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See detailEffects of valve replacement for aortic stenosis on mitral regurgitation.
Unger, Philippe; Plein, Daniele; Van Camp, Guy et al

in American Journal of Cardiology (2008), 102(10), 1378-82

We aimed to prospectively and quantitatively assess the effects of aortic valve replacement (AVR) for aortic stenosis (AS) on mitral regurgitation (MR) and to examine the determinants of the changes in MR ... [more ▼]

We aimed to prospectively and quantitatively assess the effects of aortic valve replacement (AVR) for aortic stenosis (AS) on mitral regurgitation (MR) and to examine the determinants of the changes in MR. Fifty-two patients with AS scheduled for AVR were included if holosystolic MR not being considered for replacement or repair was detected. MR was quantified using the proximal isovelocity surface area method before and 8 +/- 4 days after surgery. Mitral valvular deformation parameters did not change significantly, but the mitral effective regurgitant orifice (ERO) and regurgitant volume decreased from 11 +/- 6 mm(2) to 8 +/- 6 mm(2) and from 20 +/- 10 ml to 11 +/- 9 ml, respectively (both p <0.0001). Using multiple linear regression analysis, preoperative severity of MR, mitral leaflet coaptation height, and end-diastolic volume decrease were independently associated with postoperative reduction in MR, whereas changes in mitral valve morphology after surgery were not. MR etiology did not predict the reduction in MR. In conclusion, the decrease in MR observed in most patients after AVR is associated with the magnitude of acute left ventricular reverse remodeling. As the reduction in left ventricular systolic pressure contributes to the decrease in regurgitant volume, the preoperative quantitative assessment of MR should best be performed by measurement of the ERO. [less ▲]

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See detailEffects of various concentrations of glycolic acid at the corneoxenometry and collaxenometry bioassays.
Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Journal of Cosmetic Dermatology (2008), 7(3), 194-8

BACKGROUND: Glycolic acid is an alpha-hydroxy acid used as a chemical peeling for more than a quarter century. The primary tissue target is the stratum corneum. OBJECTIVE: This study aims to assess the ... [more ▼]

BACKGROUND: Glycolic acid is an alpha-hydroxy acid used as a chemical peeling for more than a quarter century. The primary tissue target is the stratum corneum. OBJECTIVE: This study aims to assess the effects of various concentrations of glycolic acid on the stratum corneum and collagen fibers using two selected bioassays. METHODS: Corneoxenometry was performed to test the effects on human stratum corneum. Collaxenometry was similarly designed to quantify the effect on sheets of collagen fibers. Different glycolic acid concentrations ranging from 5% to 70% in alcohol were tested, respectively, for 3- and 10-min exposure times. RESULTS: Both bioassays showed consistent reactivities with a dose-effect relationship when using a 3-min exposure time. By contrast, the tests appeared unreliable or uninformative for the 10-min exposure time. CONCLUSION: Corneoxenometry and collaxenometry appear useful for in vitro testing peeling agents during short exposure times. [less ▲]

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See detailEffects of varying antigens and adjuvant systems on the immunogenicity and safety of investigational tetravalent human oncogenic papillomavirus vaccines: Results from two randomized trials.
Van Damme, Pierre; Leroux-Roels, Geert; Simon, Philippe et al

in Vaccine (2014)

BACKGROUND: A prophylactic human papillomavirus (HPV) vaccine targeting oncogenic HPV types in addition to HPV-16 and -18 may broaden protection against cervical cancer. Two Phase I/II, randomized ... [more ▼]

BACKGROUND: A prophylactic human papillomavirus (HPV) vaccine targeting oncogenic HPV types in addition to HPV-16 and -18 may broaden protection against cervical cancer. Two Phase I/II, randomized, controlled studies were conducted to compare the immunogenicity and safety of investigational tetravalent HPV L1 virus-like particle (VLP) vaccines, containing VLPs from two additional oncogenic genotypes, with the licensed HPV-16/18 AS04-adjuvanted vaccine (control) in healthy 18-25 year-old women. METHODS: In one trial (NCT00231413), subjects received control or one of 6 tetravalent HPV-16/18/31/45 AS04 vaccine formulations at months (M) 0,1,6. In a second trial (NCT00478621), subjects received control or one of 5 tetravalent HPV-16/18/33/58 vaccines formulated with different adjuvant systems (AS04, AS01 or AS02), administered on different schedules (M0,1,6 or M0,3 or M0,6). RESULTS: One month after the third injection (Month 7), there was a consistent trend for lower anti-HPV-16 and -18 geometric mean antibody titers (GMTs) for tetravalent AS04-adjuvanted vaccines compared with control. GMTs were statistically significantly lower for an HPV-16/18/31/45 AS04 vaccine containing 20/20/10/10mug VLPs for both anti-HPV-16 and anti-HPV-18 antibodies, and for an HPV-16/18/33/58 AS04 vaccine containing 20/20/20/20mug VLPs for anti-HPV-16 antibodies. There was also a trend for lower HPV-16 and -18-specific memory B-cell responses for tetravalent AS04 vaccines versus control. No such trends were observed for CD4+ T-cell responses. Immune interference could not always be overcome by increasing the dose of HPV-16/18 L1 VLPs or by using a different adjuvant system. All formulations had acceptable reactogenicity and safety profiles. Reactogenicity in the 7-day post-vaccination period tended to increase with the introduction of additional VLPs, especially for formulations containing AS01. CONCLUSIONS: HPV-16 and -18 antibody responses were lower when additional HPV L1 VLPs were added to the HPV-16/18 AS04-adjuvanted vaccine. Immune interference is a complex phenomenon that cannot always be overcome by changing the antigen dose or adjuvant system. [less ▲]

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See detailEffects of wheat-pea intercropping on the population dynamics of Sitobion avenae (Homoptera: Aphididae) and its main natural enemies
Zhou, Haibo ULg

in Kun Chong Xue Bao = Acta Entomologica Sinica (2009), 52(7), 775-782

To study the ecological regulation effects of species diversity in wheat fields on Sitobion avenae, field experiments were carried out in Langfang Experimental Station of Institute of Plant Protection ... [more ▼]

To study the ecological regulation effects of species diversity in wheat fields on Sitobion avenae, field experiments were carried out in Langfang Experimental Station of Institute of Plant Protection, Chinese Academy of Agricultural Sciences from October of 2007 to July of 2008. The intercropping patterns of wheat and pea, by the proportion of planting row of pea and wheat in 2:2, 2:4, 2:6 and 2:8, were plotted, and the field cultivar monoculture of wheat was planted as the control. Population dynamics of apterae and alatae S. avenae, population dynamics, species richness, diversity index and evenness of main natural enemies were investigated systematically and analyzed. The results showed that, compared with monoculture of wheat, the amount of S. avenae apterae per 100 plants (square-root transformed) in aphid peak period were very significantly lower in the intercropping treatments (P<0.01), and the cascade was that wheat monoculture (77.38) > 2-2 intercropping (68.62) > 2-4 intercropping (68.51) > 2-8 intercropping (65.19) > 2-6 intercropping (64.94). Although population dynamics of main natural enemies showed a similar trend with time, wheat-pea intercropping could preserve and augment natural enemies more than monoculture of wheat, and there were higher population densities of ladybeetles and aphid parasitoids, and higher species richness and diversity index of natural enemies, but lower evenness index in each intercropping field. It is so concluded that wheat-pea intercropping system can not only reduce the population of S. avenae, but also improve the stability and sustainability of controlling wheat pests. [less ▲]

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See detailEffects of Whole body Vibration in the elderly
Bruyère, Olivier ULg

Conference (2004, May 15)

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See detailEffects of widespread fish introductions on paedomorphic newts in Europe
Denoël, Mathieu ULg; Džukić, Georg; Kalezic, Milos L.

in Conservation Biology (2005), 19(1), 162-170

As a result of factors such as global warming, habitat destruction, and species introduction, amphibians are declining worldwide. No one, however, has analyzed the status of polymorphic amphibian species ... [more ▼]

As a result of factors such as global warming, habitat destruction, and species introduction, amphibians are declining worldwide. No one, however, has analyzed the status of polymorphic amphibian species at a national or continental scale, although some local reports exist. Our aim was to report on the loss of intraspecific heterochrony as a loss to diversity in determining the consequences of fish stocking on European populations of paedomorphic newts. Paedomorphosis is a polymorphism in which larval traits are retained in the adult stage. We surveyed 39 paedomorphic populations of the alpine ( Triturus alpestris) and palmate ( T. helveticus) newts, all but one of which initially occupied fishless ponds and lakes in France, Italy, Slovenia, Bosnia, Montenegro, and Greece. Exotic fishes were found in 44% of the studied aquatic habitats, with a 100% presence in Montenegro. At all sites paedomorphs disappeared and metamorphs declined. Only fish explained these population changes because alternative factors such as drying were not significant. More catastrophically, fish introductions occurred in habitats known to support the largest populations of newts and even some endemic subspecies. If management and legislative measures are not taken to stop fish stocking, protect paedomorphs as conservation units at national and international levels, and restore natural habitats, all the largest paedomorphic populations may disappear in the near future. Their disappearance would represent a loss of one of the rare, fascinating examples of intraspecific heterochrony. [less ▲]

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See detailThe Effects of Workers’ Participation on Enterprise Performance: Empirical Evidence from French Producer Co-operatives
Defourny, Jacques ULg; Estrin, Saul; Jones, Derek C.

in International Journal of Industrial Organization (1985), 3(2), 197-218

The results of estimating production functions augmented by various measures of workers' participation on a large enterprise level data set of French cooperatives are reported. Value added is found to be ... [more ▼]

The results of estimating production functions augmented by various measures of workers' participation on a large enterprise level data set of French cooperatives are reported. Value added is found to be an increasing function of participation in profits, in collective membership and in ownership, even when a wide assortment of enterprise specific and environmental factors are taken into account. This finding is very robust, surviving tests between alternative specifications of technology, for reverse causality, for simultaneous equation bias and for multicollinearity. The typical productivity effect from participation, however, is small, around 5% of output. The results suggest that Western policymakers should investigate ways to increase workers' participation in capital stakes and profit shares. [less ▲]

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See detailEffects of α-Hederin on cells cultured in vitro
Quetin-Leclercq, Joelle; Danloy, Sophie; Coucke, Paul et al

Poster (1993, June)

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See detailEffects on animal performance of a supplement to suckling grazing calves
Dufrasne, Isabelle ULg; Istasse, Louis ULg; Limbourg, Pierre et al

in Proceedings of the 43th Annual Meeting of E.A.A.P. (1992)

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See detailEffects on cellular invasion of 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives
Kempen, I.; Pochet, L.; Papapostolu, D. et al

Poster (2001, April 21)

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See detailEffects on cellular invasion of two synthetic coumarins
Kempen, I.; Papapostolou, D.; Pochet, L. et al

Conference (2001, May)

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See detailEffects on in vitro and in vivo cellular invasion of two 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives
Kempen, I.; Pochet, L.; Papapostolou, D. et al

Poster (2001, October 16)

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See detailEffects on nicotine administered via a transdermal delivery system on vigilance : a repeated measure study
Mancuso, Giovanna; Andrès Bénito, Pilar; Ansseau, Marc ULg et al

in Psychopharmacology (1999), 142(1), 18-23

Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing ... [more ▼]

Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing test 1.3, 3 and 6.3 hrs after patch application, to verify the involvement of the dose of nicotine on the performance. The results confirm and extend the knowledge on the increasing effects of nicotine on vigilance previously found with orally and transdermally administered nicotine. Moreover, results show that such performance was independent of the time of nicotine absorption, which suggests that a relatively low dose of nicotine suffices to activate vigilance processing. Regarding motor performance, no convincing effect of nicotine was observed on reaction time. ((c) 1999 APA/PsycINFO, all rights reserved) [less ▲]

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