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See detailCuttings of the non-rooting rac tobacco mutant overaccumulate phenolic compounds
Faivre-Rampant, Odile; Charpentier, Jean Paul; Kevers, Claire ULiege et al

in Functional Plant Biology (2002), 29(1), 63-71

The auxin and phenolic contents, as well as phenylalanine ammonia-lyase (PAL) activity, were determined in in vitro cultured shoots of the recalcitrant-to-root rac mutant of tobacco, and compared with ... [more ▼]

The auxin and phenolic contents, as well as phenylalanine ammonia-lyase (PAL) activity, were determined in in vitro cultured shoots of the recalcitrant-to-root rac mutant of tobacco, and compared with wild-type shoots. The mutant and wild-type shoots showed similar auxin changes during the culture cycle, but with higher contents for the mutant. A transient peak of auxin (corresponding to the achievement of the rooting inductive phase) occurred at day 14 in both types of shoots, but earlier in the basal parts of the wild-type stems. The rac shoots contained more phenolics, corresponding with an increased PAL activity. The most abundant phenolic compound found in the two types of tobacco was chlorogenic acid, which was more abundant in the rac shoots. Rutin was also detected at a higher concentration in the mutant shoots. Basal parts of wild-type shoots treated with 10(-3) chlorogenic acid reacted by accumulating auxins and, unlike untreated controls, did not form adventitious roots. The relationships between those biochemical analyses in relation to the growth limitation of the rac mutant, and the inhibition of its root development, are discussed. [less ▲]

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See detailLes cuvettes oasiennes du Niger oriental: entre pratiques foncières et cadre législatif
Malam Boukar, Awa Krou; Yamba, Boubacar; Andres, Ludovic ULiege et al

in Revue Internationale des Sciences de Développement (2016), 4(6), 376-388

Despite the new context of the land-law with the land committee, the property owner depends on the traditional law. This paper shows the land system in the south east of the Niger. Nine basin oasis have ... [more ▼]

Despite the new context of the land-law with the land committee, the property owner depends on the traditional law. This paper shows the land system in the south east of the Niger. Nine basin oasis have selected in function of the food system and the proof of the phreatic table. An investigation with 105 producters has showed the description and the analysis of the land access and the conflicts. The analysis shows the strong influence of traditional authorities and the lack of operationalization of COFOB. Finally, the conflicts are generalized between many actors (farmers, pastoralists and agro-pastoralists) and settlement is done mainly by conciliation. Furthermore, the disparity between the men and the women land access is very important. [less ▲]

Detailed reference viewed: 43 (12 ULiège)
See detailCV 205-502 : Een niewe lang-werkende dopamine-agonist voor de behandeling van hyperprolactinemie.
Verhelst, J.; Abs, R.; Beckers, Albert ULiege et al

in Tijdschrift voor Geneeskunde (1991)

Detailed reference viewed: 19 (0 ULiège)
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See detailLe CV du chercheur. Évaluation et valeur comparative
Dozo, Björn-Olav ULiege; Fréché, Bibiane

Scientific conference (2011, December 08)

Detailed reference viewed: 31 (6 ULiège)
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See detailCWATUP : le certificat de conformité
Delnoy, Michel ULiege

in Immobilier (2003), 21

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See detailCWATUP : les arrêtés d'exécution du 17 juillet 2003
Delnoy, Michel ULiege

in Immobilier (2003), 19

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See detailLe CWATUP expliqué aux enfants
Delnoy, Michel ULiege

in Costermans D. (Ed.) Le CWATUP expliqué aux enfants (2001)

Detailed reference viewed: 142 (14 ULiège)
See detailLe CWATUP Expliqué
Delnoy, Michel ULiege

Book published by Edi.pro - 3ème édition (2007)

Detailed reference viewed: 92 (10 ULiège)
See detailLe CWATUP expliqué
Delnoy, Michel ULiege

Book published by Edi.pro (1998)

Detailed reference viewed: 93 (5 ULiège)
See detailLe CWATUP expliqué
Delnoy, Michel ULiege

Book published by Edi.pro - 2ème édition (2002)

Detailed reference viewed: 55 (1 ULiège)
See detailLe CWATUP
Delnoy, Michel ULiege

Book published by Edi.pro - 6ème édition (2008)

Detailed reference viewed: 102 (22 ULiège)
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See detailCx30 (GJB6) inhibits cell growth in human malignant gliomas but mediates radiation resistance
Artesi, Maria ULiege; Kroonen, Jerome; Poulet, Christophe ULiege et al

in Neuro-Oncology (2014)

Connexins (Cxs) are potentially key players in the control of tumor cell proliferation. Normal astrocytes express large amounts of connexin30 and we have previously demonstrated its underexpression in rat ... [more ▼]

Connexins (Cxs) are potentially key players in the control of tumor cell proliferation. Normal astrocytes express large amounts of connexin30 and we have previously demonstrated its underexpression in rat glioma cells. Here we report that a Cx30 gene deletion occurs in approximately 30% of human glioblastomas (GBMs). Cx30 mRNA levels are decreased in these tumors compared to glial tumors of lower grade and to non tumoral tissues. At the protein level, Cx30 is lost in approximately one third of the tumors in our cohort of 230 glioblastoma biopsies. Restoration of Cx30 in U87 glioma cell lines and in glioma primary cultures (GM1), effectively retards cell proliferation in vitro and inhibits tumor growth in vivo. This correlates with a decrease in TCF, CK2 and NFkappaB activity and with altered expression levels of cell cycle control proteins such as cyclin D1, P27, P21 and c-myc. In patient biopsies, Cx30 expression was found in tumor regions displaying a lower Ki-67 proliferative index. Interestingly, in our cohort of malignant glioma patients, Cx30 expression proved to be an adverse prognostic factor. Here, we demonstrate its role in mediating cell survival and a hypermetabolic state after radiation treatment in human glioma cells. Mechanistically, we propose that a HSP90- mediated Cx30 translocation into mitochondria occurs after radiation treatment. The inhibition of the HSP90 molecular chaperone with geldamycin inhibits the radiation- induced translocation of Cx30 into mitochondria, decreasing the hypermetabolic state and restoring radiation sensitivity in those cells. These results demonstrate the central regulatory role of connexin30 in the biology of human gliomas. [less ▲]

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See detailCXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone.
Goffart, Nicolas ULiege; Lombard, Arnaud; Lallemand, François ULiege et al

in Neuro-Oncology (2017), 19(1), 66-77

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that ... [more ▼]

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that might arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. In this line, it has recently been demonstrated that GSCs are able to escape the tumor mass and preferentially colonize the adult subventricular zone (SVZ). At a distance from the initial tumor site, these GSCs might therefore represent a high-quality model of clinical resilience to therapy and cancer relapses as they specifically retain tumor-initiating abilities. METHOD: While relying on recent findings that have validated the existence of GSCs in the human SVZ, we questioned the role of the SVZ niche as a potential GSC reservoir involved in therapeutic failure. RESULTS: Our results demonstrate that (i) GSCs located in the SVZ are specifically resistant to radiation in vivo, (ii) these cells display enhanced mesenchymal roots that are known to be associated with cancer radioresistance, (iii) these mesenchymal traits are specifically upregulated by CXCL12 (stromal cell-derived factor-1) both in vitro and in the SVZ environment, (iv) the amount of SVZ-released CXCL12 mediates GBM resistance to radiation in vitro, and (v) interferes with the CXCL12/CXCR4 signalling system, allowing weakening of the tumor mesenchymal roots and radiosensitizing SVZ-nested GBM cells. CONCLUSION: Together, these data provide evidence on how the adult SVZ environment, through the release of CXCL12, supports GBM therapeutic failure and potential tumor relapse. [less ▲]

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See detailThe CXCL12/CXCR4 pathway or the autocrine proliferative loop of the glioblastoma stem cells
Rogister, Bernard ULiege

in Translational Cancer Research (2017), 6(Suppl 2), 388-390

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See detailCXCL4L1-fibstatin cooperation inhibits tumor angiogenesis, lymphangiogenesis and metastasis.
Prats, A. C.; Van den Berghe, L.; Rayssac, A. et al

in Microvascular Research (2013), 89

Anti-angiogenic and anti-lymphangiogenic drugs slow tumor progression and dissemination. However, an important difficulty is that a tumor reacts and compensates to obtain the blood supply needed for tumor ... [more ▼]

Anti-angiogenic and anti-lymphangiogenic drugs slow tumor progression and dissemination. However, an important difficulty is that a tumor reacts and compensates to obtain the blood supply needed for tumor growth and lymphatic vessels to escape to distant loci. Therefore, there is a growing consensus on the requirement of multiple anti-(lymph)angiogenic molecules to stop cell invasion efficiently. Here we studied the cooperation between endogenous anti-angiogenic molecules, endostatin and fibstatin, and a chemokine, the Platelet Factor-4 variant 1, CXCL4L1. Anti-angiogenic factors were co-expressed by IRES-based bicistronic vectors and their cooperation was analyzed either by local delivery following transduction of pancreatic adenocarcinoma cells with lentivectors, or by distant delivery resulting from intramuscular administration in vivo of adeno-associated virus derived vectors followed by tumor subcutaneous injection. In this study, fibstatin and CXCL4L1 cooperate to inhibit endothelial cell proliferation, migration and tubulogenesis in vitro. No synergistic effect was found for fibstatin-endostatin combination. Importantly, we demonstrated for the first time that fibstatin and CXCL4L1 not only inhibit in vivo angiogenesis, but also lymphangiogenesis and tumor spread to the lymph nodes, whereas no beneficial effect was found on tumor growth inhibition using molecule combinations compared to molecules alone. These data reveal the synergy of CXCL4L1 and fibstatin in inhibition of tumor angiogenesis, lymphangiogenesis and metastasis and highlight the potential of IRES-based vectors to develop anti-metastasis combined gene therapies. [less ▲]

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See detailCXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation
Glauzy, Salomé; André-Schmutz, I; Larghero, J et al

in PLoS ONE (2014), 9(3), 91492

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See detailCXCR7/ACKR3 is activated by chemokines from both CXC and CC subfamilies
Szpakowska, Martyna ULiege; Counson, Manuel; Beaupain, Nadia et al

Poster (2015, June 05)

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See detailCyanidation of Jabali Ag-Zn ore (Yemen)
Bastin, David ULiege

Report (2011)

Detailed reference viewed: 36 (0 ULiège)
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See detailCyanide-resistant, ATP-synthesis-sustained, and uncoupling-protein-sustained respiration during postharvest ripening of tomato fruit
Almeida, A.; Jarmuszkiewicz, W.; Khomsi, H. et al

in Plant Physiology (1999), 119

Tomato (Lycopersicon esculentum) mitochondria contain both alternative oxidase (AOX) and uncoupling protein as energy-dissipating systems that can decrease the efficiency of oxidative phosphorylation. We ... [more ▼]

Tomato (Lycopersicon esculentum) mitochondria contain both alternative oxidase (AOX) and uncoupling protein as energy-dissipating systems that can decrease the efficiency of oxidative phosphorylation. We followed the cyanide (CN)-resistant, ATP-synthesis-sustained, and uncoupling-protein-sustained respiration of isolated mitochondria, as well as the immunologically detectable levels of uncoupling protein and AOX, during tomato fruit ripening from the mature green stage to the red stage. The AOX protein level and CN-resistant respiration of isolated mitochondria decreased with ripening from the green to the red stage. The ATP-synthesis-sustained respiration followed the same behavior. In contrast, the level of uncoupling protein and the total uncoupling-protein-sustained respiration of isolated mitochondria decreased from only the yellow stage on. We observed an acute inhibition of the CN-resistant respiration by linoleic acid in the micromolar range. These results suggest that the two energy-dissipating systems could have different roles during the ripening process. [less ▲]

Detailed reference viewed: 24 (2 ULiège)
See detailCyanoacrylate biopsy for cytologic evaluation of the epidermis
ARRESE ESTRADA, Jorge ULiege; QUATRESOOZ, Pascale ULiege; PIERARD-FRANCHIMONT, Claudine ULiege et al

in Hand-book of non-invasive methods and the skin (2005)

Detailed reference viewed: 25 (6 ULiège)