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See detailA Critical Investigation of the Concept of Life: Canguilhem or Bergson
Wong, Tai Tak Andy ULiege

Conference (2011, December 08)

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See detailCritical issues in parameter calibration of cyclic models for steel members
Francavilla, Antonella Bianca ULiege; Chisari, Corrado; Latour, Massimo et al

in Engineering Structures (2017), 132

Accurate response predictions of steel structures subjected to earthquake loading involve the use of models able to simulate properly the cyclic behaviour of the regions where nonlinear phenomena take ... [more ▼]

Accurate response predictions of steel structures subjected to earthquake loading involve the use of models able to simulate properly the cyclic behaviour of the regions where nonlinear phenomena take place. In case of full-strength joints, they are represented by the members connected, which may present softening response due to local buckling. Even though a number of phenomenological models have been developed in the last decades, their calibration seems to have received less attention. Usually, calibration is based on matching the experimental and numerical cyclic responses under loading protocols proposed by standards. Since these were not developed to this aim, the predictive capability of so calibrated models deserves investigation. In this work, a calibration procedure based on the minimisation of response misfit is presented and critically discussed, with reference to an experimental programme carried out at the University of Salerno. Different assumptions about the function to minimise, the ultimate rotation and number of objectives are compared and analysed. The main outcome of this investigation is that a calibration based on cyclic response only is not robust, since its accuracy under different loading conditions may deteriorate. The introduction of the monotonic test in a multi-objective framework may be effective, and its accuracy is confirmed by the results of pseudo-dynamic tests. [less ▲]

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See detailCritical issues in translational and clinical research for the study of new technologies to enhance bone repair.
Goldhahn, Jorg; Mitlak, Bruce; Aspenberg, Per et al

in Journal of Bone & Joint Surgery. American Volume (2008), 90 Suppl 1

Osteoporosis increases fracture risk, especially in metaphyseal bone. Fractures seriously impair function and quality of life and incur large direct and indirect costs. Although the prevention of ... [more ▼]

Osteoporosis increases fracture risk, especially in metaphyseal bone. Fractures seriously impair function and quality of life and incur large direct and indirect costs. Although the prevention of fractures is certainly the option, a fast and uneventful healing process is optimal when fractures do occur. Many new therapeutic strategies have been developed to accelerate fracture-healing or to diminish the complication rate during the course of fracture-healing. However, widely accepted guidelines are needed to demonstrate the positive or negative interactions of bioactive substances, drugs, and other agents that are being used to promote fracture-healing. For each study design, the primary study goal should be indicated. Outcome variables should include both objective and subjective parameters. The guidelines should be harmonized between European and American regulatory authorities to ensure comparability of results of studies and to foster global harmonization of regulatory requirements. [less ▲]

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See detailCritical Life: Bergson, Canguilhem and the Critical Investigation of Life and the Living
Wong, Tai Tak Andy ULiege

Doctoral thesis (2016)

The objective of my research is to offer a critical investigation of life and the living according to Bergson and Canguilhem. The ‘critical’ perspective in this investigation refers to the exploration of ... [more ▼]

The objective of my research is to offer a critical investigation of life and the living according to Bergson and Canguilhem. The ‘critical’ perspective in this investigation refers to the exploration of the difficulty, controversy and significance of the problematic concept of life in these two different forms of philosophy of life. For Bergson and Canguilhem, it is life that generates questions about knowledge of life and the living. Although Bergson and Canguilhem develop their metaphysical and epistemological approaches of life respectively, they both stand for the reciprocity between life and knowledge. Throughout this critical investigation of their philosophies of life, I would argue that there is continuity between Bergson and Canguilhem on their reflections of the knowledge and thought of life. However, thus far, there has been no recent research that has concentrated on this discussion and clarified the difference between them. This investigation, for this reason, is an attempt to understand the concept of life according to Bergson and Canguilhem from a critical perspective. [less ▲]

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See detailCritical machine cluster identification using the equal area criterion
Weckesser, Johannes ULiege; Jóhannsson, Hjörtur; Østergaard, Jacob

in Proceedings of 2015 IEEE Power & Energy Society General Meeting (2015)

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See detailCritical metals in sphalerites from Belgian MVT deposits
Goffin, Vincent; Evrard, Maxime ULiege; Pirard, Eric ULiege

in André-Mayer, Anne-Sylvie; Cathelineau, Michel; Muchez, Philippe (Eds.) et al Proceedings of the 13th SGA Biennial Meeting (2015, August)

Belgium hosts a series of well documented low temperature, carbonate hosted, lead-zinc veins and lenses clearly categorized as MVT deposits. This paper revisits the distribution of trace elements in ... [more ▼]

Belgium hosts a series of well documented low temperature, carbonate hosted, lead-zinc veins and lenses clearly categorized as MVT deposits. This paper revisits the distribution of trace elements in sphalerites from Belgian deposits with a special focus on Ge, Ga and In. By comparing with a database of worldwide deposits, this paper shows that Belgian sphalerites do not display a classical substitution pattern involving Cu+. Instead, multivariate analysis points towards similarities with the Tres Marias deposit in Mexico, although the explanation of coupled substitution with Fe++ does not seem to apply in the present case. From the limited set of sphalerites analysed in this paper, the following rithmetic means are obtained: m(Ge) = 302 ppm, m(Ga) = 2.2 ppm and m(In) < 0.06 ppm. These average values should not hide the fact that a wide variability does exist from one deposit to the other and within zoned colloform sphalerites of the same deposit. Further nd systematic work is required to better evaluate the resource and understand the mechanisms responsible for Ge incorporation into sphalerite. [less ▲]

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See detailThe Critical Neighbourhood Range for Asymptotic Overlay Connectivity in Ad Hoc Networks
Calomme, Sandrine; Leduc, Guy ULiege

in Ad Hoc & Sensor Wireless Networks (2006), 2(2), 169-187

We first motivate the use of ad hoc overlays. In particular, we argue that overlay routing could play a role in the spreading of ad hoc networks. We then define a simple criterion for neighbourhood: two ... [more ▼]

We first motivate the use of ad hoc overlays. In particular, we argue that overlay routing could play a role in the spreading of ad hoc networks. We then define a simple criterion for neighbourhood: two overlay nodes are neighbours if and only if there exists a path between them of at most R hops, and R is called the (overlay) neighbourhood range. A small R may result in a disconnected overlay, while an unnecessarily large R would generate extra control traffic. We are interested in the minimum R ensuring overlay connectivity, the so-called critical R. We study conditions on R to achieve asymptotic connectivity of the overlay almost surely, i.e. connectivity with probability 1 when the number of nodes in the underlying ad hoc network tends to infinity (so-called dense networks) or when the size of the field tends to infinity (socalled sparse networks), under the hypothesis that the underlying ad hoc network is itself asymptotically almost surely connected. For dense networks, we derive a necessary and sufficient condition on R, and for sparse networks we derive distinct necessary and sufficient conditions that are however asymptotically tight. These conditions, though asymptotic, shed some light on the relation linking the critical R to the number of nodes n, the field size the radio transmission range r and the overlay density D (i.e., the proportion of overlay nodes). These conditions can be considered as approximations when the number of nodes (resp. the field) is large enough. Since r is considered as a function of n or l , we are able to study the impact of topology control mechanisms, by showing how the shape of this function impacts the critical R. [less ▲]

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See detailThe Critical Neighbourhood Range for Asymptotic Overlay Connectivity in Dense Ad Hoc Networks
Calomme, Sandrine; Leduc, Guy ULiege

in Challenges in Ad Hoc Networking (2005, June)

We define, for an overlay built on top of an ad hoc network, a simple criterion for neighbourhood: two overlay nodes are neighbours if and only if there exists a path between them of at most R hops, and R ... [more ▼]

We define, for an overlay built on top of an ad hoc network, a simple criterion for neighbourhood: two overlay nodes are neighbours if and only if there exists a path between them of at most R hops, and R is called the (overlay) neighbourhood range. A small R may result in a disconnected overlay, while an unnecessarily large R would generate extra control traffic. We are interested in the minimum R ensuring overlay connectivity, the so-called critical R. We derive a necessary and sufficient condition on R to achieve asymptotic connectivity of the overlay almost surely, i.e. connectivity with probability 1 when the number of overlay nodes tends to infinity, under the hypothesis that the underlying ad hoc network is itself asymptotically almost surely connected. This condition, though asymptotic, sheds some light on the relation linking the critical R to the number of nodes n, the normalized radio transmission range r and the overlay density D (i.e., the proportion of overlay nodes). This condition can be considered as an approximation when the number of nodes is large enough. Since r is considered as a function of n, we are able to study the impact of topology control mechanisms, by showing how the shape of this function impacts the critical R. [less ▲]

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See detailCritical opalescence points to thermodynamic instability:relevance to small-angle X-ray scattering of resorcinol–formaldehyde gel formation at low pH
Gommes, Cédric ULiege; Job, Nathalie ULiege; Pirard, Jean-Paul ULiege et al

in Journal of Applied Crystallography (2008), 41(4), 663-668

During the formation at low pH of resorcinol–formaldehyde gels with a structure in the micrometre range, small-angle X-ray scattering exhibits a nonmonotonic intensity variation as a function of reaction ... [more ▼]

During the formation at low pH of resorcinol–formaldehyde gels with a structure in the micrometre range, small-angle X-ray scattering exhibits a nonmonotonic intensity variation as a function of reaction time. The data are analyzed in terms of scattering by statistical fluctuations of polymer concentration, the amplitude of which is maximal close to the critical point for phase separation between polymer and solvent. The data do not carry any morphological information, but they unambiguously show that the driving force of the gel formation is a thermodynamic instability of the polymerizing solution. [less ▲]

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See detailCritical parameters for the partial coalescence of a droplet
Gilet, Tristan ULiege; Mulleners, Karen; Lecomte, Jean-Paul et al

in Physical Review E (2007), 75(3, Pt 2), 36303

The partial coalescence of a droplet onto a planar liquid-liquid interface is investigated experimentally by tuning the viscosities of both liquids. The problem mainly depends on four dimensionless ... [more ▼]

The partial coalescence of a droplet onto a planar liquid-liquid interface is investigated experimentally by tuning the viscosities of both liquids. The problem mainly depends on four dimensionless parameters: The Bond number (gravity vs surface tension), the Ohnesorge numbers (viscosity in both fluids vs surface tension), and the density relative difference. The ratio between the daughter droplet size and the mother droplet size is investigated as a function of these dimensionless numbers. Global quantities such as the available surface energy of the droplet have been measured during the coalescence. The capillary waves propagation and damping are studied in detail. The relation between these waves and the partial coalescence is discussed. Additional viscous mechanisms are proposed in order to explain the asymmetric role played by both viscosities. [less ▲]

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See detailCritical parameters in deriving fire fragility functions for steel gravity frames
Gernay, Thomas ULiege; Elhami Khorasani, Negar; Garlock, Maria

in Garlock, Maria; Kodur, Venkatesh (Eds.) Structures in Fire (Proceedings of the Ninth International Conference) (2016, June 10)

Fire fragility functions can be used to characterize the probabilistic vulnerability of buildings to fire in the context of urban resilience assessment. A methodology has been proposed to develop such ... [more ▼]

Fire fragility functions can be used to characterize the probabilistic vulnerability of buildings to fire in the context of urban resilience assessment. A methodology has been proposed to develop such functions for multi-story steel buildings. However, a large number of parameters with uncertainties play a role in the process of constructing the fragility functions. The goal of this research is to identify the critical parameters that most affect the global fire safety by investigating the sensitivity of the fragility functions to different input parameters. Sensitivity in parameters affecting the fire model, the heat transfer process and the thermo-mechanical response is examined. The effects of different design assumptions at the system level are also studied. The presented approach is useful for selecting the prevailing parameters in a fire reliability analysis and it provides important information for modeling tools that can be used to evaluate resilience for fire scenarios. [less ▲]

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See detailCritical periods and critical values explaining fluxes inter-annual variability in a temperate mixed forest
Hurdebise, Quentin ULiege; Vincke, Caroline; De Ligne, Anne ULiege et al

Poster (2015, June 04)

In order to explain inter-annual variability of Net Ecosystem CO2 Exchange (NEE) above a mixed temperate forest, two approaches were followed: •Detection of critical periods using the R-squared of the ... [more ▼]

In order to explain inter-annual variability of Net Ecosystem CO2 Exchange (NEE) above a mixed temperate forest, two approaches were followed: •Detection of critical periods using the R-squared of the regression between annual NEE and cumulated NEE on a mobile window. •Identification of critical values of a threshold used to decompose annual and seasonal NEE in two components. [less ▲]

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See detailCritical points and reaction paths characterization on a potential energy hypersurface
Ramquet, Marie-Noëlle; Dive, Georges ULiege; Dehareng, Dominique ULiege

in Journal of Chemical Physics (2000), 112(11), 4923-4934

Most of the time, the definitions of minima, saddle points or more generally order p (p=0,...,n) critical points, do not mention the possibility of having zero Hessian eigenvalues. This feature reflects ... [more ▼]

Most of the time, the definitions of minima, saddle points or more generally order p (p=0,...,n) critical points, do not mention the possibility of having zero Hessian eigenvalues. This feature reflects some flatness of the potential energy hypersurface in a special eigendirection which is not often taken into account. Thus, the definitions of critical points are revisited in a more general framework within this context. The concepts of bifurcation points, branching points, and valley ridge inflection points are investigated. New definitions based on the mathematical formulation of the reaction path are given and some of their properties are outlined. (C) 2000 American Institute of Physics. [S0021-9606(00)01110-7]. [less ▲]

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See detailCritical points for Salmonella contamination during slaughter process in Belgian slaughterhouses.
De Saedeleer, L.; Maes, D.; Dewulf, J. et al

in International Pig Veterinary Society Congress (2006, July)

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See detailCritical points in glucosinolates analysis in seed and plant tis Critical points in glucosinolates analysis in seed and plant tissues by HPLC of desulfo-derivatives
Leoni, O.; Iori, R.; Wathelet, Jean-Paul ULiege et al

Poster (2004)

In the EU the ISO 9167-1 is the reference method for glucosinolates content determination in rapeseed. This method is widely used also for other seeds or Brassica plant tissues analysis also in order to ... [more ▼]

In the EU the ISO 9167-1 is the reference method for glucosinolates content determination in rapeseed. This method is widely used also for other seeds or Brassica plant tissues analysis also in order to the large diffusion of HPLC instrumentation in analytical laboratories. Anyway, in our experience the use of this method has revealed some critical points which can considerably affect the final result, thus when this method is used to analyse materials different from seeds of B. napus some methodological modifications must be done especially in reason of the kind of glucosinolate present in the sample. [less ▲]

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See detailCritical Re-Examination of the Distribution of Aromatase-Immunoreactive Cells in the Quail Forebrain Using Antibodies Raised against Human Placental Aromatase and against the Recombinant Quail, Mouse or Human Enzyme
Foidart, Agnès ULiege; Reid, J.; Absil, Philippe ULiege et al

in Journal of Chemical Neuroanatomy (1995), 8(4), 267-82

Mouse and quail aromatase cDNAs were isolated from libraries of mouse ovary and quail brain by using a human aromatase cDNA fragment (hA-24) as a probe. These three cDNAs were inserted into plasmid ... [more ▼]

Mouse and quail aromatase cDNAs were isolated from libraries of mouse ovary and quail brain by using a human aromatase cDNA fragment (hA-24) as a probe. These three cDNAs were inserted into plasmid vectors and expressed in Escherichia coli. Antisera against these purified recombinant proteins were raised in rabbit and purified by ammonium sulfate fractionation and affinity chromatography. The three antibodies directed against recombinant human, mouse and quail proteins were used to visualize aromatase-immunoreactive cells in the quail brain. They were compared with the antibody raised against human placental aromatase used in previous experiments and with another antibody recently developed by similar methods. The signal obtained with all antibodies was completely abolished by preadsorption with the homologous recombinant antigens and the signal produced by the two antibodies raised against placental aromatase was similarly abolished by a preadsorption with recombinant quail aromatase. The antibodies raised against recombinant proteins identified the major groups of aromatase cells previously described in the quail brain. The antibodies directed against the mouse and quail antigen identified more positive cells and stained them more densely than the antibodies raised against human recombinant antigen or purified placental aromatase. The new cell groups identified by the antibody raised against quail recombinant aromatase were located in an area ventral to the fasciculus prosencephali lateralis, the nucleus accumbens, the paleostriatum ventrale, the nucleus taeniae, the area around the nucleus ovoidalis, the caudal tuber and the mesencephalic central gray. A critical re-examination of the distribution and nomenclature of the aromatase-positive cells is proposed based on these new findings. [less ▲]

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See detailCritical Reflections on the Treaty on the Non-Proliferation of Nuclear Weapons
Michel, Quentin ULiege

in Nuclear Law Bulletin (2007)

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See detailCritical Review of Near-Infrared Spectroscopic Methods Validations in Pharmaceutical Applications
De Bleye, Charlotte ULiege; Chavez, Pierre-François ULiege; Mantanus, Jérôme ULiege et al

in Journal of Pharmaceutical & Biomedical Analysis (2012), 69

Based on the large number of publications reported over the past five years, near-infrared spectroscopy (NIRS) is more and more considered an attractive and promising analytical tool regarding Process ... [more ▼]

Based on the large number of publications reported over the past five years, near-infrared spectroscopy (NIRS) is more and more considered an attractive and promising analytical tool regarding Process Analytical Technology and Green Chemistry. From the reviewed literature, few of these publications present a thoroughly validated NIRS method even if some guidelines have been published by different groups and regulatory authorities. However, as any analytical method, the validation of NIRS method is a mandatory step at the end of the development in order to give enough guarantees that each of the future results during routine use will be close enough to the true value. Besides the introduction of PAT concepts in the revised document of the European Pharmacopoeia (2.2.40) dealing with near-infrared spectroscopy recently published in Pharmeuropa, it agrees very well with this mandatory step. Indeed, the latter suggests to use similar analytical performance characteristics than those required for any analytical procedure based on acceptance criteria consistent with the intended use of the method. In this context, this review gives a comprehensive and critical overview of the methodologies applied to assess the validity of quantitative NIRS methods used in pharmaceutical applications. [less ▲]

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See detailCritical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field
Cailletaud, Johan ULiege; De Bleye, Charlotte ULiege; Dumont, Elodie ULiege et al

in Journal of Pharmaceutical & Biomedical Analysis (2018), 147

Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical tool used in the pharmaceutical field in recent years. SERS keeps all the advantages of classical Raman spectroscopy while being is ... [more ▼]

Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical tool used in the pharmaceutical field in recent years. SERS keeps all the advantages of classical Raman spectroscopy while being is more sensitive allowing its use for the detection and the quantification of low-dose substances contained in pharmaceutical samples. However, the analytical performance of SERS is limited due to the difficulty to implement a quantitative methodology correctly validated. Nevertheless, some studies reported the development of SERS quantitative methods especially in pharmaceutical approaches. In this context, this review presents the main concepts of the SERS technique. The different steps that need to be applied to develop a SERS quantitative method are also deeply described. The last part of the present manuscript gives a critical overview of the different SERS pharmaceutical applications that were developed for a non-exhaustive list of pharmaceutical compounds with the aim to highlights the validation criteria for each application. [less ▲]

Detailed reference viewed: 95 (19 ULiège)