis, on the rheological properties of dough and bread characteristics, have been examined. In general, during the mixing phase, the substitution of white wheat flour for starch or wheat bran flour had a tendency to modify the flour strength from strong to weak, depending on the nature of the added fraction and the level of substitution. Yam starch and wheat bran flour weakened dough strength to a lesser extent in comparison with cassava starch, and by far, the resistant starch, C*Actistar. In addition, differences in dough expansion appeared among the botanical origins of composite dough and the blend proportions, during the fermentation phase. White wheat flour substitution for yam starch up to 30% or cassava starch up to 20% led to kinetics expansions of resulted doughs close to that of the control, while those of doughs containing C*actistar starch or wheat bran flour were significantly slower than that of the control, whatever the level of substitution. The baking phase showed that yam starch enriched breads from 10% to 40% of substitution and cassava starch enriched breads from 10% to 30% of substitution gave as bulky loaves as the refined wheat bread. Beyond these concentrations, the resulting breads were less voluminous. Hedonic tests revealed that, 30% yam starch substitution and 20% added cassava starch led to composite breads which met consumer satisfaction on all attributes, as the control. [less ▲]

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See detailEffect of block copolymers of various molecular architecture on the phase morphology and tensile properties of LDPE rich (LDPE/PS) blends
Harrats, Charef; Fayt, R.; Jérôme, Robert ULg

in Polymer (2002), 43(3), 863-873

The emulsification efficiency of three different block copolymers consisting of hydrogenated polybutadiene (HPB) and polystyrene (PS), i.e. a pure diblock , a tapered diblock and a triblock copolymer has ... [more ▼]

The emulsification efficiency of three different block copolymers consisting of hydrogenated polybutadiene (HPB) and polystyrene (PS), i.e. a pure diblock , a tapered diblock and a triblock copolymer has been compared in low density polyethylene/polystyrene (LDPE/PS) blends rich in polyethylene. The comparison relies upon the ability of these potential interfacial agents to stabilize fine phase dispersion and to promote good interfacial adhesion. Based on the phase morphology, the ultimate tensile properties and the dynamic viscosity of the modified blends, the tapered diblock copolymer is clearly the most efficient emulsifier. For instance a plateau is observed in the property-copolymer content dependence when 2 wt% tapered diblock are used compared to ca. 5 wt% in case of the pure diblock. In contrast, no plateau is observed when the triblock copolymer is used. This is assumed to result from a less quantitative localization of these two copolymers i.e. the pue diblock or the triblock at the LDPE/PS interface. [less ▲]

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See detailThe effect of blood transfusion on cerebral blood-flow in preterm infants: a Doppler study
RAMAEKERS, Vincent ULg; Casaer, P.; Marchal, G. et al

in Developmental medicine and child neurology (1988), 30(3), 334-41

Stable infants with anaemia needing a transfusion with adult red blood-cells were studied to elucidate changes in brain blood-flow velocity. Within 24 hours and at five to six days following transfusion a ... [more ▼]

Stable infants with anaemia needing a transfusion with adult red blood-cells were studied to elucidate changes in brain blood-flow velocity. Within 24 hours and at five to six days following transfusion a substantial mean flow velocity reduction was observed. Haemodynamic factors contributing to the reduction were an increase in cerebrovascular resistance and an increase in whole blood viscosity, as reflected by a raised pulsatility index. Transfusion with adult red blood-cells causes an elevation in haemoglobin concentration, thereby increasing the total oxygen-carrying capacity of arterial blood; however, this lowers the concentration of fetal haemoglobin which possesses a higher affinity for oxygen. Since cerebral oxygen transport is equal to the product of cerebral blood-flow and arterial oxygen content, this finding suggests the existence of a homeostatic mechanism for cerebral oxygen transport. The actual amount of cerebral oxygen transport was found to increase progressively as the percentage of fetal haemoglobin rose above 30 per cent. At higher fetal haemoglobin levels, appropriate elevations in cerebral blood-flow occurred, causing an increase in the supply of oxygen to the brain. [less ▲]

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See detailEffect of blue monochromatic light on non-visual functions in aging
Daneault, V; Vandewalle, Gilles ULg; Teikari, P et al

Poster (2011, June)

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See detailEffect of BM-573[N-terbutyl-N '-[2-(4 '-methylphenylamino)-5-nitro-benzenesulfonyl] urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism
Ghuysen, Alexandre ULg; Lambermont, Bernard ULg; Dogné, Jean-Michel ULg et al

in Journal of Pharmacology and Experimental Therapeutics (The) (2004), 310(3), 964-972

The aim of this study was to evaluate the effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl] urea], a dual thromboxane A(2) synthase inhibitor and receptor antagonist, on ... [more ▼]

The aim of this study was to evaluate the effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl] urea], a dual thromboxane A(2) synthase inhibitor and receptor antagonist, on the hemodynamic response to acute pulmonary embolism. Six anesthetized pigs were infused with placebo ( placebo group) and compared with six other pigs receiving a continuous infusion of BM-573 ( BM group). Pulmonary embolization with 0.3 g/kg autologous blood clots was carried out 30 min after the start of the infusion. Right ventricular pressure-volume loops were recorded using a conductance catheter, and end-systolic ventricular elastance was periodically assessed by varying right ventricular preload. Pulmonary vascular properties were studied by use of a four-element wind-kessel model. Hemodynamic data, including assessment of right ventricular-arterial coupling, were collected at baseline and every 30 min for 4 h. Blood samples were collected to assess gas exchange, thromboxane A(2), and prostacyclin plasma levels and to evaluate platelet aggregation. Mean pulmonary arterial pressure in the placebo group increased significantly more than in the BM group, mainly because of an additional increase in pulmonary vascular resistance. Arterial and end-systolic ventricular elastances increased also more in the placebo group, whereas right ventricular efficiency decreased. BM-573 prevented both platelet aggregation induced by U-46619 (9,11-dideoxy-11alpha, 9alpha-epoxymethanoprostaglandin F-2alpha) or by arachidonic acid, and thromboxane A(2) overproduction, whereas prostacyclin liberation was preserved. Oxygenation, however, was not significantly improved. We conclude that in this animal model of acute pulmonary embolism, infusion of BM-573 reduced pulmonary vasoconstriction. As a result, right ventricular-vascular coupling values were maintained at a maximal efficiency level. [less ▲]

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See detailEffect of Body Weight Loss on Cardiopulmonary Function assessed by 6-Minute Walk Test and Arterial Blood Gas Analysis in Obese Dogs
Manens; Ricci, R; Damoiseaux, C et al

in Journal of Veterinary Internal Medicine (2014), 28(2), 371-378

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See detailEffect of body weight losson pulmonary function assessed by 6-minute walk test and arterial blood gases in obese dogs
Manens, Jeff; Damoiseaux, Cécile ULg; Gault, Simon et al

in Proceedings of 22nd ECVIM Meeting - Maastricht, Netherlands (2012, September)

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See detailEffect of body weight losson pulmonary function assessed by 6-minute walk test and arterial blood gases in obese dogs
Manens, Jeff; Ricci, Rebecca; Damoiseaux et al

Poster (2012, October 19)

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See detailEffect of bolt preloading on joint behaviour
Jaspart, Jean-Pierre ULg; Maquoi, René ULg

in Proceedings of the First European Conference on Steel Structures (1995)

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See detailEffect of boundary conditions and heat source distribution on temperature distribution in friction stir welding
Simar, A.; Lecomte-Beckers, Jacqueline ULg; Pardoen, T. et al

in Science & Technology of Welding & Joining (2006), 11(2), 170-177

on Al-6005A have been carried out using a fully instrumented milling machine. The power input was calculated from the measured torque and forces. The thermal cycles were measured at various locations ... [more ▼]

on Al-6005A have been carried out using a fully instrumented milling machine. The power input was calculated from the measured torque and forces. The thermal cycles were measured at various locations close to the weld centreline. A finite element pseudothermal model was developed, taking into account the influence of the welding parameters on the power input. The distribution of the total power input between surface and volume heat sources was also studied. The measured and predicted thermal cycles are in good agreement when proper contact conditions between the workpiece and the backing plate are introduced. [less ▲]

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See detailEffect of bovine Azawak colostrum administration on plasma protein profile in red kid.
Abdou, Harouna ULg; Marichatou, Hamani; Beckers, Jean-François ULg et al

Poster (2012, October 11)

This study evaluated the impact of heterologous Azawak colostrum administration on plasma protein profile in red kids from Niger. Forty (40) newborn kids were affected to one of two treatments: control ... [more ▼]

This study evaluated the impact of heterologous Azawak colostrum administration on plasma protein profile in red kids from Niger. Forty (40) newborn kids were affected to one of two treatments: control group (access to water and the mother) and colostrum group (access to the mother, water and additional 50 ml of colostrum Azawak/animal the day of birth, then 25ml/animal/day from the 2nd to 15th day). Blood samples (10ml/animal) were obtained at the age of 10 and 30 days by jugular puncture into EDTA vacutainer tubes. The quantification of total protein was performed by the Biuret method. The agarose gel electrophoresis was used to determine serum levels of albumin, ɑ-globulin, β1-globulin, β2-globulin, γ-globulin and finally the albumin/globulin ratio. In general, the average concentrations of these proteins obtained at both ages reached higher values in colostrum than in control group. At day 10, the colostrum group tended to show (P <0.07) higher levels for ɑ-globulin and showed higher values (P <0.04) for β1-globulin. At day 30, total protein and β2-globulins were higher in colostrum group. The administration of heterologous colostrum in kid seems to have positive effects on some plasma parameters. It would be worth to discriminate the plasma proteins derived from bovine and maternal colostra. [less ▲]

Detailed reference viewed: 7 (1 ULg)