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See detailDisulfide Bonds Reduce the Toxicity of the Amyloid Fibrils Formed by an Extracellular Protein.
Mossuto, M. F.; Bolognesi, B.; Guixer, B. et al

in Angewandte Chemie (International ed. in English) (2011)

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See detailDisulfide bridges, new prospect in drug delivery systems?
Cajot, Sébastien ULg; Danhier, F.; Schol, Daureen ULg et al

Poster (2011, September 03)

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See detailThe Disulphide Mapping, Folding and Characterisation of Recombinant Ber e 1, an Allergenic Protein, and SFA8, Two Sulphur-rich 2 S Plant Albumins
Alcocer, Marcos; Murtagh, G. J.; Bailey, Kevin et al

in Journal of Molecular Biology (2002), 324

We have cloned and expressed genes encoding the allergenic brazil nut 2 S albumin (Ber e 1) and the sunflower albumin 8 (SFA8) in the methylotrophic yeast Pichia pastoris. We show that both proteins were ... [more ▼]

We have cloned and expressed genes encoding the allergenic brazil nut 2 S albumin (Ber e 1) and the sunflower albumin 8 (SFA8) in the methylotrophic yeast Pichia pastoris. We show that both proteins were secreted at high levels and that the purified proteins were properly folded. We also showed that Ber e 1 is glycosylated during secretion and that the glycan does not interfere with the folding or immunoreactivity. The disulphide map of the Ber e 1 protein was experimentally established and is in agreement with the conserved disulphide structure of other members of the 2 S albumin family. A model three-dimensional structure of the allergen was generated. During the expression studies and through mutation we have also shown that alteration of the sequences around the Kex2 endoproteolytic processing site in the expressed fusion protein can compromise the secretion by targeting part of the protein for possible degradation. The secreted production of these properly folded sulphurrich plant albumins presents an opportunity to delineate the attributes that make an allergen and to facilitate the diagnosis and therapy of type I allergy. [less ▲]

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See detailDisused Jurassic regional stage from Belgium: Virtonian
Delsate, D.; Boulvain, Frédéric ULg

in Geologica Belgica (2006), 9(1-2), 199-200

An overview of the definition and history of the Virtonian is given with the argumentation for the abandonment of this disused regional stage.

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See detailDisused Palaeozoic regional stages from Belgium: Devillian, Revinian, Salmian, Gedinnian and Burnotian.
Dejonghe, L.; Herbosch, A.; Steemans, Philippe ULg et al

in Geologica Belgica (2006), 9(1-2), 191-197

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See detailDiterpenes from the leaves of Croton Zambesicus
Block, Sébastien; Baccelli, Chiara; Tinant, Bernard et al

in Phytochemistry (2004), 65

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3b-ol, were isolated from the leaves of Croton zambesicus ... [more ▼]

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3b-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, b-sitosterol, a-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines. [less ▲]

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See detailDites-moi bonjour ou l'enfant handicapé
Delhaxhe, Arlette; Giot, Bernadette ULg

in Blondin, Christiane (Ed.) Grandir à Liège (1990)

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See detailDithiocarboxylate complexes of ruthenium(II) and osmium(II)
Naeem, Saira; Thompson, Amber L; White, Andrew J P et al

in Dalton Transactions (Cambridge, England : 2003) (2011), 40(14), 3737-3747

The ruthenium(II) complexes [Ru(R)(kappa(2)-S2C center dot IPr)(CO)(PPh3)(2)](+) (R = CH=CHBut, CH CHC6H4Me-4, C(C CPh)=CHPh) are formed on reaction of IPr center dot CS2 with [Ru(R)Cl(CO)(BTD)(PPh3)(2 ... [more ▼]

The ruthenium(II) complexes [Ru(R)(kappa(2)-S2C center dot IPr)(CO)(PPh3)(2)](+) (R = CH=CHBut, CH CHC6H4Me-4, C(C CPh)=CHPh) are formed on reaction of IPr center dot CS2 with [Ru(R)Cl(CO)(BTD)(PPh3)(2)] (BTD = 2,1,3-benzothiadiazole) or [Ru(C(C CPh)=CHPh)Cl(CO)(PPh3)(2)] in the presence of ammonium hexafluorophosphate. Similarly, the complexes [Ru(CH=CHC6H4Me-4)(kappa(2)-S2C center dot ICy)(CO)(PPh3)(2)](+) and [Ru(C(C CPh)=CHPh)(kappa(2)-S2C center dot ICy)(CO)(PPh3)(2)](+) are formed in the same manner when ICy center dot CS2 is employed. The ligand IMes center dot CS2 reacts with [Ru(R)Cl(CO)(BTD)(PPh3)(2)] to form the compounds [Ru(R)(kappa(2)-S2C center dot IMes)(CO)(PPh3)(2)](+) (R = CH=CHBut, CH=CHC6H4Me-4, C(C CPh)=CHPh). Two osmium analogues, [Os(CH CHC(6)H4(M)e-4)(kappa(2)-S2C center dot IMes)(CO)(PPh3)(2)](+) and [Os(C(C CPh)=CHPh)(kappa(2)-S2C center dot IMes)(CO)(PPh3)(2)](+) were also prepared. When the more bulky diisopropylphenyl derivative IDip center dot CS2 is used, an unusual product, [Ru(kappa(2)-SC(H)S(CH= CHC6H4Me-4)center dot IDip)Cl(CO)(PPh3)(2)](+), with a migrated vinyl group, is obtained. Over extended reaction times, [Ru(CH=CHC6H4Me-4)Cl(BTD)(CO)(PPh3)(2)] also reacts with IMes center dot CS2 and NH4PF6 to yield the analogous product [Ru{kappa(2)-SC(H)S(CH=CHC6H4Me-4)center dot IMes}Cl(CO)(PPh3)(2)](+) via the intermediate [Ru(CH=CHC6H4Me-4)(kappa(2)-S2C center dot IMes)(CO)(PPh3)(2)](+). Structural studies are reported for [Ru(CH=CHC6H4Me-4)(kappa(2)-S2C center dot IPr)(CO)(PPh3)(2)]PF6 and [Ru(C(C CPh)=CHPh)(kappa(2)-S2C center dot ICy)(CO)(PPh3)(2)]PF6. [less ▲]

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See detailDithioesters and Trithiocarbonates as Anchoring Groups for the "Grafting-To" Approach
Duwez, Anne-Sophie ULg; Guillet, Pierre; Collard, Catheline et al

in Macromolecules (2006), 39

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See detailDithioesters and Trithiocarbonates Monolayers on Gold
Fustin, Charles-André; Duwez, Anne-Sophie ULg

in Journal of Electron Spectroscopy & Related Phenomena (2009), 172

We show that dithioester and trithiocarbonate compounds, used as chain transfer agents in reversible addition fragmentation chain transfer polymerization, form monolayers on gold. We evidence that the ... [more ▼]

We show that dithioester and trithiocarbonate compounds, used as chain transfer agents in reversible addition fragmentation chain transfer polymerization, form monolayers on gold. We evidence that the monolayers are slightly less dense than those formed by long alkanethiols on gold, but show a surface coverage that is close to the one obtained for short alkanethiols. Since the grafting density of polymer brushes is limited by the steric hindrance which inhibits the diffusion of large free polymer chains to opensurface reactive sites, the relatively high grafting density of dithioesters and trithiocarbonates anchoring groups is not expected to limit the density of the brushes [less ▲]

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See detailDiuretic activity of torasemide and furosemide in chronic heart failure: a comparative double blind cross-over study.
Scheen, André ULg; Vancrombreucq, J. C.; Delarge, J. et al

in European Journal of Clinical Pharmacology (1986), 31 Suppl

The diuretic effects of torasemide and of furosemide were compared in a double blind cross-over study in 13 patients with stable chronic heart failure. Single doses of 10 mg and 20 mg of torasemide and of ... [more ▼]

The diuretic effects of torasemide and of furosemide were compared in a double blind cross-over study in 13 patients with stable chronic heart failure. Single doses of 10 mg and 20 mg of torasemide and of 40 mg of furosemide were given orally, in a randomized order on 3 consecutive days. In addition, a placebo was administered on the day preceding the 3 active drug treatment days to obtain control data. Each experimental day was divided into three urine collection periods - 0 to 4 h, 4 to 12 h and 12 to 24 h. Urine output, ion excretion and clearance were measured during each of the 3 periods as well as for the 24-h period. Torasemide 20 mg was distinctly more active in each of the 3 collection periods and in the 24-h period than furosemide 40 mg, whereas no significant difference was found between furosemide 40 mg and torasemide 10 mg for most of the experimental data. From 0 to 4 h, both torasemide and furosemide significantly increased the urinary flow rate and the urinary excretion of sodium, chloride and calcium, while they decreased the urinary osmolality when compared to placebo. All the effects persisted in the 4 to 12 h period after torasemide 20 mg in contrast to furosemide, whose effects were limited to the 0 to 4 h period. In the third period (12-24 h), the urine volume fell below the placebo value after furosemide but not torasemide, and only torasemide 20 mg was followed by a persistent decrease in the urine osmolality.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailDiuretica en arteriële hypertensie
Krzesinski, Jean-Marie ULg

in Medi-Sfeer (2003), 23

De diuretica blijven één van de nuttigste therapeutische klassen bij de behandeling van arteriële hypertensie. Momenteel worden ze aanbevolen in een lage dosis. Met deze doses behouden diuretica hun ... [more ▼]

De diuretica blijven één van de nuttigste therapeutische klassen bij de behandeling van arteriële hypertensie. Momenteel worden ze aanbevolen in een lage dosis. Met deze doses behouden diuretica hun effect op de arteriële hypertensie, terwijl ze goed verdragen worden. Ze vormen de referentiebehandeling in cardiovasculaire preventiestudies. Omwille van hun lage kostprijs bieden ze ook een onmiskenbaar economisch voordeel. In de laatste aanbevelingen van de Wereldgezondeheidsorganisatie (WHO) en de International Society of Hypertension (ISH) vormen diuretica nog één van de meest valabele therapeutische klassen, vooral bij oudere patiënten en/of patiënten met systolische hypertensie en patiënten van het zwarte ras. Ze zijn vaak onmisbaar in antihypertensieve combinaties. [less ▲]

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See detailLes diurétiques dans l'hypertension artérielle: association spironolactone/altizide et IEC
Krzesinski, Jean-Marie ULg

in Actualité Thérapeutique Internationale (1996), (175), 8

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See detailLes diurétiques et l'hypertension artérielle
Krzesinski, Jean-Marie ULg

in Medi-Sphere (2003), 23

De diuretica blijven één van de nuttigste therapeutische klassen bij de behandeling van arteriële hypertensie. Momenteel worden ze aanbevolen in een lage dosis. Met deze doses behouden diuretica hun ... [more ▼]

De diuretica blijven één van de nuttigste therapeutische klassen bij de behandeling van arteriële hypertensie. Momenteel worden ze aanbevolen in een lage dosis. Met deze doses behouden diuretica hun effect op de arteriële hypertensie, terwijl ze goed verdragen worden. Ze vormen de referentiebehandeling in cardiovasculaire preventiestudies. Omwille van hun lage kostprijs bieden ze ook een onmiskenbaar economisch voordeel. In de laatste aanbevelingen van de Wereldgezondeheidsorganisatie (WHO) en de International Society of Hypertension (ISH) vormen diuretica nog één van de meest valabele therapeutische klassen, vooral bij oudere patiënten en/of patiënten met systolische hypertensie en patiënten van het zwarte ras. Ze zijn vaak onmisbaar in antihypertensieve combinaties. [less ▲]

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See detailLes diuretiques
Krzesinski, Jean-Marie ULg

in I.N.A.M.I consensus (1999)

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See detailDiurnal and seasonal variability of CO2 fluxes over a degraded Woodland under a Sudanian climate in Northern Benin (West Africa)
Ago, Expédit Evariste; Serça, Dominique; Agbossou, Euloge Kossi et al

in Geophysical Research Abstracts (2015, April), 17

Turbulent CO2 exchanges over a degraded woodland were measured during 17 months (from November 2005 to March 2007) by an eddy-covariance system at Nangatchori in the northern part of Benin, West Africa ... [more ▼]

Turbulent CO2 exchanges over a degraded woodland were measured during 17 months (from November 2005 to March 2007) by an eddy-covariance system at Nangatchori in the northern part of Benin, West Africa. The site (Lat 9.65°N, Long 1.74°E, Alt: 432 m), under a Sudanian climate, is one of the sites that were equipped in the framework of the international AMMA-CATH program. The site was highly disturbed during preceding years by illegal tree logging, agricultural activities, cattle pasture, and bushfire. The footprint area is mainly formed by herbs and crops with some sparse shrubs and trees. Fluxes data were completed during the same period by meteorological measurements made at the Nalohou site located approximately 20 km from Nangatchori, and by an inventory of dominating species on 1km2 area around the tower during the wet season. Fluxes response to climatic variables was analyzed. The annual drought and moisture cycle was found to be the main controlling factor of the ecosystem dynamics. A very clear response of CO2 fluxes to PPFD appears, but is different according to seasons. During wet season, CO2 uptake increases with increasing PPFD following a typical curvilinear function and saturates for high PPFD (PPFD > 1000 µmol m-2 s-1), while during dry season, a very weak linear response of CO2 fluxes was observed. No clear dependency of the total ecosystem respiration on temperature was observed. At an annual scale (from November 1st 2005 to October 31st 2006), net carbon sequestered by the ecosystem was 18 +- 5 g C m-2. Finally, with respect to the water use the ecosystem appeared to be more efficient during morning and wet season than during afternoon and dry period. [less ▲]

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See detailDiurnal Centroid Of Ecosystem Energy And Carbon Fluxes At Fluxnet Sites
Wilson, Kb.; Baldocchi, D.; Falge, E. et al

in Journal of Geophysical Research. Atmospheres (2003), 108(D21),

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See detailDiurnal CO2 flux responses in cultivated savanna in Benin (West Africa)
Ago, Expédit Evariste ULg; Agbossou, Euloge Kossi; Galle, Sylvie et al

Scientific conference (2012, February 08)

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