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See detailThe Effect of Cyclodextrins on the Aqueous Solubility of a New Mmp Inhibitor: Phase Solubility, 1 H-Nmr Spectroscopy and Molecular Modeling Studies, Preparation and Stability Study of Nebulizable Solutions
Bertholet, Pascal; Guéders, Maud ULg; Dive, Georges ULg et al

in Journal of Pharmacy & Pharmaceutical Sciences : A Publication of the Canadian Society for Pharmaceutical Sciences (2005), 8(2), 164-175

PURPOSE: Ro 28-2653 (RO) is a synthetic inhibitor of matrix metalloproteinases (MMPs), which is potentially effective against bronchial remodeling. Given that this molecule has very poor aqueous ... [more ▼]

PURPOSE: Ro 28-2653 (RO) is a synthetic inhibitor of matrix metalloproteinases (MMPs), which is potentially effective against bronchial remodeling. Given that this molecule has very poor aqueous solubility, different cyclodextrins (CDs) have been tested to increase its solubility. The aim of this study was to prepare and to characterize inclusion complexes between RO and CDs, in order to develop nebulizable solutions. METHODS: The complex formation was investigated by phase solubility studies. (1)H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion complex between RO and dimethyl-beta-CD (DIMEB). Nebulizable solutions of RO were developed with CDs and a stability study was performed over 9 months. RESULTS: The phase solubility studies showed that beta-CD and its derivatives form a 1:2 complex with RO, whereas gamma-CD includes RO with a 1:1 stoichiometry and a weak stability constant. T-ROESY spectra showed that DIMEB is able to complex two RO substituents (nitrophenyl and biphenyl groups) with preferential orientations, while molecular modeling demonstrated that the configurations observed with (1)H-NMR are energetically favorable, especially owing to H-bond formation between RO and DIMEB. Two CDs were selected to develop nebulizable solutions of RO and the stability study demonstrated that RO degradation in solution is strongly dependent on the concentration of the 1:2 inclusion complex. CONCLUSIONS: CDs are able to include RO and to improve its aqueous solubility. The beta-CD derivatives can be used to formulate nebulizable solutions of RO, the stability of which depends on the concentration of the 1:2 complex. [less ▲]

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See detailEffect of cyclodextrins on the membrane permeability of liposomes
Piel, Géraldine ULg; Piette, Marie ULg; Barillaro, Valery et al

Poster (2005, November)

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See detailEffect of cyclodextrins on the viability of endothelial cells
Castagne, Delphine ULg; Belhadj Salem, Leila; Delattre, Luc ULg et al

in Journal of Inclusion Phenomena and Macrocyclic Chemistry (2007), 57(1-4), 105-107

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See detailEFFECT OF DATE FLESH FIBER CONCENTRATE ADDITION ON DOUGH PERFORMANCE AND BREAD QUALITY
Borchani,, Chema; Masmoudi, Manel; Besbes, Souhail et al

in JOURNAL OF TEXTURE STUDIES (2011), 42(4), 300-308

Date flesh fiber concentrate (DFFC) of Deglet Nour variety were extracted and incorporated in a bakery product. Dough rheological characteristics showed that water absorption, stability, index quality ... [more ▼]

Date flesh fiber concentrate (DFFC) of Deglet Nour variety were extracted and incorporated in a bakery product. Dough rheological characteristics showed that water absorption, stability, index quality, resistance to deformation increased with the amount of added fiber, whereas degree of softening and extensibility decreased in all levels of fiber. Bread evaluation revealed that DFFC addition caused an increase of bread yield especially for the highest levels, a change of crumb color and an insignificant decrease of bread volume. Breads are subjected to sensory evaluation for odor, taste, crumb color, crumb smoothness and overall acceptability. Significant differences were not found (P > 0.05) between scores for all sensory parameters. [less ▲]

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See detailEffect of deep digital flexor tendon orientation on magnetic resonance imaging signal intensity in isolated equine limbs - The magic angle effect
Busoni, Valeria ULg; Snaps, Frédéric ULg

in Veterinary Radiology & Ultrasound (2002), 43(5, Sep-Oct), 428-430

Ten normal equine isolated limbs were imaged using a knee coil in a 1.5 Tesla magnetic field, with short echo time sequences (TE < 15 ms). Magnetic resonance imaging was performed on each isolated limb in ... [more ▼]

Ten normal equine isolated limbs were imaged using a knee coil in a 1.5 Tesla magnetic field, with short echo time sequences (TE < 15 ms). Magnetic resonance imaging was performed on each isolated limb in different positions, with and without extension of the metacarpophalangeal joint. Deep digital flexor tendon orientation ranged from 20 to 60 degrees in relation to the static magnetic field. Increased intratendinous signal intensity was observed when the angle between the deep digital flexor tendon and the constant magnetic field approached 55 degrees ("magic angle"). The increased signal intensity was independent from extension of the metacarpophalangeal joint. Recognition of the magic angle phenomenon is essential for proper evaluation of magnetic resonance imaging studies of the equine foot. [less ▲]

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See detailEffect of Deferoxamine Mesylate on Freezability of Blood Supplemented Canine Semen
Van Den Berghe, Femke ULg; Rijsselaere, Tom; Van Soom, Ann et al

Poster (2011, September)

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See detailEffect of deferoxamine on the in vitro growth of Mycobacterium tuberculosis and Mycobacterium avium
MELIN, Pierrette ULg; Boelaert, J.; Chbicheb, R. et al

Conference (1997, March)

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See detailEffect of dementia severity and age on posterior cingulate cortex metabolism in Alzheimer's disease
Withofs, Nadia ULg; Salmon, Eric ULg; Hallet, Claude ULg et al

in Journal of Neurology (2007, May), 254(Suppl. 3), 146

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See detailEffect of dexamethasone on the mean plaque size of bovine herpesvirus 1.
Curvers, V.; Thiry, Etienne ULg; Leroy, Pascal ULg et al

in Annales de Recherches Vétérinaires = Annals of Veterinary Research (1985), 16(1), 80-5

The effect of dexamethasone on infectious bovine rhinotracheitis virus (Bovine herpesvirus 1: BHV 1) was studied by measuring the mean plaque size produced by eight virus strains under two concentrations ... [more ▼]

The effect of dexamethasone on infectious bovine rhinotracheitis virus (Bovine herpesvirus 1: BHV 1) was studied by measuring the mean plaque size produced by eight virus strains under two concentrations of dexamethasone phosphate (0.1 and 1 mM). Dexamethasone induced a significant reduction of the mean plaque size, whatever the strain used. Some differences were noted between the BHV 1 strains studied, depending on the dexamethasone concentration. [less ▲]

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See detailEffect of diazepam on the efficacy of dual-phase FDG PET imaging.
Zhuang, Hongming; Hustinx, Roland ULg; Alavi, Abass

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(2), 228-9230

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See detailEffect of diet and bST on mRNA for IGF-I binding proteins (BP)-2 and -3 in dairy cattle
Sharma, B. K.; Vandehaar, M. J.; Tucker, H. A. et al

in Journal of Dairy Science (1997), 80(suppl 1), 176

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See detailEffect of diet and bST on mRNA for IGF_I-binding proteins (BP) -2 and -3 in dairy cattle
Sharma, B. K.; Vandehaar, M. J.; Tucker, H. A. et al

in 80th Annual Meeting of American Association of Dairy Science (1997)

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See detailEffect of dietary lysine, linoleic acid and vitamin B of broiler breeders on embryonic growth, hatching parameters and post hatch performance of their progeny
Debonne, M.; Witters, A.; Willemsen, H. et al

in Avian and Poultry Biology Reviews (2008)

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See detailEffect of dietary polyamines and amino acids on the polyamine content of rat milk
Peulen, Olivier ULg; Dandrifosse, Guy ULg

in Morgan, D.; Hirvi, T.; Dandrifosse, Guy (Eds.) et al COST 917 Biologically active amines in food. Volume VI: Biologically active amines: metabolism and physiology and Biologically active amines in food processing and production of biologically active amines by bacteria (2002)

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See detailEffect of different contraceptive methods on the oxidative stress status in women aged 40-48 years from the ELAN study in the province of Liege, Belgium
Pincemail, Joël ULg; Vanbelle, Sophie ULg; Gaspard, Ulysse ULg et al

in Human Reproduction (2007), 22(8), 2335-2343

Oxidative stress is associated with the development of several disorders including cardiovascular disease and cancer. Among conditions known to influence oxidative stress, the use of oral contraception ... [more ▼]

Oxidative stress is associated with the development of several disorders including cardiovascular disease and cancer. Among conditions known to influence oxidative stress, the use of oral contraception (OC) in women has been a matter of ongoing discussion. METHODS: A total of 897 eligible and healthy volunteers were recruited from among the patients of 50 general practitioners participating in the ELAN study (Etude Liegeoise sur les ANtioxydants). A subsample consisting of 209 women aged 40-48 years was studied for a comprehensive oxidative stress status (OSS), including the analysis of antioxidants, trace elements and three markers of oxidative damage to lipids. Among 209 subsample, 49 (23%) were OC users (OCU), 119 (57%) non-contraception users (NCU) and 41 (20%) were intrauterine (hormonal and copper) devices users (IUD). RESULTS: After adjustment for smoking, systolic and diastolic blood pressure and BMI (or waist circumference), a marked and significant increase in lipid peroxides was observed among OCU women when compared with NCU and IUD users. A cut-off value of 660 mu M in lipid peroxides allowed the discrimination of OCU from the two other groups. In contrast, no difference was observed in the plasma concentration of both oxidized low-density lipoprotein (LDL) and their related antibodies. The increased level in lipid peroxides was strongly related to higher concentrations of copper (r < 0.84; P < 0.0001, cut-off value 1.2 mg/1). When compared with NCU and IUD users, plasma antioxidant defences were significantly altered in OCU women as shown by lower levels of beta-carotene (decrease of 39%; P < 0.01) andytocopherol (decrease by 22%; P < 0.01). In contrast, higher concentrations of selenium (increased by 11.8%; P < 0.01) were observed in OCU women. Blood concentrations of vitamin C, alpha-tocopherol and zinc were unaffected by OC use. CONCLUSIONS: The intake of OC significantly increases the lipid peroxidation in women aged 40-48 years. This may represent a potential cardiovascular risk factor for these women. [less ▲]

Detailed reference viewed: 84 (20 ULg)