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See detailEffect of a single dose of R126638 in seborrheic dermatitis
Ausma, J.; Henry, Frédérique ULg; Borgers, M. et al

in Journal of the American Academy of Dermatology (2005, March), 52(3, ,Suppl. S), 125

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See detailEffect of a single overnight topical application of miconazole nitrate paste on acne papules.
Flagothier, Caroline ULg; Vroome, Valerie; Borgers, Marcel et al

in International Journal of Dermatology (2006), 45(3), 316-9

BACKGROUND: The classical management of acne calls for prolonged oral and/or topical treatments; however, some patients request a rapid effect to make the papules disappear within a few hours or days ... [more ▼]

BACKGROUND: The classical management of acne calls for prolonged oral and/or topical treatments; however, some patients request a rapid effect to make the papules disappear within a few hours or days. OBJECTIVE: To test the effect of a single overnight application of a paste containing 0.25% miconazole nitrate on acne papules, and comparison with the effect of the same but unmedicated paste. METHOD: Narrow-band reflectance spectroscopy was used to assess the changes in E index (erythema) after overnight application of the pastes. In the first study, a total of 117 acne papules were assessed in 15 adolescents. Measurements of the E index were performed at 24-h intervals for 4 days on acne papules and the surrounding normal-looking skin. The last two assessments were performed the mornings preceding and following, respectively, a single application of the medicated paste. The second part of the study consisted of a double-blind, split-face study on 25 adolescents with acne. They applied each of the two formulations on a randomized part of the forehead. A total of 161 acne papules received the medicated paste and 160 received the same but unmedicated paste. Measurements were performed the mornings before and after the overnight treatment. RESULTS: In the first part of the study, no significant daily difference was observed between the three series of pretreatment E indices, on both acne papules and normal skin. The treatment did not affect the E index of normal skin. By contrast, it decreased significantly the E index of the acne papules. The second part of the study also showed that the medicated paste significantly decreased the E index of acne papules. This effect was significantly (P < 0.05) superior to that of the unmedicated paste. CONCLUSION: A single overnight application of miconazole nitrate paste appears to reduce the erythematous aspect of acne papules. [less ▲]

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See detailEffect of a strenuous exercise on plasma endorphin level in thoroughbred horses
Art, Tatiana ULg; Votion, Dominique ULg; Franchimont, P. et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailEffect of abrupt preload reduction on left atrial and ventricular pressures in a multi-scale mathematical model of the cardiovascular system
Pironet, Antoine ULg; Dauby, Pierre ULg; Kosta, Sarah ULg et al

in European Heart Journal Supplements : Journal of the European Society of Cardiology (2013), 34

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See detailEffect of abscisic and gibberellic acids on malate synthase transcripts in germinating castor bean seeds
Rodriguez, R.; Dommes, Jacques ULg; Northcote, D. H.

in Plant Molecular Biology (1987), 9

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See detailEffect of acepromazine on whole blood viscosity in horses
Sandersen, Charlotte ULg; Serteyn, Didier ULg; Dringenberg, Bernhard et al

in Proceedings (2008)

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See detailEffect of acepromazine on whole blood viscosity in horses
Sandersen, Charlotte ULg; Serteyn, Didier ULg; Dringenberg, Bernhard et al

in Proceedings of the AVA Spring Meeting (2008)

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See detailEffect of acidic ternary compounds on the formation of miconazole/cyclodextrin inclusion complexes by means of supercritical carbon dioxide
Barillaro, Valery; Bertholet, Pascal; Henry de Hassonville, Sandrine et al

in Journal of Pharmacy & Pharmaceutical Sciences : A Publication of the Canadian Society for Pharmaceutical Sciences (2004), 7(3), 378-388

PURPOSE: The aim of the study is to evaluate the effect of different acidic compounds on the inclusion of miconazole (MICO) in several cyclodextrins (CDs) using supercritical carbon dioxide (SCCO(2 ... [more ▼]

PURPOSE: The aim of the study is to evaluate the effect of different acidic compounds on the inclusion of miconazole (MICO) in several cyclodextrins (CDs) using supercritical carbon dioxide (SCCO(2) ) processing. METHODS: Physical mixtures were processed by SCCO(2) at 30 MPa, 125 degrees C during 60 minutes in a static mode to produce inclusion complexes. The inclusion complexes were characterized by differential solubility, Fourier transform infrared spectroscopy (FT-IR) and dissolution test. RESULTS: The best inclusion yields were achieved with the combination of MICO base and HPgammaCD with or without acids. Maleic and fumaric acids influenced the MICO inclusion differently in function of their conformation. During the process, a miconazole salt was observed with maleic acid and characterized by thermal analysis and mass spectrometry. The kinetics inclusion followed a saturation-type shape curve. FT-IR confirmed the presence of genuine inclusion complexes. The complexes MICO base/HPgammaCD/(L-tartaric acid) enhanced the dissolution rates of MICO more than the corresponding physical mixtures did. Lastly, the stability study revealed that the complexes were stable. CONCLUSIONS: The formation of stable complexes between MICO and CDs is possible using SCCO(2). Moreover an acidic ternary compound is able to modify the formation of the complex. The inclusion complexes, which show better dissolution profiles than those with the corresponding physical mixtures, could lead to an increase of the oral bioavailability of MICO. [less ▲]

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See detailThe Effect of Activating Fibroblast Growth Factor Receptor 3 Mutations on Osteogenic Differentiation and Ectopic Bone Formation by Human Periosteal Derived Cells
Bolander, Johanna; Roberts, Scott; Eyckmans, jeroen et al

in Journal of Tissue Science & Engineering (2012), 2

Activating mutations in Fibroblast Growth Factor Receptor 3 (FGFR3) have previously been shown to cause skeletal dysplasias through their effect on growth plate chondrocytes. However, the effect of FGFR3 ... [more ▼]

Activating mutations in Fibroblast Growth Factor Receptor 3 (FGFR3) have previously been shown to cause skeletal dysplasias through their effect on growth plate chondrocytes. However, the effect of FGFR3 mutations on bone progenitor cells may differ. The objective of this study was to investigate the effect of specific activating FGFR3 mutations on ectopic in vivo bone formation by periosteal derived cells (PDCs) seeded on calcium phosphate/ collagen scaffolds. PDCs were isolated from hypochondroplasic (N540K mutation) and achondroplasic (G380R mutation) patients, along with age/sex matched controls. These cells were characterised in vitro for proliferation, osteogenic differentiation, FGFR3 signalling and in vivo bone formation. Subsequently, empirical modelling was used to find correlations between in vivo formed bone and in vitro cell behaviour. These data showed that in contrast to the G380R mutation, which produced no bone, the N540K mutation induced significant ectopic bone formation on specific carriers. This allowed correlation between percentage of induced bone formation to elevated in vitro proliferation and differentiation. Correlating osteogenic markers included Collagen type 1, alkaline phosphatase and osteocalcin. Enhanced proliferation was attributed to increased phosphorylation of Erk-1/2. This study highlights the importance of FGFR3 in periosteal cell differentiation and also indicates it potential for targeted tissue engineering strategies. [less ▲]

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See detailEffect of activators and inhibitors of K+-channels on insulin secretion in the amphibian pancreas
Francini, F.; Pirotte, Bernard ULg; Gagliardino, J. J.

in Archives of Physiology & Biochemistry (1997), 105

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See detailEffect of activine on bone formation and on interleukine-6 production by human osteoblast-like cells in vitro
Franchimont, Nathalie; Franchimont; Weekers, Laurent ULg et al

Poster (1995)

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See detailEffect of acute hypoxia on the bovine ventilatory mechanics
Rollin, Frédéric ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in Archives Internationales de Physiologie et de Biochimie (1989)

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See detailEffect of acute hypoxia on the pulmonary haemodynamics in two different breeds of cattle
Amory, Hélène ULg; Rollin, Frédéric ULg; Art, Tatiana ULg et al

in Archives Internationales de Physiologie et de Biochimie (1989)

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