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See detailDefence responses induced in tobacco cells by Bacillus lipopeptides acting as elicitors of systemic resistance in plants
Henry, G.; Jourdan, E.; Thonart, Philippe ULg et al

in Journal of Plant Pathology [=JPP] (2008), 90

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See detailDéfense anti-missile et dissuasion nucléaire : un jeu contradictoire, exclusif ou complémentaire ?
Dumoulin, André ULg

in Revue Défense Nationale (2011), (2),

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See detailLa défense belge dans le futur
Dumoulin, André ULg

in Revue de Défense nationale (2015), (4),

Analyse de l'évolution récente de l'armée belge avec quelques propositions relatives à son avenir dans le cadre de la préparation d'un nouveau plan stratégique à l'horizon 2030

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See detailLa défense chimique chez les insectes
Laurent, Pascal ULg

Article for general public (2002)

Dans la nature, la survie d’une population animale est étroitement liée aux possibilités qu’elle a de se nourrir, de se reproduire et de se défendre vis-à-vis des prédateurs. Chez les insectes, cette ... [more ▼]

Dans la nature, la survie d’une population animale est étroitement liée aux possibilités qu’elle a de se nourrir, de se reproduire et de se défendre vis-à-vis des prédateurs. Chez les insectes, cette dernière nécessité est à l’origine de l’apparition, au cours de l’évolution, de mécanismes de défense plus ou moins sophistiqués chez de nombreuses espèces. Cet article discute des différents mécanismes de défense chez les insectes et présente plus particulièrement les défenses chimiques chez les chrysomèles, les coccinelles et les fourmis. [less ▲]

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See detailLa défense de Liège (1914)
Bechet, Christophe ULg

in Maréchal, Christine; Schloss, Claudine (Eds.) 1914-1918 : Vivre la guerre à Liège et en Wallonie (2014)

Christophe Bechet explique aux lecteurs le système de défense mis en place autour de Liège et la manière dont les Allemands vont s’en emparer. Il rappelle ainsi fort à propos que le point faible de cette ... [more ▼]

Christophe Bechet explique aux lecteurs le système de défense mis en place autour de Liège et la manière dont les Allemands vont s’en emparer. Il rappelle ainsi fort à propos que le point faible de cette défense est l’intervalle entre les forts. Et que Moltke, le chef d’état-major allemand qui a succédé à Schlieffen, conçoit dès lors l’idée de prendre Liège rapidement, par un coup de main, spéculant sur le fait qu’une fois la ville prise, les forts se rendraient. Mais les forts eux-mêmes ne sont pas exempts de défauts (à dire vrai plutôt nombreux !) sans compter la démoralisation des troupes qui se sentaient prises au piège. L’agonie des forts, que raconte Christophe Bechet par le détail, allait durer jusqu’au 16 août. [less ▲]

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See detailLa défense des libertés à l’épreuve des extrémismes politiques et religieux !
Jamin, Jérôme ULg

Article for general public (2008)

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See detailUne défense du contenu non conceptuel de Christopher Peacocke
Gauvry, Charlotte ULg

in Gauvry, Charlotte; Brisart, Robert (Eds.) Perception et concept. Le conceptualisme en question (in press)

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See detailDéfense et illustration de l'analyse des discours universitaires
Defays, Jean-Marc ULg

in Defays, Jean-Marc; Englebert, Annick; Pollet, Marie-Christine (Eds.) et al Principes et typologie des discours universitaires (2009)

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See detailDefense of the bovine mammary gland by polymorphonuclear neutrophil leukocytes
Paape, Max; Mehrzad, Jalil; Zhao, Xin et al

in Journal of Mammary Gland Biology and Neoplasia (2002), 7(2), 109-121

The primary phagocytic cells of the bovine mammary gland, polymorphonuclear neutrophil leukocytes (PMN), and macrophages, comprise the first line of defense against invading pathogens. In the normal ... [more ▼]

The primary phagocytic cells of the bovine mammary gland, polymorphonuclear neutrophil leukocytes (PMN), and macrophages, comprise the first line of defense against invading pathogens. In the normal healthy mammary gland, macrophages predominate and act as sentinels to invading mastitis-causing pathogens. Once invaders are detected, macrophages, and possibly mammary epithelial cells, release chemoattractants that direct migration of PMN into the area. In the mammary gland, protection is only effective if rapid influx of PMN from the circulation and subsequent phagocytosis and killing of bacteria occur. The second line of defense against infection consists of a network of memory cells and immunoglobulins that interact with the first line of defense. To minimize mammary tissue damage caused by bacterial toxins and oxidative products released by PMN, elimination of invading bacteria must proceed quickly. Therefore, the inflammatory response needs to be regulated. Hormones, metabolites, and acute phase proteins act to influence the outcome of mastitis, especially around parturition. The number of circulating PMN in cows during early lactation is highly heritable and closely related to susceptibility to clinical mastitis at this time. Advances in molecular biology are making available the tools, techniques, and products to study and modulate host-pathogen interactions. For example, the cloning and expression of proteins such as recombinant bovine soluble (rbos) CD (cluster of differentiation) 14 antigens, may provide ways of minimizing damaging effects of endotoxin during acute coliform mastitis. Soluble CD14 binds and neutralizes lipopolysacharide (LPS) and causes local recruitment of PMN after binding of CD14-LPS complexes to mammary epithelial cells. Development of transgenic animals that express rbosCD14 in their milk could prevent infection by Gram-negative pathogens. [less ▲]

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See detailLa défense sociale : réinventée ou moins paradoxale ?
Garcet, Serge ULg

Scientific conference (2014, April 29)

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See detailDéfense végétale, biotechnologies et développement de bio-insecticides
Francis, Frédéric ULg; Blecker, Christophe ULg; Deroanne, Claude et al

in Abstract book (2006)

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See detailDefensins in (lymph)angiogenesis
Herfs, Michael ULg

Conference (2014, May)

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See detailDefensins: « simple » antimicrobial peptides or broad-spectrum molecules ?
Suarez-Carmona, Meggy ULg; Hubert, Pascale ULg; Delvenne, Philippe ULg et al

in Cytokine & Growth Factor Reviews (2015), 26

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See detailDefensis induce the recruitment of dendritic cells in cervical human papillomavirus-associated (pre)neoplastic lesions formed in vitro and transplanted in vivo
Hubert, Pascale ULg; Herman, Ludivine ULg; Maillard, Catherine ULg et al

in FASEB Journal (2007), 21(11), 2765-75

In addition to their direct antimicrobial activity, defensins might also influence adaptive immunity by attracting immature dendritic cells (DC). As these cells have been shown to be deficient in uterine ... [more ▼]

In addition to their direct antimicrobial activity, defensins might also influence adaptive immunity by attracting immature dendritic cells (DC). As these cells have been shown to be deficient in uterine cervix carcinogenesis, we evaluated the ability of -defensin (HNP-2, human neutrophil defensin 2) and ß-defensin (HßD2, human beta defensin 2) to stimulate their migration in human papillomavirus (HPV)-associated (pre)cancers. We first observed, using RT-PCR and immunohistology, that HßD2 is absent in HPV-transformed keratinocytes and that it is weakly expressed in cervical (pre)neoplastic lesions in comparison with normal keratinocytes. We next demonstrated that defensins exert a chemotactic activity for DC in a Boyden Chamber assay and stimulate their infiltration in an in vitro-formed (pre)neoplastic epithelium (organotypic culture of HPV-transformed keratinocytes). To evaluate the ability of defensins also to recruit DC in vivo, we developed a model of immunodeficient mice grafted with organotypic cultures of HPV+ keratinocytes, which form an epithelium similar to a high-grade neoplastic lesion, with tumoral invasion and neovascularization. Intravenously injected human DC were able to infiltrate grafts of HPV+ keratinocytes after administration of HNP-2 in the transplantation chamber. Taken together, these results suggest that defensins could reverse a frequent immune alteration observed in cancer development. [less ▲]

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