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See detailEarly release of myeloperoxydase and lactoferin after direct stenting in patient presented for unstable angina
Gach, Olivier ULg; Biemar, C.; Pierard, Luc ULg et al

in European Heart Journal (2004), 25(Suppl. S), 450-450

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See detailEarly release of neutrophil markers of activation after direct stenting in patients with unstable angina
Gach, Olivier ULg; Biemar, Christian; Nys, Monique ULg et al

in Coronary Artery Disease (2005), 16(1), 59-65

Objective To assess polymorphonuclear neutrophils activation after stenting in acute coronary syndromes studied by myeloperoxydase, lactoferrin and elastase release in this clinical setting. Methods ... [more ▼]

Objective To assess polymorphonuclear neutrophils activation after stenting in acute coronary syndromes studied by myeloperoxydase, lactoferrin and elastase release in this clinical setting. Methods Myeloperoxydase, lactoferrin, elastase, C-reactive protein and cytokines serum levels were assessed in 20 patients undergoing catheterization for unstable angina. Serial sampling starting before arteriography and continued up to 24 h was carried out in 15 patients undergoing direct stenting (group A) and in five patients assessed by coronary angiography only (group B). Results Myeloperoxydase, lactoferrin and elastase levels remained unchanged following catheterization, whereas a significant increase in myeloperoxydase (P=0.0009) and lactoferrin (P=0.004) was observed after stenting. No change in levels of tumour necrosis factor alpha, interleukin (IL)-8 and IL-12 was found in group B after catheterization at the different sampling times, although IL-8 and IL-12 levels increased transiently following stenting. IL-6 values increased in both groups. Baseline values of C-reactive protein were similar in each group. A progressive increase in C-reactive protein was noted in both groups and appeared to be larger following stenting (group A: P=0.0002; group B: P=0.01). Conclusions In patients with unstable angina, stenting is associated by immediate neutrophil activation followed by release of inflammatory cytokines (IL-6, IL-8, IL-12) and C-reactive protein elevation. This study points out a potential role of myeloperoxydase as a trigger for inflammatory reaction in patients with unstable coronary syndromes undergoing percutaneous coronary intervention. (C) 2005 Lippincott Williams WillZins. [less ▲]

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See detailEarly response of lymphocyte proteins after gamma-radiation
Turtoi, Andrei ULg; Srivastava, Alok; Sharan, Rajesh et al

in Journal of Radioanalytical & Nuclear Chemistry (2007), 274(2), 435-39

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See detailEarly retention in kindergarten: risk factors and pathways in primary education
Lafontaine, Dominique ULg; Chenu, Florent ULg; Dupont, Virginie

Conference (2013, August 31)

In French-speaking Belgium, about 4% of the children are retained in kindergarten. What are the pupils’ characteristics and the school context variables predictive of the retention in kindergarten? What ... [more ▼]

In French-speaking Belgium, about 4% of the children are retained in kindergarten. What are the pupils’ characteristics and the school context variables predictive of the retention in kindergarten? What are the pathways in primary education of “retained” pupils compared to their peers who started 1st grade “on time”? How can this early retention be explained? A broad database with entire cohorts has been used for studying the risk factors and the pupils’ school careers in primary education. Moreover, teachers’ beliefs about retention, learning and teaching have been investigated through a questionnaire administered to a representative sample of preschool and 1st grade teachers. The multilevel regression analyses show that the following variables are significantly predictive of retention in kindergarten: month of birth, gender, socioeconomic status, country of birth and at the school level, mean school social intake. Investigation about teachers’ belief shows that the vast majority of teachers are convinced that retention in kindergarten is beneficial for later achievement and not detrimental at a psychological level. Preschool and 1st grade teachers share some mutual expectations about the level of prerequisites for entering 1st grade. Even if they are no formal instructions or benchmarks, kids who are not “ready” should not enter 1st grade, but rather stay one more year in kindergarten. Those results can be related to the “culture” of the education system in Belgium, a non-comprehensive one: pupils with learning difficulties are kept apart from their age group or peers through grade retention, early tracking and special education. [less ▲]

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See detailEarly retention in kindergarten: risk factors and school career in French-speaking Belgium primary education
Lafontaine, Dominique ULg; Chenu, Florent ULg; Dupont, Virginie ULg

Conference (2013, August 31)

In French-speaking Belgium, about 4% of the children are retained in kindergarten. What are the pupils’ characteristics and the school context variables predictive of the retention in kindergarten? What ... [more ▼]

In French-speaking Belgium, about 4% of the children are retained in kindergarten. What are the pupils’ characteristics and the school context variables predictive of the retention in kindergarten? What are the pathways in primary education of “retained” pupils compared to their peers who started 1st grade “on time”? How can this early retention be explained? A broad database with entire cohorts has been used for studying the risk factors and the pupils’ school careers in primary education. Moreover, teachers’ beliefs about retention, learning and teaching have been investigated through a questionnaire administered to a representative sample of preschool and 1st grade teachers. The multilevel regression analyses show that the following variables are significantly predictive of retention in kindergarten: month of birth, gender, socioeconomic status, country of birth and at the school level, mean school social intake. Investigation about teachers’ belief shows that the vast majority of teachers are convinced that retention in kindergarten is beneficial for later achievement and not detrimental at a psychological level. Preschool and 1st grade teachers share some mutual expectations about the level of prerequisites for entering 1st grade. Even if they are no formal instructions or benchmarks, kids who are not “ready” should not enter 1st grade, but rather stay one more year in kindergarten. Those results can be related to the “culture” of the education system in Belgium, a non-comprehensive one: pupils with learning difficulties are kept apart from their age group or peers through grade retention, early tracking and special education. [less ▲]

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See detailEarly retirement in Europe: A call for action
Jousten, Alain ULg

in CESIFO Forum (2001), 4

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See detailEarly retirement, activities after retirement and the cognitive reserve
Adam, Stéphane ULg; Bay, Christelle; Perelman, Sergio ULg

Conference (2005, September 26)

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See detailEarly seed plant radiation : an ecological hypothesis.
Prestianni, Cyrille ULg; Gerrienne, Philippe ULg

in Special Publication - Geological Society of London (2010), 339

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See detailEarly sex reversal during the embryonic development in the Nile tilapia
Rougeot, Carole ULg; Kanfitine, Samane, Yadja; Prignon, Christian ULg et al

in Cybium (2008), 32(2), 104-105

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See detailEarly Silurian cryptospores from the subsurface of Saudi Arabia
Wellman, C.; Breuer, P.; Miller, M. et al

Conference (2014, August 26)

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See detailEarly Silurian miospores from the Paraná Basin, South America
Steemans, Philippe ULg; Pereira, E.

Conference (2001)

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See detailEarly Silurian trilete spores and cryptospores, Paraguay
Steemans, Philippe ULg; Pereira, E.

Conference (2000)

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See detailEarly Stage Results after Oesophageal Resection for Malignancy - Colon Interposition Vs. Gastric Pull-Up
Kolh, Philippe ULg; Honore, Pierre ULg; Degauque, C. et al

in European Journal of Cardio - Thoracic Surgery (2000), 18(3), 293-300

OBJECTIVE: The aims of our study were to determine if using the colon as a digestive transplant after oesophagectomy for cancer was associated with increased postoperative complications, and to assess the ... [more ▼]

OBJECTIVE: The aims of our study were to determine if using the colon as a digestive transplant after oesophagectomy for cancer was associated with increased postoperative complications, and to assess the impact of preoperative radiochemotherapy on postoperative hospital outcome. METHODS: From January 1990 to December 1998, 130 patients underwent oesophageal resection for malignancy. There were 103 males and 27 females (age: 61.3+/-11.5 years). Indications were squamous cell carcinoma in 69 patients and adenocarcinoma in 61. Preoperatively 30 patients (eight in stage IIB, 18 in stage III, and four in stage IV) received radiochemotherapy. There were 84 subtotal oesophagectomies, with anastomosis in the neck in 44 patients and at the thoracic inlet in 40, and 46 distal oesophageal resections. Digestive continuity was restored with the stomach in 92 patients (age: 63.4+/-10.2 years) and the colon in 38 (age: 52.3+/-12.8 years). With the exception of age (P<0.0001), there was no significant preoperative difference between gastric and colonic groups. RESULTS: Hospital mortality was 8.5% (11 patients), decreasing from 18.5% (before 1993) to 3.8% (since 1993). One patient (2.5%) died in the colonic graft group and ten (11%) in the gastric pull-up group (P=0.17). Postoperative complications occurred in 40 patients (31%), respectively, in ten (26%) and 30 (33%) patients after colonic and gastric transplants (P=0.48), and were pulmonary insufficiency or infection in 29 patients, anastomotic fistula in six, myocardial infarction in five, recurrent nerve palsy in four, renal insufficiency in three, and cerebrovascular accident in one. All fistulas occurred in the gastric pull-up group. The incidence of postoperative pulmonary complications was 70% (21/30 patients) in the subgroup who received preoperative radiochemotherapy, as compared to 11% (5/44 patients) in the subgroup of comparable staging, but without preoperative treatment (P<0.001). CONCLUSIONS: Colonic grafts are not associated with increased postoperative mortality or complications. Our results suggest that preoperative neoadjuvant treatment significantly increases postoperative pulmonary complications. [less ▲]

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See detailThe early stages of photosystem II assembly monitored by measurements of fluorescence lifetime, fluorescence induction and isoelectric focusing of chlorophyll-proteins in barley etiochloroplasts
MysliwaKurdziel, B.; Barthelemy, X.; Strzalka, K. et al

in Plant & Cell Physiology (1997), 38(11), 1187-1196

The relationship between functional and structural aspects of PSII formation during greening of etiolated barley leaves has been investigated using fluorescence life-time measurements, fluorescence ... [more ▼]

The relationship between functional and structural aspects of PSII formation during greening of etiolated barley leaves has been investigated using fluorescence life-time measurements, fluorescence kinetics analysis and analysis of chlorophyll-protein complexes by IEF-PAGE, Two phases of different character could be distinguished in the course of the greening process in dark-grown plants, An early phase covering the first 3-4 h after the onset of illumination and a late phase covering the subsequent greening, During the first phase the formation of PSII reaction centers and their minor antenna components was observed as manifested by the IEF-PAGE polypeptide pattern, This was accompanied by shortening of the slow and middle components of the fluorescence lifetime, as well as by the rapid drop in the amplitude of the slow component, A room temperature emission band at 676 nm was associated with uncoupled chlorophyll and with the slow fluorescence lifetime component during the first hours of greening. During the late greening phase peripheral light-harvesting complexes of PSII were formed concomitantly to an increase in lifetime and amplitude of the fast component and to a further decrease in the lifetime of the middle component, The gradual increase in PSII complexity during both phases of greening was also manifested by changes in proportion and kinetic properties of PSIIalpha and PSIIbeta units. Similar changes in fluorescence lifetime components as in the late greening of dark-grown plants were also observed in intermittent-light plants during continuous greening associated with the development of PSII antenna. The relationships between fluorescence lifetime characteristics and development of PSII are discussed in terms of a stepwise mechanism invoving a first step of Chl integration into small size PSII units followed by progressive increase of antenna size. [less ▲]

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See detailEarly Structural Assessment and Optimisation of Passenger Ships
Caprace, Jean-David ULg; Bair, Frédéric ULg; Rigo, Philippe ULg

in Procceding of the International Conference on Design and Operation of Passenger Ships (2011, February 23)

A multi-criteria optimisation of a passenger ship is conducted in this paper. Minimum production cost and minimum steel weight are the both objective studied. Moreover the study answers to the following ... [more ▼]

A multi-criteria optimisation of a passenger ship is conducted in this paper. Minimum production cost and minimum steel weight are the both objective studied. Moreover the study answers to the following question: "From when will the higher costs of high tensile steel should be offset by a gain of steel weight?". For a passenger ship, a significant reduction of the steel weight, for a controlled raise of the gravity centre, should lead either to a reduction of fuel consumption either to an additional deck, which for a ship owner means a faster return on investment. Pareto frontiers are obtained and results are validated by classification rules. [less ▲]

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See detailearly surfactant changes afetr surfactant therapy in premature infants assisted by HFOV
Battisti, Oreste ULg

in Pediatric Research (1998), 2

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See detailEarly termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults.
Robe, Pierre ULg; Martin, Didier ULg; Nguyen-Khac, Minh-Tuan ULg et al

in BMC Cancer (2009), 9

BACKGROUND: Sulfasalazine, a NF-kappaB and x(c)-cystine/glutamate antiport inhibitor, has demonstrated a strong antitumoral potential in preclinical models of malignant gliomas. As it presents an ... [more ▼]

BACKGROUND: Sulfasalazine, a NF-kappaB and x(c)-cystine/glutamate antiport inhibitor, has demonstrated a strong antitumoral potential in preclinical models of malignant gliomas. As it presents an excellent safety profile, we initiated a phase 1/2 clinical study of this anti-inflammatory drug for the treatment of recurrent WHO grade 3 and 4 astrocytic gliomas in adults. METHODS: 10 patients with advanced recurrent anaplastic astrocytoma (n = 2) or glioblastoma (n = 8) aged 32-62 years were recruited prior to the planned interim analysis of the study. Subjects were randomly assigned to daily doses of 1.5, 3, 4.5, or 6 grams of oral sulfasalazine, and treated until clinical or radiological evidence of disease progression or the development of serious or unbearable side effects. Primary endpoints were the evaluation of toxicities according to the CTCAE v.3.0, and the observation of radiological tumor responses based on MacDonald criteria. RESULTS: No clinical response was observed. One tumor remained stable for 2 months with sulfasalazine treatment, at the lowest daily dose of the drug. The median progression-free survival was 32 days. Side effects were common, as all patients developed grade 1-3 adverse events (mean: 7.2/patient), four patients developed grade 4 toxicity. Two patients died while on treatment or shortly after its discontinuation. CONCLUSION: Although the proper influence of sulfasalazine treatment on patient outcome was difficult to ascertain in these debilitated patients with a large tumor burden (median KPS = 50), ISRCTN45828668 was terminated after its interim analysis. This study urges to exert cautiousness in future trials of Sulfasalazine for the treatment of malignant gliomas. TRIAL REGISTRATION: Current Controlled Trials ISRCTN45828668. [less ▲]

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