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See detailDevelopment of a high throughput de novo sequencing platform for peptidic toxins combining proteomics and transcriptomics
Degueldre, Michel ULg; Verdenaud, Marion; Zuniga, Sheila et al

Poster (2014, November 07)

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See detailDevelopment of a high-dynamic range imaging instrument for a single telescope by a pupil remapping system
Kotani, Takayuki; Lacour, Sylvestre; Choquet, Elodie et al

in Optical and Infrared Interferometry II (2010, July 01)

We present the laboratory demonstration of a very high-dynamic range imaging instrument FIRST (Fibered Imager foR Single Telescope). FIRST combines the techniques for aperture masking and a single-mode ... [more ▼]

We present the laboratory demonstration of a very high-dynamic range imaging instrument FIRST (Fibered Imager foR Single Telescope). FIRST combines the techniques for aperture masking and a single-mode fiber interferometer to correct wavefront errors, which leads to a very high-dynamic range up to 106 around very near the central object (~ λ/D) at visible to near-infrared wavelengths. Our laboratory experiments successfully demonstrated that the original image can be reconstructed through a pupil remapping system. A first on-sky test will be performed at the Lick Observatory 3- m Shane telescope for operational tests in the summer of 2010. [less ▲]

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See detailDevelopment of a high-order interior penalty discontinuous Galerkin method for compressible turbulent flows. Application to Reynolds-averaged Navier-Stokes and large eddy simulations
Drosson, Marcus ULg

Doctoral thesis (2013)

Over the last decade several studies and workgroups came to the conclusion that high-order discretisation schemes are the most suited to overcome the limitations of today’s flow solvers. The latter are at ... [more ▼]

Over the last decade several studies and workgroups came to the conclusion that high-order discretisation schemes are the most suited to overcome the limitations of today’s flow solvers. The latter are at most second-order accurate and therefore often deliver poor results on currently used meshes. Within this context, discontinuous Galerkin (DG) methods have recently been identified as having the biggest potential for future flow solvers. Further research is however needed to improve the computational efficiency and the robustness of these schemes. Both issues are faced in the subsequent chapters of the thesis. The first part of the thesis is devoted to the solution of the Reynolds-averaged Navier-Stokes (RANS) equations using an interior penalty (IP) formulation. Whereas the intention is not to develop new turbulence models, the focus lies on the adaptation of existing models to the particular features of high-order discretisation schemes. In contrast to classical low-order methods, high-order schemes are prone to Gibbs oscillations which – if no care is taken – can lead to the breakdown of the algorithm. Given the stability issues caused by negative values of the eddy viscosity, different changes of the one-equation Spalart-Allmaras (S-A) model are discussed. Whilst having identical sparsity patterns as the popular second Bassi-Rebay scheme (BR2), the simpler IP formulation is up to 30% less time-consuming. Unfortunately, its stability strongly depends on a seemingly more or less arbitrary penalty parameter. As this parameter also effects the conditioning of the resulting system of discretised equations, its choice is of utmost importance. This might explain why the IP formulation has received only little attention over the past decades. The thesis analyses for the first time the use of the interior penalty discretisation to solve a system of RANS equations. One of the principal contributions of this work is the generalisation of the penalty parameter to anisotropic meshes and a highly variable viscosity. Several numerical examples are presented to illustrate the effect of the newly proposed definition of the penalty parameter. The focus of the second part lies on turbulent boundary layer resolution. Based on detailed grid convergence analyses as a function of interpolation order, element type and grid size, clear guidelines for the choice of boundary layer meshes for practical applications are provided. Besides straight boundaries, the effect of boundary curvature or a hybrid discretisation are investigated. Moreover, the concept of “quasi-straight” elements is introduced. Following this innovative approach, the accuracy of the calculated shear friction can further be improved by a proper choice of the position of the inner-element nodes, without increasing the total number of unknowns. Finally, several numerical applications clearly demonstrate the potential of the method to solve industrial problems. In the last part, large eddy simulations of the Taylor-Green vortex and the decay of homogeneous isotropic turbulence are presented. This last chapter constitutes a first step towards the use of discontinuous Galerkin methods for large eddy simulations. Besides a validation study for the Smagorinsky and the WALE subgrid scale model, the resolution requirements of resolved LES are determined. Furthermore different subgrid filters are compared and the choice of the Smagorinsky constant in the case of filtered LES is briefly examined. [less ▲]

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See detailDevelopment of a HPLC/UV-FLD method to detect the 15(+1) EU priority Polycyclic Aromatic Hydrocarbons (PAHs) in food supplements
Danyi, Sophie ULg; Brose, François ULg; Melens, Danielle ULg et al

in Book of abstracts - 3rd International Symposium on Recent Advances in Food Analysis (2007)

Detailed reference viewed: 59 (15 ULg)
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See detailDevelopment of a hydrogel containing GM-CSF to improve the dendritic cells colonisation of HPV+ epithelium
Evrard, Brigitte ULg; Hubert, Pascale ULg; Delvenne, Philippe ULg et al

in Proceedings of Eur conference on drug delivery and pharmaceutical technology (2004)

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See detailDevelopment of a LC-UV-MS analytical method for malondialdehyde.
Douny, Caroline ULg; Dure, Remy; Brose, François ULg et al

Poster (2011)

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See detailDevelopment of a liquid chromatographic method for thesimultaneous quantification of curcumin, -arteether,tetrahydrocurcumin and dihydroartemisinin. Application to lipid-based formulations
Memvanga Bondo, Patrick; Mbinze Kindenge, Jérémie ULg; Rozet, Eric ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2014), 88

A liquid chromatographic method was developed for the simultaneous separation of curcumin, B-arteether, tetrahydrocurcumin and dihydroartemisinin based on the design of experiments and the design space ... [more ▼]

A liquid chromatographic method was developed for the simultaneous separation of curcumin, B-arteether, tetrahydrocurcumin and dihydroartemisinin based on the design of experiments and the design space methodology. The influence of the percentage of organic modifier, flow rate of the mobile phase and column temperature on the analytes separation was investigated. The optimal chromatographic separation was achieved on a C18 column (125 mm × 4 mm, 5 µm) using an isocratic elution with a mobile phase consisting of methanol:ammonium acetate (pH 4; 10 mM) (80/20, v/v) at a flow rate of 0.45 ml/min and a column temperature of 32.5◦C. This method was then validated for simultaneous quantification of curcumin and B -arteether contained in lipid-based formulations taking into account the B -expectation tolerance interval for the total error measurement. Finally, the suitability of the proposed liquid chromatographic method for routine analysis of curcumin and B -arteether loaded in lipid-based formulations has been proven. [less ▲]

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See detailDevelopment of a long-acting sulfamethazine bolus for sheep
Evrard, Brigitte ULg; Dechesne, Jean-Paul; Fagetton, Xavier et al

in Proceedings of 6th International Conference of Pharmaceutical Technology (1992)

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See detailDevelopment of a low actuation voltage RF MEMS switch
Kiang, Kian Shen; Kraft, Michaël ULg

in Eurosensors XXII (2008, September)

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See detailDevelopment of a low voltage MEMS switch for RF applications
Kiang, Kian Shen; Kraft, Michaël ULg

in Proc. MME 2006 Conference (2006, September)

Detailed reference viewed: 1 (0 ULg)