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See detailEarly asteroseismic results from Kepler: structural and core parameters of the hot B subdwarf KPD 1943+4058 as inferred from g-mode oscillations
Van Grootel, Valérie ULg; Charpinet, Stéphane; Fontaine, Gilles et al

in Astrophysical Journal Letters (2010), 718

We present a seismic analysis of the pulsating hot B subdwarf KPD 1943+4058 (KIC 005807616) on the basis of the long-period, gravity-mode pulsations recently uncovered by Kepler. This is the first time ... [more ▼]

We present a seismic analysis of the pulsating hot B subdwarf KPD 1943+4058 (KIC 005807616) on the basis of the long-period, gravity-mode pulsations recently uncovered by Kepler. This is the first time that g-mode seismology can be exploited quantitatively for stars on the extreme horizontal branch, all previous successful seismic analyses having been confined so far to short-period, p-mode pulsators. We demonstrate that current models of hot B subdwarfs can quite well explain the observed g-mode periods, while being consistent with independent constraints provided by spectroscopy. We identify the 18 pulsations retained in our analysis as low- degree (l = 1 and 2), intermediate-order (k = −9 through −58) g-modes. The periods (frequencies) are recovered, on average, at the 0.22% level, which is comparable to the best results obtained for p-mode pulsators. We infer the following structural and core parameters for KPD 1943+4058 (formal fitting uncertainties only): Teff = 28,050 ± 470 K, log g = 5.52 ± 0.03, M∗ = 0.496 ± 0.002 M⊙, log (Menv/M∗) = −2.55 ± 0.07, log (1 − Mcore/M∗) = −0.37 ± 0.01, and Xcore (C+O) = 0.261 ± 0.008. We additionally derive the age of the star since the zero-age extended horizontal branch 18.4 ± 1.0 Myr, the radius R = 0.203 ± 0.007 R⊙, the luminosity L = 22.9 ± 3.13 L⊙, the absolute magnitude MV = 4.21 ± 0.11, the reddening index E(B − V ) = 0.094 ± 0.017, and the distance d = 1180 ± 95 pc. [less ▲]

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See detailEarly Bifrontal Brain Injury: Disturbances in Cognitive Function Development
Bonnier, Christine; Costet, Aurélie; Hmaimess, Ghassan et al

in Neurology Research International (2010)

We describe six psychomotor, language, and neuropsychological sequential developmental evaluations in a boy who sustained a severe bifrontal traumatic brain injury (TBI) at 19 months of age. Visuospatial ... [more ▼]

We describe six psychomotor, language, and neuropsychological sequential developmental evaluations in a boy who sustained a severe bifrontal traumatic brain injury (TBI) at 19 months of age. Visuospatial, drawing, and writing skills failed to develop normally. Gradually increasing difficulties were noted in language leading to reading and spontaneous speech difficulties. The last two evaluations showed executive deficits in inhibition, flexibility, and working memory. Those executive abnormalities seemed to be involved in the other impairments. In conclusion, early frontal brain injury disorganizes the development of cognitive functions, and interactions exist between executive function and other cognitive functions during development. [less ▲]

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See detailEarly bifrontal brain injury: sequential neuropsychological developmental features
Bonnier, Christine; Potelle, Dominique; Buelens, M et al

in Revista de neurologia (2006)

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See detailEarly boost and slow consolidation in motor skill learning
Hotermans, C.; Peigneux, Philippe ULg; Maertens De Noordhout, Alain ULg et al

in Learning & Memory (Cold Spring Harbor, N.Y.) (2006), 13(5, Sep-Oct), 580-583

Motorskill learning is a dynamic process that continues covertly after training has ended and eventually leads to delayed increments in performance. Current theories Suggest that this off-line improvement ... [more ▼]

Motorskill learning is a dynamic process that continues covertly after training has ended and eventually leads to delayed increments in performance. Current theories Suggest that this off-line improvement takes time and appears only after several hours. Here we show an early transient and short-lived boost in performance, emerging as early as 5-30 min after training but no longer observed 4 h later. This early boost is predictive of the performance achieved 48 h later, Suggesting its functional relevance for memory processes. [less ▲]

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See detailEarly Bronze Age Houses in Upper Mesopotamia: An Evidence of Dwellings or Private Enterprises?
Mas, Juliette ULg

in Workshop Household and Household Economies in 3rd Millennium B.C. Syro-Mesopotamia Proceedings (in press)

This paper deals with the research I carried out on domestic architecture and private economy during Early Bronze Age in Upper-Mesopotamia. Archaeological records, as well as textual evidence, has been ... [more ▼]

This paper deals with the research I carried out on domestic architecture and private economy during Early Bronze Age in Upper-Mesopotamia. Archaeological records, as well as textual evidence, has been used to try to define private households activities and their relationships with official institutions. Households were the main source of production, distribution and consumption during the Early Bronze Age. As it seems that these private economic entities produced goods and crafts in their own houses, analyzing domestic architecture could be a way to approach Mesopotamian economic activities. In Northern Mesopotamia the economic system was already strongly articulated; beyond palatial organizations it was also largely based on private group activities, often structured by kinship. [less ▲]

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See detailEarly changes in myocardial carbohydrate oxidative metabolism during E. Coli endotoxin infusion in dog
D'Orio, Vincenzo ULg; EL ALLAF, D; VAIRA, S et al

in Archives Internationales de Physiologie et de Biochimie (1985), 93

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See detailEarly clinical experience with subcutaneous naratriptan in the acute treatment of migraine: a dose-ranging study.
Dahlof, C.; Hogenhuis, L.; Olesen, J. et al

in European Journal of Neurology (1998), 5(5), 469-477

Naratriptan is a novel, potent agonist at the 5HT1B/1D receptor. A total of 335 migraine patients were treated in this randomized, double-blind, placebo-controlled, dose-ranging, in-clinic study, to ... [more ▼]

Naratriptan is a novel, potent agonist at the 5HT1B/1D receptor. A total of 335 migraine patients were treated in this randomized, double-blind, placebo-controlled, dose-ranging, in-clinic study, to evaluate the efficacy, safety and tolerability of five doses of subcutaneous (sc) naratriptan (0.5, 1, 2.5, 5 or 10 mg) in comparison with sc sumatriptan (6 mg) and placebo in the acute treatment of a moderate/severe migraine attack. Headache relief [reduction of headache severity from moderate or severe (grade 2/3) to mild or none (grade 1/0)] at 1 and 2 h after each dose, was reported by a statistically significantly higher proportion of patients for all doses of sc naratriptan and sc sumatriptan (6 mg) than for placebo. The percentages of patients with headache relief at 2 h post-dose were: naratriptan (0.5 mg) 65%, (1 mg) 75%, (2.5 mg) 83%, (5 mg) 94% and (10 mg) 91%; sumatriptan (6 mg) 89%; placebo 41%, (P < 0.005). The earliest report of a statistically significant difference compared with placebo for the times assessed was with sc naratriptan (10 mg) at 10 min post-dose (P = 0.023). The percentages of patients reporting adverse events were dose-related; sc naratriptan (0.5 mg) 33%, (1 mg) 29%, (2.5 mg) 43%, (5 mg) 59% and (10 mg) 71%; sc sumatriptan 53%; placebo 22%. There were no clinically significant changes in electrocardiogram (ECG), vital signs or laboratory parameters. Systemic exposure increased proportionally to the dose, the absorption of sc naratriptan was rapid (tmax = 10 min) and the half-life was 5 h. In conclusion, sc naratriptan was an effective and well-tolerated acute treatment for migraine. Copyright 1998 Lippincott Williams & Wilkins [less ▲]

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See detailEarly colonization of Posidonia oceanica (L.) Delile by epiphytes: Comparison between natural and artificial seagrass leaves
Pete, Dorothée ULg; Gobert, Sylvie ULg; Lepoint, Gilles ULg et al

in Pergent-Martini, Christine; El Asmi, Souha; Le Ravallec, Célia (Eds.) Proceedings of the third Mediterranean symposium on marine vegetation (2007, March)

Posidonia oceanica is an important marine Magnoliophyta of the Mediterranean coastal zone that can form dense meadows. The leaves of this seagrass are colonized by a lot of organisms, from bacteria to ... [more ▼]

Posidonia oceanica is an important marine Magnoliophyta of the Mediterranean coastal zone that can form dense meadows. The leaves of this seagrass are colonized by a lot of organisms, from bacteria to polychaetes and algae. However, the early stages of colonization are not well known. A preliminary is proposed to examine the nine first days of colonization by epiphytes on natural leaves and on Artificial Seagrass Units (ASUs). Aims of this work were to understand which species are the first to set up, to compare colonization on both leaves and to determine the interest of ASUs in ecological studies. It was shown that the setting up of epiphytes on the bases of both leaves is rapid (first algae on the second day) but the number of organisms increases quicker on ASUs than on natural leaves and on the smooth faces than the rough ones. Shannon-Wiener diversity and evenness were higher for the P. oceanica leaves and the use of Bray-Curtis similarity index showed that colonisation is not similar (between 20 and 30 % similarity) on both leaves for the same day. It can be explained by the lower colonization rate of natural leaves. This lower rate is probably due to a less developed biofilm on natural leaves than on ASUs, to a difficult access to the bases of P. oceanica leaves for epiphytes and microoganisms, and the production of phenol compounds by the plant. Even if ASUs used here do not seem to be similar to natural leaves in early stages of colonization, they could be used in ecological studies thanks to their rapid covering by epiphytes. [less ▲]

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See detailEarly contribution of phonological awareness and later influence of phonological memory throughout reading acquisition
Nithart, C.; Demont, E.; Majerus, Steve ULg et al

in Journal of Research in Reading (2011), 34

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See detailAn Early Cretaceous ichthyosaur from SE France: implications on the evolution of post-Liassic Ichthyosauria
Fischer, Valentin ULg; Clément, Arnaud; Guiomar, Myette et al

Conference (2010, June)

A complete ichthyosaur rostrum with 124 associated teeth was recently discovered in Laux-Montaux locality, department of Drôme, southeastern France. The associated belemnites and ammonites indicate a late ... [more ▼]

A complete ichthyosaur rostrum with 124 associated teeth was recently discovered in Laux-Montaux locality, department of Drôme, southeastern France. The associated belemnites and ammonites indicate a late Valanginian age (Neocomites peregrinus Zone, Olcostephanus nicklesi Subzone) for this fossil, which consequently represents the first diagnostic ichthyosaur ever reported from Valanginian strata. Despite its incompleteness, this specimen is perfectly consistent with Aegirosaurus leptospondylus WAGNER 1853 and is therefore referred to this rare taxon. This specimen thus greatly increases the temporal and geographic biozones of this taxon, which was previously restricted to the Tithonian (Upper Jurassic) lithographic limestones of Bavaria (southern Germany). Moreover, it indicates that Late Jurassic ichthyosaurs actually crossed the Jurassic-Cretaceous boundary with a much lighter diversity drop than previously supposed. Finally, tooth morphology and wear pattern suggest that Aegirosaurus belonged to the “Pierce II/ Generalist” feeding guild sensu Massare (1987; 1997), which was hitherto not represented in post-Liassic ichthyosaurs. [less ▲]

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See detailEarly decision support for net zero energy buildings design using building performance simulation
Attia, Shady ULg; Gratia, Elisabeth; De Herde, Andre et al

in Clean Technology for Smart Cities and Buildings (2013, September)

This paper aims to investigate the use of building performance simulation tools as a method of informing the design decision of NZEBs. The aim of this study is to evaluate the effect of a simulation-based ... [more ▼]

This paper aims to investigate the use of building performance simulation tools as a method of informing the design decision of NZEBs. The aim of this study is to evaluate the effect of a simulation-based decision aid, ZEBO, on informed decision-making using sensitivity analysis. The objective is to assess the effect of ZEBO and other BPS tools on three specific outcomes: (i) knowledge and satisfaction when using simulation for NZEB design; (ii) users’ decision-making attitudes and patterns, and (iii) performance robustness based on an energy analysis. The paper utilizes three design case studies comprising a framework to test the use of BPS tools. Two types of data were collected, mainly preference and performance data. The preference data were used to collect information from participants using self-reported metrics. The performance data were used to collect information on the energy performance of the final design. The energy evaluations were compared with the results of a quantitative assessment of the overall design performance. Finally the results were compared and presented. The paper provides results that shed light on the effectiveness of sensitivity analysis as an approach for informing the design decisions of NZEBs. [less ▲]

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See detailEarly design simulation tools for net zero energy buildings: a comparison of ten tools
Attia, Shady ULg; De Herde, André

in Conference Proceedings of 12th International Building Performance Simulation Association, 2011 (2011, November)

Given the challenges to design Net Zero Energy Buildings (NZEBs), the use of Building Performance Simulation (BPS) tools during early design phases has been indispensable. In this context, we compare ten ... [more ▼]

Given the challenges to design Net Zero Energy Buildings (NZEBs), the use of Building Performance Simulation (BPS) tools during early design phases has been indispensable. In this context, we compare ten early design BPS tools. The aim is to define the potential of using and integrating the tools by architect during the design of NZEBs. The examined tools include HEED, e-Quest, ENERGY-10, Vasari, Solar Shoebox, Open Studio Plug-in, IES-VE- Ware, DesignBuilder, ECOTECT and BEopt. The comparison is based on two different criteria sets. The results describe tools limitations and major requirements to meet the NZEBs objective implications. [less ▲]

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See detailEarly detection of abnormal left ventricular relaxation in acute myocardial ischemia with a quadratic model.
MORIMONT, Philippe ULg; Pironet, Antoine ULg; Desaive, Thomas ULg et al

in Medical engineering & physics (2014)

AIMS: The time constant of left ventricular (LV) relaxation derived from a monoexponential model is widely used as an index of LV relaxation rate, although this model does not reflect the non-uniformity ... [more ▼]

AIMS: The time constant of left ventricular (LV) relaxation derived from a monoexponential model is widely used as an index of LV relaxation rate, although this model does not reflect the non-uniformity of ventricular relaxation. This study investigates whether the relaxation curve can be better fitted with a "quadratic" model than with the "conventional" monoexponential model and if changes in the LV relaxation waveform due to acute myocardial ischemia could be better detected with the quadratic model. METHODS AND RESULTS: Isovolumic relaxation was assessed with quadratic and conventional models during acute myocardial ischemia performed in 6 anesthetized pigs. Mathematical development indicates that one parameter (Tq) of the quadratic model reflects the rate of LV relaxation, while the second parameter (K) modifies the shape of the relaxation curve. Analysis of experimental data obtained in anesthetized pigs showed that the shape of LV relaxation consistently deviates from the conventional monoexponential decay. During the early phase of acute myocardial ischemia, the rate and non-uniformity of LV relaxation, assessed with the quadratic function, were significantly enhanced. Tq increased by 16% (p<0.001) and K increased by 12% (p<0.001) within 30 and 60min, respectively, after left anterior descending (LAD) coronary artery occlusion. However, no significant changes were observed with the conventional monoexponential decay within 60min of ischemia. CONCLUSIONS: The quadratic model better fits LV isovolumic relaxation than the monoexponential model and can detect early changes in relaxation due to acute myocardial ischemia that are not detectable with conventional methods. [less ▲]

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See detailEarly detection of alien plants in xeric Natura 2000 sites in Southern Belgium
Monty, Arnaud ULg; Frisson, Gwenn; Mahy, Grégory ULg

Poster (2012)

The Natura 2000 network consists of sites designated by the member States of the European Union, under the Habitats and Birds Directives. Setting up that network is one of the biggest challenge in nature ... [more ▼]

The Natura 2000 network consists of sites designated by the member States of the European Union, under the Habitats and Birds Directives. Setting up that network is one of the biggest challenge in nature conservation in Europe, since habitats and species for which Natura 2000 sites are designated must be maintained in a “favorable conservation status”. Little is known so far, however, about how Natura 2000 sites are invaded by exotics species. Xeric habitats of high biological value included in the Natura 2000 network are among the most species-rich in Southern Belgium. They include calcareous grasslands, sandy meadows, dry heathlands, boxwood stands, siliceous rocks and calcareous rocks. We randomly sampled 15% of sites in each of these six categories (with a minimum of five sites per category) , with a total of 86 sites out of 470 existing sites. In each site, we recorded the presence/absence of 63 alien plants know to develop in xeric habitats (species list based on Verloove (2006) and expert’s personnal observations.), and estimated species cover. 25 naturalized alien plant species were observed in xeric habitats of the Natura 2000 network in Southern Belgium. Generally, alien species populations were still limited. [less ▲]

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See detailEarly detection of relapse by whole-body positron emission tomography in the follow-up of patients with Hodgkin's disease.
Jerusalem, Guy ULg; Beguin, Yves ULg; Fassotte, Marie-France ULg et al

in Annals of Oncology (2003), 14(1), 123-30

BACKGROUND: Relapse after treatment of Hodgkin's disease (HD) is usually identified as a result of the investigation of symptoms. We undertook this study to examine the value of whole-body positron ... [more ▼]

BACKGROUND: Relapse after treatment of Hodgkin's disease (HD) is usually identified as a result of the investigation of symptoms. We undertook this study to examine the value of whole-body positron emission tomography (PET) for the detection of preclinical relapse. PATIENTS AND METHODS: Thirty-six patients underwent 2-[fluorine-18]fluoro-2-deoxy-D-glucose ((18)F-FDG) PET at the end of treatment and than every 4-6 months for 2-3 years after the end of polychemotherapy and/or radiotherapy. In those cases of abnormal (18)F-FDG accumulation a confirmatory study was performed 4-6 weeks later. RESULTS: One patient had residual tumor and four patients relapsed during a follow-up of 5-24 months. All five events were correctly identified early by (18)F-FDG PET. Residual tumor or relapse was never first diagnosed based on clinical examination, laboratory findings or computed tomography (CT) studies. Two patients presented B symptoms and the three others were asymptomatic at the time of residual disease or relapse. Confirmation of residual disease or relapse was obtained by biopsy in four patients 1, 1, 5 and 9 months after PET and by unequivocal clinical symptoms and CT studies in one patient 3 months after PET. False-positive (18)F-FDG PET studies incorrectly suggested possible relapse in six other patients, but the confirmatory PET was always negative. Our study also provides important information about physiological (18)F-FDG uptake in the thymus. CONCLUSIONS: Our data suggest the potential of (18)F-FDG PET to detect preclinical relapse in patients with HD. This could help identify patients requiring salvage chemotherapy at the time of minimal disease rather than at the time of clinically overt relapse. Further studies are warranted to determine the impact of PET on treatment management and outcome. In fact, the aim of follow-up procedures is not only to detect preclinical relapse but mainly to obtain better results by starting salvage treatment earlier. A cost-benefit analysis will also be necessary before (18)F-FDG PET can be used routinely in the follow-up of patients with HD. [less ▲]

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See detailEarly detection of university students in potential difficulty : a case study
Hoffait, Anne-Sophie ULg; Schyns, Michael ULg

Conference (2014, November)

Rate of success in the first year at University in Belgium is very low regarding other foreign universities. The University of Liege, as other Universities, has already taken different initiatives. But by ... [more ▼]

Rate of success in the first year at University in Belgium is very low regarding other foreign universities. The University of Liege, as other Universities, has already taken different initiatives. But by early identifying students who have a high probability to face difficulties if nothing is done, the Universities might develop adapted methods to attack the problem with more emphasis where it is more needed and when it is still possible. Thus we want to develop a decision tool able to identify these students to help them. For that, we consider three standard datamining methods: logistic regression, artificial neural networks and decision trees and focus on early detection, i.e. before starting at the University. Then, we suggest to adapt these three methods as well as the classification framework in order to increase the probability of correct identification of the students. In our approach, we do not restrict the classification to two extreme classes, e.g. failure or success, but we create subcategories for different levels of confidence: high risk of failure, risk of failure, expected success or high probability of success. The algorithms are modified accordingly and to give more weight to the class that really matters. Note that this approach remains valid for any other classification problems for which the focus is on some extreme classes; e.g. fraud detection, credit default... Finally, simulations are conducted to measure the performances of the three methods, with and without the suggested adaptation. We check if the factors of success/failure we can identify are similar to those reported in the literature. We also make a ``what-if sensitivity analysis''. The goal is to measure in more depth the impact of some factors and the impact of some solutions, e.g., a complementary training or a reorientation. [less ▲]

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See detailEarly development of stricturing or penetrating pattern in Crohn's disease is influenced by disease location, number of flares, and smoking but not by NOD2/CARD15 genotype
Louis, Edouard ULg; Michel, V.; Hugot, J. P. et al

in Gut (2003), 52(4), 552-557

Background: Crohn's disease is a heterogeneous entity. Disease behaviour, characterised as structuring, penetrating, or non-stricturing non-penetrating, is a clinically important phenotype as it is ... [more ▼]

Background: Crohn's disease is a heterogeneous entity. Disease behaviour, characterised as structuring, penetrating, or non-stricturing non-penetrating, is a clinically important phenotype as it is associated with complications and need for surgery. It has recently been showed that the behaviour of Crohn's disease changes over the course of the disease. Aim: To assess the association between rapid development of a penetrating or stricturing pattern of Crohn's disease and demographic and clinical characteristics as well as NOD2/CARD15 genotype. Patients and methods: A total of 163 patients with a firm diagnosis of Crohn's disease and who had non-penetrating non-stricturing disease at diagnosis were studied. Various demographic and clinical characteristics as well as anitsaccharomyces cerevisiae antibody status and NOD2/CARD15 genotype were documented in these patients. These characteristics were compared in subgroups of patients according to evolution of disease behaviour five years after diagnosis. Results: Five years after diagnosis there were 110 (67.5%) patients with non-structuring non-penetrating disease, 18 (11%) with stricturing disease, and 35 (21.5%) with penetrating disease. In multivariate analysis, only disease location and number of flares per year were significantly discriminant between the three subgroups (p=0.0009 and 0.0001, respectively). Ileal location of the disease was associated with a stricturing pattern while a high number of flares was associated with a penetrating pattern. Active smoking was also associated with a penetrating pattern compared with a non-stricturing non-penetrating pattern only. Conclusions: Early development of stricturing or penetrating behaviour in Crohn's disease is influenced by disease location, clinical activity of the disease, and smoking habit, but not by NOD2/CARD15 genotype. [less ▲]

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