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See detailDesign of new multifunctional nanocarriers for protein delivery
Parilti, Rahmet ULg; Jérôme, Christine ULg; Howdle, Steven M. et al

Conference (2015, May 18)

Polymeric nanoparticles have been extensively investigated for their biomedical applications especially as drug carriers. However, efficient encapsulation and delivery of therapeutic proteins in targeted ... [more ▼]

Polymeric nanoparticles have been extensively investigated for their biomedical applications especially as drug carriers. However, efficient encapsulation and delivery of therapeutic proteins in targeted manner still present challenges. This project aims to develop a novel one-pot strategy to obtain nanoparticles able to carry proteins in their core, as well as bearing targeting and/or imaging agents on their surface. In addition to this objective, polymerizations are carried out in supercritical carbon dioxide (scCO2), which confers environmentally benign features to the process. Dispersion polymerizations of hydrophilic monomer 2-hydroxyethyl methacrylate (HEMA) in are carried out in scCO2 in the presence of an initiator, cross-linker and CO2-philic photoclevable stabilizer. Upon exposure to UV light, the o-nitrobenzyl junctions present at the surface of the particles are cleaved, thus providing water dispersible hydrogels. Spherical monodisperse nanoparticles were successfully synthesized in scCO2 with two different conditions. Milder reaction conditions were achieved by using 2,2'-Azobis(4-methoxy-2,4-dimethyl valeronitrile (V70) as an initiator which opens up the platform for one-pot protein encapsulation in scCO2. [less ▲]

Detailed reference viewed: 86 (5 ULg)
Peer Reviewed
See detailDesign of new potential hypoglycemic drugs
Masereel, B.; De Tullio, Pascal ULg; Dogne, J.-M. et al

in Journal de Pharmacie de Belgique (1998), 53

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailDesign of new potential hypoglycemic drugs
Masereel, B.; De Tullio, Pascal ULg; Dogne, J. M. et al

Poster (1997, May)

Detailed reference viewed: 8 (0 ULg)
See detailDesign of new stealthy and pH-sensitive polymer micelles for potential solid tumor targeting
Van Butsele, Kathy

Doctoral thesis (2008)

Detailed reference viewed: 64 (30 ULg)
See detailDesign of novel copolymers by cobalt-mediated radical polymerization of N-vinyl amides
Debuigne, Antoine ULg

Conference (2012, September 21)

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See detailDesign of novel polyphosphoesters (co)polymers for improving a drug delivery system based on calcium carbonate particles
Ergül, Zeynep ULg; Boury, Frank; Debuigne, Antoine ULg et al

Poster (2013, October)

Biomedical applications, especially drug delivery systems, often require biodegradable and biocompatible materials that permit safe retention as well as controlled delivery of a drug. CaCO3 particles are ... [more ▼]

Biomedical applications, especially drug delivery systems, often require biodegradable and biocompatible materials that permit safe retention as well as controlled delivery of a drug. CaCO3 particles are safe and biodegradable drug carriers that have excellent properties such as low density, high specific surface areas and porosity for drugs microencapsulation. The encapsulation of a model protein within CaCO3 particles has been successfully investigated by Boury and coworkers but the release profiles still need to be improved. In this project, we would like to slow down the kinetics of protein release. One strategy consists in loading the CaCO3 particles with degradable micelles containing the protein/drug in their core. In this perspective, we have developed a novel class of degradable polyphosphoesters (PPE) (co)polymers able to self-assemble into micelles. Note that the degradation products of PPEs, like phosphates, associated with calcium from the inorganic carrier could favor some reconstruction processes like bone regeneration. Pendant carboxylic acid functions were introduced along the backbone of the copolymers in order to increase their affinity for calcium and facilitate their incorporation in the CaCO3 particles. First, an alkynyl-functionalized phospholane monomer, i.e. butynyl phosphate (BYP), was prepared by condensation of 2-chloro-2-oxo-1,3,2-dioxaphospholane and 3-butyn-1-ol (43 % yield), according to a reported procedure. Then, a series of well-defined (Ɖ < 1.2) alkyne-containing PBYP (co)polymers were synthesized by ring opening polymerization using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and thiourea (TU) as catalysts[5] (see scheme below). The structures of the PPE (co)polymers were characterized by 1H NMR, 31P NMR and size exclusion chromatography (SEC). Next, carboxylic acid functions were introduced along the PPE backbone by click-type thiol-yne addition of mercaptopropionic acid onto the pendant alkynes. The degradability of the PPEs was investigated at different pH. In the future, the self-assembly behavior of the PPE-based copolymers will be studied as well as their drug loading capacity and ability to accumulate within the CaCO3 particles. In addition, the acid-bearing PPE-based copolymers will be tested as templating agents for the synthesis of CaCO3 particles. [less ▲]

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See detailDesign of perfluorinated macroligand for the implementation of atom transfer radical polymerization in supercritical carbon dioxide
Grignard, Bruno ULg; Jérôme, Christine ULg; Calberg, Cédric ULg et al

Conference (2008, November 28)

Due to an increasing need for polymers with well-defined architecture (diblock-, graft-, star-shaped copolymers), molecular weight and/or functional end-groups, the use of controlled radical ... [more ▼]

Due to an increasing need for polymers with well-defined architecture (diblock-, graft-, star-shaped copolymers), molecular weight and/or functional end-groups, the use of controlled radical polymerization (CRP) in scCO2 has started to gain attention. Among all the controlled processes, Atom Transfer Radical Polymerization has emerged as a robust tool for the preparation of polymers with well-defined molecular weight, architecture and chain-end functionality. The goal of the research relies on the development of ATRP of vinyl monomers in scCO2. Perfluorinated polymethacrylate, i.e. poly2,2,2-trifluoroethyl methacrylate (PFMA), was successfully prepared by homogenous ATRP using a polymeric ligand in order to complex the copper catalyst. CO2-soluble poly(2,2,2-trifluoroethylmethacrylate) was also prepared in supercritical CO2 by supported ATRP using a “pseudo-homogeneous” catalyst consisting of copper (I) ligated by macroligand immobilized onto an inorganic support, that results in polymers with well defined molecular weight and low polydispersity. The first efficient dispersion ATRP of methyl methacrylate (MMA) in scCO2 using a fluorinated polymeric ligand that had a dual role, i.e., the complexation of the copper salt and the stabilization of PMMA growing particles was also reported and the concept of dispersion ATRP was extended to the dispersion ATRP of styrene, to the synthesis of diblock copolymers beads using PMMA beads as macroinitiators, leading to (co)polymers with predictable molecular weight and narrow polydispersity. Finally, because both ATRP and alkyne-azide Huisgen’s 1,3-dipolar cycloaddition relies on the use of a Cu(I) catalyst, synthesis of pyrene end-functionalized polymers by simultaneous dispersion ATRP and click reaction was also investigated in supercritical carbon dioxide, leading to the formation of PMMA of well defined characteristics that was collected as fluorescent micropheres. [less ▲]

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See detailThe design of performance monitoring systems in healthcare organizations : a stakeholder perspective
Rouhana, Rima; Van Caillie, Didier ULg

in Journal Medical Libanais = Lebanese Medical Journal (2015), 64/1

Monitoring the hospital’s performance is evolving over time in search of more efficiency by integrating additional levels of care, reducing costs and keeping stuff up-to-date. To fulfill these three ... [more ▼]

Monitoring the hospital’s performance is evolving over time in search of more efficiency by integrating additional levels of care, reducing costs and keeping stuff up-to-date. To fulfill these three potentially divergent aspects and to monitor performance, healthcare administrators are using dissimilar management control tools. To explain why, we suggest to go beyond traditional contingent factors to assess the role of the different stakeholders (governments, patients, authorities, personnel and administrators) that are at the heart of any healthcare organization. So, the main interest of our empirical study is to appraise how healthcare managers can foster strategic “alignment” in chaotic environments. To investigate this subject, we rely first on seminal studies to appraise the role of the main healthcare players and their influence on some organizational attributes (essentially size, lifecycle, structure, climate and technology in use). We then consider the managerial awareness and the perception of a suitable management control system (MCS) to promote a strategy-focused organization. Our methodology is based on a qualitative approach of twenty-two case studies, lead in two heterogeneous environments (Belgium and Lebanon). This method allows to illustrate, for each healthcare player, its positioning within the healthcare systems. Thus, we define how its role, its perception and its responsiveness manipulate the organization’s internal climate and shape the design of the performance monitoring systems. Our findings are expected to add knowledge on the reasons of the choice of adequate management systems, within three different healthcare organizational structures: university, general/university and general hospitals. [less ▲]

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See detailDesign of photochemical materials for carbohydrate production via the immobilisation of whole plant cells into a porous silica matrix
Meunier, C. F.; Rooke, J. C.; Léonard, Alexandre ULg et al

in Journal of Materials Chemistry (2010), 20(5), 929-936

Photochemical materials that act as bioreactors by exploiting the photosynthesis mechanism have been fabricated by entrapping whole plant cells within a porous silica matrix. The immobilisation step has ... [more ▼]

Photochemical materials that act as bioreactors by exploiting the photosynthesis mechanism have been fabricated by entrapping whole plant cells within a porous silica matrix. The immobilisation step has been achieved via the in situ co-polymerisation of an aqueous silica precursor and a biocompatible trifunctional silane directly around cells. The cells remain undivided whilst the photochemical activity of the cells is well preserved over time. The design of a photochemical material that can act like a leaf, converting water into O2 and produce valuable organic compounds from CO2 under light irradiation is described. In particular, the increased excretion of polysaccharides by this photochemical material has been highlighted. The organic compounds formed have been extracted and analysed. The success of this work could open the door to new exciting photochemical materials with long-term photosynthetic activity and stability and to new green chemical processes for the conversion of solar energy into chemical energy with a concomitant reduction in CO2. © 2010 The Royal Society of Chemistry. [less ▲]

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See detailDesign of Photoreactive Orthosteric GABAA Ligands Potentially Useful for Studying Localization and Function of GABAA Receptors
Francotte, Pierre ULg; Nielsen, Birgitte; Krogsgaard Larsen, Povl et al

Poster (2011, May 08)

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See detailDesign of polymer blend rheology: 4. Effect of polymethacrylic ionomers on the melt viscosity of polyamide m x D,6
Degée, Philippe; Vankan, R.; Teyssié, Philippe et al

in Polymer (1997), 38(15), 3861-3867

Rheological properties of blends of polyamide m x D,6 (PA) with random copolymers of methyl methacrylate and methacrylic acid (P(MMA-co-MAA)) and the related ionomers (P(MMA-co-metal MA)), respectively ... [more ▼]

Rheological properties of blends of polyamide m x D,6 (PA) with random copolymers of methyl methacrylate and methacrylic acid (P(MMA-co-MAA)) and the related ionomers (P(MMA-co-metal MA)), respectively, have been investigated at 260°C. Addition of small amounts of suitable ionomers (up to 5 wt%) remarkably increases the melt viscosity of PA. At low shear rates and depending on the metal cation of the ionomer, the rheofluidity of PA is reduced by at least two orders of magnitude. The PA melt viscosity increases with the cation as follows: Ni2+ < Ba2+ < Mg2+ < Li+ < Na+ < K+ < Cs+. The major effect is believed to occur when the polymer compatibility is improved to the point where a finely dispersed two-phase system with a low interfacial tension is reached, as a result of strong ion-dipole interactions. Polyblends show a rheothinning behaviour which agrees with the reversibility of H-bonding and dipolar interactions. [less ▲]

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See detailDesign of polymeric dispersants for waterborne coatings
Creutz, Serge; Jérôme, Robert ULg; Kaptijn, G. M. P. et al

in Journal of Coatings Technology (1998), 70(883), 41-46

Detailed reference viewed: 12 (4 ULg)
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See detailDesign of Pt/carbon xerogel catalysts for PEM fuel cells
Job, Nathalie ULg; Lambert, Stéphanie ULg; Zubiaur, Anthony ULg et al

in Catalysts (2015), 5

Detailed reference viewed: 29 (5 ULg)