Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailDosimetry for 6-[18F]Fluoro-L-DOPA in Humans Based on Biodistribution in Mice
Bretin, Florian ULg; Warnock, Geoffrey ULg; Bahri, Mohamed Ali ULg et al

Poster (2012, October)

Aim. The objective of this work was to estimate human dosimetry for 6-[18F]Fluoro-L-DOPA (F-DOPA) from biodistribution in mice, obtained from organ harvesting at different time points and from a hybrid ... [more ▼]

Aim. The objective of this work was to estimate human dosimetry for 6-[18F]Fluoro-L-DOPA (F-DOPA) from biodistribution in mice, obtained from organ harvesting at different time points and from a hybrid method combining dynamic PET followed by organ harvesting. Materials and methods. The tissue distribution of F-DOPA over time was determined in isoflurane-anaesthetized mice. Radioassay was performed on harvested organs at 2, 5, 10, 30, 60 and 120 minutes post administration (n = 5 at each time point). Dynamic PET images were acquired in list-mode with a Siemens FOCUS 120 microPET for 120 minutes after injection and followed by radioassay of harvested organs (n = 4). List-mode data were histogrammed in 6*5s, 6*10s, 3*20s, 5*30s, 5*60s, 8*150s, 6*300s, 6*600s 3D sinograms. Final images were obtained using filtered backprojection with correction for all physical effects except for scatter. Attenuation correction resulted from a pre-injection transmission scan with a cobalt-57 point source. Organs were manually delineated. The organ time-activity-curves (TACs) from both methods were extrapolated from a simulated 35 g standard mouse to a 70 kg standard male human using a technique based on organ to bodyweight ratios. A bladder voiding scenario was used to simulate excretion every 2 h. The absorbed doses in major human organs were calculated using the extrapolated TACs with the commercially available software OLINDA/EXM (Version 1.1). Results. The extrapolated organ activity curves obtained using the harvesting and imaging methods showed a high correlation (r = 0.94 ± 0.05, p < 0.001). However, TACs from PET alone under- or overestimated the activity in individual organs in contrast to TACs obtained using the cross-calibration of the PET data with the activity in post-scan dissected organs. Those organs in the excretion pathways, comprising bladder wall, kidneys and liver, received the highest organ doses. The total body absorbed dose was 0.0118 mGy/MBq for both the imaging based and harvesting based methods. The effective dose was 0.0193 mSv/MBq for the hybrid imaging-harvesting technique and 0.0189 mSv/MBq for the pure harvesting technique. Conclusion. The doses obtained agreed well with the few results available in the literature. The hybrid technique combining dynamic PET scanning followed by organ harvesting appeared to be a good alternative to the gold standard ex vivo radioassay method. It is much faster and minimizes the effect of some weakness of the pure imaging technique, such as partial volume effect. [less ▲]

Detailed reference viewed: 46 (8 ULg)
Full Text
Peer Reviewed
See detailDosimetry for 6-[18F]Fluoro-L-DOPA in humans based on in vivo microPET scans and ex vivo tissue distribution in mice
Bretin, Florian ULg; Warnock, Geoffrey ULg; Bahri, Mohamed Ali ULg et al

Poster (2012, September)

Radiation dosimetry of new radiopharmaceuticals generally starts with studies in small animals such as mice and rats. The traditional technique has long been ex vivo measurement of the biodistribution ... [more ▼]

Radiation dosimetry of new radiopharmaceuticals generally starts with studies in small animals such as mice and rats. The traditional technique has long been ex vivo measurement of the biodistribution over time using harvested organs at different times post administration of the radiopharmaceutical. Since this approach requires a significant amount of animals, dynamic microPET studies, where the biodistribution of the tracer over time can be determined in vivo in a single scan, are an invaluable alternative. Due to known imaging artifacts and limitations, such as partial volume effect, a hybrid technique combining harvesting organs (post-scan) and dynamic imaging was introduced to achieve a cross-calibration to account for these limitations. Since 6-[18F]Fluoro-L-DOPA is a widely used PET tracer to study the dopaminergic system in neurology and oncology and there is no sound published dosimetry data, absorbed doses for major organs in humans were estimated using the traditional ex vivo technique and by dynamic microPET imaging in mice, allowing direct comparison of the results from the two techniques. The tissue distribution over time of 6-[18F]Fluoro-L-DOPA was determined by radioassay of harvested organs at 2, 5, 10, 30, 60, 120 minutes post administration (n=5 at each time point) in isoflurane-anaesthetized mice. Dynamic PET images were acquired with a FOCUS 120 microPET for 120 minutes after injection of 6-[18F]Fluoro-L-DOPA followed by radioassay of harvested organs (n=4). A bladder voiding scenario was used to simulate excretion every 2 h. The organ time-activity-curves (TACs) from both methods were extrapolated from a simulated 35 g standard mouse to a 70 kg standard male human using a technique based on organ to bodyweight ratios. The absorbed doses in major human organs were calculated with the commercially available human dosimetry software OLINDA/EXM (Version 1.1) using the extrapolated TACs. The extrapolated organ TACs obtained using the two methods showed a high correlation (average r = 0.94 ± 0.05, p < 0.001). However, TACs from PET alone under- or overestimated the activity in individual organs in contrast to TACs obtained using the cross-calibration of the PET data with the activity in post-scan dissected organs. Those organs in the excretion pathways, comprising bladder wall, kidneys and liver, received the highest organ doses. The total body absorbed dose was 0.0118 mGy/MBq for both the imaging based and harvesting based methods. The effective dose was 0.0193 mSv/MBq for the hybrid imaging-harvesting technique and 0.0189 mSv/MBq for the pure harvesting technique. Scaling errors in the PET TACs are likely caused by quantification errors such as partial volume effects and image artifacts. The use of a hybrid imaging technique to cross-calibrate the TACs improved the accuracy of the imaging-based dosimetry estimates. Therefore the hybrid technique combining dynamic imaging and harvesting organs (post-scan) is a suitable alternative to the gold standard ex vivo radioassay method. It yields comparable results yet reduces significantly the amount of animals needed in the study and can accelerate data acquisition. [less ▲]

Detailed reference viewed: 82 (20 ULg)
See detailDoss, Adolf von
Pirenne, Christophe ULg

in Finscher, Ludwig (Ed.) Die Musik in Geschichte und Gegenwart (2001)

Detailed reference viewed: 20 (2 ULg)
Full Text
See detailDossier Texas - Alan Govenar
Sacré, Robert ULg

Article for general public (2012)

Detailed reference viewed: 9 (1 ULg)
See detailDossier : Politique et religieux. Relativiser les débats au regard de l'histoire
Pirenne-Delforge, Vinciane ULg

Article for general public (2010)

Dans nos sociétés sécularisées, le politique et le religieux occupent des sphères séparées et l'irruption des signes religieux dans l'espace public suscite régulièrement des débats passionnés. Le présent ... [more ▼]

Dans nos sociétés sécularisées, le politique et le religieux occupent des sphères séparées et l'irruption des signes religieux dans l'espace public suscite régulièrement des débats passionnés. Le présent dossier entend replacer la question des relations entre politique et religion dans une perspective historique et critique. Quelques moments-clés de cette interaction ont été privilégiés, de l'Antiquité à nos jours : les polythéismes grec et romain où politique et religieux sont enchevêtrés ; les débuts du christianisme où l'adhésion volontaire à une profession de foi change la donne ; la période moderne, où la réflexion philosophique, d'une part, et l'émergence des États européens, d'autre part, questionnent la place de l'Église dans la cité ; la relation entre islam et politique, remise en perspective dans une comparaison avec le christianisme ; la définition du fait d'être « laïque » aujourd'hui. Un tel parcours historique permet de nourrir la réflexion sur des enjeux contemporains, en leur donnant une profondeur de champ qui a le mérite de relativiser les positions. [less ▲]

Detailed reference viewed: 27 (4 ULg)
See detailDossier Culture Censure et liberté d'expression
Hamers, Jérémy ULg; Cormann, Grégory ULg

Diverse speeche and writing (2013)

Detailed reference viewed: 29 (12 ULg)
Full Text
See detailDossier de candidature INNOVACT Campus Award
Goffin, Dorothée ULg

Report (2011)

Detailed reference viewed: 16 (3 ULg)
Full Text
See detailDossier de documentation 2012-2013 : les entreprises publiques locales
Durviaux, Ann-Lawrence ULg

Learning material (2012)

Detailed reference viewed: 26 (1 ULg)
Full Text
Peer Reviewed
See detailDossier de progression et dossier de réussite : deux outils complémentaires au service de la professionnalisation enseignante dans le supérieur
Poumay, Marianne ULg; Georges, François ULg

in Collected Essays on Learning and Teaching (2009), II

Cet article aborde et illustre les notions de référentiel de compétences, de dossier de progression et de dossier de réussite (Tardif, 2006) tels qu’ils sont mis en oeuvre au sein du programme Formasup ... [more ▼]

Cet article aborde et illustre les notions de référentiel de compétences, de dossier de progression et de dossier de réussite (Tardif, 2006) tels qu’ils sont mis en oeuvre au sein du programme Formasup, master complémentaire en pédagogie de l’enseignement supérieur organisé à l’université de Liège. Les auteurs présentent l’articulation interne de ce programme qui cible un nombre limité de compétences critiques, accompagne le développement de ces compétences chez les enseignants participants et mesure ce développement à travers un portfolio. Ils discutent enfin des défis et difficultés qui persistent ainsi que des moyens mis en place par l’équipe encadrante pour tenter de les surmonter. [less ▲]

Detailed reference viewed: 167 (41 ULg)
Full Text
Peer Reviewed
See detailLe dossier des ouvrages médicaux attribués à Cléopâtre dans le fonds M.D. Grmek conservé à l'IMEC
Marganne, Marie-Hélène ULg

in Histoire des Sciences Médicales (2011, June), 45(2), 149-154

After describing the dossier of the medical works attributed to Cleopatra in the M.D. Grmek fund deposited at IMEC (Institut Mémoires de l'Édition Contemporaine, Abbaye d'Ardenne, Saint-Germain-la-Blanche ... [more ▼]

After describing the dossier of the medical works attributed to Cleopatra in the M.D. Grmek fund deposited at IMEC (Institut Mémoires de l'Édition Contemporaine, Abbaye d'Ardenne, Saint-Germain-la-Blanche-Herbe, near Caen), this paper reports some recent papyrological discoveries (P. Oxy. 71.4809, third century AD, and P. Berol. inv. 25239, BC 33), as well as some new studies in the field over the past ten years, and presents the project of the Centre de Documentation de Papyrologie Littéraire (CEDOPAL, University of Liège) for an edition of the fragments of Cleopatra's Kosmetikon. [less ▲]

Detailed reference viewed: 57 (1 ULg)
Full Text
See detailDossier en souffrance
Frankignoulle, Pierre ULg; Stevens, Barbara

in A+ (2003)

Detailed reference viewed: 14 (2 ULg)
See detailLe dossier historique des châsses en Wallonie
George, Philippe ULg

in Les châsses en Wallonie (1999) (2002)

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailLe dossier informatisé en réanimation
Micheels, Jean ULg; Wolfs, C.; Lamy, Maurice ULg

in Annales de l'Anesthésiologie Française (1980), 21(3), 215-222

Detailed reference viewed: 31 (1 ULg)
Full Text
Peer Reviewed
See detailLe dossier papyrologique de Favorinos d'Arles
Marganne, Marie-Hélène ULg

Conference (2013, November 14)

La mise en série et la comparaison des trois papyrus littéraires grecs en relation avec Favorinos révèlent maints points communs : même datation au IIIe siècle, même utilisation d'un support d'écriture de ... [more ▼]

La mise en série et la comparaison des trois papyrus littéraires grecs en relation avec Favorinos révèlent maints points communs : même datation au IIIe siècle, même utilisation d'un support d'écriture de réemploi, même type d'écriture, informelle ou cursive, et même contexte de production ou d'utilisation. Provenant, l’un, de la Marmarique, et un autre, sûrement, d'Oxyrhynchus, ils attestent la connaissance de l'auteur arlésien (c. 80-150/160), dans la chôra égyptienne au sens large, moins d'un siècle après sa mort, probablement dans le cadre particulier des intérêts liés à la rhétorique et à son enseignement ou son apprentissage ou sa pratique. [less ▲]

Detailed reference viewed: 17 (1 ULg)
See detailDossier pédagogique de l'exposition De demain à Delvaux
Duchesne, Jean-Patrick ULg

Book published by Grand Curtius (2009)

Detailed reference viewed: 35 (8 ULg)
See detailDossier pédagogique inetrdisciplinaire-La santé
Roosen, Antoine ULg; Lecocq, Berthe; Robert, Jocelyne ULg et al

Learning material (1980)

Detailed reference viewed: 31 (0 ULg)
See detailDossier pédagogique interdisciplinaire-L'homme et l'Etat
CERM; Roosen, Antoine ULg; lecocq, Berthe et al

Learning material (1982)

Detailed reference viewed: 14 (0 ULg)
Full Text
See detailDossier presse - expo les horlogers du ciel
Champenois, Carole ULg; Moreau, Didier ULg; Nazé, Yaël ULg

Diverse speeche and writing (2011)

Detailed reference viewed: 41 (18 ULg)