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See detailThe effect of BaZrO3 addition on transport properties of Dy-based 123-211 composite materials: electrical resistivity, thermal conductivity and thermoelectric power
Bougrine, Hassan ULg; Ausloos, Marcel ULg; Pekala, M. et al

in Superconductor Science & Technology (1998), 11(8), 803-809

Composite samples made of 123-211 DyBaCuO-based systems with 1, 4, 10 and 15% in weight BaZrO3 additions have been synthesized. Their electrical resistivity, thermal conductivity and thermoelectric power ... [more ▼]

Composite samples made of 123-211 DyBaCuO-based systems with 1, 4, 10 and 15% in weight BaZrO3 additions have been synthesized. Their electrical resistivity, thermal conductivity and thermoelectric power have been measured. The electrical resistivity has also been measured in a magnetic field less than 1 T. The data show that BaZrO3 addition has a non-trivial effect: beside mildly reducing the critical temperature of the superconductor, it increases the scattering at small concentration, and effectively reduces weak link features in the electrical property, but increases the thermal conductivity. The field influence on T-c is shown to be T-c(O)- T-c(B) approximate to B-1/2. [less ▲]

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See detailEffect of BaZrO3 additions on the microstructure and physical properties of melt-textured Y-123 superconducting materials
Cloots, Rudi ULg; Robertz, B.; Auguste, F. et al

in Materials Science & Engineering : B (1998), 53(1-2), 154-158

The effect of BaZrO3 additions on the microstructure and physical properties of melt-textured Y-123 have been investigated. The distribution of the 211 particles is strongly modified by the presence of ... [more ▼]

The effect of BaZrO3 additions on the microstructure and physical properties of melt-textured Y-123 have been investigated. The distribution of the 211 particles is strongly modified by the presence of such an additive. In fact, BaZrO3 is effective in reducing the size of the 211 particles. As a consequence, a strong interaction in terms of repulsion takes place between the 123 growth front and the 211 particles which are partially dissolved in the reactive liquid phase. New types of patterns are also reported in the microstructure of such materials and are related to the presence of BaZrO3 in the melt. [less ▲]

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See detailEffect of Beclomethasone Dipropionate and Dexamethasone Isonicotinate on Lung Function, Bronchoalveolar Lavage Fluid Cytology, and Transcription Factor Expression in Airways of Horses with Recurrent Airway Obstruction
Couetil, L.; Art, Tatiana ULg; de Moffarts, Brieuc et al

in Journal of Veterinary Internal Medicine (2006), 20

Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti-inflammatory properties of GC are thought to be mediated by suppression of ... [more ▼]

Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti-inflammatory properties of GC are thought to be mediated by suppression of inflammatory gene expression via inhibition of transcription factors such as nuclear factor-kB (NF-kB) and activator protein-1 (AP-1). The purpose of this study was to evaluate the effect of low-dose inhaled beclomethasone dipropionate and injectable dexamethasone 21- isonicotinate on clinical signs, pulmonary function, airway cytology, and activity of NF-kB and AP-1 in bronchial cells of RAO-affected horses. Seven horses with RAO were exposed to moldy hay until they developed airway obstruction on 3 separate occasions. In a crossover design, they were then treated with a placebo (injection on day 1), inhaled beclomethasone (500 mg q12h for 10 days), or dexamethasone (0.06 mg/kg, IM on day 1) and monitored for 10 days. Pulmonary function, bronchoalveolar lavage fluid cytology, and NF-kB and AP-1 activity in bronchial brushing cells were measured before (day 1) and after treatment (day 10). Treatment with beclomethasone resulted in significantly improved pulmonary function of RAOaffected horses compared with placebo and dexamethasone treatments. However, none of the treatments had an effect on bronchoalveolar lavage fluid cytology or NF-kB and AP-1 activity. These findings reveal that, in a model of severe RAO, the benefits of low-dose inhaled beclomethasone on pulmonary function are not accompanied by a decrease in airway inflammatory cells or a suppression of transcription factors NF-kB and AP-1 DNA-binding activity. [less ▲]

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See detailEffect of beef type, body weight and dietary protein content on voluntary feed intake, digestibility, blood and urine metabolites and nitrogen retention
Fiems, Leo; Cottyn, B. G.; Boucqué, Charly et al

in Journal of Animal Physiology & Animal Nutrition (1997), 77

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See detailEffect of Benchmark Misspecification on Risk-Adjusted Performance Measures
Bodson, Laurent ULg; Hübner, Georges ULg

in Gregoriou, Greg N.; Hoppe, Christian; Wehn, Carsten (Eds.) The Risk Modeling Evaluation Handbook (2010)

Detailed reference viewed: 95 (25 ULg)
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See detailEffect of benzoic acid analogs on myeloperoxidase activity measured by a new technique to study their direct interaction with the enzyme.
Franck, Thierry ULg; Mazloum, Ali; Mouithys-Mickalad, Ange ULg et al

Poster (2011, May)

Myeloperoxidase (MPO) plays a key role in inflammatory response and constitutes a target for new drug development. The effects of some benzoic acid analogs were studied on the specific activity of human ... [more ▼]

Myeloperoxidase (MPO) plays a key role in inflammatory response and constitutes a target for new drug development. The effects of some benzoic acid analogs were studied on the specific activity of human MPO measured by SIEFED (“Specific Immunologic Extraction Followed by Enzymatic Detection”), an original method that consists of incubation of the compound with MPO, followed by capture of the enzyme by specific antibodies, washing (elimination of the compounds) and enzymatic detection of the immunocaptured enzyme. The compounds tested at 10-4, 10-5 and 10-6 M were studied in terms of structure activity relationship. Gallic acid (3,4,5-trihydroxybenzoic acid) with 3 hydroxyl groups had an important dose dependent inhibitory effect on MPO activity. Other molecules with less or without hydroxyl groups [3,4-dihydroxybenzoic acid, 2-hydroxybenzoic acid (salicylic acid) and benzoic acid] had rather an activator effect at 10-5 and 10-6 M. 2,4,6-Trihydroxybenzoic acid, with two hydroxyl groups adjacent to the carboxyl group, had a less efficient inhibitory effect. Caffeic acid (3,4-dihydroxycinnamic acid) with a propenoic acid group presented a dose dependent inhibitory effect on MPO activity contrary to its analog 3,4-dihydroxybenzoic acid. The esterification of the carboxyl group of gallic acid to obtain propyl gallate induced an activation of MPO at 10-5 and 10-6 M. Finally, the substitution of one or two hydroxyl groups by methoxyl ones (ferulic and syringic acids) decreased the efficiency of the molecules on the enzyme inhibition. The SIEFED technique appears as an innovative pharmacological tool to study the direct interaction of compounds with MPO. Number and position of hydroxyl groups and the extension of the carboxyl group of benzoic acid play a crucial role in the inhibition of MPO activity probably by facilitating the interaction with the active site or another elements of the enzyme structure. [less ▲]

Detailed reference viewed: 37 (3 ULg)
See detailThe effect of bequest motives on the composition and distribution of assets in France
Arrondel, L.; Pestieau, Pierre ULg; Perelman, Sergio ULg

in Tachibanaki, T. (Ed.) Saving and Bequest (1994)

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See detailTHE EFFECT OF BETA MICROPROBE IMPLANTATION ON THE BLOOD BRAIN BARRIER
Warnock, Geoffrey ULg; Dedeurwaardere, Stefanie; Bahri, Mohamed Ali ULg et al

Poster (2010, September)

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See detailEffect of BHT-920 on monoaminergic neurons of the rat brain : an electrophysiological in vivo and in vitro study
Seutin, Vincent ULg; Scuvée-Moreau, Jacqueline ULg; Giesbers, Irène ULg et al

in Mededelingen van de Faculteit Landbouwwetenschappen (Rijksuniversiteit te Gent) (1990), 342

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See detailEffect of bi-level positive airway pressure (BiPAP) nasal ventilation on the postoperative pulmonary restrictive syndrome in obese patients undergoing gastroplasty.
Joris, Jean ULg; Sottiaux, Thierry; Chiche, Jean-Daniel et al

in CHEST (1997), 111(3), 665-70

STUDY OBJECTIVE: Upper abdominal surgery results in a postoperative restrictive pulmonary syndrome. Bi-level positive airway pressure (BiPAP System; Respironics Inc; Murrysville, Pa), which combines ... [more ▼]

STUDY OBJECTIVE: Upper abdominal surgery results in a postoperative restrictive pulmonary syndrome. Bi-level positive airway pressure (BiPAP System; Respironics Inc; Murrysville, Pa), which combines pressure support ventilation and positive end-expiratory pressure via a nasal mask, could allow alveolar recruitment during inspiration and prevent expiratory alveolar collapse, and therefore limit the postoperative pulmonary restrictive syndrome. This study investigated the effect of BiPAP on postoperative pulmonary function in obese patients after gastroplasty. DESIGN: Prospective controlled randomized study. SETTING: GI surgical ward in a university hospital. PATIENTS: Thirty-three morbidly obese patients scheduled for gastroplasty were studied. INTERVENTION: The patients were assigned to one of three techniques of ventilatory support during the first 24 h postoperatively: O2 via a face mask, BiPAP System 8/4, with inspiratory and expiratory positive airway pressure set at 8 and 4 cm H2O, respectively, or BiPAP System 12/4 set at 12 and 4 cm H2O. Pulmonary function (FVC, FEV1, and peak expiratory flow rate [PEFR]) were measured the day before surgery, 24 h after surgery, and on days 2 and 3. Oxygen saturation by pulse oximeter (SpO2) was also recorded during room air breathing. RESULTS: Three patients were excluded. After surgery, FVC, FEV1, PEFR, and SpO2 significantly decreased in the three groups. On day 1, FVC and FEV1 were significantly improved in the group BiPAP System 12/4, as compared with no BiPAP; SpO2 was also significantly improved. After removal of BiPAP System 12/4, these benefits were maintained, allowing faster recovery of pulmonary function. No significant effects were observed on PEFR. BiPAP System 8/4 had no significant effect on the postoperative pulmonary restrictive syndrome. CONCLUSION: Prophylactic use of BiPAP System 12/4 during the first 24 h postoperatively significantly reduces pulmonary dysfunction after gastroplasty in obese patients and accelerates reestablishment of preoperative pulmonary function. [less ▲]

Detailed reference viewed: 120 (2 ULg)
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See detailEffect of bilateral stimulation on spinal evoked potentials in dogs
Poncelet, Luc; Delauche, A.; Vinals, C. et al

in American Journal of Veterinary Research (1992)

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See detailEffect of bio-sourced compounds on activation of immune cells in the view of to improve immunotherapy of malignant pleural mesothelioma
Hamaïdia, Malik ULg

Poster (2013, July)

Glycans are macromolecules (O-glycosidic and N-glycosidic linkage of monosacharides) which can be extracted from various agricultural products (i.e. cellulose, lignin, starch, insect). Preliminary data ... [more ▼]

Glycans are macromolecules (O-glycosidic and N-glycosidic linkage of monosacharides) which can be extracted from various agricultural products (i.e. cellulose, lignin, starch, insect). Preliminary data indicate that glycans can stimulate inflammation without initiating an anti-inflammatory feedback loop. Notwithstanding, inhibition of immune response by anti-inflammatory cytokines is a major cause of cancer therapy failure in human. The goal of the project is to study the ability of glycans to modulate the functions of macrophages and dendritic cells in order to stimulate anti-tumor immune response. The project aims to assess this hypothesis in a high incidence cancer: Malignant Pleural Mesothelioma. Glycan extracts will be isolated from a variety of agroforestry resources and especially broadleaved trees of the different systems tested on the platform AgricultureIsLife (zones 1-3 : hedges, tree lines, agrisilviculture, short rotation coppice) and modified by physical, chemical, enzymatic or microbiotic approaches. [less ▲]

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See detailEffect of biologically active coating on biocompatibility of Nitinol devices designed for the closure of intra-atrial communications.
Kong, Xiangqing; Grabitz, R. G.; van Oeveren, W. et al

in Biomaterials (2002), 23(8), 1775-83

Anti-thrombogenicity and rapid endothelialisation are prerequisites for the use of closure devices of intra-atrial communications in order to reduce the risk of cerebral embolism. The purpose of this ... [more ▼]

Anti-thrombogenicity and rapid endothelialisation are prerequisites for the use of closure devices of intra-atrial communications in order to reduce the risk of cerebral embolism. The purpose of this study was therefore to assess the effect of bioactive coatings on biocompatibility of Nitinol coils designed for the closure of intra-atrial communications. Nitinol coils (n = 10, each) and flat Nitinol bands (n = 3, each) were treated by basic coating with poly(amino-p-xylylene-co-p-xylylene) and then coated with either heparin, r-hirudin or fibronectin. Anti-thrombogenicity was studied in vitro in a dynamic model with whole blood by partial thromboplastin time (PTT), platelet binding and thrombin generation, respectively, and cytotoxicity by hemolysis. Endothelialisation was studied on Nitinol bands with human umbilical venous endothelial cells (HUVEC) by 3-(4,5-dimethylthiazole-2yl)-2,5-triphenyl tetrazolium (MTT) assay and immnuofluorescence analysis of Ki67, vinculin, fibronectin and von Willebrand Factor. Uncoated or coated devices did not influence hemolysis and PTT. r-Hirudin (but not heparin) and fibronectin coating showed lower platelet binding than uncoated Nitinol (p < 0.005, respectively). Heparin and r-hirudin coating reduced thrombin formation (p < 0.05 versus Nitinol, respectively). HUVEC adhesion, proliferation, and matrix formation decreased in the order: fibronectin coating > uncoated Nitinol > r-hirudin coating > heparin coating > basic coating. MTT assay corroborated these findings. In conclusion, r-hirudin and fibronectin coating, by causing no acute cytotoxicity, decreasing thrombogenicity and increasing endothelialisation improve in vitro biocompatibility of Nitinol devices designed for the closure of intra-atrial communications. [less ▲]

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See detailEffect of blend levels on composite wheat doughs performance made from yam and cassava native starches and bread quality
Nindjin, Charlemagne; Amani, G. N.; Sindic, Marianne ULg

in Carbohydrate Polymers (2011), 86

The effects of refined wheat flour substitution with two native starches from yam tuber and cassava root, and two commercial products, a specialty starch, C*Actistar and a wheat bran flour, at 10%, 20 ... [more ▼]

The effects of refined wheat flour substitution with two native starches from yam tuber and cassava root, and two commercial products, a specialty starch, C*Actistar and a wheat bran flour, at 10%, 20%, 30%, 40% and 60% dry basis, on the rheological properties of dough and bread characteristics, have been examined. In general, during the mixing phase, the substitution of white wheat flour for starch or wheat bran flour had a tendency to modify the flour strength from strong to weak, depending on the nature of the added fraction and the level of substitution. Yam starch and wheat bran flour weakened dough strength to a lesser extent in comparison with cassava starch, and by far, the resistant starch, C*Actistar. In addition, differences in dough expansion appeared among the botanical origins of composite dough and the blend proportions, during the fermentation phase. White wheat flour substitution for yam starch up to 30% or cassava starch up to 20% led to kinetics expansions of resulted doughs close to that of the control, while those of doughs containing C*actistar starch or wheat bran flour were significantly slower than that of the control, whatever the level of substitution. The baking phase showed that yam starch enriched breads from 10% to 40% of substitution and cassava starch enriched breads from 10% to 30% of substitution gave as bulky loaves as the refined wheat bread. Beyond these concentrations, the resulting breads were less voluminous. Hedonic tests revealed that, 30% yam starch substitution and 20% added cassava starch led to composite breads which met consumer satisfaction on all attributes, as the control. [less ▲]

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See detailEffect of block copolymers of various molecular architecture on the phase morphology and tensile properties of LDPE rich (LDPE/PS) blends
Harrats, Charef; Fayt, R.; Jérôme, Robert ULg

in Polymer (2002), 43(3), 863-873

The emulsification efficiency of three different block copolymers consisting of hydrogenated polybutadiene (HPB) and polystyrene (PS), i.e. a pure diblock , a tapered diblock and a triblock copolymer has ... [more ▼]

The emulsification efficiency of three different block copolymers consisting of hydrogenated polybutadiene (HPB) and polystyrene (PS), i.e. a pure diblock , a tapered diblock and a triblock copolymer has been compared in low density polyethylene/polystyrene (LDPE/PS) blends rich in polyethylene. The comparison relies upon the ability of these potential interfacial agents to stabilize fine phase dispersion and to promote good interfacial adhesion. Based on the phase morphology, the ultimate tensile properties and the dynamic viscosity of the modified blends, the tapered diblock copolymer is clearly the most efficient emulsifier. For instance a plateau is observed in the property-copolymer content dependence when 2 wt% tapered diblock are used compared to ca. 5 wt% in case of the pure diblock. In contrast, no plateau is observed when the triblock copolymer is used. This is assumed to result from a less quantitative localization of these two copolymers i.e. the pue diblock or the triblock at the LDPE/PS interface. [less ▲]

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See detailThe effect of blood transfusion on cerebral blood-flow in preterm infants: a Doppler study
RAMAEKERS, Vincent ULg; Casaer, P.; Marchal, G. et al

in Developmental medicine and child neurology (1988), 30(3), 334-41

Stable infants with anaemia needing a transfusion with adult red blood-cells were studied to elucidate changes in brain blood-flow velocity. Within 24 hours and at five to six days following transfusion a ... [more ▼]

Stable infants with anaemia needing a transfusion with adult red blood-cells were studied to elucidate changes in brain blood-flow velocity. Within 24 hours and at five to six days following transfusion a substantial mean flow velocity reduction was observed. Haemodynamic factors contributing to the reduction were an increase in cerebrovascular resistance and an increase in whole blood viscosity, as reflected by a raised pulsatility index. Transfusion with adult red blood-cells causes an elevation in haemoglobin concentration, thereby increasing the total oxygen-carrying capacity of arterial blood; however, this lowers the concentration of fetal haemoglobin which possesses a higher affinity for oxygen. Since cerebral oxygen transport is equal to the product of cerebral blood-flow and arterial oxygen content, this finding suggests the existence of a homeostatic mechanism for cerebral oxygen transport. The actual amount of cerebral oxygen transport was found to increase progressively as the percentage of fetal haemoglobin rose above 30 per cent. At higher fetal haemoglobin levels, appropriate elevations in cerebral blood-flow occurred, causing an increase in the supply of oxygen to the brain. [less ▲]

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See detailEffect of blue monochromatic light on non-visual functions in aging
Daneault, V; Vandewalle, Gilles ULg; Teikari, P et al

Poster (2011, June)

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See detailEffect of BM-573[N-terbutyl-N '-[2-(4 '-methylphenylamino)-5-nitro-benzenesulfonyl] urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism
Ghuysen, Alexandre ULg; Lambermont, Bernard ULg; Dogné, Jean-Michel ULg et al

in Journal of Pharmacology and Experimental Therapeutics (The) (2004), 310(3), 964-972

The aim of this study was to evaluate the effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl] urea], a dual thromboxane A(2) synthase inhibitor and receptor antagonist, on ... [more ▼]

The aim of this study was to evaluate the effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl] urea], a dual thromboxane A(2) synthase inhibitor and receptor antagonist, on the hemodynamic response to acute pulmonary embolism. Six anesthetized pigs were infused with placebo ( placebo group) and compared with six other pigs receiving a continuous infusion of BM-573 ( BM group). Pulmonary embolization with 0.3 g/kg autologous blood clots was carried out 30 min after the start of the infusion. Right ventricular pressure-volume loops were recorded using a conductance catheter, and end-systolic ventricular elastance was periodically assessed by varying right ventricular preload. Pulmonary vascular properties were studied by use of a four-element wind-kessel model. Hemodynamic data, including assessment of right ventricular-arterial coupling, were collected at baseline and every 30 min for 4 h. Blood samples were collected to assess gas exchange, thromboxane A(2), and prostacyclin plasma levels and to evaluate platelet aggregation. Mean pulmonary arterial pressure in the placebo group increased significantly more than in the BM group, mainly because of an additional increase in pulmonary vascular resistance. Arterial and end-systolic ventricular elastances increased also more in the placebo group, whereas right ventricular efficiency decreased. BM-573 prevented both platelet aggregation induced by U-46619 (9,11-dideoxy-11alpha, 9alpha-epoxymethanoprostaglandin F-2alpha) or by arachidonic acid, and thromboxane A(2) overproduction, whereas prostacyclin liberation was preserved. Oxygenation, however, was not significantly improved. We conclude that in this animal model of acute pulmonary embolism, infusion of BM-573 reduced pulmonary vasoconstriction. As a result, right ventricular-vascular coupling values were maintained at a maximal efficiency level. [less ▲]

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See detailEffect of Body Weight Loss on Cardiopulmonary Function assessed by 6-Minute Walk Test and Arterial Blood Gas Analysis in Obese Dogs
Manens; Ricci, R; Damoiseaux, C et al

in Journal of Veterinary Internal Medicine (2014), 28(2), 371-378

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See detailEffect of body weight losson pulmonary function assessed by 6-minute walk test and arterial blood gases in obese dogs
Manens, Jeff; Damoiseaux, Cécile ULg; Gault, Simon et al

in Proceedings of 22nd ECVIM Meeting - Maastricht, Netherlands (2012, September)

Detailed reference viewed: 20 (6 ULg)