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See detaildel 15N - del 13C relationships in suspended particles from the Gulf of Biscay
Dauby, Patrick ULg; Elskens, Marc

Conference (1996, July)

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See detailLe délai de prescription de l'action civile résultant d'une infraction : fin d'une controverse
Monville, Pierre ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailDelay in feed access and spread of hatch: Importance of early nutrition
Willemsen, H.; Debonne, M.; Swennen, Q. et al

in World's Poultry Science Journal (2010), 66(2), 177-188

In a commercial hatchery, chicks (or poults) hatch over a 24-48 hour period. All chicks remain in the incubator until the majority of the chicks have emerged from the shell. Once removed from the ... [more ▼]

In a commercial hatchery, chicks (or poults) hatch over a 24-48 hour period. All chicks remain in the incubator until the majority of the chicks have emerged from the shell. Once removed from the incubator, the newly hatched chick has to undergo several hatchery treatments and is then transported before being placed on the broiler farm. This means that, under practical conditions, chicks are deprived of feed and water for up to 72 hours. In addition, the time of hatch within the hatching window and the spread of hatch cause variability in the amount of time that chicks are feed deprived. Literature on feed deprivation after hatch clearly demonstrates the detrimental effects of any delay in feed access on performance of the chicks with respect to growth, immune system activation, digestive enzyme stimulation and organ development. Improved management strategies, such as shortening the hatching window or the time to first feeding by specific management measures, provide an alternative in dealing with the negative effects caused by a delay in feed access. The development of pre-starter diets that better meet the needs of the newly hatched chicks or in ovo feeding to bridge the gap between hatch and first feeding provide other alternatives in overcoming these problems. However, speculation remains regarding the importance of in ovo or early feeding, or whether the in ovo or early feeding itself is responsible for the beneficial effects reported. The aim of the following review is to discuss the current status of research into early feeding and to stimulate future and further research regarding these topics. © World's Poultry Science Association 2010. [less ▲]

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See detailDelay in the execution of voluntary movement by electrical or magnetic brain stimulation in intact man. Evidence for the storage of motor programs in the brain.
Day, B. L.; Rothwell, J. C.; Thompson, P. D. et al

in Brain : A Journal of Neurology (1989), 112 ( Pt 3)

Experiments were undertaken to study the effect on voluntary movement of an electrical or magnetic stimulus delivered to the brain through the scalp. Subjects were trained to flex or extend their wrist ... [more ▼]

Experiments were undertaken to study the effect on voluntary movement of an electrical or magnetic stimulus delivered to the brain through the scalp. Subjects were trained to flex or extend their wrist rapidly in response to an auditory tone. A single brain stimulus (electrical or magnetic) delivered after the tone and before the usual time of onset of the voluntary reaction could delay the execution of the movement for up to 150 ms, without affecting the pattern of the agonist and antagonist EMG bursts. The delay increased with increasing stimulus intensity and with stimuli which were applied nearer to the usual time of onset of the voluntary reaction. A stimulus given after the onset of the first voluntary agonist EMG burst only delayed the onset of the first antagonist and later EMG bursts. Movement was not delayed when similar experiments were performed with supramaximal stimulation of the median nerve instead of the brain stimulus. The delay following a cortical shock was not due to spinal motoneurons being inaccessible to descending input during the delay period since a second brain stimulus, given in the middle of the delay period, was capable of producing a direct muscle response. Neither could the delay be explained by the brain stimulus altering the time of the subject's intention to respond since a stimulus delivered to one hemisphere before an attempted simultaneous bilateral wrist movement produced a far greater delay of the contralateral than the ipsilateral movement. We suggest that the brain stimulus delayed movement by inhibiting a group of strategically placed neurons in the brain (probably in the motor cortex) which made them unresponsive for a brief period to the command signals they receive which initiate the motor program of agonist and antagonist muscle activity. The results have implications for the issues of the storage of motor programs, internal monitoring of central movement commands and the site of organization of the antagonist EMG burst. [less ▲]

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See detailDelayed and reduced coccolithophorid calcification under elevated PCO2
Delille, Bruno ULg; Harlay, Jérôme ULg; Zondervan, Ingrid et al

Poster (2004, May 10)

Numerous experiments to date have demonstrated that elevated PCO2 is detrimental to biogenic calcification rates. However, most of these experiments have been realized in batch or continuous cultures and ... [more ▼]

Numerous experiments to date have demonstrated that elevated PCO2 is detrimental to biogenic calcification rates. However, most of these experiments have been realized in batch or continuous cultures and give little information on the dynamics of calcification in natural conditions. The present work describes the development and decay of a nutrient-induced bloom of the coccolithophorid Emiliania huxleyi in a mesocosm experiment. The monitoring of Dissolved Inorganic Carbon (DIC) and Total Alkalinity (TAlk) within the seawater enclosures allowed us to describe comprehensively day to day dynamics of both calcification and organic carbon production. Three atmospheric PCO2 conditions (glacial, present and next century) were simulated by bubbling CO2 mixtures, while total alkalinity was left to evolve from its present value. No conspicuous change of Net Community Production under elevated PCO2 was recorded while the production of inorganic carbon appeared to be affected in two ways. Firstly, the production rate of inorganic carbon appeared to be lowered by 40% in the next century PCO2 conditions, decreasing concomitantly the calcification to photosynthesis ratio from 0.75 (glacial conditions) to 0.45 (next century conditions). Secondly, the onset of calcification was delayed by 24~48h under elevated PCO2 conditions, reducing the overall length of calcification in the course of the bloom. These two effects would act to reduce the amount of precipitated CaCO3 by coccolithophorids in a High CO2 world [less ▲]

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See detailDelayed chlorophyll accumulation and pigment photodestruction in the epicotyls of dark-grown pea (Pisum sativum)
Boddi, B.; Loudeche, R.; Franck, Fabrice ULg

in Physiologia Plantarum (2005), 125(3), 365-372

A comparison was performed of the tetrapyrrole transformations that occur upon irradiation of epicotyl or leaves of dark-grown Pisum sativum L. (var. Zsuzsi, Hungary). High performance liquid ... [more ▼]

A comparison was performed of the tetrapyrrole transformations that occur upon irradiation of epicotyl or leaves of dark-grown Pisum sativum L. (var. Zsuzsi, Hungary). High performance liquid chromatography analysis after continuous or flash-irradiation showed that the biosynthetic pathway from protochlorophyllide (Pchlide) to chlorophyll (Chl) a was markedly slowed down at the step of the reduction of geranylgeranyl(gg)-Chl to dihydrogeranylgeranyl (dhgg)-Chl in epicotyls, whereas phytyl-Chl was synthesized in leaves subjected to the same light treatments. Quantitative pigment analysis during continuous irradiations of different intensities also showed that significant Pchlide photodestruction occurred in epicotyls even under weak light. When both Pchlide and chlorophyllide and/or chlorophylls were present in epicotyls, Pchlide photodestruction was faster under 630-nm light than under 670-nm light, which indicates that this process is most efficiently promoted by Pchlide excitation. Pre-incubation of epicotyl segments with 10 mM ascorbate partly alleviated pigment photodestruction in white light. It is concluded that formation of photoactive Pchlide-Pchlide oxidoreductase complexes is important to prevent fast pigment photooxidation after Pchlide accumulation in the dark. [less ▲]

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See detailDelayed colopericardial fistula and pyopneumopericardium.
JOURET, François ULg; Castanares-Zapatero, Diego; Laterre, Pierre-Francois

in Intensive Care Medicine (2010), 36(3), 557-8

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See detailDelayed control of axial compressors
Aernouts, Werner; Sepulchre, Rodolphe ULg; Roose, Dirk

in International Journal of Bifurcation & Chaos in Applied Sciences & Engineering (2000), 10(5),

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See detailDelayed decision-making in bistable models
Trotta, Laura ULg; Sepulchre, Rodolphe ULg; Bullinger, Eric ULg

in Proceedings of the 49th IEEE Conference on Decision and Control (2010, December)

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See detailDelayed diagnosis of cardiomyopathy in a girl treated for asthma bronchiale
MASTOURI, M.; FUDVOYE, Julie ULg; ANTOLE, N. et al

Conference (2013, March)

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See detailDelayed GM-CSF treatment stimulates axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous macrophages
Bouhy, Delphine; Malgrange, Brigitte ULg; Multon, Sylvie ULg et al

in FASEB Journal (2006), 20(8), 12391241

Macrophages (monocytes/microglia) could play a critical role in central nervous system repair. We have previously found a synchronism between the regression of spontaneous axonal regeneration and the ... [more ▼]

Macrophages (monocytes/microglia) could play a critical role in central nervous system repair. We have previously found a synchronism between the regression of spontaneous axonal regeneration and the deactivation of macrophages 3-4 wk after a compression-injury of rat spinal cord. To explore whether reactivation of endogenous macrophages might be beneficial for spinal cord repair, we have studied the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) in the same paraplegia model and in cell cultures. There was a significant, though transient, improvement of locomotor recovery after a single delayed intraperitoneal injection of 2 mu g GM-CSF, which also increased significantly the expression of Cr3 and brain-derived neurotrophic factor ( BDNF) by macrophages at the lesion site. At longer survival delays, axonal regeneration was significantly enhanced in GMCSF-treated rats. In vitro, BV2 microglial cells expressed higher levels of BDNF in the presence of GM-CSF and neurons cocultured with microglial cells activated by GM-CSF generated more neurites, an effect blocked by a BDNF antibody. These experiments suggest that GM-CSF could be an interesting treatment option for spinal cord injury and that its beneficial effects might be mediated by BDNF.-Bouhy, D., Malgrange, B., Multon, S., Poirrier, A. L., Scholtes, F., Schoenen, J., Franzen, R. Delayed GM-CSF treatment stimulates axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous macrophages. [less ▲]

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See detailDelayed graft function does not harm the future of donation-after- cardiac-death kidney transplants
LeDinh, H; WEEKERS, Laurent ULg; BONVOISIN, Catherine ULg et al

Conference (2012, March 29)

Introduction: Delayed graft function (DGF) occurs more frequently in kidney transplants from donation after cardiac death (DCD) than from donation after brain death (DBD). We investigated the effect of ... [more ▼]

Introduction: Delayed graft function (DGF) occurs more frequently in kidney transplants from donation after cardiac death (DCD) than from donation after brain death (DBD). We investigated the effect of DGF on post-transplant outcomes in controlled DCD kidney grafts. Patients and Methods: This single-center retrospective study recruited 80 controlled DCD kidney allo- grafts which have been performed at the University Hospital of Sart Tilman, University of Liège, from Jan 2005 to Dec 2011. Results: Mean patient follow-up was 28.5 months. No primary non-function grafts were encountered. DGF rate was 36%. Overall graft survivals between groups with and without DGF were 92.4% and 95.1% at 1 year, 92.4% and 91.7% at 3 years, and 84.7% and 91.7% at 5 years (p=ns), respectively. Patients with and without DGF had the same survival rates at the corresponding time points (92.4% and 97.1%, 92.4% and 93.7%, and 84.7% and 93.7%, p=ns, respectively). Estimated glomerular filtration rate (eGFR) was significantly lower in DGF group compared to non-DGF group at hospital discharge (29 vs 42 ml/min, p=0.001) and up to 1 year post-transplant (46 vs 53 ml/min, p=0.045), but the differ- ence disappeared afterwards (50 vs 48 ml/min at 3 years, and 54 vs 53 ml/min at 5 years, p=ns). DGF did not increase the risk of acute rejection or surgical complications. 29.6% of recipients with DGF de- veloped acute rejection (biopsy-proven rejection and clinically suspected rejection) compared with 29.2% of recipients without DGF (p=ns). The rate of all surgical complications was 33.3% and 25% in recipients with and without DGF (p=ns). However, DGF prolonged significantly the length of hospitaliza- tion in DGF than non-DGF group (18.9 vs 13 days, p=0.000). Donor BMI 􏰤 30 kg/m2􏰁􏰀􏰚􏰌􏰈􏰏􏰥􏰏􏰌􏰝􏰣􏰀􏰕􏰉􏰂􏰀􏰤 30 kg/m2 and pre-transplant dialysis duration increased the risk of DGF in a multivariate logistic regression analysis. Conclusions: Apart from longer hospital stay, DGF had no deleterious impact on the future of DCD kidney allografts. Comparable graft and patient survival, renal function, rejection rate and surgical com- plications were observed between groups with and without DGF. [less ▲]

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See detailDelayed graft function does not harm the future of donation-after-cardiac death in kidney transplantation.
Le Dinh, Hieu; WEEKERS, Laurent ULg; BONVOISIN, Catherine ULg et al

in Transplantation Proceedings (2012), 44(9), 2795-802

INTRODUCTION: Delayed graft function (DGF) occurs more frequently in kidney transplants from donation after cardiac death (DCD) than from donation after brain death (DBD). We investigated the effect of ... [more ▼]

INTRODUCTION: Delayed graft function (DGF) occurs more frequently in kidney transplants from donation after cardiac death (DCD) than from donation after brain death (DBD). We investigated the effect of DGF on posttransplantation outcomes among grafts from controlled DCD kidneys. PATIENTS AND METHODS: This single-center retrospective study recruited 80 controlled DCD kidneys transplanted from January 2005 to December 2011. Mean patient follow-up was 28.5 months. RESULTS: There were no primary nonfunction grafts; the DGF rate was 35.5%. Overall graft survival rates between groups with versus without DGF were 92.4% and 95.2% at 1 year, 92.4% and 87.1% at 3 years, and 84.7% and 87.1% at 5 years, respectively (P = not significant (NS)). Patients with versus without DGF showed the same survival rates at the corresponding time 92.4% vs 97.2%, 92.4% vs 93.9%, and 84.7% vs 93.9% (P = NS). Estimated glomerular filtration rate was significantly lower in the DGF compared with the non-DGF group at hospital discharge (29 vs 42 mL/min; P = .00) and at 6 months posttransplantation (46 vs 52 mL/min; P = .04), but the difference disappeared thereafter: 47 vs 52 mL/min at 1 year, 50 vs 48 mL/min at 3 years, and 54 vs 53 mL/min at 5 years (P = NS). DGF did not increase the risk of an acute rejection episode (29.6% vs 30.6%; P = NS) or rate of surgical complications (33.3% vs 26.5%; P = NS). However, DGF prolonged significantly the length of hospitalization in the DGF versus the non- DGF group (18.9 vs 13 days; P = .00). Donor body mass index (BMI) >/= 30 kg/m(2), recipient BMI >/=30 kg/m(2), and pretransplantation dialysis duration increased the risk of DGF upon multivariate logistic regression analysis. CONCLUSIONS: Apart from the longer hospital stay, DGF had no deleterious impact on the future of kidney allografts from controlled DCD, which showed comparable graft and patient survivals, renal function, rejection rates, and surgical complications as a group without DGF. Therefore, DGF should no longer be considered to be a medical barrier to the use of kidney grafts from controlled DCD. [less ▲]

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See detailDelayed information flow effect in economy systems. An ACP model study
Miskiewicz, J.; Ausloos, Marcel ULg

in Physica A-Statistical Mechanics and its Applications (2007), 382(1), 179-186

Applying any strategy requires some knowledge about the past state of the system. Unfortunately in the case of economy. collecting information is a (difficult, expensive and time consuming process ... [more ▼]

Applying any strategy requires some knowledge about the past state of the system. Unfortunately in the case of economy. collecting information is a (difficult, expensive and time consuming process. Therefore, the information about the system is usually known only at the end of some well-defined intervals, e.g. through company, national bank inflation data and Gross Domestic Product (GDP) reports, etc. They describe a (market) situation in the past. The time delay is specific to the market branch. It can be very short (e.g. stock market offer is updated every minute or so and this information is quasi-immediately available) or long, like months in the case of agricultural markets, when the decisions are taken based on the results from the previous harvest. The analysis of the information flow delay can be based oil the Ausloos-Clippe-Pekalski (ACP) model of spatial evolution of economic systems. The entities can move on a (square) lattice and when meeting take one of the two following decisions: merge or create a new entity. The decision is based on the system state, which is known with some time delay. The effect of system's feedback is hereby investigated. We consider the case of company distribution evolution in a heterogeneous field. The information flow time delay implies different final states, including cycles; it is like a control parameter in a logistic map. (C) 2007 Elsevier BN. All rights reserved. [less ▲]

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See detailDelayed introduction of reduced-dose tacrolimus, and renal function in liver transplantation: the 'ReSpECT' study
Neuberger, J. M.; Mamelok, R. D.; Neuhaus, P. et al

in American Journal of Transplantation (2009), 9(2), 327-336

We report a multicenter, prospective, randomized, open-label trial investigating the effect of lower levels and delayed introduction of tacrolimus on renal function in liver transplant recipients. Adult ... [more ▼]

We report a multicenter, prospective, randomized, open-label trial investigating the effect of lower levels and delayed introduction of tacrolimus on renal function in liver transplant recipients. Adult patients with good renal function undergoing primary liver transplant were randomized to either: group A (standard-dose tacrolimus [target trough levels >10 ng/mL] and corticosteroids; n = 183); group B (mycophenolate mofetil [MMF] 2g/day, reduced-dose tacrolimus [target trough levels </=8 ng/mL], and corticosteroids; n = 170); group C (daclizumab induction, MMF, reduced-dose tacrolimus delayed until the fifth day posttransplant and corticosteroids, n = 172). The primary endpoint was change from baseline in estimated glomerular filtration rate (eGFR) at 52 weeks. The eGFR decreased by 23.61, 21.22 and 13.63 mL/min in groups A, B and C, respectively (A vs C, p = 0.012; A vs B, p = 0.199). Renal dialysis was required less frequently in group C versus group A (4.2% vs. 9.9%; p = 0.037). Biopsy-proven acute rejection rates were 27.6%, 29.2% and 19.0%, respectively. Patient and graft survival was similar. In conclusion, daclizumab induction, MMF, corticosteroids and delayed reduced-dose tacrolimus was associated with less nephrotoxicity than therapy with standard-dose tacrolimus and corticosteroids without compromising efficacy or tolerability. [less ▲]

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See detailDelayed massive immune hemolysis mediated by minor ABO incompatibility after allogeneic peripheral blood progenitor cell transplantation.
Salmon, Jean ULg; Michaux, S.; Hermanne, J. P. et al

in Transfusion (1999), 39(8), 824-7

BACKGROUND: Bone marrow transplantation with minor ABO incompatibility may be followed by moderate delayed hemolysis of the recipient's red cells by donor-derived ABO antibodies. This reaction may be more ... [more ▼]

BACKGROUND: Bone marrow transplantation with minor ABO incompatibility may be followed by moderate delayed hemolysis of the recipient's red cells by donor-derived ABO antibodies. This reaction may be more severe after transplantation of peripheral blood progenitor cells (PBPCs). CASE REPORT: A 16-year-old boy underwent an allogeneic PBPC transplant from his HLA-mismatched mother as treatment for acute myeloblastic leukemia that had proved resistant to induction chemotherapy. Transfusion of the unmanipulated PBPCs proceeded without any complication, despite the difference in ABO blood group (donor, O Rh-positive; recipient, A Rh-positive). On Day 7, a rapid drop in hemoglobin to 4 g per dL was observed, which was attributed to a massive hemolysis. All the recipient's group A red cells were destroyed within 36 hours. This delayed and rapidly progressive hemolytic anemia was not associated with the transfusion of the donor's plasma. Rather, the anti-A titer increased in parallel with marrow recovery, which suggested an active synthesis of these antibodies by immunocompetent cells from the donor against the recipient's red cells. The mother's anti-A titer was retrospectively found to be 2048. Her unusually high titer is probably due to prior sensitization during pregnancies. On Day 12, the patient developed grade IV graft-versus-host disease, which proved resistant to all treatments instituted and led to his death on Day 35. CONCLUSION: PBPC transplantation with minor ABO incompatibility may be associated with significant risk of massive delayed hemolysis. [less ▲]

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See detailDelayed neuroendocrine sexual maturation in female rats after a very low dose of Bisphenol A through altered GABAergic neurotransmission and opposing effects of a high dose.
Franssen, Delphine ULg; GERARD, Arlette ULg; HENNUY, Benoit ULg et al

in Endocrinology (2016)

Rat sexual maturation is preceded by a reduction of the interpulse interval (IPI) of gonadotropinreleasing hormone (GnRH) neurosecretion. This work aims at studying disruption of that neuroendocrine event ... [more ▼]

Rat sexual maturation is preceded by a reduction of the interpulse interval (IPI) of gonadotropinreleasing hormone (GnRH) neurosecretion. This work aims at studying disruption of that neuroendocrine event in females after early exposure to a very low dose of Bisphenol A (BPA), a ubiquitous endocrine disrupting chemical. Female rats were exposed to vehicle or BPA 25 ng/kg.day, 25 g/kg.day, or 5 mg/kg.day from postnatal day (PND) 1 to 5 or 15. Exposure to 25 ng/kg.day of BPA for 5 or 15 days was followed by a delay in developmental reduction of GnRH IPI studied ex vivo on PND 20. After 15 days of exposure to that low dose of BPA, vaginal opening tended to be delayed. In contrast, exposure to BPA 5 mg/kg.day for 15 days resulted in a premature reduction inGnRHIPI and a trend toward early vaginal opening. RNAseq analysis on PND20 indicated that exposure to BPA resulted in opposing dose effectsonthemRNAexpression of hypothalamic genes involved inGABAA neurotransmission. The study of GnRH secretion in vitro in the presence of GABAA receptor agonist/antagonist confirmed an increased or a reduced GABAergic tone after in vivo exposure to the very low or the high dose of BPA, respectively. Overall, we show for the first time that neonatal exposure to BPA leads to opposing dose-dependent effects on the neuroendocrine control of puberty in the female rat. A very low and environmentally relevant dose of BPA delays neuroendocrine maturation related to puberty through increased inhibitory GABAergic neurotransmission. [less ▲]

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See detailDelayed neutrophil apoptosis in bovine subclinical mastitis.
Boutet, Philippe ULg; Boulanger, D.; Gillet, Laurent ULg et al

in Journal of Dairy Science (2004), 87(12), 4104-4114

Bovine subclinical mastitis can be defined as a moderated inflammatory disease characterized by a persistent accumulation of neutrophils in milk. As GMCSF-mediated delay of neutrophil apoptosis ... [more ▼]

Bovine subclinical mastitis can be defined as a moderated inflammatory disease characterized by a persistent accumulation of neutrophils in milk. As GMCSF-mediated delay of neutrophil apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many human diseases, we sought to determine whether subclinical mastitis in cows is also associated with a GMCSF-dependent increase in milk-neutrophil survival. We first addressed the hypothesis that GMCSF delays bovine neutrophil apoptosis by activation of the signal transducer and activator of transcription (STAT) family members STAT3 and STAT5, which are critical regulators of the expression of various Bcl-2 family proteins. Granulocyte-macrophage colony-stimulating factor significantly delayed apoptosis of blood neutrophils obtained from healthy cows. In these cells, GMCSF activated STAT5, but not STAT3, and induced an increase in the mRNA of the antiapoptotic Bcl-2 member, Bcl-xL. Granulocyte-macrophage colony-stimulating factor-dependent STAT5 activation and up-regulation of Bcl-xL mRNA were blocked by the Jak inhibitor, AG-490. This inhibition was associated with abrogation of the prosurvival effect of GMCSF, demonstrating a key role for STAT5 in delayed neutrophil apoptosis. We further found that GMCSF expression was increased in milk cells from cows affected with subclinical mastitis. Neutrophils from these cows demonstrated a significant delay of apoptosis as compared with neutrophils obtained from healthy cows and were unresponsive to GMCSF. Active STAT5 complexes were detected in these neutrophils. Finally, in the presence of AG-490, apoptosis was induced and a time-dependent down-regulation of Bcl-xL mRNA was observed in milk neutrophils from mastitis-affected cows. These results indicate that neutrophil survival is enhanced in milk of subclinical mastitis-affected cows and suggest a role for a GMCSF-activated STAT5 signaling pathway in this phenomenon. This pathway could thus represent a target for the control of persistent accumulation of neutrophils in the bovine mammary gland [less ▲]

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See detailDelayed onset muscle soreness induced by eccentric isokinetic exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Forthomme, Bénédicte ULg et al

in Isokinetics & Exercise Science (2003), 11(1), 21-29

Delayed onset muscle soreness (DOMS) follows unaccustomed muscular exercise, most notably in the eccentric mode. That concept refers to a dull ache combined with tenderness, stiffness and weakness of the ... [more ▼]

Delayed onset muscle soreness (DOMS) follows unaccustomed muscular exercise, most notably in the eccentric mode. That concept refers to a dull ache combined with tenderness, stiffness and weakness of the previously active muscles. lsokinetic device constitutes a specific model in generating and investigating DOMS. Respective effects of concentric and eccentric actions have been compared, emphasizing on the variability in the response (serum activity of CK for instance). The particular sensitivity of the hamstrings was underlined although causes remained unexplained. Some treatment have been proposed in the management of DOMS. Several studies reported that anti-inflammatory agents fail to alleviate pain and discomfort even if other authors indicated a relative effectiveness. Based on the repeated-bout effect, submaximal eccentric exercise currently represent the most useful preventive strategy. [less ▲]

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