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See detailDémonstration d'une propriété sur les triangles (solution de la question 396)
Catalan, Eugène ULg

in Nouvelle Correspondance Mathématique (1879), 5

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See detailDémonstration d'une propriété sur les triangles (solution de la question 498)
Catalan, Eugène ULg

in Nouvelle Correspondance Mathématique (1879), 5

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See detailDémonstration de l'existence d'isotopes de l'atome de soufre, au moyen de l'analyse de la structure fine du spectre de résonance des molécules diatomiques S2
Swings, Polydore ULg

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1931), XVII(8-9), 1095-1097

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See detailDemonstration in Vivo That Stromelysin-3 Functions through Its Proteolytic Activity
Noël, Agnès ULg; Boulay, A.; Kebers, F. et al

in Oncogene (2000), 19(12), 1605-12

Stromelysin-3 (ST3), a matrix metalloproteinase (MMP) expressed in aggressive carcinomas, has been shown to promote tumor development in different in vivo experimental models. However, the inability of ... [more ▼]

Stromelysin-3 (ST3), a matrix metalloproteinase (MMP) expressed in aggressive carcinomas, has been shown to promote tumor development in different in vivo experimental models. However, the inability of its mature form to degrade extracellular matrix components casts doubt on whether ST3 functions in vivo as a protease. In this study, we evaluated whether the ST3 tumor-promoting effect could be ascribed to its proteolytic activity and whether this putative protease could be targeted with MMP inhibitors. Catalytically inactive mutant cDNA of human (h) ST3 or mouse (m) ST3 were generated and transfected into MCF7 cells. When injected into nude mice in the presence of matrigel, the mutant-bearing cells did not exhibit the enhanced tumorigenicity elicited by MCF7 cells transfected with wild-type ST3 cDNA. In a second approach, TIMP2 overproduction in MCF7 cells expressing hST3 was induced by retroviral infection. The co-expression of ST3 and TIMP2 failed to enhance the tumorigenicity of MCF7 cells. Notably, matrigel depleted of low-molecular-weight proteins and growth factors failed to promote the tumorigenicity of ST3-expressing MCF7 cells. These findings provide the first in vivo evidence that ST3 is indeed a protease that can modulate cancer progression by remodeling extracellular matrix and probably by inducing it to release the necessary microenvironmental factors. Thus, ST3 represents an interesting target for specific MMP inhibition. [less ▲]

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See detailDemonstration of anti-laminin antibodies in the serum of healthy subjects
Bernard, A.; Passelecq, B.; Foidart, Jean-Michel ULg et al

in Biomedicine & Pharmacotherapy (1987), 41(4), 183-6

Antibodies directed against laminin, a glycoprotein of basement membranes, have been sought for in the sera of 347 healthy subjects by a method relying on the agglutination of laminin-coated latex ... [more ▼]

Antibodies directed against laminin, a glycoprotein of basement membranes, have been sought for in the sera of 347 healthy subjects by a method relying on the agglutination of laminin-coated latex particles. Fifty-five subjects (15.9%) hae been found to be positive, 37 with a titre of 2, 14 with a titre of 4 and 4 with a titer of 8. Applied to 106 patients whose a renal biopsy had been examined by immunofluorescence, the test yielded positive results in 91% of patients with linear deposits as compared to 10.3 and 15.4% respectively in patients presenting with and without granular deposits along the glomerular basement membrane. The titers in anti-laminin antibodies observed in these patients ranged from 2 to 8. The discovery of circulating anti-laminin antibodies in serum from subjects without clinical or subclinical sign of renal impairment rises several questions regarding the pathogenicity of these auto-antibodies and their possible association with genetic or environmental factors. [less ▲]

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See detailDemonstration of generalized infection with caprine herpesvirus 1 diagnosed in an aborted caprine fetus by PCR
Keuser, V.; Gogev, S.; Schynts, F. et al

in Veterinary Research Communications (2002), 26(3), 221-226

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See detailDemonstration of laminin, a basement membrane glycoprotein, in routinely processed formalin-fixed human tissues.
Ekblom, P.; Miettinen, M.; Rapola, J. et al

in Histochemistry (1982), 75(3), 301-7

Laminin was demonstrated by immunoperoxidase and immunofluorescence staining in sections of normal human tissues fixed in formalin and routinely processed in paraffin. Exposure of the sections to a ... [more ▼]

Laminin was demonstrated by immunoperoxidase and immunofluorescence staining in sections of normal human tissues fixed in formalin and routinely processed in paraffin. Exposure of the sections to a solution of pepsin (Burns et al. (1980) Histochemistry 67:73-78) revealed the antigenicity of this basement membrane glycoprotein. Sections from paraffin blocks stored for years at room temperature could be stained with this procedure. Normal human tissues, developing fetal tissues and tumors could be stained with this method. The staining patterns were similar to those seen in unfixed frozen sections. It thus appears that basement membrane components can be detected by immunohistological means from routinely processed histological samples, once the sections are pretreated with proteases. Staining for laminin could be used in embryonic studies and in histopathology to study the relation of cells to basement membranes and for the visualization of normal and abnormal vascularization. [less ▲]

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See detailDemonstration of neuronotoxic activity in the cerebrospinal fluid of severe head injured patients
LEFEBVRE, Philippe ULg; Rigo, J. M.; Leprince, Pierre ULg et al

in Agressologie : Revue Internationale de Physio-Biologie et de Pharmacologie Appliquées aux Effets de l'Agression (1988), 29(4), 241-242

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See detailDemonstration of somatogenic receptors in bovine corpus luteum
Beckers, Jean-François ULg; Wouters-Ballman, P; Donnay, I et al

in Proceedings of the 11th International Congress on Animal Reproduction and Artificial Insemination (1988)

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See detailDemonstration of the expression of CD95 ligand transcript and protein in human placenta
Zorzi, Willy ULg; Thellin, Olivier ULg; Coumans, Bernard ULg et al

in Placenta (1998), 19(4), 269-277

Tolerance of the fetal allograft enables the human conceptus to implant itself into the maternal uterus and survive and grow there. This tolerance phenomenon remains largely obscure, notably because it ... [more ▼]

Tolerance of the fetal allograft enables the human conceptus to implant itself into the maternal uterus and survive and grow there. This tolerance phenomenon remains largely obscure, notably because it appears to be controlled by multiple mechanisms. CD95 ligand (CD95-L), which can trigger death of CD95-positive cells by apoptosis, may participate in inducing anti-fetus-sensitized CD95-positive T lymphocytes to enter apoptosis. Using immunohistochemistry (first trimester and term placentae), FAGS assays (term placenta) and RT-PCR assays (term placenta), the presence of CD95-L protein and mRNA has been shown in crude placental tissue preparations and isolated placental cells. Among the latter, CD95-L expression was detected in trophoblastic cells, fetal blood cells (mRNA only) and also the Hofbauer macrophages. No CD95-L was detected in fibroblasts or fetal endothelial cells. Thus trophoblastic cells, Hofbauer macrophages, and perhaps also fetal blood cells could form a sequential barrier blocking maternal activated defence cells bearing CD95 molecules. (C) 1998 W. B. Saunders Company Ltd. [less ▲]

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See detailDemonstration of the pituitary expression of the human GH-V gene as assessed by a competitive hybridization technique.
Scippo, Marie-Louise ULg; Frankenne, F.; Igout, Ahmed ULg et al

in Proceedings of the 72nd Annual Meeting of the Endocrine Society (1990)

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See detailDemonstration of the two-way nesting in the Gulf of Lions
Vandenbulcke, Luc ULg; Barth, Alexander ULg; Ben Bouallegue, Z. et al

Conference (2003, September)

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See detailDémonstration pratique de l'existence de la nutation diurne
Folie, François ULg

in Comptes Rendus de l'Académie des Sciences. Série 2, Sciences de la Terre et des Planètes (1886), 103

Introduction of a François Folie’s note about the existence of diurnal nutation of the world’s axis. Nutation that can be sensitive if the globe consists of a fluid core and a solid crust.

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See detailDémonstration pratique de l'existence de la nutation diurne par M. Niesten : rapport de F. Folie
Folie, François ULg

in Bulletins de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique (1887), 3e série, t. 13(4), 398-404

The author establishes a report on the Mr. Niesten’s thesis on the practical demonstration of the diurnal nutation existence.

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See detailDemonstrationof somatogenic receptors in bovine corpus luteum: conjectural effect of trophic hormone on follicular growth and development.
Beckers, Jean-François ULg; Wouters-Ballman, P.; Viviers-Donnay, I. et al

Poster (1989, September 09)

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See detailDémystifier la consultation démence
Adam, Stéphane ULg

Conference given outside the academic context (2008)

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See detailDemystifying Comprehensive GC
Focant, Jean-François ULg

Conference (2013, October)

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See detailDemystifying ethnic/sex differences in kidney function: is the difference in (estimating) glomerular filtration rate or in serum creatinine concentration?
Pottel, Hans; Hoste, Liesbeth; DELANAYE, Pierre ULg et al

in Clinica Chimica Acta (2012), 413(19-20), 1612-17

BACKGROUND: The recent evaluation of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating the glomerular filtration rate (GFR) in multiple ethnicities has raised the ... [more ▼]

BACKGROUND: The recent evaluation of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating the glomerular filtration rate (GFR) in multiple ethnicities has raised the question on how well this equation performs for African-American and Asian subjects. There is no doubt that serum creatinine (Scr) concentration differs between ethnicities and sexes. We show that creatinine-based equations for white populations may be inaccurate for estimating GFR in other ethnic/gender groups, especially in populations from Asia. METHODS: This study presents a mathematical analysis of the CKD-EPI-equation complemented with a literature review of median and reference values for IDMS-standardized Scr-concentrations for multiple ethnicities. RESULTS: The study shows that at equal eGFR-CKD-EPI-values, the ratio of Scr between females and males equals 0.79 and between other ethnicities/sexes and white males is constant too. From this information, it is possible to calculate mean Scr-values that correspond very well with literature values directly obtained from Scr-distributions in healthy white males and females and in black males, but the discrepancy is larger for other populations. CONCLUSIONS: Our results confirm the criticism that has been raised for using the CKD-EPI-equation for these ethnicities. An alternative eGFR-model is proposed based on a population-normalized Scr that needs further validation. [less ▲]

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See detailDenCity: Zero Energy Light Weight Construction Households for Urban Densification
Amer, Mohamed ULg; Attia, Shady ULg

in Rencontres Universitaires de Génie Civil de l'AUGC (2016, May 25)

This paper is a part of an ongoing research in the field of sustainable urban densification through providing innovative solutions for zero energy light weight construction. The focus aim of this research ... [more ▼]

This paper is a part of an ongoing research in the field of sustainable urban densification through providing innovative solutions for zero energy light weight construction. The focus aim of this research is to identify the gaps in the construction solutions for roof stacking, to feed in the innovation pipeline of the European construction landscape in the coming years. This paper presents a comprehensive review of different case studies and efforts in the field of roof raising and its repetition potentials. Based on a structured review, 8 different cases from three different European countries were sorted, placing a variety of methods in comparison with each other. The main contribution of this review lies in the analyses of the existing information in this field and the classification of the different validated methods and approaches that has been used. Finally, despite the existing challenges, it was found that the concept of roof stacking can be widely spread and applied in different contexts. Future research is going to investigate possible solution and to formulate structured scientific approaches to widen its application. [less ▲]

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