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See detailE.coli virulence factors
Mainil, Jacques ULg

Conference (2011)

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See detailE.T.A. Hoffmann und das Experiment
Küpper, Achim ULg

Scientific conference (2013, May 30)

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See detailE.T.A. Hoffmann: Das Majorat. Rezension
Küpper, Achim ULg

E-print/Working paper (2004)

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See detailE1 Transitions of Astrophysical Interest in Neutral Oxygen
Hibbert, A.; Biémont, Emile ULg; Godefroid, M. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1991), 24

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See detailEACTS guidelines for the use of patient safety checklists.
Clark, SC; Dunning, J; Alfieri, OR et al

in European Journal of Cardio - Thoracic Surgery (2012), 41(5), 993-1004

The Safety Checklist concept has been an integral part of many industries that face high-complexity tasks for many decades and in industries such as aviation and engineering checklists have evolved from ... [more ▼]

The Safety Checklist concept has been an integral part of many industries that face high-complexity tasks for many decades and in industries such as aviation and engineering checklists have evolved from their very inception. Investigations of the causes of surgical deaths around the world have repeatedly pointed to medical errors that could be prevented as an important cause of death and disability. As a result, the World Health Organisation developed and evaluated a three-stage surgical checklist in 2007 demonstrating that complications were significantly reduced, including surgical infection rates and even mortality. Together with the results from other large cohort studies into the utility of the surgical checklist, many countries have fully implemented the use of surgical checklists into routine practice. A key factor in the successful implementation of a surgical checklist is engagement of the staff implementing the checklist. In surgical specialties such as our own it was quickly seen that there were many important omissions in the generic checklist that did not cover issues particular to our specialty, and thus the European Association for Cardio-Thoracic Surgery embarked on a process to create a version of the checklist that might be more appropriate and specific to cardiothoracic surgery, including checks on preparations for excessive bleeding, perfusion arrangements and ICU preparations, for example. The guideline presented here summarizes the evidence for the surgical checklist and also goes through in detail the changes recommended for our specialty. [less ▲]

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See detailL'EAD à l'Université de Liège, Le dispositif d'accompagnement du LabSET
Lecomte, Béatrice ULg

Scientific conference (2005)

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See detailEAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography.
Lang, Roberto M.; Badano, Luigi P.; Tsang, Wendy et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2012), 25(1), 3-46

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See detailEAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography.
Lang, Roberto M.; Badano, Luigi P.; Tsang, Wendy et al

in European Heart Journal - Cardiovascular Imaging (2012), 13(1), 1-46

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See detailEANA European Astrobiology workhop, Program and abstracts
Javaux, Emmanuelle ULg; Dehant, Véronique; Muller, Christian

Book (2009)

EANA Euroepan Astrobiology workhop, Program and abstracts, Brussels 12-14 oct 2009

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See detailEAO Summer Camp Session
LAMBERT, France ULg

Conference (2012, October 11)

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See detailEarlier onset of delta-retrovirus-induced leukemia after splenectomy.
Florins, ARNAUD-FRANCOIS ULg; Reichert, Michal; Asquith, Becca et al

in PLoS ONE (2009), 4(9), 6943

Infection by delta-retroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) is mostly asymptomatic. Indeed, only a minority (<5%) of delta-retrovirus infected hosts ... [more ▼]

Infection by delta-retroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) is mostly asymptomatic. Indeed, only a minority (<5%) of delta-retrovirus infected hosts will develop either lymphoproliferative or neurodegenerative diseases after long latency periods. In fact, the host immune response is believed to tightly control viral replication but this assumption has not been definitely proven in vivo. Here, we provide direct experimental evidence demonstrating that integrity of the spleen is required to control pathogenesis. In the BLV model, we show that asplenia decreases efficiency of the immune response and induces an imbalance in cell dynamics resulting in accelerated onset of leukemia. These observations enlighten a potential threat in splenectomized HTLV-1 carriers and justify a regular preventive evaluation. [less ▲]

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See detailEarlier onset of tumoral anglogenesis in matrix metalloproteinase-19-deficient mice
Jost, M.; Folgueras, A. R.; Frerart, F. et al

in Cancer Research (2006), 66(10), 5234-5241

Among matrix metalloproteinases (MMP), MMP-19 displays unique structural features and tissue distribution. In contrast to most MMPs, MMP-19 is expressed in normal human epidermis and down-regulated during ... [more ▼]

Among matrix metalloproteinases (MMP), MMP-19 displays unique structural features and tissue distribution. In contrast to most MMPs, MMP-19 is expressed in normal human epidermis and down-regulated during malignant transformation and dedifferentiation. The contribution of MMP-19 during tumor angiogenesis is presently unknown. In an attempt to give new insights into MMP-19 in vivo functions, angiogenic response of mutant mice lacking MMP-19 was analyzed after transplantation of murine malignant PDVA keratinocytes and after injection of Matrigel supplemented with basic fibroblast growth factor. In situ hybridization and immunohistochemical analysis revealed that MMP-19 is produced by host mesenchymal cells but not by endothelial capillary cells or CD11b-positive inflammatory cells. Based on a new computer-assisted method of quantification, we provide evidence that host MMP-19 deficiency was associated with an increased early angiogenic response. In addition, increased tumor invasion was observed in MMP-19-/- mice. We conclude that, in contrast to most MMPs that promote tumor progression, MMP-19 is a negative regulator of early steps of tumor angiogenesis and invasion. These data highlight the requirement to understand the individual functions of each MMP to improve anticancer strategies. [less ▲]

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See detailThe earlier the smaller the better for natalizumab-associated PML: in MRI vigilance veritas ?
PHAN BA, Remy ULg; Belachew, Shibeshih ULg; Outteryck, Olivier et al

in Neurology (2012), 79

Natalizumab-associated progressive multifocal leukoencephalopathy (N-PML) in multiple sclerosis (MS) is due to CNS infection by the opportunistic JC virus (JCV). As of december 2011, 193 confirmed cases ... [more ▼]

Natalizumab-associated progressive multifocal leukoencephalopathy (N-PML) in multiple sclerosis (MS) is due to CNS infection by the opportunistic JC virus (JCV). As of december 2011, 193 confirmed cases of N-PML have been observed, giving rise to an overall risk of approximately 0,202%. N-PML pathogenesis remains partially elusive although risk factors have now been clearly delineated. In patients with prior JCV infection detected by serum anti-JCV antibodies, duration of therapy and prior use of immunosuppressants (IS) increase the risk of N-PML. The clinical outcome of MS patients who developed N-PML was highly variable, ranging from asymptomatic case to varying degrees of neurological disability or even death. It was also observed in real life setting that the earlier N-PML was diagnosed and treated, the better was the clinical outcome. Clinical vigilance is now considered as the established cornerstone of PML risk-management algorithm. Here we present early MRI features of 4 out of 8 N-PML cases, which were observed in Wallonia-Brussels and Northern France in more than 4 years of post-marketing utilization of natalizumab for both regions. We are not aware of the specific context and outcome of the 4 other N-PML cases, which were diagnosed and treated in other centers. The reported cases emphasize that (i) N-PML can have a long presymptomatic course while still being clearly detectable with MR imaging, (ii) N-PML can have a benign outcome provided it is diagnosed and treated early, (iii) a clinically symptomatic N-PML may be a further advanced infection with a poorer prognosis, and (iv) periodic brain MR scans, particularly in high risk situations, are likely to provide earlier detection of N-PML and better outcomes. [less ▲]

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See detailEarliest Taeniate Bisaccates from the Amazon basin are not older than Westphalian.
Loboziak, S; Melo, J.H.G.; Dino, R et al

in Geobios (1997), 30(4), 467-474

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See detailEarly abortion in reciprocal crosses between phaseolus vulgaris and phaseolus polyanthus, and in vitro culture of immature embryos from these species
Toussaint, André ULg; Geerts, P.; Clement, F. et al

in Belgian Journal of Botany (2004), 137(1), 47-54

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See detailEarly activation of cardiac and renal endothelin systems in experimental heart failure
Motte, S.; van Beneden, R.; Mottet, J. et al

in American Journal of Physiology - Heart and Circulatory Physiology (2003), 285(6), 2482-2491

We investigated the time course of the expression of cardiac and renal endothelin systems in tachycardia-induced heart failure in dogs. Eleven beagles underwent rapid pacing at a progressively increased ... [more ▼]

We investigated the time course of the expression of cardiac and renal endothelin systems in tachycardia-induced heart failure in dogs. Eleven beagles underwent rapid pacing at a progressively increased rate over a period of 5 wk, with a weekly clinical examination, echocardiography, measurement of circulating and urinary endothelin-1 (ET-1), and myocardial and renal tissue biopsies. Real-time quantitative PCR was used for determinations of tissue prepro-ET-1 (ppET-1), ET-1-converting enzyme (ECE-1), and ETA and ETB receptor mRNA. Cardiac and renal tissue ET-1 contents were evaluated by immunostaining and measured by radioimmunoassay at autopsy. Rapid pacing caused a progressive increase in end-systolic and end-diastolic ventricular volumes (P<0.05) from week 2 together with a decrease in ejection fraction and in mean velocity of circumferential shortening (P<0.05) from week 1. These changes were tightly correlated to myocardial ppET-1 and renal ETA receptor mRNA and less so to myocardial ECE-1 mRNA, and they occurred before any increase in plasma and urinary ET-1 (P<0.05 from week 4) and clinical signs of heart failure. Renal ppET-1 did not change. Both cardiac and renal ET-1 peptide contents were increased at autopsy. We conclude that tachycardia-induced heart failure in dogs is characterized by an early activation of the cardiac and renal tissue endothelin systems, which occurs before any changes in circulating and urinary ET-1 and is closely related to altered ventricular function. [less ▲]

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