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See detailLes dispositifs transdermiques et la fonction barrière cutanée.
Uhoda, Emmanuelle ULg; Salomon Neira, Martin; Pierard, Gérald ULg

in Skin (2004), 7

La couche cornée, exerce une remarquable fonction barrière limitant à la fois la perte d’eau et d’électrolytes par la peau et la pénétration de xénobiotiques dans l'organisme. Les dispositifs ... [more ▼]

La couche cornée, exerce une remarquable fonction barrière limitant à la fois la perte d’eau et d’électrolytes par la peau et la pénétration de xénobiotiques dans l'organisme. Les dispositifs transdermiques cherchent à contourner cette propriété afin de forcer le passage d’une quantité contrôlée de substances pharmacologiquement actives au travers de la peau. Le but est de transférer par la microvascularisation cutanée la substance souhaitée, tout en évitant les aléas tant de la dégradation et l'absorption irrégulière par le tractus digestif que de la métabolisation au cours du premier passage hépatique. Cette méthode est indiquée pour un nombre limité de principes actifs puissants ayant une biodisponibilité orale faible ou courte. La sonophorèse et l'iontophorèse sont deux autres méthodes recherchant le même but. [less ▲]

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See detailDispositifs. Le point de vue d'un psychosociologue
Faulx, Daniel ULg

in TransFormations : Recherche en Education des Adultes (2012), 7

(par Gilles Leclercq) Daniel Faulx quant à lui porte un regard décalé sur la notion de dispositif. La lecture des articles lui a enseigné que « la notion de dispositif occupe une place centrale dans la ... [more ▼]

(par Gilles Leclercq) Daniel Faulx quant à lui porte un regard décalé sur la notion de dispositif. La lecture des articles lui a enseigné que « la notion de dispositif occupe une place centrale dans la réflexion sur la formation, mais aussi sur l’apprentissage (Saderi et Triby ; Pagani), l’alternance (Coiduras, Carrera & Jové), les valeurs (Dumet), la place des technologies dans la formation (Farla-Fortecoëf), l’activité professionnelle, la professionnalisation (Briquet-Duhaze & Moal) et la socialisation professionnelle (Frétigné), l’identité (Amblard), le développement individuel (Farla-Fortecoëf ) et collectif (Pagani) ». Pour Faulx, une vision commune du dispositif se dégage des différentes contributions. Il la résume en mentionnant la formule emblématique suggérée dans l’appel à contributions : la conception d’un dispositif se poursuit dans son usage. Le dispositif devient un entre-deux (Amblard ; Pagani), une construction sociale relative devant être abordée dans toute sa complexité humaine, historique (Sadéry et Triby ; Frétigné) et socio-relationnelle (Clénet). Cette vision lui semble particulièrement heuristique car elle conduit à passer d’une conception du dispositif comme simple anticipation à mettre en œuvre de la manière la plus efficace et fidèle possible au profit d’une construction permanente. En ce sens, ce numéro participe pour Faulx au développement d’une anthropologie des dispositifs. En regard de cela, il nous propose un éclairage oblique sur ce numéro de TransFormations en prenant appui sur la psychosociologie de l’intervention. [less ▲]

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See detailLa disposition anti-abus dans tous ses états : examen de cas concrets
Herve, Luc ULg

Conference (2013, March 25)

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See detailLa disposition générale anti-abus de l'article 344, § 1er, CIR/92
Bourgeois, Marc ULg

Conference (2011, December 01)

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See detailThe dispositional inference strikes back: Situational focus and dispositional suppression in causal attribution
Yzerbyt, V. Y.; Corneille, O.; Dumont, Muriel ULg et al

in Journal of Personality & Social Psychology (2001), 81(3), 365-376

The authors propose that correction of dispositional inferences involves the examination of situational constraints and the suppression of dispositional inferences. They hypothesized that suppression ... [more ▼]

The authors propose that correction of dispositional inferences involves the examination of situational constraints and the suppression of dispositional inferences. They hypothesized that suppression would result in dispositional rebound. In Study 1, participants saw a video of either a free or a forced speaker. Participants shown a forced speaker later made stronger dispositional inferences about a 2nd, free speaker than control participants did. Study 2 provided evidence for higher rebound among participants who reported trying harder to suppress dispositional inferences during the Ist video. In Study 3, participants were asked to focus on situational constraints or to avoid thinking about the speaker's characteristics. Only the latter instructions led to a dispositional rebound. These data support the view that the correction of dispositional inferences involves 2 processes that lead to distinct consequences in subsequent attribution work. [less ▲]

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See detailLes dispositions de la convention collective de travail: obligatoires ou normatives
Clesse, Jacques ULg

in Les 40 ans de la loi du 5 décembre 1968 sur les conventions collectives de travail (2008)

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See detailDispositions générales
Boularbah, Hakim ULg

in Les voies des recours (Jurisprudence du Code judiciaire) (2001)

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See detail« Il Dispregio del mondo di Girolamo Savonarola, nella copia inedita conservata da Jacopo Guicciardini»
Moreno, Paola ULg

in Studi e Problemi di Critica Testuale (2005), LXX

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See detailDisproportionate contribution of riparian inputs to organic carbon in freshwater systems
Marwick, TR; Van Acker, K; Darchambeau, François ULg et al

Conference (2014, April 27)

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See detailDisproportionate contribution of riparian inputs to organic carbon pools in freshwater systems
Marwick, T.R.; Borges, Alberto ULg; Van Acker, K. et al

in Ecosystems (2014), 17

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See detailDispute Resolution in the Construction Industry: Belgium
Kohl, Benoît ULg; Bourgois, S.; De Block, D. et al

in International Construction Disputes Book (2013)

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See detailLa dispute: un mode particulier du conflit verbal enfantin
Meunier, Deborah ULg

in Ionescu-Ruxndoiu (Ed.) Cooperation and conflict in ingroup and intergroup communication: selected papers from Xth biennial Congress of the IADA (2006)

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See detailDisputes au village chinois. Formes du juste et recompositions locales des espaces normatifs
Florence, Eric ULg

in Revue Bibliographique de Sinologie = Review of Bibliography in Sinology (2001), Vol. XVI

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See detailDisrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive and NMDA response deficit
Grisar, Thierry ULg; Adamantidis, Antoine ULg; Thomas, Elizabeth et al

in Journal of the Neurological Sciences (2005, November 15), 238(Suppl. 1), 288

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See detailDisrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function.
Adamantidis, Antoine ULg; Thomas, Elizabeth; Foidart, Agnès ULg et al

in European Journal of Neuroscience (2005), 21(10), 2837-44

In order to investigate the physiological properties of the melanin-concentrating hormone (MCH) we have generated and used mice from which the MCH receptor 1 gene was deleted (MCHR1(Neo/Neo) mice ... [more ▼]

In order to investigate the physiological properties of the melanin-concentrating hormone (MCH) we have generated and used mice from which the MCH receptor 1 gene was deleted (MCHR1(Neo/Neo) mice). Complementary experimental approaches were used to investigate alterations in the learning and memory processes of our transgenic model. The ability of the knockout strain to carry out the inhibitory passive avoidance test was found to be considerably impaired although no significant differences were observed in anxiety levels. This impaired cognitive property prompted us to explore modifications in N-methyl D-aspartate (NMDA) responses in the hippocampus. Intracellular recordings of CA1 pyramidal neurons in hippocampal slices from the MCHR1(Neo/Neo) mice revealed significantly decreased NMDA responses. Finally, using in situ hybridization we found a 15% reduction in NMDAR1 subunit in the CA1 region. These results show for the first time a possible role for MCH in the control of the function of the NMDA receptor. [less ▲]

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See detailDisruption in energy metabolism and mitochondrial function in a cellular model of inflammation-induced acute kidney injury
Quoilin, Caroline ULg; Mouithys-Mickalad, Ange ULg; Lécart, Sandrine et al

Poster (2013, September)

Sepsis is a very complex clinical condition characterized by stimulation of a systemic inflammatory response due to an infection. It has a profound deleterious effect on kidney functions leading to sepsis ... [more ▼]

Sepsis is a very complex clinical condition characterized by stimulation of a systemic inflammatory response due to an infection. It has a profound deleterious effect on kidney functions leading to sepsis-induced acute kidney injury (AKI). This failure seems to occur through complex mechanisms involving the immune system response, inflammatory pathways, cellular dysfunction and hemodynamic instability. To study the role of cellular energetic metabolism dysfunction and mitochondrial impairment in the occurrence of AKI during sepsis, we developed an inflammation-induced in vitro model using proximal tubular epithelial cells (HK-2) exposed to a bacterial endotoxin (lipopolysaccharide, LPS). This investigation has provided key features on the relationship between endotoxic stress and mitochondrial respiratory chain assembly defects. Firstly, we have shown that renal cells subjected to LPS are no longer capable to use adequately the available oxygen to maintain their metabolic functions. One hypothesis of this down-regulation suggests that impairment in mitochondria oxidative phosphorylation could prevent cells from using oxygen for adenosine triphosphate (ATP) production and potentially could cause sepsis-induced organ failure. Our study has then investigated this possible mitochondrial impairment to explain the decreased O2 consumption rate observed in LPS-treated HK-2 cells. After exposure to LPS, functionality of mitochondria was affected without any disturbance in their spatial organization. LPS seemed rather to interrupt mitochondrial oxidative phosphorylation by blocking cytochrome c oxidase activity. As a consequence, disruptions in the electron transport and the proton pumping across the system occurred, leading to a decrease of the mitochondrial membrane potential, an electron leakage as the form of superoxide anion, a release of cytochrome c in the cytosol and a decrease in ATP production. This irreversible defect in the production of cellular energy would support the concept that kidney failure in sepsis may occur on the basis of cytopathic hypoxia. [less ▲]

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See detailDisruption of CIC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus
Stobrawa, SM; Breiderhoff, T; Takamori, S et al

in Neuron (2001), 29(1), 185-96

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See detailDisruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin
Neilan, Tomas; Doherty, Glen; Chen, Gang et al

in American Journal of Physiology - Heart and Circulatory Physiology (2006), 291(2), 532-536

To determine the role of cyclooxygenase (COX)-2 in anthracycline-induced cardiac toxicity, we administered doxorubicin (Dox) to mice with genetic disruption of COX-2 (COX-2−/−). After treatment with Dox ... [more ▼]

To determine the role of cyclooxygenase (COX)-2 in anthracycline-induced cardiac toxicity, we administered doxorubicin (Dox) to mice with genetic disruption of COX-2 (COX-2−/−). After treatment with Dox, COX-2−/− mice had increased cardiac dysfunction and cardiac cell apoptosis compared with Dox-treated wild-type mice. The expression of the death-associated protein kinase-related apoptosis-inducing protein kinase-2 was also increased in Dox-treated COX-2−/− animals. The altered gene expression, cardiac injury, and dysfunction after Dox treatment in COX-2−/− mice was attenuated by a stable prostacyclin analog, iloprost. Wild-type mice treated with Dox developed cardiac fibrosis that was absent in COX-2−/− mice and unaffected by iloprost. These results suggest that genetic disruption of COX-2 increases the cardiac dysfunction after treatment with Dox by an increase in cardiac cell apoptosis. This Dox-induced cardiotoxicity in COX-2−/− mice was attenuated by a prostacyclin analog, suggesting a protective role for prostaglandins in this setting. [less ▲]

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See detailDisruption of PDZ protein-protein interactions inhibits Tax transformation and HTLV-1 infection capacities.
Twizere, Jean-Claude ULg; DEWULF, Jean-François; Blibek, Karim ULg et al

Poster (2011, June 06)

Human T-cell leukemia virus type I (HTLV-1) encodes a Tax oncoprotein that is critical for both viral replication and cellular transformation. HTLV-1 Tax possesses a PDZ domain binding motif (PBM) at its ... [more ▼]

Human T-cell leukemia virus type I (HTLV-1) encodes a Tax oncoprotein that is critical for both viral replication and cellular transformation. HTLV-1 Tax possesses a PDZ domain binding motif (PBM) at its C-terminus that is essential for its transforming activity in a Rat-1 model and for IL-2. Tax has been shown to interact with several PDZ domain containing proteins including PSD-95, Beta1-syntrophin, the precursor of interleukin-16, the mammalian homolog of the Drosophila discs large tumor suppressor protein Dlg, PDLIM2, Lin7, hTid1, Tip1, hScrib and MAGI3. In the 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses, we will present a specificity map for the Tax/PDZ domain interactions generated using the human ORFeome 5.1. and we will focus on some of the new Tax/PDZ interactions. [less ▲]

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