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See detailEffects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation
De Leval, X.; Benoit, V.; Neven, P. et al

in Fundamental & Clinical Pharmacology (2002)

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See detailEffects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation
De Leval, X.; Benoit, V.; Neven, P. et al

in Fundamental & Clinical Pharmacology (2002), 16

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See detailEffects of time of day on age-related differences in cognitive tests.
Schmitz, Xavier ULg; Willems, Sylvie ULg; Meulemans, Thierry ULg

Poster (2009, June 03)

Previous studies have shown a shift in the circadian rhythm – and more particularly in the optimal time of day (OTD) – across the adult life span (May et al., 1993). The aim of this study was to ... [more ▼]

Previous studies have shown a shift in the circadian rhythm – and more particularly in the optimal time of day (OTD) – across the adult life span (May et al., 1993). The aim of this study was to investigate the relationship between cognitive efficiency and OTD in 113 healthy old adults (Age: M = 69, SD = 6.1, Range = 60-80) and 175 younger adults (M = 40.8, SD = 12.9, Range = 20-59). Participants performed a large battery of cognitive tests that assessed episodic memory, working memory, executive and attentional functions. Results on the MEQ (Morningness-Eveningness Questionnaire; Horne & Östberg, 1976) confirmed the age-related shift toward a self-reported morning preference in older adults. Second, the categorization of participants according to their MEQ scores and the time of testing revealed that the OTD has a greater impact upon cognitive performance in older than in younger adults. Third, the age-related OTD impact was more striking in working memory (Brown-Peterson and Pasat) and episodic memory tasks (Buschke) than in other aspects of the cognitive functioning. In conclusion, older participants tested during their peak circadian periods tend to show greater performance on memory tasks that require careful or strategic processing relative to older participants who are tested at off-peak times of day. Taken together, these findings indicate that care must be taken when investigators are considering the effects of age on effortful memory tasks, which are particularly modulated by OTD in older adults. [less ▲]

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See detailEffects of trace metals on mouse B16 melanoma cells in culture
Bahbouth, Eliane; Siwek, Brigitte; Gillet, Marie-Claire ULg et al

in Biological Trace Element Research (1993), 36(2), 191-201

The effects of fourteen metal ions on B16 cell proliferation, differentiation and melanogenesis have been analysed.

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See detailEffects of training on delayed onset muscle soreness following isokinetic eccentric exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Ledent, M. et al

in Archives of Physiology & Biochemistry (1999, September), 107(suppl september 1999), 101

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See detailEffects of Training on Exercise-Induced Muscle Damage and Interleukin 6 Production
Croisier, Jean-Louis ULg; Camus, G.; Venneman, Ingrid ULg et al

in Muscle & Nerve (1999), 22(2), 208-12

To address the question of whether the increased plasma concentration of interleukin 6 (IL-6) following strenuous muscular work could be related to exercise-induced muscle damage, 5 moderately active male ... [more ▼]

To address the question of whether the increased plasma concentration of interleukin 6 (IL-6) following strenuous muscular work could be related to exercise-induced muscle damage, 5 moderately active male volunteers underwent two isokinetic exercise sessions in the eccentric mode, separated by a period of 3 weeks during which the subjects underwent five training sessions. Before training, exercise was followed by severe muscle pain (delayed-onset muscle soreness; DOMS), and by significant increases in plasma IL-6 level and serum myoglobin concentration (SMb) (P < 0.001). After training, postexercise DOMS and SMb values were significantly lower than those measured before training. There was no significant difference between plasma IL-6 levels measured at the same time points before and after training. We conclude that the hypothetical relationship between exercise-induced muscle damage and increased postexercise levels of circulating IL-6 is not substantiated by the present results. [less ▲]

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See detailEffects of training on myocellular enzyme leakage and delayed onset muscle soreness following maximal isokinetic eccentric exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Duchateau, J. et al

in Mediators of Inflammation (1997), 6

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See detailThe effects of training on ventilation and blood gases in exercising Thoroughbreds
Roberts, C. A.; Marlin, D. J.; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1999), 30

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the ... [more ▼]

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the type frequently used for Thoroughbred racehorses in Great Britain. Standardized treadmill exercise tests (2 min canter at 8 and 10 m/s C8 and C10[ and 2 min gallop at 12 m/s [G12], on a level surface) were performed prior to and after 16 weeks of training. Respiratory flow rates were measured using ultrasound flow transducers. Blood samples were drawn from a transverse facial artery and the right atrium. Minute ventilation, respiratory frequency and tidal volume were not significantly altered by training. Peak inspiratory flow rate was lower following training at 8 and 10 m/s, but not at 12 m/s. Arterial oxygen tension was decreased during trot and canter following training. Blood lactate concentration post G12 decreased following training (10.5 +/- 2.2 mmol/l vs. 7.7 +/- 2.2 mmol/l; P < 0.05). The increase in the degree of exercise-induced arterial hypoxaemia following training may reflect a lack of pulmonary adaptation to training in the face of improved cardiovascular and muscular function. [less ▲]

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See detailEffects of transfusion on serum iron, serum lactate dehydrogenase and platelets in megaloblastic anemia
Fillet, Georges ULg; Andrien, J.-M.; Bury, Jean

in American Journal of Clinical Pathology (1977), 68

In 11 patients with megaloblastic anemia, transfusion of packed erythrocytes or washed erythrocytes invariably resulted in a decline in plasma iron concentration to a range of 20-90 µg/dl (3.6 - 16 µmol/l ... [more ▼]

In 11 patients with megaloblastic anemia, transfusion of packed erythrocytes or washed erythrocytes invariably resulted in a decline in plasma iron concentration to a range of 20-90 µg/dl (3.6 - 16 µmol/l) after 36 or 48 hours. The same phenomenon was observed in two of six cases of ineffective erythropoiesis without megaloblastosis and in none of five cases of aplastic anemia. The observed changes did not result from a specific hematinic response or from iron uptake by a non-erythroid compartment. In megaloblastic anemia, alteration in marrow function in response to transfusion was reflected by plasma iron kinetics and serum lactate dehydrogenase values, which indicated marked reductions in both marrow hyperplasia and ineffective erythropoieseis. Transfusion in megaloblastic anemia was also responsible for a 50% reduction in platelet count after 2 to 6 days. The significance of these changes is discussed. [less ▲]

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See detailEffects of tree species diversity on earthworm communities in European forests
de Wandeler, Hans; Ottoy, Sam; Hermy, Martin et al

Poster (2012, July)

The belowground food web holds a big part of the associated biodiversity in forest ecosystems and plays a major role in essential ecosystem processes, e.g. litter decomposition and nutrient turnover. So ... [more ▼]

The belowground food web holds a big part of the associated biodiversity in forest ecosystems and plays a major role in essential ecosystem processes, e.g. litter decomposition and nutrient turnover. So far, important interactions between diversity and composition of above-and belowground food webs have been observed. However the effects of tree species diversity on the belowground food web are so far not conclusive. This study aims at elucidating the effect of tree species mixtures, species diversity and trait diversity on the composition of the earthworm communities in European forests. Experimental platforms of planted tree species diversity assemblages in Finland (Satakunta) and Germany (Biotree) are therefore intensively sampled for earthworms using the combined mustard extraction/hand sorting method. First results are reported and discussed and diversity effects are evaluated with overyielding tests. [less ▲]

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See detailEffects of tributyltin (TBT) and triphenyltin (TPT) on the reproduction of the freshwater snail Lymnaea stagnalis
Lagadic, Laurent; Giusti, Arnaud ULg; Barsi, Alpar et al

Conference (2012, December 10)

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See detailEffects of two 1-year calcium and vitamin D3 treatments on bone remodeling markers and femoral bone density in elderly women
DEROISY, Rita ULg; Collette, Julien ULg; Chevalier, T et al

in Current Therapeutic Research (1998), 59(12), 850-862

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See detailEffects of Two Calculated Plasma Sufentanil Concentrations on the Hemodynamic and Bispectral Index Responses to Mayfield Head Holder Application
Hans, Pol ULg; Brichant, Jean-François ULg; Dewandre, Pierre-Yves et al

in Journal of Neurosurgical Anesthesiology (1999), 11(2), 81-5

The effects of two calculated plasma sufentanil (SUF) concentrations on the hemodynamic and bispectral index (BIS) responses to Mayfield head holder (MH) application were studied in 20 patients scheduled ... [more ▼]

The effects of two calculated plasma sufentanil (SUF) concentrations on the hemodynamic and bispectral index (BIS) responses to Mayfield head holder (MH) application were studied in 20 patients scheduled for intracranial surgery. Premedication consisted of hydroxyzine, alprazolam, and atropine given orally 1 hour before surgery. Anesthesia was provided with propofol (PPF) and SUF using a target-controlled infusion device. Patients were randomly assigned to one of two groups according to calculated plasma concentrations: 3 microg/mL(-1) of PPF and 0.5 ng/mL(-1) of SUF in group I (GI) and 3 microg/mL(-1) of PPF and 1 ng/mL(-1) of SUF in group II (GII). The MH was fixed 33.0+/-6.6 minutes (mean +/- SD) after induction. Systolic (SAP), diastolic (DAP), and mean arterial pressure (MAP) as well as heart rate (HR) and BIS were recorded 1 minute before pinning (baseline) as well as 1 minute (P1), 2 minutes (P2), and 3 minutes (P3) after pinning. Multivariate repeat-measured analyses of variance were applied to the baseline-subtracted measurements of hemodynamic and BIS values. Groups were compared using the Student's t test, and P < .05 was considered to be statistically significant. Patients' characteristics, baseline hemodynamic values, and BIS values were similar in both groups. A significant overall time effect was observed for all variables, but no significant overall SUF effect was detected. Increases in SAP, MAP, DAP, and HR did not differ significantly between groups. The increase in hemodynamic variables did not exceed 20% of baseline value in either group. In contrast, at P1, the increase in BIS over the baseline value was significantly higher in GI (15.0+/-7.9) than in GII (6.7+/-6.5). In conclusion, MH application was associated with a significant, although not clinically relevant, increase in hemodynamic variables whatever the calculated plasma SUF concentration (0.5 or 1.0 ng/mL(-1)). In contrast, the increase in BIS observed at pinning was significantly higher in patients with the lowest calculated plasma SUF concentrations. This suggests that the BIS response to noxious stimulation is modulated by the analgesic regimen. [less ▲]

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See detailEffects of two levels of energy allowances and of hibernation on growth in hatchling Testudo hermanni boettgeri (Mojsisovic, 1889)
Diez, Marianne ULg; Vanstrazeele, Boris; Detilleux, Johann ULg et al

in Fidgett, Andrea; Noble, Jacqueline E (Eds.) Abstract book of the 5th European Zoo Nutrition Conference (2008, January)

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See detailEffects of two PBDE congeners on the moulting enzymes of the freshwater amphipod Gammarus pulex
Gismondi, Eric ULg; Thomé, Jean-Pierre ULg

in Environmental Pollution (2014)

Polybrominated diphenyl ethers (PBDEs) are abundant in aquatic environment. However, only few studies have investigated their impacts on freshwater invertebrates. This work aimed to study the effects of ... [more ▼]

Polybrominated diphenyl ethers (PBDEs) are abundant in aquatic environment. However, only few studies have investigated their impacts on freshwater invertebrates. This work aimed to study the effects of BDE-47 and BDE-99 congeners on the chitobiase and chitinolytic enzymes activities of the freshwater amphipod Gammarus pulex, according to gender, PBDE concentration and time of exposure. In addition, the bioaccumulation of BDE-47 and BDE-99 were measured. Results revealed that females have bioaccumulated more PBDE than males, and BDE-99 was more accumulated than BDE-47. PBDE exposures for 96hrs have caused chitobiase and chitinolytic enzymes inhibition. This study not only indicate the importance of taking into account various confounding factors (gender, congeners, concentration) to understand PBDE effects, but underline also disruptions of molting enzymes activities. These disturbances suggest effects on the gammarid development and reproduction, and consequently effects on the gammarid population, and on a larger scale, a dysfunction of the ecosystem. [less ▲]

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See detailEffects of U-46619 on Pulmonary Hemodynamics before and after Administration of Bm-573, a Novel Thromboxane A2 Inhibitor
Lambermont, Bernard ULg; Kolh, Philippe ULg; Dogné, Jean-Michel ULg et al

in Archives of Physiology & Biochemistry (2003), 111(3), 217-23

We studied the effects on pulmonary hemodynamics of U-46619, a thromboxane A2 (TXA2) agonist, before and after administration of a novel TXA2 receptor antagonist and synthase inhibitor (BM-573). Six ... [more ▼]

We studied the effects on pulmonary hemodynamics of U-46619, a thromboxane A2 (TXA2) agonist, before and after administration of a novel TXA2 receptor antagonist and synthase inhibitor (BM-573). Six anesthetized pigs (Ago group) received 6 consecutive injections of U-46619 at 30-min interval and were compared with six anesthetized pigs (Anta group) which received an increasing dosage regimen of BM-573 10 min before each U-46619 injection. Consecutive changes in pulmonary hemodynamics, including characteristic resistance, vascular compliance, and peripheral vascular resistance, were continuously assessed during the experimental protocol using a four-element Windkessel model. At 2 mg/kg, BM-573 completely blocked pulmonary hypertensive effects of U-46619 but pulmonary vascular compliance still decreased. This residual effect can probably be explained by a persistent increase in the tonus of the pulmonary vascular wall smooth muscles sufficient to decrease vascular compliance but not vessel lumen diameter. Such molecule could be a promising therapeutic approach in TXA2 mediated pulmonary hypertension as it is the case in pulmonary embolism, hyperacute lung rejection and endotoxinic shock. [less ▲]

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See detailEffects of Unfractionated and Fractionated Heparins on Myeloperoxidase Activity and Interactions with Endothelial Cells: Possible Effects on the Pathophysiology of Equine Laminitis
de la Rebière de Pouyade, Geoffroy ULg; Franck, Thierry ULg; Dupont, Ginette ULg et al

in Veterinary Journal (2007), 178(1), 62-69

As heparins are sometimes used to prevent equine laminitis, the interactions between equine neutrophil myeloperoxidase (MPO), unfractionated (UFH) and fractionated low molecular weight (LMWH) heparins and ... [more ▼]

As heparins are sometimes used to prevent equine laminitis, the interactions between equine neutrophil myeloperoxidase (MPO), unfractionated (UFH) and fractionated low molecular weight (LMWH) heparins and digital endothelium have been investigated. The effects of the heparins on purified equine MPO activity were tested by immunocapture followed by enzymatic detection. Endothelium-MPO interactions were assessed by measuring total and active MPO uptake by arterial and venous digital endothelial cells in culture with or without the addition of heparins. A dose-dependent MPO inhibition by UFH and LMWH was seen, with the greatest reduction in MPO activity noted with the highest concentration of LMWH. The MPO capture was greater in arterial cells, but heparins better inhibited MPO capture in venous cells. The activity of cell-bound MPO was almost completely suppressed by the heparins, and no differences were observed between UFH and LMWH. The results confirm the anti-inflammatory properties of heparins and allow a better understanding of the potential role of MPO in laminitis. [less ▲]

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See detailEffects of vaccination with live or inactivated aqueous-suspension NDV vaccine in pigeons previously infected with paramyxovirus type 1
Duchatel, Jean-Pierre ULg

in Vlaams Diergeneeskundig Tijdschrift (1987), 56(2), 135-140

The authors compared the effects of vaccination of previously PMV1 infected pigeons, either with live-NDV-LaSota strain or with the inactivated aqueous-suspension vaccine (Colombovac PMV). Young ... [more ▼]

The authors compared the effects of vaccination of previously PMV1 infected pigeons, either with live-NDV-LaSota strain or with the inactivated aqueous-suspension vaccine (Colombovac PMV). Young susceptible pigeons were inoculated by intramuscular injectionwith pigeon PMV1 and vaccinated 4 days later ocularly/intranasally with live-LaSota strain or by subcutaneous injection of one 0.2 ml dose of Colombovac PMV. Cumulative nervous signs/mortality rates reached 95% in the live-LaSota vaccinated group, 70% in the control group and 60% in the Colombovac PMV vaccinated group. As compared to the control group, vaccination with Colombovac PMV had no beneficial but no disadvantageous effects on the disease while vaccination with live-LaSota significantly increased viral excretion in the faeces and number of pigeons with polyuria at the beginning of the clinical phase of infection. Consequently, percentages of pigeons having developed polyuria and cumulative percentages of nervous signs/mortality were significantly lower in the Colombovac PMV vaccinated group than in the live LaSota vaccinated group. In conclusion, when first symptoms are appearing in a PMV1 infected pigeon-house, vaccinated with Colombovac PMV may be attempted without heightening the disease while vaccination with live-Lasota increases the severity of the disease. [less ▲]

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