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See detailLe CWATUP expliqué
Delnoy, Michel ULiege

Book published by Edi.pro (1998)

Detailed reference viewed: 93 (5 ULiège)
See detailLe CWATUP expliqué
Delnoy, Michel ULiege

Book published by Edi.pro - 2ème édition (2002)

Detailed reference viewed: 55 (1 ULiège)
See detailLe CWATUP
Delnoy, Michel ULiege

Book published by Edi.pro - 6ème édition (2008)

Detailed reference viewed: 102 (22 ULiège)
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See detailCx30 (GJB6) inhibits cell growth in human malignant gliomas but mediates radiation resistance
Artesi, Maria ULiege; Kroonen, Jerome; Poulet, Christophe ULiege et al

in Neuro-Oncology (2014)

Connexins (Cxs) are potentially key players in the control of tumor cell proliferation. Normal astrocytes express large amounts of connexin30 and we have previously demonstrated its underexpression in rat ... [more ▼]

Connexins (Cxs) are potentially key players in the control of tumor cell proliferation. Normal astrocytes express large amounts of connexin30 and we have previously demonstrated its underexpression in rat glioma cells. Here we report that a Cx30 gene deletion occurs in approximately 30% of human glioblastomas (GBMs). Cx30 mRNA levels are decreased in these tumors compared to glial tumors of lower grade and to non tumoral tissues. At the protein level, Cx30 is lost in approximately one third of the tumors in our cohort of 230 glioblastoma biopsies. Restoration of Cx30 in U87 glioma cell lines and in glioma primary cultures (GM1), effectively retards cell proliferation in vitro and inhibits tumor growth in vivo. This correlates with a decrease in TCF, CK2 and NFkappaB activity and with altered expression levels of cell cycle control proteins such as cyclin D1, P27, P21 and c-myc. In patient biopsies, Cx30 expression was found in tumor regions displaying a lower Ki-67 proliferative index. Interestingly, in our cohort of malignant glioma patients, Cx30 expression proved to be an adverse prognostic factor. Here, we demonstrate its role in mediating cell survival and a hypermetabolic state after radiation treatment in human glioma cells. Mechanistically, we propose that a HSP90- mediated Cx30 translocation into mitochondria occurs after radiation treatment. The inhibition of the HSP90 molecular chaperone with geldamycin inhibits the radiation- induced translocation of Cx30 into mitochondria, decreasing the hypermetabolic state and restoring radiation sensitivity in those cells. These results demonstrate the central regulatory role of connexin30 in the biology of human gliomas. [less ▲]

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See detailCXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone.
Goffart, Nicolas ULiege; Lombard, Arnaud; Lallemand, François ULiege et al

in Neuro-Oncology (2017), 19(1), 66-77

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that ... [more ▼]

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that might arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. In this line, it has recently been demonstrated that GSCs are able to escape the tumor mass and preferentially colonize the adult subventricular zone (SVZ). At a distance from the initial tumor site, these GSCs might therefore represent a high-quality model of clinical resilience to therapy and cancer relapses as they specifically retain tumor-initiating abilities. METHOD: While relying on recent findings that have validated the existence of GSCs in the human SVZ, we questioned the role of the SVZ niche as a potential GSC reservoir involved in therapeutic failure. RESULTS: Our results demonstrate that (i) GSCs located in the SVZ are specifically resistant to radiation in vivo, (ii) these cells display enhanced mesenchymal roots that are known to be associated with cancer radioresistance, (iii) these mesenchymal traits are specifically upregulated by CXCL12 (stromal cell-derived factor-1) both in vitro and in the SVZ environment, (iv) the amount of SVZ-released CXCL12 mediates GBM resistance to radiation in vitro, and (v) interferes with the CXCL12/CXCR4 signalling system, allowing weakening of the tumor mesenchymal roots and radiosensitizing SVZ-nested GBM cells. CONCLUSION: Together, these data provide evidence on how the adult SVZ environment, through the release of CXCL12, supports GBM therapeutic failure and potential tumor relapse. [less ▲]

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See detailThe CXCL12/CXCR4 pathway or the autocrine proliferative loop of the glioblastoma stem cells
Rogister, Bernard ULiege

in Translational Cancer Research (2017), 6(Suppl 2), 388-390

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See detailCXCL4L1-fibstatin cooperation inhibits tumor angiogenesis, lymphangiogenesis and metastasis.
Prats, A. C.; Van den Berghe, L.; Rayssac, A. et al

in Microvascular Research (2013), 89

Anti-angiogenic and anti-lymphangiogenic drugs slow tumor progression and dissemination. However, an important difficulty is that a tumor reacts and compensates to obtain the blood supply needed for tumor ... [more ▼]

Anti-angiogenic and anti-lymphangiogenic drugs slow tumor progression and dissemination. However, an important difficulty is that a tumor reacts and compensates to obtain the blood supply needed for tumor growth and lymphatic vessels to escape to distant loci. Therefore, there is a growing consensus on the requirement of multiple anti-(lymph)angiogenic molecules to stop cell invasion efficiently. Here we studied the cooperation between endogenous anti-angiogenic molecules, endostatin and fibstatin, and a chemokine, the Platelet Factor-4 variant 1, CXCL4L1. Anti-angiogenic factors were co-expressed by IRES-based bicistronic vectors and their cooperation was analyzed either by local delivery following transduction of pancreatic adenocarcinoma cells with lentivectors, or by distant delivery resulting from intramuscular administration in vivo of adeno-associated virus derived vectors followed by tumor subcutaneous injection. In this study, fibstatin and CXCL4L1 cooperate to inhibit endothelial cell proliferation, migration and tubulogenesis in vitro. No synergistic effect was found for fibstatin-endostatin combination. Importantly, we demonstrated for the first time that fibstatin and CXCL4L1 not only inhibit in vivo angiogenesis, but also lymphangiogenesis and tumor spread to the lymph nodes, whereas no beneficial effect was found on tumor growth inhibition using molecule combinations compared to molecules alone. These data reveal the synergy of CXCL4L1 and fibstatin in inhibition of tumor angiogenesis, lymphangiogenesis and metastasis and highlight the potential of IRES-based vectors to develop anti-metastasis combined gene therapies. [less ▲]

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See detailCXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation
Glauzy, Salomé; André-Schmutz, I; Larghero, J et al

in PLoS ONE (2014), 9(3), 91492

Detailed reference viewed: 9 (1 ULiège)
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See detailCXCR7/ACKR3 is activated by chemokines from both CXC and CC subfamilies
Szpakowska, Martyna ULiege; Counson, Manuel; Beaupain, Nadia et al

Poster (2015, June 05)

Detailed reference viewed: 30 (6 ULiège)
See detailCyanidation of Jabali Ag-Zn ore (Yemen)
Bastin, David ULiege

Report (2011)

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See detailCyanide-resistant, ATP-synthesis-sustained, and uncoupling-protein-sustained respiration during postharvest ripening of tomato fruit
Almeida, A.; Jarmuszkiewicz, W.; Khomsi, H. et al

in Plant Physiology (1999), 119

Tomato (Lycopersicon esculentum) mitochondria contain both alternative oxidase (AOX) and uncoupling protein as energy-dissipating systems that can decrease the efficiency of oxidative phosphorylation. We ... [more ▼]

Tomato (Lycopersicon esculentum) mitochondria contain both alternative oxidase (AOX) and uncoupling protein as energy-dissipating systems that can decrease the efficiency of oxidative phosphorylation. We followed the cyanide (CN)-resistant, ATP-synthesis-sustained, and uncoupling-protein-sustained respiration of isolated mitochondria, as well as the immunologically detectable levels of uncoupling protein and AOX, during tomato fruit ripening from the mature green stage to the red stage. The AOX protein level and CN-resistant respiration of isolated mitochondria decreased with ripening from the green to the red stage. The ATP-synthesis-sustained respiration followed the same behavior. In contrast, the level of uncoupling protein and the total uncoupling-protein-sustained respiration of isolated mitochondria decreased from only the yellow stage on. We observed an acute inhibition of the CN-resistant respiration by linoleic acid in the micromolar range. These results suggest that the two energy-dissipating systems could have different roles during the ripening process. [less ▲]

Detailed reference viewed: 24 (2 ULiège)
See detailCyanoacrylate biopsy for cytologic evaluation of the epidermis
ARRESE ESTRADA, Jorge ULiege; QUATRESOOZ, Pascale ULiege; PIERARD-FRANCHIMONT, Claudine ULiege et al

in Hand-book of non-invasive methods and the skin (2005)

Detailed reference viewed: 25 (6 ULiège)
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See detailCyanoacrylate skin surface / follicular stripping.
PIERARD, Gérald ULiege; Franchimont, Claudine ULiege; Delvenne, Philippe ULiege et al

in Berardesca, Enzo; Wilhelm, KP; Maibach, H.I. (Eds.) Non invasive diagnostic techniques in clinical dermatology. (2014)

Detailed reference viewed: 47 (16 ULiège)
See detailCyanoacrylate skin surface strippings
PIERARD-FRANCHIMONT, Claudine ULiege; ARRESE ESTRADA, Jorge ULiege; QUATRESOOZ, Pascale ULiege et al

in Textbook of aging skin (2010)

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See detailCyanoacrylate skin surface strippings and the 3S-Bioket advent in tropical dermatology. A look from Liège.
PIERARD, Gérald ULiege; Franchimont, Claudine ULiege; PAQUET, Philippe ULiege et al

in Scientific World Journal (The) (2014), 2014

In the dermatopathology field, some simple available laboratory tests require minimum equipment for establishing a diagnosis. Among them, the cyanoacrylate skin surface stripping (CSSS), formerly named ... [more ▼]

In the dermatopathology field, some simple available laboratory tests require minimum equipment for establishing a diagnosis. Among them, the cyanoacrylate skin surface stripping (CSSS), formerly named skin surface biopsy or follicular biopsy, represents a convenient low cost procedure. It is a minimally invasive method collecting a continuous sheet of stratum corneum and horny follicular casts. In the vast majority of cases, it is painless and is unassociated with adverse events. CSSS can be performed in subjects of any age. The method has a number of applications in diagnostic dermatopathology and cosmetology, as well as in experimental dermatology settings. A series of derived analytic procedures include xerosis grading, comedometry, corneofungimetry, corneodynamics of stratum corneum renewal, corneomelametry, corneosurfametry, and corneoxenometry. [less ▲]

Detailed reference viewed: 28 (9 ULiège)
See detailCyanobacteria - the constructors of travertines?
Kleinteich, Julia; Stelmach Pessi, Igor ULiege; Velazquez, David et al

Conference (2015, February)

Cyanobacteria are participating in carbonate build-up and travertine formation in the Belgian river Hoyoux and its tributaries. In this study, we sampled calcareous material from travertines and oncoliths ... [more ▼]

Cyanobacteria are participating in carbonate build-up and travertine formation in the Belgian river Hoyoux and its tributaries. In this study, we sampled calcareous material from travertines and oncoliths from four sampling sites on the Hoyoux river and Triffoy brook. In addition, the water chemistry was determined. The structure of the material was analyzed by Scanning Electron Microscopy and Raman microscopy (?°. The dominant cyanobacterial species was isolated and identified on the basis of microscopic observation and amplification of the 16S-ITS fragment as Phormidium sp., likely functioning as the ‘architect’ of the travertine system. In order to describe the full diversity of the travertine system and to discriminate between the active fraction and inactive or dead organic matter, DNA as well as RNA was extracted from the travertine material, amplified using cyanobacteria specific primers and sequenced by 454 pyrosequencing. To detect seasonal changes in the biological activity, summer and winter time points were compared. This study reveals the ecology of an overlooked environment in Belgian river systems and tries to explain the build-up of travertines. [less ▲]

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See detailCyanobacteria from benthic mats of Antarctic lakes as a source of new bioactivities
Biondi, Natascia; Tredici, Mario; Taton, Arnaud et al

in Journal of Applied Microbiology (2008), 105(1), 105-115

Aims: To exploit the cyanobacterial diversity of microbial mats growing in the benthic environment of Antarctic lakes for the discovery of novel antibiotic and antitumour activities. Methods and results ... [more ▼]

Aims: To exploit the cyanobacterial diversity of microbial mats growing in the benthic environment of Antarctic lakes for the discovery of novel antibiotic and antitumour activities. Methods and results: In all, 51 Antarctic cyanobacteria isolated from benthic mats were cultivated in the laboratory by optimizing temperature, irradiance and mixing. Productivity was generally very low (£60 mg l)1 d)1) with growth rates (l) in the range of 0Æ02–0Æ44 d)1. Growth rates were limited by photosensitivity, sensitivity to air bubbling, polysaccharide production or cell aggregation. Despite this, 126 extracts were prepared from 48 strains and screened for antimicrobial and cytotoxic activities. Seventeen cyanobacteria showed antimicrobial activity (against the Gram-positive Staphylococcus aureus, the filamentous fungus Aspergillus fumigatus or the yeast Cryptococcus neoformans), and 25 were cytotoxic. The bioactivities were not in accordance with the phylogenetic grouping, but rather strain-specific. One active strain was cultivated in a 10-l photobioreactor. Conclusions: Isolation and mass cultivation of Antarctic cyanobacteria and LCMS (liquid chromatography ⁄ mass spectrometry) fractionation of extracts from a subset of those strains (hits) that exhibited relatively potent antibacterial and ⁄ or antifungal activities, evidenced a chemical novelty worthy of further investigation. Significance and impact of the study: Development of isolation, cultivation and screening methods for Antarctic cyanobacteria has led to the discovery of strains endowed with interesting antimicrobial and antitumour activities. [less ▲]

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See detailCyanobacteria immobilised in porous silica gels: Exploring biocompatible synthesis routes for the development of photobioreactors
Léonard, Alexandre ULiege; Rooke, J. C.; Meunier, C. F. et al

in Energy and Environmental Science (2010), 3(3), 370-377

With the aim of designing photobioreactors (PBR) based on a smart exploitation of microalgae for the production of biofuels and metabolites of interest, this paper describes a novel approach where ... [more ▼]

With the aim of designing photobioreactors (PBR) based on a smart exploitation of microalgae for the production of biofuels and metabolites of interest, this paper describes a novel approach where cyanobacteria are entrapped within highly porous silica matrices. With this concept, it would be possible to work with a constant population of organisms for a continuous (and increased) photoproduction of metabolites, in contrast to "one-shot" uses of liquid cultures. Different hybrid materials based on porous silica gels are described with a special emphasis on finding the most appropriate immobilisation conditions for prolonged cell survival. It is found that an aqueous route based on acid-exchanged sodium silicate combined with the use of silica nanoparticles as a gel-strengthening species shows the best results with a high primary production rate post immobilisation and a preservation of the photosynthetic pigments of up to 35 weeks. Oxygen production, though very low, could be evidenced up to 17 weeks after entrapment, demonstrating the suitability of using porous silica matrices in PBR design. © 2010 The Royal Society of Chemistry. [less ▲]

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See detailCyanobacteria in cold environments
Zakhia, Frederic; Jungblut, Anne-Dorothee; Taton, Arnaud et al

in Margesin, Rosi; Schinner, Frederic; Marx, Jean-Claude (Eds.) et al 'Psychrophiles: from Biodiversity to Biotechnology (2007)

Cyanobacteria evolved under the harsh conditions of the Precambrian and their modern representatives retain a remarkable ability to adapt to and survive within extreme conditions. They dominate ... [more ▼]

Cyanobacteria evolved under the harsh conditions of the Precambrian and their modern representatives retain a remarkable ability to adapt to and survive within extreme conditions. They dominate terrestrial and freshwater cold ecosystems of the Arctic, Antarctic and alpine regions, even though they do not seem to be specifically adapted to optimal growth at low temperatures. They play a major ecological role as they often are primary colonisers of substrates and major primary producers in these ecosystems. The application of molecular tools in combination with classic morphological techniques has begun to provide new insights into the real diversity of cyanobacteria and their biogeographical distribution in cold environments. Our survey of recent studies suggests complex distributional patterns of cyanobacteria, with cosmopolitan, endemic, and habitat-specific genotypes. This ongoing research will help to identify specific geographical areas that have unique microbial communities. However, many more studies are needed to unravel the enormous diversity of cyanobacteria and to better define their biogeographical patterns in cold environments. This is an urgent task in view of the climatic changes that will undoubtedly alter the structure and functioning of microbial communities in polar and alpine ecosystems. [less ▲]

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See detailCyanobacteria in microbial mats of Antarctic lakes (East Antarctica) - A microscopical approach
Taton, Arnaud; Hoffmann, Lucien; Wilmotte, Annick ULiege

in Algological Studies (2008), 168

The cyanobacterial diversity in microbial mats of 56 lakes located in the Larsemann Hills and Bølingen Islands (East Antarctica) was studied by light microscopy. Thirty taxa belonging to 13 genera of ... [more ▼]

The cyanobacterial diversity in microbial mats of 56 lakes located in the Larsemann Hills and Bølingen Islands (East Antarctica) was studied by light microscopy. Thirty taxa belonging to 13 genera of Chroococcales, Oscillatoriales and Nostocales were described. Photomicrographs of the different taxa are provided and their taxonomical assignment as well as their ecology and distribution are discussed. In addition, a semi-quantitative estimation of the abundance of the different morphotypes in the samples was realized and correlated with the mat physiognomy. [less ▲]

Detailed reference viewed: 102 (9 ULiège)