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See detailEarly Silurian cryptospores from the subsurface of Saudi Arabia
Wellman, C.; Breuer, P.; Miller, M. et al

Conference (2014, August 26)

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See detailEarly Silurian miospores from the Paraná Basin, South America
Steemans, Philippe ULg; Pereira, E.

Conference (2001)

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See detailEarly Silurian trilete spores and cryptospores, Paraguay
Steemans, Philippe ULg; Pereira, E.

Conference (2000)

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See detailEarly Stage Results after Oesophageal Resection for Malignancy - Colon Interposition Vs. Gastric Pull-Up
Kolh, Philippe ULg; Honore, Pierre ULg; Degauque, C. et al

in European Journal of Cardio - Thoracic Surgery (2000), 18(3), 293-300

OBJECTIVE: The aims of our study were to determine if using the colon as a digestive transplant after oesophagectomy for cancer was associated with increased postoperative complications, and to assess the ... [more ▼]

OBJECTIVE: The aims of our study were to determine if using the colon as a digestive transplant after oesophagectomy for cancer was associated with increased postoperative complications, and to assess the impact of preoperative radiochemotherapy on postoperative hospital outcome. METHODS: From January 1990 to December 1998, 130 patients underwent oesophageal resection for malignancy. There were 103 males and 27 females (age: 61.3+/-11.5 years). Indications were squamous cell carcinoma in 69 patients and adenocarcinoma in 61. Preoperatively 30 patients (eight in stage IIB, 18 in stage III, and four in stage IV) received radiochemotherapy. There were 84 subtotal oesophagectomies, with anastomosis in the neck in 44 patients and at the thoracic inlet in 40, and 46 distal oesophageal resections. Digestive continuity was restored with the stomach in 92 patients (age: 63.4+/-10.2 years) and the colon in 38 (age: 52.3+/-12.8 years). With the exception of age (P<0.0001), there was no significant preoperative difference between gastric and colonic groups. RESULTS: Hospital mortality was 8.5% (11 patients), decreasing from 18.5% (before 1993) to 3.8% (since 1993). One patient (2.5%) died in the colonic graft group and ten (11%) in the gastric pull-up group (P=0.17). Postoperative complications occurred in 40 patients (31%), respectively, in ten (26%) and 30 (33%) patients after colonic and gastric transplants (P=0.48), and were pulmonary insufficiency or infection in 29 patients, anastomotic fistula in six, myocardial infarction in five, recurrent nerve palsy in four, renal insufficiency in three, and cerebrovascular accident in one. All fistulas occurred in the gastric pull-up group. The incidence of postoperative pulmonary complications was 70% (21/30 patients) in the subgroup who received preoperative radiochemotherapy, as compared to 11% (5/44 patients) in the subgroup of comparable staging, but without preoperative treatment (P<0.001). CONCLUSIONS: Colonic grafts are not associated with increased postoperative mortality or complications. Our results suggest that preoperative neoadjuvant treatment significantly increases postoperative pulmonary complications. [less ▲]

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See detailThe early stages of photosystem II assembly monitored by measurements of fluorescence lifetime, fluorescence induction and isoelectric focusing of chlorophyll-proteins in barley etiochloroplasts
MysliwaKurdziel, B.; Barthelemy, X.; Strzalka, K. et al

in Plant & Cell Physiology (1997), 38(11), 1187-1196

The relationship between functional and structural aspects of PSII formation during greening of etiolated barley leaves has been investigated using fluorescence life-time measurements, fluorescence ... [more ▼]

The relationship between functional and structural aspects of PSII formation during greening of etiolated barley leaves has been investigated using fluorescence life-time measurements, fluorescence kinetics analysis and analysis of chlorophyll-protein complexes by IEF-PAGE, Two phases of different character could be distinguished in the course of the greening process in dark-grown plants, An early phase covering the first 3-4 h after the onset of illumination and a late phase covering the subsequent greening, During the first phase the formation of PSII reaction centers and their minor antenna components was observed as manifested by the IEF-PAGE polypeptide pattern, This was accompanied by shortening of the slow and middle components of the fluorescence lifetime, as well as by the rapid drop in the amplitude of the slow component, A room temperature emission band at 676 nm was associated with uncoupled chlorophyll and with the slow fluorescence lifetime component during the first hours of greening. During the late greening phase peripheral light-harvesting complexes of PSII were formed concomitantly to an increase in lifetime and amplitude of the fast component and to a further decrease in the lifetime of the middle component, The gradual increase in PSII complexity during both phases of greening was also manifested by changes in proportion and kinetic properties of PSIIalpha and PSIIbeta units. Similar changes in fluorescence lifetime components as in the late greening of dark-grown plants were also observed in intermittent-light plants during continuous greening associated with the development of PSII antenna. The relationships between fluorescence lifetime characteristics and development of PSII are discussed in terms of a stepwise mechanism invoving a first step of Chl integration into small size PSII units followed by progressive increase of antenna size. [less ▲]

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See detailEarly Structural Assessment and Optimisation of Passenger Ships
Caprace, Jean-David ULg; Bair, Frédéric ULg; Rigo, Philippe ULg

in Procceding of the International Conference on Design and Operation of Passenger Ships (2011, February 23)

A multi-criteria optimisation of a passenger ship is conducted in this paper. Minimum production cost and minimum steel weight are the both objective studied. Moreover the study answers to the following ... [more ▼]

A multi-criteria optimisation of a passenger ship is conducted in this paper. Minimum production cost and minimum steel weight are the both objective studied. Moreover the study answers to the following question: "From when will the higher costs of high tensile steel should be offset by a gain of steel weight?". For a passenger ship, a significant reduction of the steel weight, for a controlled raise of the gravity centre, should lead either to a reduction of fuel consumption either to an additional deck, which for a ship owner means a faster return on investment. Pareto frontiers are obtained and results are validated by classification rules. [less ▲]

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See detailearly surfactant changes afetr surfactant therapy in premature infants assisted by HFOV
Battisti, Oreste ULg

in Pediatric Research (1998), 2

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See detailEarly termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults.
Robe, Pierre ULg; Martin, Didier ULg; Nguyen-Khac, Minh-Tuan ULg et al

in BMC Cancer (2009), 9

BACKGROUND: Sulfasalazine, a NF-kappaB and x(c)-cystine/glutamate antiport inhibitor, has demonstrated a strong antitumoral potential in preclinical models of malignant gliomas. As it presents an ... [more ▼]

BACKGROUND: Sulfasalazine, a NF-kappaB and x(c)-cystine/glutamate antiport inhibitor, has demonstrated a strong antitumoral potential in preclinical models of malignant gliomas. As it presents an excellent safety profile, we initiated a phase 1/2 clinical study of this anti-inflammatory drug for the treatment of recurrent WHO grade 3 and 4 astrocytic gliomas in adults. METHODS: 10 patients with advanced recurrent anaplastic astrocytoma (n = 2) or glioblastoma (n = 8) aged 32-62 years were recruited prior to the planned interim analysis of the study. Subjects were randomly assigned to daily doses of 1.5, 3, 4.5, or 6 grams of oral sulfasalazine, and treated until clinical or radiological evidence of disease progression or the development of serious or unbearable side effects. Primary endpoints were the evaluation of toxicities according to the CTCAE v.3.0, and the observation of radiological tumor responses based on MacDonald criteria. RESULTS: No clinical response was observed. One tumor remained stable for 2 months with sulfasalazine treatment, at the lowest daily dose of the drug. The median progression-free survival was 32 days. Side effects were common, as all patients developed grade 1-3 adverse events (mean: 7.2/patient), four patients developed grade 4 toxicity. Two patients died while on treatment or shortly after its discontinuation. CONCLUSION: Although the proper influence of sulfasalazine treatment on patient outcome was difficult to ascertain in these debilitated patients with a large tumor burden (median KPS = 50), ISRCTN45828668 was terminated after its interim analysis. This study urges to exert cautiousness in future trials of Sulfasalazine for the treatment of malignant gliomas. TRIAL REGISTRATION: Current Controlled Trials ISRCTN45828668. [less ▲]

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See detailEarly thalamic and cortical hypometabolism in adult-onset dementia due to metachromatic leukodystrophy
Salmon, Eric ULg; Van der Linden, Martial ULg; Maertens De Noordhout, Alain ULg et al

in Acta Neurologica Belgica (1999), 99(3), 185-188

A case of early-onset adult dementia with family history of dementia is reported, characterised by neuropsychological deficits, suggesting frontal involvement, with mild non specific white matter ... [more ▼]

A case of early-onset adult dementia with family history of dementia is reported, characterised by neuropsychological deficits, suggesting frontal involvement, with mild non specific white matter abnormalities on CT scan. Familial Alzheimer's disease was suspected but the neuropathological diagnosis on brain biopsy was metachromatic leukodystrophy. 18FDG-PET revealed a very peculiar pattern of metabolic impairment in thalamic areas, in medial and frontopolar regions, and in occipital lobes. Neuropsychological follow-up showed relatively stable difficulties of long-term memory and signs of frontal lobe dysfunction, similar to those observed in subcortical dementias. MRI subsequently showed periventricular leukoencephalopathy. The brain metabolic pattern observed in that case of metachromatic leukodystrophy was quite different from that reported in other types of dementia. [less ▲]

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See detailEarly to Middle Devonian miospores from northern Saudi Arabia
Breuer, P.; Al-Ghazi, A.; Al-Ruwaili, M. et al

in Revue de Micropaléontologie (2007), 50

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See detailEarly use of HFOW in the management of hyaline membrane disease in prematurely born neonates
Battisti, Oreste ULg; Bertrand, J. M.; Guissard, F. et al

Conference (1993)

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See detailEarly versus delayed, provisional eptifibatide in acute coronary syndromes.
Giugliano, Robert P.; White, Jennifer A.; Bode, Christoph et al

in New England Journal of Medicine [=NEJM] (2009), 360(21), 2176-90

BACKGROUND: Glycoprotein IIb/IIIa inhibitors are indicated in patients with acute coronary syndromes who are undergoing an invasive procedure. The optimal timing of the initiation of such therapy is ... [more ▼]

BACKGROUND: Glycoprotein IIb/IIIa inhibitors are indicated in patients with acute coronary syndromes who are undergoing an invasive procedure. The optimal timing of the initiation of such therapy is unknown. METHODS: We compared a strategy of early, routine administration of eptifibatide with delayed, provisional administration in 9492 patients who had acute coronary syndromes without ST-segment elevation and who were assigned to an invasive strategy. Patients were randomly assigned to receive either early eptifibatide (two boluses, each containing 180 microg per kilogram of body weight, administered 10 minutes apart, and a standard infusion > or = 12 hours before angiography) or a matching placebo infusion with provisional use of eptifibatide after angiography (delayed eptifibatide). The primary efficacy end point was a composite of death, myocardial infarction, recurrent ischemia requiring urgent revascularization, or the occurrence of a thrombotic complication during percutaneous coronary intervention that required bolus therapy opposite to the initial study-group [less ▲]

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See detailEarly-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks.
Li, Yue; Yang, Xiaojing; Ni, Yingdong et al

in Journal of animal science and biotechnology (2012), 3(1), 33

BACKGROUND: Muscle growth depends on the fusion of proliferate satellite cells to existing myofibers. We reported previously that 0-14 day intermittent feeding led to persistent retardation in myofiber ... [more ▼]

BACKGROUND: Muscle growth depends on the fusion of proliferate satellite cells to existing myofibers. We reported previously that 0-14 day intermittent feeding led to persistent retardation in myofiber hypertrophy. However, how satellite cells respond to such nutritional insult has not been adequately elucidated. RESULTS: One-day-old broiler chicks were allocated to control (Con, ad libitum feeding), intermittent feeding (IF, feed provided on alternate days) and re-feeding (RF, 2 days ad libitum feeding after 12 days of intermittent feeding) groups. Chickens were killed on Day 15 and satellite cells were isolated. When cultured, satellite cells from the IF group demonstrated significant retardation in proliferation and differentiation potential, while RF partly restored the proliferation rate and differentiation potential of the satellite cells. Significant up-regulation of insulin like growth factor I receptor (IGF-IR) (P<0.05) and thyroid hormone receptor alpha (TRalpha) (P<0.05), and down-regulation of growth hormone receptor (GHR) (P<0.01) and IGF-I (P<0.01) mRNA expression was observed in freshly isolated IF satellite cells when compared with Con cells. In RF cells, the mRNA expression of IGF-I was higher (P<0.05) and of TRalpha was lower (P<0.01) than in IF cells, suggesting that RF restored the mRNA expression of TRalpha and IGF-I, but not of GHR and IGF-IR. The Bax/Bcl-2 ratio tended to increase in the IF group, which was reversed in the RF group (P<0.05), indicating that RF reduced the pro-apoptotic influence of IF. Moreover, no significant effect of T3 was detected on cell survival in IF cells compared with Con (P<0.001) or RF (P<0.05) cells. CONCLUSIONS: These data suggest that early-age feed restriction inhibits the proliferation and differentiation of satellite cells, induces changes in mRNA expression of the GH/IGF-I and thyroid hormone receptors in satellite cells, as well as blunted sensitivity of satellite cells to T3, and that RF partially reverses these effects. Thus, a moderate nutritional strategy for feed restriction should be chosen in early chick rearing systems. [less ▲]

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See detailEarly-stage endometriosis: adhesion and growth of human menstrual endometrium in nude mice
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Donnez, Jacques

in Fertility and Sterility (2000), 74(2), 306-12

Objective: To evaluate the implantation of menstrual endometrium and the early stages of evolution of endometriotic lesions. Design: Experimental prospective study. Setting: An academic research ... [more ▼]

Objective: To evaluate the implantation of menstrual endometrium and the early stages of evolution of endometriotic lesions. Design: Experimental prospective study. Setting: An academic research environment. Animals: Ten nude mice. Intervention(s): A minilaparotomy was performed to place fresh human menstrual endometrial samples in the peritoneal cavity. Removal of the transplants was performed successively on days 1, 3, and 5 by laparotomy. Main Outcome Measure(s): Adhesion of endometrial fragments and early stages of endometrial lesions was morphologically and immunohistochemically studied. Result(s): As early as day 1, stromal cells were found to be attached to the mesothelium. A progressive reorganization of epithelial and stromal cells into endometrial glands was observed. On day 5, cystic endometriotic lesions were characterized by more extensive proliferative activity in glandular cells and a higher VEGF score in stromal cells than that observed in previously removed transplants. Conclusion(s): Menstrual human endometrium is able to implant on intact mesothelium and to reorganize itself into structured glands and stroma under the influence of unknown factors. We suggest that stromal and glandular cells have two distinct roles: stromal cells are involved in the attachment process and glandular cells in the growth of the endometriotic lesion. [less ▲]

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See detailThe early-type close binary CV Velorum revisited
Yakut, K.; Aerts, C.; Morel, Thierry ULg

in Astronomy and Astrophysics (2007), 467

Aims:Our goal was to improve the fundamental parameters of the massive close double-lined eclipsing B2.5V+B2.5V binary CV Velorum. <BR />Methods: We gathered new high-resolution échelle spectroscopy on ... [more ▼]

Aims:Our goal was to improve the fundamental parameters of the massive close double-lined eclipsing B2.5V+B2.5V binary CV Velorum. <BR />Methods: We gathered new high-resolution échelle spectroscopy on 13 almost consecutive nights covering two orbits. We computed a simultaneous solution to all the available high-quality radial-velocity and light data with the latest version of the Wilson-Deviney code. <BR />Results: We obtained the following values for the physical parameters: M[SUB]1[/SUB] = 6.066(74)~M_ȯ, M[SUB]2[/SUB] = 5.972(70)~M_ȯ, R[SUB]1[/SUB] = 4.126(24)~R_ȯ, R[SUB]2[/SUB] = 3.908(27)~R_ȯ, log L[SUB]1[/SUB] = 3.20(5)~L_ȯ, and log L[SUB]2[/SUB] = 3.14(5)~L_ȯ. The quoted errors contain a realistic estimate of systematic uncertainties mainly stemming from the effective temperature estimation. We derived abundances for both components and found them to be compatible with those of B stars in the solar neighbourhood. We discovered low-amplitude periodic line-profile variations with the orbital frequency for both components. Their interpretation requires new data with a longer time span. The primary rotates subsynchronously while the secondary's v sin i and radius are compatible with synchronous rotation. We provide an update of the empirical mass-luminosity relation for main-sequence B stars which can be used for statistical predictions of masses or luminosities. Based on spectroscopic observations gathered with the CORALIE spectrograph mounted on the 1.2 m Euler telescope at La Silla, Chile. [less ▲]

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See detailEarly-type stars in the core of the young open cluster Westerlund 2
Rauw, Grégor ULg; Manfroid, Jean ULg; Gosset, Eric ULg et al

in Astronomy and Astrophysics (2007), 463(3), 981-991

Aims. The properties of the early-type stars in the core of the Westerlund 2 cluster are examined in order to establish a link between the cluster and the very massive Wolf-Rayet binary WR 20a as well as ... [more ▼]

Aims. The properties of the early-type stars in the core of the Westerlund 2 cluster are examined in order to establish a link between the cluster and the very massive Wolf-Rayet binary WR 20a as well as the H II complex RCW 49. Methods. Photometric monitoring as well as spectroscopic observations of Westerlund 2 are used to search for light variability and to establish the spectral types of the early-type stars in the cluster core. Results. The first light curves of the eclipsing binary WR 20a in B and V filters are analysed and a distance of 8 kpc is inferred. Three additional eclipsing binaries, which are probable late O or early B-type cluster members, are discovered, but none of the known early O-type stars in the cluster displays significant photometric variability above 1% at the 1-sigma level. The twelve brightest O-type stars are found to have spectral types between O3 and O6.5, significantly earlier than previously thought. Conclusions. The distance of the early-type stars in Westerlund 2 is established to be in excellent agreement with the distance of WR20a, indicating that WR20a actually belongs to the cluster. Our best estimate of the cluster distance thus amounts to 8.0 +/- 1.4 kpc. Despite the earlier spectral types, the currently known population of early-type stars in Westerlund 2 does not provide enough ionizing photons to account for the radio emission of the RCW49 complex. This suggests that there might still exist a number of embedded early O-stars in RCW49. [less ▲]

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See detailEarly-type stars in the young open cluster IC 1805 - I. The SB2 system BD+60 degrees 497 and the probably single stars BD+60 degrees 501 and BD+60 degrees 513
Rauw, Grégor ULg; De Becker, Michaël ULg

in Astronomy and Astrophysics (2004), 421(2), 693-702

We investigate the multiplicity of three O-type stars in the very young open cluster IC 1805. All our targets were previously considered as spectroscopic binaries, but no orbital solution was available ... [more ▼]

We investigate the multiplicity of three O-type stars in the very young open cluster IC 1805. All our targets were previously considered as spectroscopic binaries, but no orbital solution was available for any of them. Our results confirm the binarity of BD+60degrees 497 and we provide the very first orbital solution for this double-lined spectroscopic binary. This is only the second O-star binary in IC 1805, and the first SB2 system, for which an orbital solution is now available. BD+60degrees 497 has an orbital period of 3.96 days and consists of an evolved 06.5 V((f)) primary and an 08.5-9.5 V((f)) secondary with minimum masses of m, sin(3) i = 13.9 M-circle dot and m(2) sin 3 i = 10.9 M-circle dot. The observed primary/secondary mass ratio (1.28) appears lower than expected from a comparison with single star evolutionary models (1.60-1.74). For the other two stars, BD+60degrees 501 and BD+60degrees 513, we find no significant radial velocity variations, suggesting that they are most probably single. Although a fraction of binaries among the early-type stars of IC 1805 as high as 80% has been advocated in the literature, our results suggest that this number might be overestimated. [less ▲]

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See detailEarly-type stars in the young open cluster IC 1805. II. The probably single stars HD 15570 and HD 15629, and the massive binary/triple system HD 15558
De Becker, Michaël ULg; Rauw, Grégor ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (2006), 456

Aims.We address the issue of the multiplicity of the three brightest early-type stars of the young open cluster IC 1805, namely HD 15570, HD 15629 and HD 15558. Methods: .For the three stars, we measured ... [more ▼]

Aims.We address the issue of the multiplicity of the three brightest early-type stars of the young open cluster IC 1805, namely HD 15570, HD 15629 and HD 15558. Methods: .For the three stars, we measured the radial velocity by fitting Gaussian curves to line profiles in the optical domain. In the case of the massive binary HD 15558, we also used a spectral disentangling method to separate the spectra of the primary and of the secondary in order to derive the radial velocities of the two components. These measurements were used to compute orbital solutions for HD 15558. Results: .For HD 15570 and HD 15629, the radial velocities do not present any significant trend attributable to a binary motion on time scales of a few days, nor from one year to the next. In the case of HD 15558 we obtained an improved SB1 orbital solution with a period of about 442 days, and we report for the first time on the detection of the spectral signature of its secondary star. We derive spectral types O5.5III(f) and O7V for the primary and the secondary of HD 15558. We tentatively compute a first SB2 orbital solution although the radial velocities from the secondary star should be considered with caution. The mass ratio is rather high, i.e. about 3, and leads to very extreme minimum masses, in particular for the primary object. Minimum masses of the order of 150 ± 50 and 50 ± 15 M_ȯ are found respectively for the primary and the secondary. Conclusions: .We propose that HD 15558 could be a triple system. This scenario could help to reconcile the very large minimum mass derived for the primary object with its spectral type. In addition, considering new and previously published results, we find that the binary frequency among O-stars in IC 1805 has a lower limit of 20%, and that previously published values (80%) are probably overestimated. [less ▲]

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