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See detailDeletion of the 5'-ABL region: a recurrent anomaly detected by fluorescence in situ hybridization in about 10% of Philadelphia-positive chronic myeloid leukaemia patients.
Herens, Christian ULg; Tassin, Françoise ULg; Lemaire, Véronique ULg et al

in British Journal of Haematology (2000), 110(1), 214-6

Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This ... [more ▼]

Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This anomaly was observed in 5/51 cases (9.8%). Cytological and clinical data suggest that the 5'-ABL deletion may be associated with dysplastic features of polymorphonuclear cells and metamyelocytes and a short chronic phase duration. [less ▲]

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See detailDeletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis.
Docampo Martinez, Elisa ULg; Rabionet, Raquel; Riveira-Munoz, Eva et al

in Arthritis and rheumatism (2010), 62(5), 1246-51

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the ... [more ▼]

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the late cornified envelope (LCE) gene cluster, LCE3C and LCE3B, has been associated with psoriasis in several populations. The purpose of this study was to assess whether this polymorphic gene deletion could also be involved in susceptibility to RA. METHODS: We tested for association between the LCE3C_LCE3B copy number variant and a single-nucleotide polymorphism in strong linkage disequilibrium with this variant (rs4112788) and RA in 2 independent case-control data sets (197 and 400 samples from patients with RA, respectively, and 411 and 567 samples from control subjects, respectively), collected at 4 Spanish hospitals. All samples were directly typed for presence of the LCE3C_LCE3B deletion (LCE3C_LCE3B-del) by polymerase chain reaction, and association analysis was performed using the SNPassoc R package. RESULTS: An association of homozygosity for the LCE3C_LCE3B-del and rs4112788 C allele with the risk of RA was observed in the first data set and was replicated in an independent case-control set. A combined analysis showed an overall P value of 0.0012 (odds ratio [OR] 1.45, 95% confidence interval [95% CI] 1.16-1.81) for association of the LCE3C_LCE3B-del. When the analysis was stratified for serologic data, we observed association in anti-cyclic citrullinated peptide (anti-CCP)-positive patients (P = 0.012, OR 1.51 [95% CI 1.09-2.13]) but not in anti-CCP-negative patients. CONCLUSION: We have identified an association between the LCE3C_LCE3B-del and RA, and we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and RA. [less ▲]

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See detailDeletion of the ORF9p acidic cluster impairs the nuclear egress of Varicella-zoster virus capsids.
Riva, Laura ULg; Thiry, Marc ULg; Lebrun, Marielle ULg et al

in Journal of virology (2014)

The protein encoded by the ORF9 is essential for Varicella-zoster virus (VZV) replication. Previous studies documented its presence in the trans-Golgi network and its involvement in secondary envelopment ... [more ▼]

The protein encoded by the ORF9 is essential for Varicella-zoster virus (VZV) replication. Previous studies documented its presence in the trans-Golgi network and its involvement in secondary envelopment. In this work, we deleted the ORF9p acidic cluster, destroying its interaction with ORF47p and resulting in a nuclear accumulation of both proteins. This phenotype results to an accumulation of primary enveloped capsids in the perinuclear space, reflecting a capsid de-envelopment defect. [less ▲]

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See detailDeletion of Xpter encompassing the SHOX gene and PAR1 region in familial patients with Leri-Weill Dyschondrosteosis syndrome.
Mutesa, L.; Vanbellinghen, Jean-François ULg; Hellin, Anne-Cécile ULg et al

in Genetic Counseling (Geneva, Switzerland) (2009), 20(1), 9-17

Heterozygote deletions or mutations of pseudoautosomal 1 region (PAR1) encompassing the short stature homeobox-containing (SHOX) gene cause Leri-Weill Dyschondrosteosis (LWD), which is a dominantly ... [more ▼]

Heterozygote deletions or mutations of pseudoautosomal 1 region (PAR1) encompassing the short stature homeobox-containing (SHOX) gene cause Leri-Weill Dyschondrosteosis (LWD), which is a dominantly inherited osteochondroplasia characterized by short stature with mesomelic shortening of the upper and lower limbs and Madelung deformity of the wrists. SHOX is expressed by both sex chromosomes in males and females and plays an important role in bone growth and development. Clinically, the LWD expression is variable and more severe in females than males due to sex differences in oestrogen levels. Here, we report two familial cases of LWD with a large Xp terminal deletion (approximately 943 kb) of distal PAR1 encompassing the SHOX gene. In addition, the proband had mental retardation which appeared to be from recessive inheritance in the family. [less ▲]

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See detailDeletions of the 3 ' BCR and 5 ' ABL regions in patients with Philadelphia-positive chronic myeloid leukemia: a one-step process occurring in about 10% of the cases without any evidence of genetic instability in the target cells
Fournier, M.; Lacrosse, S.; Jamar, Mauricette ULg et al

in Cancer Genetics & Cytogenetics (2005), 160(2), 184-187

Deletions of the 5' ABL region adjacent to the t(9;22)(q34;q11) have recently been reported in 8-32.7% of patients with chronic myeloid leukemia (CML). The deletions were visualized with fluorescence in ... [more ▼]

Deletions of the 5' ABL region adjacent to the t(9;22)(q34;q11) have recently been reported in 8-32.7% of patients with chronic myeloid leukemia (CML). The deletions were visualized with fluorescence in situ hybridization using, in the majority of the cases, the Vysis LSI BCR/ABL ES (extra signal) probe. In our series, 10 of 99 CML patients (10.1%) were characterized by a 5'ABL deletion. We show that 3' BCR losses are observed in nearly all the cases with 5' ABL deletions. Moreover, the different genetic events (Philadelphia chromosome formation; 5' ABL and 3' BCR deletions) occur simultaneously in a one-step process without any evidence for genetic instability in the target bone marrow cells. (c) 2005 Elsevier Inc. All rights reserved. [less ▲]

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See detailDeleuze
Krtolica, Igor ULg

Book published by PUF (2015)

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See detailDeleuze : une esthétique baroque
Steinmetz, Rudy ULg

in L'atelier d'esthétique (Ed.) Esthétique et philosophie de l'art (2002)

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See detailDeleuze on the revival of Bergson’s élan vital
Wong, Tai Tak Andy ULg

Conference (2011, June 28)

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See detailDeleuze, entre Nietzsche et Marx : l'histoire universelle, le fait moderne et le devenir-révolutionnaire
Krtolica, Igor ULg

in Actuel Marx (2012), 52(2), 62-77

This article examines how Deleuze attempts to conceive the possibility of a non-hegelian universal history by referring simultaneously to Nietzsche’s history of nihilism and Marx’s history of social ... [more ▼]

This article examines how Deleuze attempts to conceive the possibility of a non-hegelian universal history by referring simultaneously to Nietzsche’s history of nihilism and Marx’s history of social formations in the light of capitalism. It shows that this attempt involves a diagnosis of modernity after the historic failures of the nineteenth century messianisms, and also leads to the notion of becoming-revolutionary, which replaces Marx’s conception of revolution. From this triple point of view (universal history, diagnosis of modernity, becoming-revolutionary), it seems that Deleuze’s reading of Marx comes from his interpretation of Nietzsche. [less ▲]

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See detailDeliberate metaphors in political discourse: the case of citizen discourse
Perrez, Julien ULg; Reuchamps, Min

in Metaphorik (2014)

This article proposes to apply Steen’s (2008) 3D model of metaphor analysis in communication to a corpus of political discourse, in this case citizen discourse. Our corpus has accordingly been analysed by ... [more ▼]

This article proposes to apply Steen’s (2008) 3D model of metaphor analysis in communication to a corpus of political discourse, in this case citizen discourse. Our corpus has accordingly been analysed by making a distinction between three layers of metaphor, respectively at the linguistic (direct vs. indirect metaphors), conceptual (novel vs. conventional metaphors) and communicative levels (deliberate vs. non-deliberate metaphors). Our results suggest that making the distinction between deliberate and non-deliberate metaphors lead to meaningful political insights, notably pointing to differences in saliency of the source domains in terms of which citizens make sense of Belgian federalism. In this regard, the family domain, and more especially the metaphor BELGIAN FEDERALISM IS A LOVE RELATIONSHIP appears to function as an important conceptual reference point for the citizens’ understanding of the political relations in the Belgian context. [less ▲]

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See detailDeliberative Polls and Citizens’ Assemblies
Reuchamps, Min ULg

Scientific conference (2008, October 13)

In the first part of this presentation, the research techniques of delibarative polls and citizens' assemblies are presented and discussed. The second part presents the preliminary results from a small ... [more ▼]

In the first part of this presentation, the research techniques of delibarative polls and citizens' assemblies are presented and discussed. The second part presents the preliminary results from a small version of the citizens' assemblies technique applied in the context of deep-divided societies such as Belgium and Canada. [less ▲]

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See detailLa délimitation des concepts
Lotze, Hermann; Dewalque, Arnaud ULg

in Boccaccini, Federico (Ed.) Lotze et son héritage. Son influence et son impact sur la philosophie du XXe siècle (2015)

Dans ce texte, Lotze développe les grandes lignes d'une théorie des concepts, d'après laquelle les concepts que nous employons sont délimités conformément à certaines relations (de similarité, d ... [more ▼]

Dans ce texte, Lotze développe les grandes lignes d'une théorie des concepts, d'après laquelle les concepts que nous employons sont délimités conformément à certaines relations (de similarité, d'opposition, ou d'hétérogénéité) entre nos contenus de représentation. Cette théorie s'applique notamment aux contenus sensoriels (couleurs, sons, odeurs, etc.) et postule que la manière dont nous les décrivons conceptuellement est fondée dans la manière dont ils nous apparaissent. [less ▲]

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See detailDélimitation des hinterlands des agglomérations urbaines au départ d’une image de télédétection
Donnay, Jean-Paul ULg

in Revue Belge de Géographie (1995), 3-4(59), 325-331

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See detailDélimitation et classement des entités commerciales
Vazquez Parras, Juan ULg

Speech/Talk (2012)

This study develops a method classifying retail spaces through geometry. It attempts to objectify quantitatively several criterions (usually based on empirical observation) which define retail supply. The ... [more ▼]

This study develops a method classifying retail spaces through geometry. It attempts to objectify quantitatively several criterions (usually based on empirical observation) which define retail supply. The method developed shows that it is possible to characterize different commercial forms by using relatively simple indicators. In order to apply this method, this study drawn upon a database of 20,000 stores geolocalised and gathered by shopping areas all over Wallonia. This paper is divided into three main points: the construction of indicators, their compilation and the identification of a classification of retail spaces. [less ▲]

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See detailDélimitation, intensité et spécialisation des entités commerciales. Considérations méthodologiques
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (1982), (18), 77-89

The aim of this article is to confront various methods that are used to delimit commercial entities, to mesure the intensity of commercial activity of the various business spaces and sub-spaces and to ... [more ▼]

The aim of this article is to confront various methods that are used to delimit commercial entities, to mesure the intensity of commercial activity of the various business spaces and sub-spaces and to translate their specialisation. By showing the limits and performances of the various index numbers and processes, it tries to propose adequate methodological tools for a more precise analysis of the commercial function. [less ▲]

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See detailDélimiter des forêts communautaires : une approche par contraintes multiples
Schippers, C.; Bracke, C.; Ndouna Ango, A. et al

in Vermeulen, Cédric; Doucet, Jean-Louis (Eds.) Les premières forêts communautaires du Gabon : Récits d'une expérience pilote (2008)

La délimitation des forêts communautaires est une des premières étapes dans la mise en place de celles-ci. Ce processus étapes dans la mise en place de celles-ci. Ce processus que coutumières. Cet article ... [more ▼]

La délimitation des forêts communautaires est une des premières étapes dans la mise en place de celles-ci. Ce processus étapes dans la mise en place de celles-ci. Ce processus que coutumières. Cet article présente une méthodologie de délimitation participative, techniquement accessible aux communautés villageoises et respectant ces différentes contraintes. L’approche suivie intègre d’une part les obligations légales (limites des permis forestiers, dispositions réglementaires…) et d’autre part l’occupation actuelle de l’espace par les populations villageoises ainsi que les attentes de celles-ci, tout en veillant à limiter les conflits éventuels. Deux cas de délimitation de forêts communautaires pilotes au Gabon sont abordés, le cas du village de La Scierie et le cas du regroupement de villages de Ebe Messe Melane. [less ▲]

Detailed reference viewed: 102 (6 ULg)